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Journal Articles

Dual Targeting of Mitochondrial Unfolded Protein Response and BCL2 in Acute Myeloid Leukemia

Ran Zhao, BS, Sarah Zarabi, MD, Takenobu Nii, PhD, Ondrej Halgas, PhD, Yulia Jitkova, PhD, Vivian Ruvolo, Lauren Heese, Yuki Nishida, MD PhD, Gautam M. Borthakur, MD, Kensuke Kojima, MD PhD, Martin Stogniew, Wolfgang Oster, MD, Emil Pai, PhD, Eric Davis, MD, Hagop M. Kantarjian, MD, Aaron D Schimmer, MD PhD, Michael Andreeff, MD PhD, Jo Ishizawa, MD PhD

Blood (2019) 134 (Supplement_1): 2562.

https://doi.org/10.1182/blood-2019-127101

Published: 2019

Journal Articles

The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Complex and Supercomplex Formation and Is Necessary for AML Viability

Blood (2019) 134 (Supplement_1): 729.

https://doi.org/10.1182/blood-2019-122784

Published: 2019

Journal Articles

The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Supercomplex Formation and Represents a New Therapeutic Target for AML

Sara Mirali, Botham Aaron, Veronique Voisin, PhD, Yihua Qiu, Fieke W Hoff, BSc, Rose Hurren, BSc, Marcela Gronda, MSc, Yulia Jitkova, PhD, G. Wei Xu, Neil MacLean, Xiaoming Wang, Terzah M. Horton, MD PhD, Steven M. Kornblau, MD, Steven M Chan, MD PhD, Gary D Bader, Aaron Schimmer, MD PhD

Blood (2018) 132 (Supplement 1): 1335.

https://doi.org/10.1182/blood-2018-99-110869

Published: 2018

Journal Articles

Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism

Blood (2018) 132 (Supplement 1): 1339.

https://doi.org/10.1182/blood-2018-99-111015

Published: 2018

Journal Articles

The Thymidine Dideoxynucleoside Analogue, Alovudine, Inhibits the Mitochondrial DNA Polyermase, POLG, Impairs Oxidative Phosphorylation and Promotes Monocytic Differentiation in AML

Dana Yehudai-Ofir, MD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Rose Hurren, BSc, Marcela Gronda, MSc, Danny V. Jeyaraju, PhD, Xiaoming Wang, Thirushi Siriwardena, Yulia Jitkova, PhD, Aaron D. Schimmer, MDPhD, Biljana Rizoska, PhD, Paul Targett-Adams, PhD, Mark Albertella, PhD

Blood (2017) 130 (Supplement 1): 2524.

https://doi.org/10.1182/blood.V130.Suppl_1.2524.2524

Published: 2017

Journal Articles

Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells

Danny V. Jeyaraju, PhD, Veronique Voisin, Changjiang Xu, Samir H. Barghout, BSPharm, MSc, Dilshad H. Khan, Rose Hurren, BSc, Marcela Gronda, MSc, Xiaoming Wang, Yulia Jitkova, PhD, David Sharon, PhD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Joelle Soriano, Eric R. Lechman, PhD, Neil MacLean, Mark D. Minden, MD PhD, Steven M. Chan, MDPhD, John E. Dick, PhD, Gary D Bader, Aaron D. Schimmer, MDPhD

Blood (2017) 130 (Supplement 1): 881.

https://doi.org/10.1182/blood.V130.Suppl_1.881.881

Published: 2017

Journal Articles

Chronic Inhibition of Mitochondrial Translation Alters Metabolism and Stemness in AML

Jhas Bozhena, BSc, Shrivani Sriskanthadevan, PhD, Marko Skrtic, PhD, Mahadeo A. Sukhai, PhD, Veronique Voisin, PhD, Yulia Jitkova, PhD, Marcela Gronda, MSc, Rose Hurren, BSc, Xiaoming Wang, Rob C. Laister, PhD, Gary D. Bader, Ph.D., Mark D. Minden, MD, PhD, Aaron D. Schimmer, MD

Blood (2012) 120 (21): 1364.

https://doi.org/10.1182/blood.V120.21.1364.1364

Published: 2012

Journal Articles

Clinical Proof of Concept Trial of Oral Ciclopirox Olamine in Patients with Relapsed/Refractory Hematologic Malignancy

Mark D. Minden, MD, PhD, FRCPC, Donna E. Hogge, MD, PhD, FRCPC, Scott Weir, PharmD, PhD, Jim Kasper, MS, Lavonne Patton, PhD, Yulia Jitkova, PhD, Marcela Gronda, MSc, Rose Hurren, BSc, Lian Rajewski, Kevin Schorno, MBA, Hong Chang, Joseph M. Brandwein, MD, Vikas Gupta, MD, FRCP, FRCPath, Andre C. Schuh, MD, FRCPC, Suzanne Trudel, MD, MSC, FRCPC, Karen W.L. Yee, MD, FRCP, Greg Reed, Aaron D Schimmer, MD, PhD

Blood (2012) 120 (21): 1372.

https://doi.org/10.1182/blood.V120.21.1372.1372

Published: 2012

Journal Articles

AML Cells Have Altered Mitochondrial Biogenesis and Low Spare Reserve Capacity in Their Respiratory Chain That Renders Them Susceptible to Oxidative Metabolic Stress.

Shrivani Sriskanthadevan, PhD, Timothy E Chung, Marko Skrtic, PhD, Bozhena Jhas, BSc, Rose Hurren, BSc, Marcela Gronda, MSc, Xiao Ming Wang, Yulia Jitkova, PhD, Mahadeo A. Sukhai, PhD, Feng-Hsu Lin, PhD, Neil Maclean, BSc, Rob C. Laister, PhD, Peter Mullen, PhD, Stephanie Xie, Linda Penn, PhD, Ian M. Rogers, PhD, John E. Dick, PhD $, Mark D. Minden, MD, PhD, Aaron D Schimmer, MD, PhD

Blood (2012) 120 (21): 2581.

https://doi.org/10.1182/blood.V120.21.2581.2581

Published: 2012

Journal Articles

Inhibition of Mitochondrial Translation As a Therapeutic Strategy for Acute Myeloid Leukemia (AML)

Blood (2011) 118 (21): 233.

https://doi.org/10.1182/blood.V118.21.233.233

Published: 2011

Journal Articles

AML Cells Have Increased Mitochondrial Mass but Less Reserve in Their Respiratory Chain Complexes Leading to Heightened Sensitivity to Inhibition of Mitochondrial Protein Translation,

Shrivani Sriskanthadevan, PhD, Skrtic Marko, BSc, Bozhena Livak, BSc, Yulia Jitkova, PhD, Rose Hurren, BSc, Marcela Gronda, MSc, Rob Laister, PhD, Peter Mullen, PhD, Linda Penn, PhD, Mark D. Minden, MD, PhD, Aaron D Schimmer, MD, PhD

Blood (2011) 118 (21): 3585.

https://doi.org/10.1182/blood.V118.21.3585.3585

Published: 2011

NARROW

Dual Targeting of Mitochondrial Unfolded Protein Response and BCL2 in Acute Myeloid Leukemia

The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Complex and Supercomplex Formation and Is Necessary for AML Viability

The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Supercomplex Formation and Represents a New Therapeutic Target for AML

Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism

The Thymidine Dideoxynucleoside Analogue, Alovudine, Inhibits the Mitochondrial DNA Polyermase, POLG, Impairs Oxidative Phosphorylation and Promotes Monocytic Differentiation in AML

Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells

Chronic Inhibition of Mitochondrial Translation Alters Metabolism and Stemness in AML

Clinical Proof of Concept Trial of Oral Ciclopirox Olamine in Patients with Relapsed/Refractory Hematologic Malignancy

AML Cells Have Altered Mitochondrial Biogenesis and Low Spare Reserve Capacity in Their Respiratory Chain That Renders Them Susceptible to Oxidative Metabolic Stress.

Inhibition of Mitochondrial Translation As a Therapeutic Strategy for Acute Myeloid Leukemia (AML)

AML Cells Have Increased Mitochondrial Mass but Less Reserve in Their Respiratory Chain Complexes Leading to Heightened Sensitivity to Inhibition of Mitochondrial Protein Translation,

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ASH Publications

American Society of Hematology

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ASH Publications

American Society of Hematology

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