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Journal Articles

GTx011, an Anti-Sickling Compound, Improves SS Blood Rheology By Reduction of HbS polymerization Via Allosteric Modulation of O 2 Affinity

Mira Patel, PhD, Pedro Cabrales, PhD, Kobina Dufu, PhD, Brian Metcalf, PhD, Uma Sinha, PhD

Blood (2014) 124 (21): 1370.

https://doi.org/10.1182/blood.V124.21.1370.1370

Published: 2014

Journal Articles

GTx011, a Novel Agent That Improves Rheological Properties Of Sickle Cell Blood By Increasing Oxygen Affinity For Hemoglobin

Mira Patel, PhD, Donna Oksenberg, PhD, Abel Silva, BS, Andreas Betz, PhD, Brian Metcalf, PhD, Uma Sinha, PhD

Blood (2013) 122 (21): 2207.

https://doi.org/10.1182/blood.V122.21.2207.2207

Published: 2013

Journal Articles

GTx011, a Potent Allosteric Modifier Of Hemoglobin Oxygen Affinity, Delays Polymerization and Prevents Sickling

Kobina Dufu, PhD, Donna Oksenberg, PhD, Brian Metcalf, PhD, Uma Sinha, PhD

Blood (2013) 122 (21): 316.

https://doi.org/10.1182/blood.V122.21.316.316

Published: 2013

Journal Articles

Heparin rescues factor V Leiden–associated placental failure independent of anticoagulation in a murine high-risk pregnancy model

Jianzhong An, Magarya S. Waitara, Michelle Bordas, Vidhyalakshmi Arumugam, Raymond G. Hoffmann, Brian G. Petrich, Uma Sinha, Paula E. North, Rashmi Sood

Blood (2013) 121 (11): 2127–2134.

https://doi.org/10.1182/blood-2012-08-448209

Published: 2013

Includes: Supplemental data

Journal Articles

Efficacy of PRT060318, a Novel Highly Specific SYK Inhibitor, in Acute Lymphoblastic Leukemia (ALL)

Stefan KÖhrer, MD, Greg Coffey, PhD, Ekaterina Kim, MS, Nathalie Y Rosin, PhD, Uma Sinha, PhD, Anjali Pandey, PhD, Medhat Shehata, Ulrich Jäger, Susan M. O'Brien, MD, William G. Wierda, MD, Ph.D., Zeev Estrov, MD, PhD, Deborah Thomas, MD, Hagop M Kantarjian, Jan A. Burger, MD, PhD

Blood (2012) 120 (21): 3532.

https://doi.org/10.1182/blood.V120.21.3532.3532

Published: 2012

Journal Articles

PRT064445 but Not Recombinant Fviia Reverses Rivaroxaban Induced Anticoagulation As Measured by Reduction in Blood Loss in a Rabbit Liver Laceration Model

Stanley J Hollenbach, BS, JD, Genmin Lu, PhD, Siusze Tan, BS, Gail Lee, BS, Hutchaleelaha Athiwat, PhD, Mayuko Inagaki, BS, Uma Sinha, PhD

Blood (2012) 120 (21): 3414.

https://doi.org/10.1182/blood.V120.21.3414.3414

Published: 2012

Journal Articles

PRT062070: A Dual Syk/JAK Inhibitor with Potent Immune Regulatory Capacity in Rodent Models of Inflammation and Cancer.

Greg Coffey, PhD, Francis DeGuzman, PhD, Gail Lee, BS, Lynn Kamen, PhD, Dale Baker, PhD, Stanley J Hollenbach, BS, JD, Anjali Pandey, PhD, Uma Sinha, PhD

Blood (2012) 120 (21): 2764.

https://doi.org/10.1182/blood.V120.21.2764.2764

Published: 2012

Journal Articles

SYK inhibition and response prediction in diffuse large B-cell lymphoma

Shuhua Cheng, Greg Coffey, X. Hannah Zhang, Rita Shaknovich, Zibo Song, Pin Lu, Anjali Pandey, Ari M. Melnick, Uma Sinha, Y. Lynn Wang

Blood (2011) 118 (24): 6342–6352.

https://doi.org/10.1182/blood-2011-02-333773

Published: 2011

Includes: Supplemental data

Journal Articles

Critical role for Syk in responses to vascular injury

Blood (2011) 118 (18): 5000–5010.

https://doi.org/10.1182/blood-2011-06-360743

Published: 2011

Includes: Supplemental data

Journal Articles

Suppression of HTLV-1 replication by Tax-mediated rerouting of the p13 viral protein to nuclear speckles

Vibeke Andresen, Cynthia A. Pise-Masison, Uma Sinha-Datta, Marcia Bellon, Valerio Valeri, Robyn Washington Parks, Valentina Cecchinato, Risaku Fukumoto, Christophe Nicot, Genoveffa Franchini

Blood (2011) 118 (6): 1549–1559.

https://doi.org/10.1182/blood-2010-06-293340

Published: 2011

Includes: Supplemental data

Journal Articles

PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model

Michael P. Reilly, Uma Sinha, Pierrette André, Scott M. Taylor, Yvonne Pak, Francis R. DeGuzman, Nisha Nanda, Anjali Pandey, Moritz Stolla, Wolfgang Bergmeier, Steven E. McKenzie

Blood (2011) 117 (7): 2241–2246.

https://doi.org/10.1182/blood-2010-03-274969

Published: 2011

Includes: Supplemental data

Journal Articles

P505-15, a Highly Selective SYK Inhibitor, Shows Significant Activity In Primary CLL Cells and Is Synergistic with Fludarabine at Low Concentrations

Stephen Spurgeon, MD, Luke B Fletcher, Jeffrey W Tyner, PhD, Brian J Druker, MD, Anjali Pandey, PhD, Uma Sinha, PhD, Marc M Loriaux, MD, PhD

Blood (2010) 116 (21): 2839.

https://doi.org/10.1182/blood.V116.21.2839.2839

Published: 2010

Journal Articles

Specific Inhibition of Syk Suppresses Leukocyte Immune Function and Alleviates Inflammation In Rodent Models of Rheumatoid Arthritis

Greg Coffey, PhD, DeGuzman Francis, Ph.D., Mayuko Inagaki, Yvonne Pak, Suzanne Delaney, Andreas Betz, Zhaozhong J Jia, Qing Xu, Shawn Bauer, Yonghong Song, Anjali Pandey, PhD, Dale Baker, DVM, PhD, Stanley Hollenbach, David R. Phillips, PhD, Uma Sinha, PhD

Blood (2010) 116 (21): 1727.

https://doi.org/10.1182/blood.V116.21.1727.1727

Published: 2010

Journal Articles

Spleen Tyrosine Kinase (Syk) Inhibitors Block B Cell Receptor Signaling and Survival In Chronic Lymphocytic Leukemia

Julia Hoellenriegel, Greg Coffey, PhD, Uma Sinha, PhD, Anjali Pandey, PhD, William G. Wierda, MD, PhD, Michael J Keating, MD, Jan A. Burger, MD, PhD

Blood (2010) 116 (21): 3604.

https://doi.org/10.1182/blood.V116.21.3604.3604

Published: 2010

Journal Articles

PRT060318, a Novel Syk Inhibitor, Prevents Heparin-Induced Thrombocytopenia in a Transgenic Mouse Model

Michael P. Reilly, PhD, Uma Sinha, PhD, Pierrette Andre, Scott M. Taylor, MS, Yvonne Pak, PhD, Francis R. DeGuzman, Nisha Nanda, PhD, Anjali Pandey, PhD, Steven E. McKenzie, MD, PhD

Blood (2008) 112 (11): 269.

https://doi.org/10.1182/blood.V112.11.269.269

Published: 2008

Journal Articles

Specific Pharmacological Targeting of the Syk Kinase Activity in Platelets: A Novel, Safe Anti-Thrombotic Strategy

Suzanne Delaney, PhD, Uma Sinha, PhD, Nisha Nanda, PhD, Yibing Yan, PhD, Anjali Pandey, PhD, Stan Hollenbach, Whyte Owen, PhD, David Phillips, PhD, Patrick Andre, Ph.D.

Blood (2008) 112 (11): 409.

https://doi.org/10.1182/blood.V112.11.409.409

Published: 2008

Journal Articles

Specific Inhibition of Syk Is Sufficient to Disrupt Proliferation and Survival of Non-Hodgkin’s Lymphoma Cell Lines without Concomitant Inhibition of JAK.

Greg Coffey, Ph.D., Peng Luan, Ph.D., Suzanne Delaney, Ph.D., Anjali Pandey, Ph.D., Zhaozhong Jia, Ph.D., Qing Xu, Ph.D., Shawn Bauer, Ph.D., Yonghong Song, Ph.D., Pamela B. Conley, Ph.D., David Phillips, Ph.D., Uma Sinha, Ph.D.

Blood (2008) 112 (11): 1794.

https://doi.org/10.1182/blood.V112.11.1794.1794

Published: 2008

Journal Articles

Recombinant Antidote for Reversal of Anticoagulation by Factor Xa Inhibitors.

Genmin Lu, PhD, Francis R. DeGuzman, Sanjay Lakhotia, PhD, Stanley J Hollenbach, David R Phillips, PhD, Uma Sinha, PhD

Blood (2008) 112 (11): 983.

https://doi.org/10.1182/blood.V112.11.983.983

Published: 2008

Journal Articles

Inhibition of Syk Activity Is Sufficient for Inhibitory Effect in Animal Models of Autoimmune Diseases

Stanley J Hollenbach, Greg Coffey, Francis R DeGuzman, Mayuko Inagaki, Anjali Pandey, Zhaozhong J Jia, Qing Xu, Shawn Bauer, Dale Baker, Nisha Nanda, David R Phillips, Uma Sinha

Blood (2008) 112 (11): 680.

https://doi.org/10.1182/blood.V112.11.680.680

Published: 2008

Journal Articles

Animal Models of Thrombosis Help Predict the Human Therapeutic Concentration of PRT54021, a Potent Oral Factor Xa Inhibitor.

Keith Abe, Gail Siu, Susan Edwards, Pei Hua Lin, Bing Yan Zhu, Ulla Marzec, Stephen Hanson, Yvonne Pak, Stanley Hollenbach, Uma Sinha

Blood (2006) 108 (11): 901.

https://doi.org/10.1182/blood.V108.11.901.901

Published: 2006

NARROW

GTx011, an Anti-Sickling Compound, Improves SS Blood Rheology By Reduction of HbS polymerization Via Allosteric Modulation of O 2 Affinity

GTx011, a Novel Agent That Improves Rheological Properties Of Sickle Cell Blood By Increasing Oxygen Affinity For Hemoglobin

GTx011, a Potent Allosteric Modifier Of Hemoglobin Oxygen Affinity, Delays Polymerization and Prevents Sickling

Heparin rescues factor V Leiden–associated placental failure independent of anticoagulation in a murine high-risk pregnancy model

Efficacy of PRT060318, a Novel Highly Specific SYK Inhibitor, in Acute Lymphoblastic Leukemia (ALL)

PRT064445 but Not Recombinant Fviia Reverses Rivaroxaban Induced Anticoagulation As Measured by Reduction in Blood Loss in a Rabbit Liver Laceration Model

PRT062070: A Dual Syk/JAK Inhibitor with Potent Immune Regulatory Capacity in Rodent Models of Inflammation and Cancer.

SYK inhibition and response prediction in diffuse large B-cell lymphoma

Critical role for Syk in responses to vascular injury

Suppression of HTLV-1 replication by Tax-mediated rerouting of the p13 viral protein to nuclear speckles

PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model

P505-15, a Highly Selective SYK Inhibitor, Shows Significant Activity In Primary CLL Cells and Is Synergistic with Fludarabine at Low Concentrations

Specific Inhibition of Syk Suppresses Leukocyte Immune Function and Alleviates Inflammation In Rodent Models of Rheumatoid Arthritis

Spleen Tyrosine Kinase (Syk) Inhibitors Block B Cell Receptor Signaling and Survival In Chronic Lymphocytic Leukemia

PRT060318, a Novel Syk Inhibitor, Prevents Heparin-Induced Thrombocytopenia in a Transgenic Mouse Model

Specific Pharmacological Targeting of the Syk Kinase Activity in Platelets: A Novel, Safe Anti-Thrombotic Strategy

Specific Inhibition of Syk Is Sufficient to Disrupt Proliferation and Survival of Non-Hodgkin’s Lymphoma Cell Lines without Concomitant Inhibition of JAK.

Recombinant Antidote for Reversal of Anticoagulation by Factor Xa Inhibitors.

Inhibition of Syk Activity Is Sufficient for Inhibitory Effect in Animal Models of Autoimmune Diseases

Animal Models of Thrombosis Help Predict the Human Therapeutic Concentration of PRT54021, a Potent Oral Factor Xa Inhibitor.

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American Society of Hematology

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American Society of Hematology

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