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Journal Articles

Iron, FRDA, and intermediary metabolism

Kostas Pantopoulos

Blood (2021) 137 (15): 1994–1995.

https://doi.org/10.1182/blood.2021010835

Published: 2021

Journal Articles

Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia

Blood (2020) 136 (10): 1161–1168.

https://doi.org/10.1182/blood.2020005064

Published: 2020

Includes: Supplemental data

Journal Articles

Mitochondrial carrier homolog 2 is necessary for AML survival

Blood (2020) 136 (1): 81–92.

https://doi.org/10.1182/blood.2019000106

Published: 2020

Includes: Supplemental data

Journal Articles

AMP-activated protein kinase links acetyl-CoA homeostasis to BRD4 recruitment in acute myeloid leukemia

Yajian Jiang, Tianyuan Hu, Tao Wang, Xiangguo Shi, Ayumi Kitano, Kenneth Eagle, Kevin A. Hoegenauer, Marina Y. Konopleva, Charles Y. Lin, Nicolas L. Young, Daisuke Nakada

Blood (2019) 134 (24): 2183–2194.

https://doi.org/10.1182/blood.2019001076

Published: 2019

Includes: Supplemental data

Journal Articles

Effect of Extended Platelet Storage on Platelet Metabolism and Clot Retraction

Prajeeda M Nair, PhD, Michael Adam Meledeo, PhD, Xiaowu Wu, MD MSc, Grantham Peltier, MS, Bin Liu, BS, Kristin M Reddoch-Cardenas, PhD, James Bynum, PhD, Andrew P. Cap, MD PhD

Blood (2019) 134 (Supplement_1): 2450.

https://doi.org/10.1182/blood-2019-131116

Published: 2019

Journal Articles

Mutant ASXL1 Promotes Expansion of the Phenotypic Hematopoietic Stem Cell Compartment

Takeshi Fujino, MD, Susumu Goyama, MD PhD, Yuki Sugiura, PhD, Daichi Inoue, MD PhD, Satoshi Yamasaki, PhD, Akiko Matsumoto, Naru Sato, MD, Hironobu Morinaga, PhD, Shiori Shikata, Tomofusa Fukuyama, MD PhD, Yosuke Tanaka, PhD, Shuhei Asada, MD PhD, Tsuyoshi Fukushima, MD PhD, Hiroaki Honda, MD PhD, Emi K Nishimura, MD PhD, Tatsuhiro Shibata, MD PhD, Makoto Suematsu, MD PhD, Toshio Kitamura, MD PhD

Blood (2019) 134 (Supplement_1): 821.

https://doi.org/10.1182/blood-2019-127904

Published: 2019

Journal Articles

Glutaminase Inhibition Overcomes Acquired Resistance to Mitochondrial Complex I in NOTCH1-Driven T-Cell Acute Lymphoblastic Leukemias (T-ALL) Via Block of Glutamine Driven Reductive Metabolism

Blood (2019) 134 (Supplement_1): 806.

https://doi.org/10.1182/blood-2019-128930

Published: 2019

Journal Articles

Identification of GPAT1 As a Novel Therapeutic Target for Acute Leukemia By Inhibiting Leukemia Specific Metabolism

Hidetoshi Irifune, MD, Yu Kochi, MD, Masayasu Hayashi, MD PhD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2019) 134 (Supplement_1): 1384.

https://doi.org/10.1182/blood-2019-125661

Published: 2019

Journal Articles

Dnmt3a Mutation Confers a Selective Advantage Specifically to Cells within the Long-Term Hematopoietic Stem Cell (LT-HSC) Compartment

Elizabeth Eudy, BS, Matthew Loberg, BA, Rebecca Bell, BA, Tim Stearns, Jennifer Trowbridge, PhD

Blood (2019) 134 (Supplement_1): 448.

https://doi.org/10.1182/blood-2019-124540

Published: 2019

Journal Articles

Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms

Blood (2019) 134 (Supplement_1): 474.

https://doi.org/10.1182/blood-2019-127235

Published: 2019

Journal Articles

Alterations in Sphingomyelin Metabolism Influences Tissue Factor Procoagulant Activity and the Release of TF-Positive Microvesicles

Jue Wang, PhD, Usha Pendurthi, PhD, L. Vijaya Mohan Rao, PhD

Blood (2019) 134 (Supplement_1): 1103.

https://doi.org/10.1182/blood-2019-125933

Published: 2019

Journal Articles

Lineage Tracing in Chronic Lymphocytic Leukemia Reveals Clones with Stable Gene Expression States That Differentially Respond to Therapy

Catherine Gutierrez, Aziz Al'Khafaji, B.S., Eric Brenner, B.S., Russell Durrett, B.S., M.S., Kaitlyn Johnson, B.S., M.S., Wandi Zhang, MD, Shuqiang Li, PhD, Kenneth J. Livak, PhD, Donna S Neuberg, ScD, Amy Brock, PhD, Catherine J. Wu, MD

Blood (2019) 134 (Supplement_1): 1229.

https://doi.org/10.1182/blood-2019-129303

Published: 2019

Journal Articles

GDF1 Is a Regulator of Sphingolipid Metabolism in Acute Myeloid Leukemia

Weiyuan Wang, Emily Sullivan, Vasiliki Papakotsi, Andrea Cote, Paul Toran, PhD, Thomas P Loughran, Jr., MD, Brian Barth, PhD MS, BS

Blood (2019) 134 (Supplement_1): 1245.

https://doi.org/10.1182/blood-2019-130964

Published: 2019

Journal Articles

Characterization of Congenital Sideroblastic Anemia Model Due to ABCB7 Defects: How Do Defects in Iron-Sulfur Cluster Metabolism Lead to Ring Sideroblast Formation?

Tohru Fujiwara, MD PhD, Chie Suzuki, Tetsuro Ochi, Koya Ono, MD, Kei Saito, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Hisayuki Yokoyama, MD PhD, Shinichi Fujimaki, Yukio Nakamura, MD PhD, Hideo Harigae, MD PhD

Blood (2019) 134 (Supplement_1): 2232.

https://doi.org/10.1182/blood-2019-123918

Published: 2019

Journal Articles

The GPR68/BCL2 Axis Remodels Metabolism in AML By Relocating Calcium

Xiaofei He, B.S., Caleb Hawkins, B.S., Lauren Lawley, B.S., Mark Wunderlich, MS, Benjamin Mizukawa, Xiang-ming Zha, PhD, Stephanie Halene, MD, Jing Fang, MD PhD

Blood (2019) 134 (Supplement_1): 2661.

https://doi.org/10.1182/blood-2019-125455

Published: 2019

Journal Articles

Human Acute Leukemia Is Addicted to Branched-Chain Amino Acid Metabolism to Maintain Leukemia Stemness

Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Takahiro Maeda, MD PhD, Koichi Akashi, MD PhD

Blood (2019) 134 (Supplement_1): 2516.

https://doi.org/10.1182/blood-2019-129372

Published: 2019

Journal Articles

GDF1 Regulation of Ceramide Metabolism Restores Effective Hematopoiesis in Myelodysplastic Syndrome

Brian Barth, PhD MS, BS, Weiyuan Wang, Emily Sullivan, Vasiliki Papakotsi, Andrea Cote, Paul Toran, PhD, Sarah Walker, PhD, Thomas P Loughran, Jr., MD

Blood (2019) 134 (Supplement_1): 1700.

https://doi.org/10.1182/blood-2019-131623

Published: 2019

Journal Articles

Integrated Systems Level Examination of Proteasome Inhibitor Stress Recovery in Myeloma Cells Reveals Druggable Vulnerabilities Linked to Multiple Metabolic Processes

Paula Saavedra-Garcia, PhD, Hibah A Al-Sadah, MSc, Lucy Penfold, PhD, Xiaobei Xiong, MRes, Elena Lopez-Jimenez, PhD, Katarzyna Parzych, PhD, Valentina S Caputo, Kevin Blighe, PhD, Martin F. Kaiser, Paolo Piazza, PhD, Vesela Encheva, PhD, Ambrosius P Snijders, PhD, Hector C Keun, DPhil, Diego Oyarzun, PhD, Denise Thiel, MSc, Zijing Liu, PhD, Mauricio Barahona, PhD, Holger W Auner, MD PhD

Blood (2019) 134 (Supplement_1): 1818.

https://doi.org/10.1182/blood-2019-121549

Published: 2019

Journal Articles

Single-Cell Deconvolution Identifies T-Cell Correlates of Response to PD-1 Blockade Treatment in AML

Xingyue An, Jay R Adolacion, Mansour Alfayez, MD, Jairo Matthews, Wilmer Flores, Steven M. Kornblau, MD, Arash Saeedi, Sreyashi Basu, PhD, Naval G. Daver, MD, Navin Varadarajan, PhD

Blood (2019) 134 (Supplement_1): 1950.

https://doi.org/10.1182/blood-2019-122081

Published: 2019

Journal Articles

Impact of U2AF1 Mutations on Clinical Characteristics and RNA Splicing in Myelodysplastic Syndromes (MDS)

Bing Li, MD, Jinqin Liu, Tiejun Qin, Zefeng Xu, MD, Gang Huang, PhD, Zhijian Xiao, MD

Blood (2019) 134 (Supplement_1): 2979.

https://doi.org/10.1182/blood-2019-126346

Published: 2019

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Iron, FRDA, and intermediary metabolism

Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia

Mitochondrial carrier homolog 2 is necessary for AML survival

AMP-activated protein kinase links acetyl-CoA homeostasis to BRD4 recruitment in acute myeloid leukemia

Effect of Extended Platelet Storage on Platelet Metabolism and Clot Retraction

Mutant ASXL1 Promotes Expansion of the Phenotypic Hematopoietic Stem Cell Compartment

Glutaminase Inhibition Overcomes Acquired Resistance to Mitochondrial Complex I in NOTCH1-Driven T-Cell Acute Lymphoblastic Leukemias (T-ALL) Via Block of Glutamine Driven Reductive Metabolism

Identification of GPAT1 As a Novel Therapeutic Target for Acute Leukemia By Inhibiting Leukemia Specific Metabolism

Dnmt3a Mutation Confers a Selective Advantage Specifically to Cells within the Long-Term Hematopoietic Stem Cell (LT-HSC) Compartment

Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms

Alterations in Sphingomyelin Metabolism Influences Tissue Factor Procoagulant Activity and the Release of TF-Positive Microvesicles

Lineage Tracing in Chronic Lymphocytic Leukemia Reveals Clones with Stable Gene Expression States That Differentially Respond to Therapy

GDF1 Is a Regulator of Sphingolipid Metabolism in Acute Myeloid Leukemia

Characterization of Congenital Sideroblastic Anemia Model Due to ABCB7 Defects: How Do Defects in Iron-Sulfur Cluster Metabolism Lead to Ring Sideroblast Formation?

The GPR68/BCL2 Axis Remodels Metabolism in AML By Relocating Calcium

Human Acute Leukemia Is Addicted to Branched-Chain Amino Acid Metabolism to Maintain Leukemia Stemness

GDF1 Regulation of Ceramide Metabolism Restores Effective Hematopoiesis in Myelodysplastic Syndrome

Integrated Systems Level Examination of Proteasome Inhibitor Stress Recovery in Myeloma Cells Reveals Druggable Vulnerabilities Linked to Multiple Metabolic Processes

Single-Cell Deconvolution Identifies T-Cell Correlates of Response to PD-1 Blockade Treatment in AML

Impact of U2AF1 Mutations on Clinical Characteristics and RNA Splicing in Myelodysplastic Syndromes (MDS)

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