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Journal Articles

Conformation of von Willebrand factor in shear flow revealed with stroboscopic single-molecule imaging

Hans T. Bergal, Yan Jiang, Darren Yang, Timothy A. Springer, Wesley P. Wong

Blood (2022) 140 (23): 2490–2499.

https://doi.org/10.1182/blood.2022016969

Published: 2022

Includes: Supplemental data

Journal Articles

Structures of VWF tubules before and after concatemerization reveal a mechanism of disulfide bond exchange

Jacob R. Anderson, Jing Li, Timothy A. Springer, Alan Brown

Blood (2022) 140 (12): 1419–1430.

https://doi.org/10.1182/blood.2022016467

Published: 2022

Includes: Multimedia, Supplemental data

Journal Articles

Single-molecule imaging of von Willebrand factor reveals tension-dependent self-association

Hongxia Fu, Yan Jiang, Wesley P. Wong, Timothy A. Springer

Blood (2021) 138 (23): 2425–2434.

https://doi.org/10.1182/blood.2021012595

Published: 2021

Includes: Supplemental data

Journal Articles

Disulfide exchange in multimerization of von Willebrand factor and gel-forming mucins

Xianchi Dong, Timothy A. Springer

Blood (2021) 137 (9): 1263–1267.

https://doi.org/10.1182/blood.2020005989

Published: 2021

Includes: Supplemental data

Journal Articles

The von Willebrand factor D′D3 assembly and structural principles for factor VIII binding and concatemer biogenesis

Xianchi Dong, Nina C. Leksa, Ekta Seth Chhabra, Joseph W. Arndt, Qi Lu, Kevin E. Knockenhauer, Robert T. Peters, Timothy A. Springer

Blood (2019) 133 (14): 1523–1533.

https://doi.org/10.1182/blood-2018-10-876300

Published: 2019

Includes: Multimedia, Supplemental data

Journal Articles

Congenital X-Linked Myelodysplasia with Tetraploidy Is Associated with De Novo Germline C-Terminal Mutation of SEPT6, a Septin Filament Protein

Raffaele Renella, MD PhD, Katelyn Gagne, BS, Ellen Beauchamp, BA, Thorsten Schlaeger, PhD, Inga Hofmann, MD, Akiko Shimamura, MD PhD, Jonathan Fogel, BSc, Suneet Agarwal, MDPhD, Benjamin L. Ebert, MDPhD, Kyriacos Markianos, Timothy A. Springer, PhD, Mark D. Fleming, MD DPhil, David A. Williams, MD

Blood (2018) 132 (Supplement 1): 644.

https://doi.org/10.1182/blood-2018-99-114682

Published: 2018

Journal Articles

Sorting zebrafish thrombocyte lineage cells with a Cd41 monoclonal antibody enriches hematopoietic stem cell activity

John M. Gansner, Alexander D. Leung, Michael Superdock, Megan C. Blair, Michelle B. Ammerman, Ellen M. Durand, Bruce Barut, Robert I. Handin, David L. Stachura, Chafen Lu, Timothy A. Springer, Leonard I. Zon

Blood (2017) 129 (10): 1394–1397.

https://doi.org/10.1182/blood-2016-12-759993

Published: 2017

Includes: Supplemental data

Journal Articles

Structural Basis for Quinine-Dependent Antibody Binding to Platelet Integrin alphaIIbbeta3

Jianghai Zhu, PhD, Jieqing Zhu, PhD, Daniel W. Bougie, PhD, Richard H. Aster, MD, Timothy A. Springer, PhD

Blood (2015) 126 (23): 1063.

https://doi.org/10.1182/blood.V126.23.1063.1063

Published: 2015

Journal Articles

Structural basis for quinine-dependent antibody binding to platelet integrin α IIb β 3

Jianghai Zhu, Jieqing Zhu, Daniel W. Bougie, Richard H. Aster, Timothy A. Springer

Blood (2015) 126 (18): 2138–2145.

https://doi.org/10.1182/blood-2015-04-639351

Published: 2015

Journal Articles

von Willebrand factor, Jedi knight of the bloodstream

Timothy A. Springer

Blood (2014) 124 (9): 1412–1425.

https://doi.org/10.1182/blood-2014-05-378638

Published: 2014

Includes: Multimedia, Supplemental data

Journal Articles

Highly reinforced structure of a C-terminal dimerization domain in von Willebrand factor

Yan-Feng Zhou, Timothy A. Springer

Blood (2014) 123 (12): 1785–1793.

https://doi.org/10.1182/blood-2013-11-523639

Published: 2014

Includes: Supplemental data

Journal Articles

Activation of A1 Domain Adhesiveness in von Willebrand Factor by Elongational Force

Timothy A. Springer, PhD, Jongseong Kim, PhD

Blood (2012) 120 (21): SCI-16.

https://doi.org/10.1182/blood.V120.21.SCI-16.SCI-16

Published: 2012

Journal Articles

Sequence and structure relationships within von Willebrand factor

Yan-Feng Zhou, Edward T. Eng, Jieqing Zhu, Chafen Lu, Thomas Walz, Timothy A. Springer

Blood (2012) 120 (2): 449–458.

https://doi.org/10.1182/blood-2012-01-405134

Published: 2012

Includes: Supplemental data

Journal Articles

A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13

Minyun Zhou, Xianchi Dong, Carsten Baldauf, Hua Chen, Yanfeng Zhou, Timothy A. Springer, Xinping Luo, Chen Zhong, Frauke Gräter, Jianping Ding

Blood (2011) 117 (17): 4623–4631.

https://doi.org/10.1182/blood-2010-11-321596

Published: 2011

Includes: Supplemental data

Journal Articles

Closed headpiece of integrin α IIb β 3 and its complex with an α IIb β 3 -specific antagonist that does not induce opening

Jieqing Zhu, Jianghai Zhu, Ana Negri, Davide Provasi, Marta Filizola, Barry S. Coller, Timothy A. Springer

Blood (2010) 116 (23): 5050–5059.

https://doi.org/10.1182/blood-2010-04-281154

Published: 2010

Includes: Supplemental data

Journal Articles

Structural, Functional, and Dynamic Characterization of the Binding Site of RUC-1, a Novel αIIb-Specific Inhibitor of Integrin αIIbβ3.

Jieqing Zhu, PhD, Jianghai Zhu, PhD, Ana Negri, PhD, Davide Provasi, PhD, Marta Filizola, PhD, Barry S. Coller, MD, Timothy A Springer, PhD

Blood (2009) 114 (22): 151.

https://doi.org/10.1182/blood.V114.22.151.151

Published: 2009

Journal Articles

Requirement of α and β subunit transmembrane helix separation for integrin outside-in signaling

Jieqing Zhu, Christopher V. Carman, Minsoo Kim, Motomu Shimaoka, Timothy A. Springer, Bing-Hao Luo

Blood (2007) 110 (7): 2475–2483.

https://doi.org/10.1182/blood-2007-03-080077

Published: 2007

Includes: Supplemental data

Journal Articles

RIAM, a New Rap1 Effector, Functions Downstream of Rap1 and Regulates Rap1 Localization at the Plasma Membrane and Rap1-Induced Adhesion.

Esther M. Lafuente, PhD, Christopher V. Carman, PhD, Matthias Krause, PhD, Timothy A. Springer, PhD, Frank B. Gertler, PhD, Vassiliki A. Boussiotis, MD, PhD

Blood (2004) 104 (11): 510.

https://doi.org/10.1182/blood.V104.11.510.510

Published: 2004

Journal Articles

A Small-Molecule Antagonist to Integrin LFA-1 Reveals a Crucial Inter-Domain Communication as a Novel Therapeutic Target.

Motomu Shimaoka, MD, PhD, Azucena Salas, PhD, Wei Yang, PhD, Gabriele Weitz-Schmidt, PhD, Timothy A. Springer, PhD

Blood (2004) 104 (11): 650.

https://doi.org/10.1182/blood.V104.11.650.650

Published: 2004

Journal Articles

Crystal Structure of the Integrin αIIBβ3 Headpiece at 2.7–3.1 Å: Structure, Mechanisms of Activation and Ligand Binding, Inhibition by Eptifibatide, Tirofiban, and mAb 10E5, and Structure of the HPA-1 Alloantigen Epitope.

Timothy A. Springer, PhD, Junichi Takagi, PhD, Barry S. Coller, MD, Jia-Huai Wang, PhD, Tsan Xiao, PhD

Blood (2004) 104 (11): 327.

https://doi.org/10.1182/blood.V104.11.327.327

Published: 2004

NARROW

Conformation of von Willebrand factor in shear flow revealed with stroboscopic single-molecule imaging

Structures of VWF tubules before and after concatemerization reveal a mechanism of disulfide bond exchange

Single-molecule imaging of von Willebrand factor reveals tension-dependent self-association

Disulfide exchange in multimerization of von Willebrand factor and gel-forming mucins

The von Willebrand factor D′D3 assembly and structural principles for factor VIII binding and concatemer biogenesis

Congenital X-Linked Myelodysplasia with Tetraploidy Is Associated with De Novo Germline C-Terminal Mutation of SEPT6, a Septin Filament Protein

Sorting zebrafish thrombocyte lineage cells with a Cd41 monoclonal antibody enriches hematopoietic stem cell activity

Structural Basis for Quinine-Dependent Antibody Binding to Platelet Integrin alphaIIbbeta3

Structural basis for quinine-dependent antibody binding to platelet integrin α IIb β 3

von Willebrand factor, Jedi knight of the bloodstream

Highly reinforced structure of a C-terminal dimerization domain in von Willebrand factor

Activation of A1 Domain Adhesiveness in von Willebrand Factor by Elongational Force

Sequence and structure relationships within von Willebrand factor

A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13

Closed headpiece of integrin α IIb β 3 and its complex with an α IIb β 3 -specific antagonist that does not induce opening

Structural, Functional, and Dynamic Characterization of the Binding Site of RUC-1, a Novel αIIb-Specific Inhibitor of Integrin αIIbβ3.

Requirement of α and β subunit transmembrane helix separation for integrin outside-in signaling

RIAM, a New Rap1 Effector, Functions Downstream of Rap1 and Regulates Rap1 Localization at the Plasma Membrane and Rap1-Induced Adhesion.

A Small-Molecule Antagonist to Integrin LFA-1 Reveals a Crucial Inter-Domain Communication as a Novel Therapeutic Target.

Crystal Structure of the Integrin αIIBβ3 Headpiece at 2.7–3.1 Å: Structure, Mechanisms of Activation and Ligand Binding, Inhibition by Eptifibatide, Tirofiban, and mAb 10E5, and Structure of the HPA-1 Alloantigen Epitope.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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