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Journal Articles

Genetics of Monosomy 7 and Del(7q) in MDS Informs Potential Therapeutic Targets

Cassandra M Kerr, MS, Vera Adema, PhD, Wencke Walter, PhD, Stephan Hutter, PhD, Christina A. Snider, BA, Yasunobu Nagata, MD PhD, Manja Meggendorfer, PhD, Claudia Haferlach, MD, Valeria Visconte, PhD, Mikkael A. Sekeres, MD MS, Thomas Laframboise, PhD, Torsten Haferlach, MD, Jaroslaw P. Maciejewski, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1703.
https://doi.org/10.1182/blood-2019-126866
Published: 2019
Journal Articles

Development and Performance of Risk Stratification Models for AML Patients Utilizing ELN-2017 Guidelines and Additional Prognostic Factors: A SWOG Report

Era L Pogosova-Agadjanyan, BS, Anna Moseley, M.S., Megan Othus, PhD, Frederick R. Appelbaum, MD, Thomas R. Chauncey, MD PhD, I-Ming L. Chen, DVM, MS, Harry P. Erba, MD PhD, John E. Godwin, MD, Isaac C. Jenkins, MS, Min Fang, MD PhD, Mike Huynh, Kenneth J Kopecky, Alan F. List, MD, Jasmine Naru, PhD, Jerald P. Radich, MD, Emily Stevens, MD PhD, Brooke E Willborg, BS, Cheryl L. Willman, MD, Brent L Wood, MD PhD, Qing Zhang, Soheil Meshinchi, MD PhD, Derek Stirewalt, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2691.
https://doi.org/10.1182/blood-2019-124529
Published: 2019
Journal Articles

A Novel HCK and BTK Dual Inhibitor Kin-8194 Shows Superior Activity over Ibrutinib and Overcomes BTK C481S Mediated Ibrutinib Resistance in Vitro and In Vivo in MYD88 Mutated B-Cell Lymphomas

Guang Yang, PhD, Jinhua Wang, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji G Chen, Amanda Kofides, Lian Xu, MS, Nicholas Tsakmaklis, Maria Demos, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Cristina Jimenez, PhD, Zachary R Hunter, PhD, Christopher Patterson, Jorge J. Castillo, MD, Sara J Buhrlage, PhD, Nathanael Gray, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 394.
https://doi.org/10.1182/blood-2019-130636
Published: 2019
Journal Articles

Concentration-QTc (C-QTc) Analysis of the MDM2 Inhibitor KRT-232 (formerly AMG 232) in Subjects with Advanced Solid Tumors, Multiple Myeloma, or Acute Myeloid Leukemia

Adekemi Taylor, PhD, Martine Allard, PhD, Cecile Kresja, PhD, Dana Lee, PharmD, Greg Slatter, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5768.
https://doi.org/10.1182/blood-2019-131481
Published: 2019
Journal Articles

A Novel HCK Inhibitor Kin-8193 Blocks BTK Activity in BTK Cys481 Mutated Ibrutinib Resistant B-Cell Lymphomas Driven By Mutated MYD88

Guang Yang, PhD, Jinhua Wang, PhD, Li Tan, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji G Chen, Lian Xu, MS, Nickolas Tsakmaklis, Maria Demos, Amanda Kofides, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Zachary R Hunter, PhD, Christopher Patterson, MAcc, Jorge J. Castillo, MD, Sara J Buhrlage, PhD, Nathanael S. Gray, PhD, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2018) 132 (Supplement 1): 40.
https://doi.org/10.1182/blood-2018-99-119171
Published: 2018
Journal Articles

Identification of Somatic Mutation Contributing to Chemotherapy Resistance in Acute Myeloid Leukemia

Akira Honda, MD, PhD, Junji Koya, MD, PhD, Akihide Yoshimi, MD PhD, Keisuke Kataoka, MD PhD, Shunya Arai, MD, PhD, Mineo Kurokawa, MD, PhD
Journal: Blood
Blood (2016) 128 (22): 600.
https://doi.org/10.1182/blood.V128.22.600.600
Published: 2016
Journal Articles

Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia

Qiao-Yang Sun, PhD, Ling-wen Ding, PhD, Kar-Tong Tan, Wenwen Chien, Anand Mayakonda, Allen Eng Juh Yeoh, MD, Norihiko Kawamata, Yasunobu Nagata, MD,PhD, Xiao Jin-Fen, Xin-Yi Loh, De-Chen Lin, Manoj Garg, PhD, Yan-Yi Jiang, Liang Xu, Su-Lin Lim, Li-Zhen Liu, Vikas Madan, PhD, Masashi Sanada, MD PhD, Lucia Torres Fernández, Hema Preethi S.S., Michael Lill, MD BS, Hagop M. Kantarjian, MD, Steven M. Kornblau, MD, Satoru Miyano, PhD, Der-Cherng Liang, MD, Seishi Ogawa, MD PhD, Lee-Yung Shih, Henry Yang, PhD, H. Phillip Koeffler, MD
Journal: Blood
Blood (2016) 128 (22): 452.
https://doi.org/10.1182/blood.V128.22.452.452
Published: 2016
Journal Articles

Improved Prognostic Significance of Genomic and Transcriptional Biomarkers By Examining Enriched Populations of AML Blasts: A SWOG Report

Era L. Pogosova-Agadjanyan, Anna Moseley, Brent L. Wood, MD PhD, Frederick R. Appelbaum, Thomas Chauncey, I-Ming L. Chen, DVM, MS, Harry P. Erba, MD PhD, John E. Godwin, Min Fang, Kenneth J. Kopecky, Alan F. List, Megan Othus, Jerald P. Radich, Cheryl L. Willman, Soheil Meshinchi, Derek L. Stirewalt
Journal: Blood
Blood (2016) 128 (22): 2890.
https://doi.org/10.1182/blood.V128.22.2890.2890
Published: 2016
Journal Articles

Therapeutic Synergy from Combined Inhibition of the SERCA Channel and MAPK Signaling Pathway in MAPK-Dependent Leukemia

Meng Wang, MD PhD MRCP, Ugur Eskiocak, PhD, Michalis Agathokleous, PhD, Stacy Yuan, Charles Crawley, MD(London) FRCP FCPath, Sean J. Morrison, PhD
Journal: Blood
Blood (2015) 126 (23): 1264.
https://doi.org/10.1182/blood.V126.23.1264.1264
Published: 2015
Journal Articles

Increased Expression of HERG1 K+ Channels Contribute to MDS Progression and Display Correlation with Prognosis Stratification

Li Lu, Master's Degree, Wen Du, Master's Degree, Wei Liu, Master's Degree, Dongmei Guo, Master's Degree, Shiang Huang, Huiyu Li, Doctor's Degree
Journal: Blood
Blood (2015) 126 (23): 5193.
https://doi.org/10.1182/blood.V126.23.5193.5193
Published: 2015
Journal Articles

Clinical Pharmacokinetics of Apto-253 Support Its Use As a Novel Agent for the Treatment of Relapsed or Refractory Hematologic Malignancies

William G. Rice, PhD, Jeff Lightfoot, PhD, Hongying Zhang, MD PhD, Tiffany Cheng, MSc, Avanish Vellanki, Robert Peralta, MSc, DVM, Stephen B Howell, MD, Andrea Local, Fannie Chau, Luis Esquivies
Journal: Blood
Blood (2015) 126 (23): 4934.
https://doi.org/10.1182/blood.V126.23.4934.4934
Published: 2015
Journal Articles

Galectin-1 Is Highly Expressed By Myeloma Cells and the Bone Marrow Microenvironment and Its Suppression Delineates a New Therapeutic in Vitro and in Vivo Strategy in Multiple Myeloma

Paola Storti, PhD, Gaetano Donofrio, PhD, Valentina Marchica, Daniela Guasco, Katia Todoerti, PhD, Irma Airoldi, PhD, Judith Anderson, Marina Bolzoni, Valentina Ferri, Eugenia Martella, MD, Cristina Mancini, MD, Nicoletta Campanini, Antonino Neri, G. David Roodman, MD, PhD, Franco Aversa, MD, Nicola Giuliani, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3373.
https://doi.org/10.1182/blood.V124.21.3373.3373
Published: 2014
Journal Articles

Preclinical Evaluation of Orally Bioavailable Small-Molecule Inhibitors of Complement Factor D As a Potential Treatment for Paroxysmal Nocturnal Hemoglobinuria

Jason Wiles, PhD, Steven Podos, PhD, Jane Thanassi, Avinash Phadke, PhD, Venkat Gadhachanda, PhD, Godwin Pais, PhD, Akihiro Hashimoto, PhD, Qiuping Wang, PhD, Dawei Chen, PhD, Xiangzhu Wang, PhD, Atul Agarwal, PhD, Jose Rivera, Michael Elliot, Christopher Marlor, Jay Zhang, Milind Deshpande, PhD, Mingjun Huang, PhD, Yongqing Huang, PhD
Journal: Blood
Blood (2014) 124 (21): 4819.
https://doi.org/10.1182/blood.V124.21.4819.4819
Published: 2014
Journal Articles

NPM1 Mutated AML Is Associated With Lower Expression Of Poor Prognostic Markers BAALC, ERG and MN1 In Adult Patients With Acute Myeloid Leukaemia

Poonkuzhali Balasubramanian, Ph.D, Ashok kumar Jayavelu, M.Sc, Ajay Abraham, M.Sc, Savitha Varatharajan, M.Sc, Sreeja Karathedath, M.Sc, Senthamizhselvi Anandan, M.Sc, Vivi Srivastava, MD, Aby Abraham, MD, Auro Viswabandya, MD, Alok Srivastava, MD, Vikram Mathews, MD, DM
Journal: Blood
Blood (2013) 122 (21): 4945.
https://doi.org/10.1182/blood.V122.21.4945.4945
Published: 2013
Journal Articles

Evaluation Of The Effect Of Idelalisib On The QT/QTc Interval In Healthy Subjects

Feng Jin, PhD, Michelle Robeson, ND, Huafeng Zhou, PhD, Andie Nichols, Srini Ramanathan, PhD
Journal: Blood
Blood (2013) 122 (21): 5573.
https://doi.org/10.1182/blood.V122.21.5573.5573
Published: 2013
Journal Articles

Genomic Signature Predicts Resistance To Busulfan In AML Cell Lines

Pritesh R. Patel, MB, ChB, Dolores Mahmud, Ph.D., Wei Zhang, PhD, Joe GN Garcia, MD, Damiano Rondelli, MD
Journal: Blood
Blood (2013) 122 (21): 3850.
https://doi.org/10.1182/blood.V122.21.3850.3850
Published: 2013
Journal Articles

Perturbation of fetal hematopoiesis in a mouse model of Down syndrome’s transient myeloproliferative disorder

Yehudit Birger, Liat Goldberg, Timothy M. Chlon, Benjamin Goldenson, Inna Muler, Ginette Schiby, Jasmin Jacob-Hirsch, Gideon Rechavi, John D. Crispino, Shai Izraeli
Journal: Blood
Blood (2013) 122 (6): 988–998.
https://doi.org/10.1182/blood-2012-10-460998
Published: 2013
Includes: Supplemental data
Journal Articles

Role of the Ether-a-gò-gò-Related Gene 1B Isoform in Hematopoiesis

Serena Pillozzi, Marika Masselli, Marinella Veltroni, MD, Emanuele De Lorenzo, Antonella Fiore, Massimo D'Amico, Henry Duff, Andrea Becchetti, Annarosa Arcangeli, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1222.
https://doi.org/10.1182/blood.V120.21.1222.1222
Published: 2012
Journal Articles

Anti-Leukemic Activity Is Increased with Low Dose Busulfan and Irradiation: A Preclinical Model

Pritesh R. Patel, MB, ChB, Dolores Mahmud, PhD, Wei Zhang, PhD, Tong Zhou, PhD, Nadim Mahmud, MD, PhD, Ralph R Weichselbaum, MD, Joe GN Garcia, MD, Damiano Rondelli, MD
Journal: Blood
Blood (2011) 118 (21): 4696.
https://doi.org/10.1182/blood.V118.21.4696.4696
Published: 2011
Journal Articles

HERG1 K+ Channels Regulate Leukemia Angiogenesis through VEGF Signaling In Leukemic Cells.

Shiang Huang, MD, Huiyu Li, Dongmei Guo, Shenghua Jie, Kaiwei Liang, Fang Zheng
Journal: Blood
Blood (2010) 116 (21): 1036.
https://doi.org/10.1182/blood.V116.21.1036.1036
Published: 2010