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Journal Articles

Deletion of TLR4 in Townes SS Mice Prevents Microvascular Stasis in Response to Hemin, LPS and Hypoxia/Reoxygenation: Role of Inflammation

John D Belcher, PhD, Fuad Abdulla, Chunsheng Chen, Ping Zhang, PhD, Dormarie Rivera-Rodriguez, Rachel Kirchner, Julia Nguyen, Zachary Monroe Kiser, BS, PhD, Kristine Nachbor, Jacob Lloyd, MD, Gregory M Vercellotti, MD

Blood (2019) 134 (Supplement_1): 3555.

https://doi.org/10.1182/blood-2019-127114

Published: 2019

Journal Articles

Innate Immune Mechanism of Hemarthrosis in Hemophilia-a Mice

Tomasz W. Kaminski, PharmD, Egemen Tutuncuoglu, MSc, Margaret V. Ragni, MD MPH, Mark T Gladwin, MD, Prithu Sundd, PhD

Blood (2019) 134 (Supplement_1): 1043.

https://doi.org/10.1182/blood-2019-130471

Published: 2019

Journal Articles

Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes

Grace A Ward, BS, Kathy McGraw, PhD, Amy F McLemore, M.S., Nghi B Lam, M.S., Hsin-An Hou, Benjamin S. Meyer, Alan F. List, MD

Blood (2019) 134 (Supplement_1): 774.

https://doi.org/10.1182/blood-2019-122358

Published: 2019

Journal Articles

S100A9 Contributes to T Cell Dysfunction through Its Interaction with RAGE in MDS

Wendy Kandell, BS, Thu Le Trinh, PhD, Xianghong Chen, PhD, Pingyan Cheng, MD, Danielle Gilvary, BS, Yin-Kai Chen, MD, Alexandra Calescibetta, Erika Adriana Eksioglu, MS PhD, Alan F. List, MD, Sheng Wei, MD

Blood (2019) 134 (Supplement_1): 4228.

https://doi.org/10.1182/blood-2019-128717

Published: 2019

Journal Articles

Lactate Dehydrogenase to Carboxyhemoglobin Ratio As a Biomarker of Heme Release to Heme Processing Is Associated with Higher Tricuspid Regurgitant Jet Velocity and Early Death in Sickle Cell Disease

Annelies J. Van Vuren, MD, Laurel Mendelsohn, BS, Richard van Wijk, PhD, Caterina P. Minniti, MD, John Baird, MD, Gregory J Kato, MD, Eduard J. van Beers, MD PhD

Blood (2019) 134 (Supplement_1): 2274.

https://doi.org/10.1182/blood-2019-124048

Published: 2019

Journal Articles

A Unique Monocyte Transcriptome Discriminates Sickle Cell Disease from Other Hereditary Hemolytic Anemias and Shows the Particular Importance of Lipid and Interferon Signaling

Annelies J. Van Vuren, MD, Stephanie van Straaten, MD PhD, Michal Mokry, PhD, Richard van Wijk, PhD, Eduard J. van Beers, MD PhD

Blood (2019) 134 (Supplement_1): 980.

https://doi.org/10.1182/blood-2019-124070

Published: 2019

Journal Articles

Signaling mechanisms inducing hyporesponsiveness of phagocytes during systemic inflammation

Nicole Freise, Alina Burghard, Theresa Ortkras, Niklas Daber, Achmet Imam Chasan, Saskia-L. Jauch, Olesja Fehler, Julia Hillebrand, Mosab Schakaki, Jessica Rojas, Bodo Grimbacher, Thomas Vogl, Andreas Hoffmeier, Sven Martens, Johannes Roth, Judith Austermann

Blood (2019) 134 (2): 134–146.

https://doi.org/10.1182/blood.2019000320

Published: 2019

Includes: Supplemental data

Journal Articles

Heme Induces Significant Neutrophil Adhesion in Vitro Via an Nfκb -Dependent Pathway

Lediana I. Miguel, M.Sc., Lidiane S. Torres, PhD, Wilson A. Ferreira, Jr., PhD, Fernanda C. Z. Fabris, B.Sc., Flavia C. Leonardo, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2018) 132 (Supplement 1): 3610.

https://doi.org/10.1182/blood-2018-99-118974

Published: 2018

Journal Articles

18β-Glycyrrhetic Acid Modulates Th1/Th17/Th22/Regulatory T Cells Homeostasis Via HMGB1/NF-κB Signaling Pathway in Immune Thrombocytopenia

Haoyi Wang, Yajing Zhao, BA, MD, Ning An, Panpan Han, Sun Yunqi, Ming Hou, MD

Blood (2018) 132 (Supplement 1): 1144.

https://doi.org/10.1182/blood-2018-99-115137

Published: 2018

Journal Articles

Regulatory Genetic Variation at the S100B Gene Associates with Vaso-Occlusive Manifestations in Sickle Cell Disease

Xu Zhang, PhD, Wei Zhang, PhD, Santosh L. Saraf, MD, Sergei Nekhai, PhD, Mark T Gladwin, MD, Roberto Machado, Victor R. Gordeuk, MD

Blood (2018) 132 (Supplement 1): 1063.

https://doi.org/10.1182/blood-2018-99-115395

Published: 2018

Journal Articles

SNP-Array Genome Wide Association Study Meta-Analysis Identifies Innate Immune Susceptibility Loci Associated with Non-Del(5q) Myelodysplastic Syndromes Predisposition

Blood (2018) 132 (Supplement 1): 107.

https://doi.org/10.1182/blood-2018-99-118747

Published: 2018

Journal Articles

HMGB1 Causes Anemia of Inflammation By Modulating Erythropoietin Signal Transduction

Brian M Dulmovits, MS, Julien Papoin, MS, Jian Hua Li, MS, Huan Yang, PhD, Ronak H Shah, MS, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Yousef Al-Abed, MD, Lily Huang, PhD, Betty Diamond, MD, Jeffrey M Lipton, MD PhD, Mohandas Narla, DSc, Ulf Andersson, MDPhD, Kevin Tracey, MD, Lionel Blanc, PhD

Blood (2018) 132 (Supplement 1): 628.

https://doi.org/10.1182/blood-2018-99-119553

Published: 2018

Journal Articles

Oxidized Mitochondrial DNA Is a Catalyst and Biomarker of Pyroptotic Cell Death in Myelodysplastic Syndromes

Grace A Ward, BS, Kathy L McGraw, PhD, Amy F McLemore, M.S., Farnoosh Abbas-Aghababazadeh, PhD, Hsin-An Hou, MD PhD, Thu Le Trinh, PhD, Nicole D. Vincelette, PhD, Benjamin S. Meyer, Alexis H Onimus, BS, Alexandra Calescibetta, Erika A Eksioglu, PhD MS, Sheng Wei, MD, Alan F. List, MD

Blood (2018) 132 (Supplement 1): 3076.

https://doi.org/10.1182/blood-2018-99-118493

Published: 2018

Journal Articles

The S100A9/Fto Axis Induces Formation of RNA:DNA Hybrids That Serve As Damps Initiating Myeloid Skewing & Genetic Injury in MDS

Erika Eksioglu, PhD MS, Xianghong Chen, PhD, Pingyan Cheng, MD, Jinhong Liu, MD, Kathy McGraw, PhD, David A Sallman, MD, Eric Padron, MD, Alan F List, MD, Sheng Wei, MD

Blood (2017) 130 (Supplement 1): 52.

https://doi.org/10.1182/blood.V130.Suppl_1.52.52

Published: 2017

Journal Articles

High Mobility Group Box 1 Protein (HMGB1) Mediates Anemia of Inflammation through Lineage Skewing and Direct Inhibition of EPO Signaling

Brian M Dulmovits, MS, Julien Papoin, MS, Jian Hua Li, MS, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Yousef Al-Abed, MD, Luanne L. Peters, PhD, Betty Diamond, MD, Anupama Narla, MD, Jeffrey M Lipton, MDPhD, Mohandas Narla, DSc, Kevin Tracey, MD, Lionel Blanc, PhD

Blood (2017) 130 (Supplement 1): 2196.

https://doi.org/10.1182/blood.V130.Suppl_1.2196.2196

Published: 2017

Journal Articles

HMGB1 Accelerates Regeneration of Multiple Tissues By Transitioning Stem Cells to G Alert

Geoffrey Lee, MD, Ana Espirito Santo, Stefan Zwingenberger, Emilie Venereau, Lawrence Cai, Thomas Vogl, Marc Feldmann, Nicole Horwood, Marco Bianchi, James Chan, Jagdeep Nanchahal

Blood (2017) 130 (Supplement 1): 3767.

https://doi.org/10.1182/blood.V130.Suppl_1.3767.3767

Published: 2017

Journal Articles

Increased Mitochondrial DNA in an ECMO Model Is Associated with Loss of Platelet Function

James Bynum, PhD, Andrew Meyer, MD MS, Daniel N Darlington, PhD, Colby McIntosh, BS, Grantham Peltier, MS, Ashley S Taylor, BA, Michael Meledeo, PhD, Andrew P. Cap, MD PhD

Blood (2017) 130 (Supplement 1): 1126.

https://doi.org/10.1182/blood.V130.Suppl_1.1126.1126

Published: 2017

Journal Articles

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Blood (2016) 128 (25): 2960–2975.

https://doi.org/10.1182/blood-2016-07-730556

Published: 2016

Includes: Supplemental data

Journal Articles

Heme Induces NLRP3 Inflammasome Formation in Primary Human Macrophages and May Propagate Hemolytic Inflammatory Processes By Inducing S100A8 Expression

Angelica A. Silveira, M.Sc., Clare Cunningham, PhD, Emma Corr, B.Sc., Wilson Alves Ferreira, Jr., PhD, Fernando F. Costa, MD, PhD, Camila B. Almeida, PhD, Nicola Conran, PhD, Aisling Dunne, PhD

Blood (2016) 128 (22): 1256.

https://doi.org/10.1182/blood.V128.22.1256.1256

Published: 2016

Journal Articles

Dual Deficiency of mDia1 and Mir-146a in an Age-Related Inflammatory Bone Marrow Microenvironment Induces Ineffective Erythropoiesis in Del(5q) MDS

Yang Mei, PhD, Ashley Basiorka, Baobing Zhao, PhD, Jing Yang, Alan F List, MD, Peng Ji, MD PhD

Blood (2016) 128 (22): 3146.

https://doi.org/10.1182/blood.V128.22.3146.3146

Published: 2016

NARROW

Deletion of TLR4 in Townes SS Mice Prevents Microvascular Stasis in Response to Hemin, LPS and Hypoxia/Reoxygenation: Role of Inflammation

Innate Immune Mechanism of Hemarthrosis in Hemophilia-a Mice

Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes

S100A9 Contributes to T Cell Dysfunction through Its Interaction with RAGE in MDS

Lactate Dehydrogenase to Carboxyhemoglobin Ratio As a Biomarker of Heme Release to Heme Processing Is Associated with Higher Tricuspid Regurgitant Jet Velocity and Early Death in Sickle Cell Disease

A Unique Monocyte Transcriptome Discriminates Sickle Cell Disease from Other Hereditary Hemolytic Anemias and Shows the Particular Importance of Lipid and Interferon Signaling

Signaling mechanisms inducing hyporesponsiveness of phagocytes during systemic inflammation

Heme Induces Significant Neutrophil Adhesion in Vitro Via an Nfκb -Dependent Pathway

18β-Glycyrrhetic Acid Modulates Th1/Th17/Th22/Regulatory T Cells Homeostasis Via HMGB1/NF-κB Signaling Pathway in Immune Thrombocytopenia

Regulatory Genetic Variation at the S100B Gene Associates with Vaso-Occlusive Manifestations in Sickle Cell Disease

SNP-Array Genome Wide Association Study Meta-Analysis Identifies Innate Immune Susceptibility Loci Associated with Non-Del(5q) Myelodysplastic Syndromes Predisposition

HMGB1 Causes Anemia of Inflammation By Modulating Erythropoietin Signal Transduction

Oxidized Mitochondrial DNA Is a Catalyst and Biomarker of Pyroptotic Cell Death in Myelodysplastic Syndromes

The S100A9/Fto Axis Induces Formation of RNA:DNA Hybrids That Serve As Damps Initiating Myeloid Skewing & Genetic Injury in MDS

High Mobility Group Box 1 Protein (HMGB1) Mediates Anemia of Inflammation through Lineage Skewing and Direct Inhibition of EPO Signaling

HMGB1 Accelerates Regeneration of Multiple Tissues By Transitioning Stem Cells to G Alert

Increased Mitochondrial DNA in an ECMO Model Is Associated with Loss of Platelet Function

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Heme Induces NLRP3 Inflammasome Formation in Primary Human Macrophages and May Propagate Hemolytic Inflammatory Processes By Inducing S100A8 Expression

Dual Deficiency of mDia1 and Mir-146a in an Age-Related Inflammatory Bone Marrow Microenvironment Induces Ineffective Erythropoiesis in Del(5q) MDS

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American Society of Hematology

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American Society of Hematology

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