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David Cullins
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Journal Articles

Sf3b1+/K700E hematopoietic stem cells create their own expansion niche

Free
Elodie Henriet, LaShanale Wallace, John Harper, Cyrielle Holuka, Jeffrey Steinberg, Jacquelyn Myers, David Cullins, Emilia Kooienga, Mark Engelken, Guillem Castro-Bono, Brittnie-lee Duffus, Marta Derecka, Esther Obeng
Journal: Blood
Blood (2025) 146 (Supplement 1): 861.
https://doi.org/10.1182/blood-2025-861
Published: 2025
Journal Articles

Impact of different Sf3b1 mutations on hematopoietic function and erythropoiesis

Free
Brittnie-lee Duffus, Cyrielle Holuka, John Harper, Chun-Chih Tseng, Guillem Castro-Bono, Elodie Henriet, David Cullins, Steven Tittley, Salima Benbarche, Heather Sheppard, LaShanale Wallace, Omar Abdel-Wahab, Esther Obeng
Journal: Blood
Blood (2025) 146 (Supplement 1): 5620.
https://doi.org/10.1182/blood-2025-5620
Published: 2025
Journal Articles

SF3B1 mutations K700E, K666N, and R625H: Gene expression and aberrant splicing consequences

Free
Cyrielle Holuka, Brittnie-lee Duffus, John Harper, Steven Tittley, Salima Benbarche, David Cullins, Elodie Henriet, Chun-Chih Tseng, Guillem Castro-Bono, Heather Sheppard, LaShanale Wallace, Omar Abdel-Wahab, Esther Obeng
Journal: Blood
Blood (2025) 146 (Supplement 1): 5618.
https://doi.org/10.1182/blood-2025-5618
Published: 2025
Journal Articles

Single-cell analysis reveals distinct γ-globin expression profiles in sickle cell disease with pancellular fetal hemoglobin

Free
Phillip Doerfler, Yichao Li, Yu Yao, Ruopeng Feng, Thiyagaraj Mayuranathan, Jingjing Zhang, Emilia Kooienga, David Cullins, Rohith Jesudas, Dillon Williams, David Wood, Jane Hankins, Yong Cheng, Mitchell Weiss
Journal: Blood
Blood (2025) 146 (Supplement 1): 1149.
https://doi.org/10.1182/blood-2025-1149
Published: 2025
Journal Articles

Dnmt3a-mutant hematopoietic stem cells generate alloreactive T cells with graft vs host disease and graft vs leukemia effects

Free
LaShanale Wallace, Mark Engelken, John Harper, Cyrielle Holuka, Qiong Zhang, Katherine Verbist, Brandi Clark, Jaquelyn Zoine, David Cullins, Stefan Schattgen, Mireya Paulina Velasquez, Douglas Green, Heather Sheppard, Jeremy Crawford, Paul Thomas, Esther Obeng
Journal: Blood
Blood (2025) 146 (Supplement 1): 7618.
https://doi.org/10.1182/blood-2025-7618
Published: 2025
Journal Articles

Dnmt3a Mutant Hematopoietic Stem Cells Produce Hyperactive T Cells with Increased Alloimmune and Anti-Leukemic Activity

Free
LaShanale Wallace, Mark Engelken, Jacquelyn A. Myers, John Harper, Brandi Clark, David Cullins, Jaquelyn T. Zoine, Raghuvaran Shanmugam, Stefan Schattgen, M. Paulina Velasquez, Heather Sheppard, Jeremy Chase Crawford, Paul G. Thomas, Esther A. Obeng
Journal: Blood
Blood (2024) 144 (Supplement 1): 1288.
https://doi.org/10.1182/blood-2024-208666
Published: 2024
Journal Articles

SAGES1: Clinical Translation of CRISPR Genome Editing Strategy to Induce Fetal Hemoglobin to Treat Sickle Cell Disease

Free
Rachel M Levine, Erin A Dempsey, Nikitha Nimmagadda, Yoonjeong Jang, Kalin Mayberry, Jingjing Zhang, David Cullins, Catherine Willis, Alicia Powers, Young-In Kim-Hoehammer, Jie Lin, Fei Zhang, Neha Das Gupta, Will Lewis, Varun Katta, Yichao Li, Timothy Lockey, Yong Cheng, Patti Lehigh, Frank Fazio, Alexis Kristine Leonard, Akshay Sharma, Sheng Zhou, Shengdar Q Tsai, Mitchell J Weiss, Jonathan S Yen
Journal: Blood
Blood (2024) 144 (Supplement 1): 146.
https://doi.org/10.1182/blood-2024-211182
Published: 2024
Journal Articles

SF3B1 K700E Alters the Splicing of Metabolism and Stress Response Genes, Attenuating the Effect of DNMT3A Mutations in MDS

Free
Lashanale Wallace, Jacquelyn A. Myers, Mark Engelken, David Cullins, Heather Sheppard, Esther A. Obeng
Journal: Blood
Blood (2023) 142 (Supplement 1): 3215.
https://doi.org/10.1182/blood-2023-190288
Published: 2023
Journal Articles

Sequential Infusion of Tcrαβ- and CD45RA-Depleted Haploidentical Progenitor Cells Is Safe and Allows for Rapid Immune Reconstitution in Pediatric Patients with Recurrent Hematological Malignancies

Free
Ali Y Suliman, MD MSc, Ying Li, MD PhD, David Cullins, Amanda J Sooter, Janice Riberdy, PhD, Madden Renee, MD, Ewelina Mamcarz, MD, Amr Qudeimat, MD, Akshay Sharma, MBBS, Ashok Srinivasan, MD, Aimee Talleur, MD, Anusha Sunkara, MS, Guolian Kang, PhD, Stephen Gottschalk, MD, Brandon Triplett, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4574.
https://doi.org/10.1182/blood-2018-99-110886
Published: 2018