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Journal Articles

Factor VIIa Induces Biased Cytoprotective Signaling through the Cleavage of Protease Activated Receptor 1 at Canonical Arg41 Site

Vijay Kumar Reddy Kondreddy, MSc,PhD, Usha R. Pendurthi, PhD, Xiao Xu, John H. Griffin, PhD, L. Vijaya Mohan Rao, PhD

Blood (2019) 134 (Supplement_1): 481.

https://doi.org/10.1182/blood-2019-124976

Published: 2019

Journal Articles

Factor VIIa induces anti-inflammatory signaling via EPCR and PAR1

Vijay Kondreddy, Jue Wang, Shiva Keshava, Charles T. Esmon, L. Vijaya Mohan Rao, Usha R. Pendurthi

Blood (2018) 131 (21): 2379–2392.

https://doi.org/10.1182/blood-2017-10-813527

Published: 2018

Includes: Supplemental data

Journal Articles

Increased Palmitoylation Modulates Cytoskeletal Regulators to Enhance CXCR4-Mediated Motility of Malignant B Cells

Andrea Haerzschel, PhD, Dunja Baatout, PhD, Valeska Berg, PhD, Manuela Paunovic, Karin Oberascher, PhD, Hubert Kerschbaum, PhD, Richard Greil, MD, Michael J. Hallek, MD, Tanja N. Hartmann, PhD, Lukas P. Frenzel, MD

Blood (2017) 130 (Supplement 1): 3988.

https://doi.org/10.1182/blood.V130.Suppl_1.3988.3988

Published: 2017

Journal Articles

The Novel Imipridone ONC212 Induces Pronounced Anti-Leukemia Effects in Vitro and In Vivo and Is Highly Synergistic with the BCL-2 Inhibitor ABT-199

Takenobu Nii, PhD, Jo Ishizawa, MD PhD, Varun Vijay Prabhu, BPharm, MS, PhD, Vivian Ruvolo, PhD, Neel Madhukar, Ran Zhao, Hong Mu, MD PhD, Lauren Heese, Kensuke Kojima, MD PhD, Mathew Garnett, Ultan McDermott, Cyril H Benes, Neil Charter, Sean Deacon, Olivier Elemento, PhD, Joshua E. Allen, PhD, Wolfgang Oster, MD, Martin Stogniew, Michael Andreeff, MD PhD

Blood (2017) 130 (Supplement 1): 2616.

https://doi.org/10.1182/blood.V130.Suppl_1.2616.2616

Published: 2017

Journal Articles

Novel R41Q- and R46Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for In Vivo Protective Mechanisms of Action for Activated Protein C (APC) in Sepsis and Stroke

Ranjeet Kumar Sinha, PhD MSc, Yaoming Wang, PhD, Zhen Zhao, PhD, Jose A. Fernandez, MD PhD, Naveen Gupta, Xiao Xu, MSc, Greg Martin, MSc, Sergey Kupriyanov, PhD MSc, Laurent O Mosnier, PhD, Berislav Zlokovic, PhD, John H. Griffin, PhD

Blood (2016) 128 (22): 13.

https://doi.org/10.1182/blood.V128.22.13.13

Published: 2016

Journal Articles

Eicosanoid-GPCR Signaling Enhances Hematopoiesis and Marrow Transplant

Jamie L Lahvic, BA, Michelle B Ammerman, BA, Pulin Li, PhD, Song Yang, PhD, Nan Chiang, PhD, Michael Chase, BA, Olivia Weis, Yi Zhou, PhD, Charles Serhan, PhD, Leonard I. Zon, MD

Blood (2016) 128 (22): 495.

https://doi.org/10.1182/blood.V128.22.495.495

Published: 2016

Journal Articles

Activated Protein C (APC) Therapy Ameliorates Chronic Graft Versus Host Disease By Cell Signaling Mechanisms That Require Cleavage at Arg46 in PAR1 on T Cells

Ranjeet Kumar Sinha, PhD MSc, Ryan P Flynn, PhD, Jose A. Fernandez, MD PhD, Xiao Xu, MSc, Greg Martin, MSc, Sergey Kupriyanov, PhD MSc, John H. Griffin, PhD, Bruce R. Blazar, MD

Blood (2016) 128 (22): 808.

https://doi.org/10.1182/blood.V128.22.808.808

Published: 2016

Journal Articles

Occupancy of human EPCR by protein C induces β-arrestin-2 biased PAR1 signaling by both APC and thrombin

Ram Vinod Roy, Abdolreza Ardeshirylajimi, Peyman Dinarvand, Likui Yang, Alireza R. Rezaie

Blood (2016) 128 (14): 1884–1893.

https://doi.org/10.1182/blood-2016-06-720581

Published: 2016

Includes: Supplemental data

Journal Articles

Protease-activated receptors in hemostasis

Marvin T. Nieman

Blood (2016) 128 (2): 169–177.

https://doi.org/10.1182/blood-2015-11-636472

Published: 2016

Journal Articles

CXCR7 Participates in Chemotaxis and Homing Mediated By CXCL12

Rita de Cassia Carvalho Melo, MSc, Juliana M. Xavier-Ferrucio, PhD, Lauremilia Ricon, PhD, Karla Priscila Vieira Vieira Ferro, PhD, Carolina L. Bigarella, PhD, Gilberto C. Franchi, Jr., Alexandre Nowill, PhD MD, Sara Teresinha Olalla Saad, PhD MD

Blood (2015) 126 (23): 3601.

https://doi.org/10.1182/blood.V126.23.3601.3601

Published: 2015

Journal Articles

Activated protein C: biased for translation

John H. Griffin, Berislav V. Zlokovic, Laurent O. Mosnier

Blood (2015) 125 (19): 2898–2907.

https://doi.org/10.1182/blood-2015-02-355974

Published: 2015

Journal Articles

CXCR7 participates in CXCL12-induced CD34 + cell cycling through β-arrestin–dependent Akt activation

Frédéric Torossian, Adrienne Anginot, Aurélie Chabanon, Denis Clay, Bernadette Guerton, Christophe Desterke, Laetitia Boutin, Stefano Marullo, Mark G. H. Scott, Jean-Jacques Lataillade, Marie-Caroline Le Bousse-Kerdilès

Blood (2014) 123 (2): 191–202.

https://doi.org/10.1182/blood-2013-05-500496

Published: 2014

Includes: Supplemental data

Journal Articles

Somatic Activating Mutations In CXCR4 Are Common In Patients With Waldenstrom’s Macroglobulinemia, and Their Expression In WM Cells Promotes Resistance To Ibrutinib

Yang Cao, MD, Zachary Hunter, Xia Liu, MD, Lian Xu, Guang Yang, PhD, Christina K Tripsas, MA, Robert Manning, Christopher Patterson, Steven Peter Treon, MD, MA, PhD

Blood (2013) 122 (21): 4424.

https://doi.org/10.1182/blood.V122.21.4424.4424

Published: 2013

Journal Articles

CXCR7 Functions Together with CXCR4 in SDF-1/CXCL12 Induced CD34 + Hematopoietic Progenitor Cell Cycling Through β-Arrestin 2-Dependent Akt Activation

Frederic Torossian, PhD, Aurélie Chabanon, PhD, Denis Clay, Bernadette Guerton, Adrienne Anginot, PhD, Richard Proust, Jean-Francois Ottavi, Emmanuel Dornier, Laetitia Boutin, Christophe Desterke, PhD, Mark Scott, PhD, Jean-Jacques Lataillade, MD, PhD, Marie-Caroline Le Bousse-Kerdiles, PhD

Blood (2012) 120 (21): 3448.

https://doi.org/10.1182/blood.V120.21.3448.3448

Published: 2012

Journal Articles

Direct Association of PAR4 with P2Y12 Is Required for PAR4-Induced Recruitment of Arrestin-2: Structural and Functional Analysis of a GPCR Heterodimer,

Aasma Khan, Dongjun Li, Salam Ibrahim, Emer Smyth, Donna Woulfe, PhD

Blood (2011) 118 (21): 3253.

https://doi.org/10.1182/blood.V118.21.3253.3253

Published: 2011

Journal Articles

β-Arrestin-1 Regulates Epigenetics of Whole Genome in Chronic Myeloid Leukemia Cells

Lin Zou, Kang Li, Xiaoyan Zhou, Liming Bao, MD, PhD

Blood (2011) 118 (21): 4636.

https://doi.org/10.1182/blood.V118.21.4636.4636

Published: 2011

Journal Articles

Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development

Florence Schaffner, Henri H. Versteeg, Anja Schillert, Naho Yokota, Lars C. Petersen, Barbara M. Mueller, Wolfram Ruf

Blood (2010) 116 (26): 6106–6113.

https://doi.org/10.1182/blood-2010-06-289314

Published: 2010

Journal Articles

Significant functional heterogeneity among KIR2DL1 alleles and a pivotal role of arginine 245

Rafijul Bari, Teresa Bell, Wai-Hang Leung, Queenie P. Vong, Wing Keung Chan, Neha Das Gupta, Martha Holladay, Barbara Rooney, Wing Leung

Blood (2009) 114 (25): 5182–5190.

https://doi.org/10.1182/blood-2009-07-231977

Published: 2009

Includes: Supplemental data

Journal Articles

β-Arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation

Raffaella Molteni, Carolina Lage Crespo, Sara Feigelson, Christian Moser, Monica Fabbri, Valentin Grabovsky, Fritz Krombach, Carlo Laudanna, Ronen Alon, Ruggero Pardi

Blood (2009) 114 (5): 1073–1082.

https://doi.org/10.1182/blood-2008-10-183699

Published: 2009

Includes: Supplemental data

Journal Articles

Arrestin-2 Differentially Regulates PAR4 and P2Y12 Receptor Signaling in Platelets

Dongjun Li, MD, PhD, Donna Woulfe, PhD

Blood (2008) 112 (11): 110.

https://doi.org/10.1182/blood.V112.11.110.110

Published: 2008

NARROW

Factor VIIa Induces Biased Cytoprotective Signaling through the Cleavage of Protease Activated Receptor 1 at Canonical Arg41 Site

Factor VIIa induces anti-inflammatory signaling via EPCR and PAR1

Increased Palmitoylation Modulates Cytoskeletal Regulators to Enhance CXCR4-Mediated Motility of Malignant B Cells

The Novel Imipridone ONC212 Induces Pronounced Anti-Leukemia Effects in Vitro and In Vivo and Is Highly Synergistic with the BCL-2 Inhibitor ABT-199

Novel R41Q- and R46Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for In Vivo Protective Mechanisms of Action for Activated Protein C (APC) in Sepsis and Stroke

Eicosanoid-GPCR Signaling Enhances Hematopoiesis and Marrow Transplant

Activated Protein C (APC) Therapy Ameliorates Chronic Graft Versus Host Disease By Cell Signaling Mechanisms That Require Cleavage at Arg46 in PAR1 on T Cells

Occupancy of human EPCR by protein C induces β-arrestin-2 biased PAR1 signaling by both APC and thrombin

Protease-activated receptors in hemostasis

CXCR7 Participates in Chemotaxis and Homing Mediated By CXCL12

Activated protein C: biased for translation

CXCR7 participates in CXCL12-induced CD34 + cell cycling through β-arrestin–dependent Akt activation

Somatic Activating Mutations In CXCR4 Are Common In Patients With Waldenstrom’s Macroglobulinemia, and Their Expression In WM Cells Promotes Resistance To Ibrutinib

CXCR7 Functions Together with CXCR4 in SDF-1/CXCL12 Induced CD34 + Hematopoietic Progenitor Cell Cycling Through β-Arrestin 2-Dependent Akt Activation

Direct Association of PAR4 with P2Y12 Is Required for PAR4-Induced Recruitment of Arrestin-2: Structural and Functional Analysis of a GPCR Heterodimer,

β-Arrestin-1 Regulates Epigenetics of Whole Genome in Chronic Myeloid Leukemia Cells

Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development

Significant functional heterogeneity among KIR2DL1 alleles and a pivotal role of arginine 245

β-Arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation

Arrestin-2 Differentially Regulates PAR4 and P2Y12 Receptor Signaling in Platelets

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American Society of Hematology

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ASH Publications

American Society of Hematology

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