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Journal Articles

Fedratinib Induces Cytokine Changes Correlating with Clinical Response in Ruxolitinib Exposed Myelofibrosis Patients: Biomarker Analysis from the Freedom Trial

Danny V Jeyaraju, Sheida Hayati, Ann Polonskaia, Maryam Alapa, Manuel Ugidos, Andrew Browne, Alberto Risueño, Patrick Hagner, Vikas Gupta, Moshe Talpaz, Christopher Hernandez, Vincent Chia, Patricia Martin-Regueira, Daniel Lopes de Menezes, Ross La Motte-Mohs, Rajasekhar NVS Suragani, Anita K. Gandhi

Blood (2022) 140 (Supplement 1): 3865–3867.

https://doi.org/10.1182/blood-2022-166407

Published: 2022

Journal Articles

Suppression of Myeloid Cell-Derived Proinflammatory Cytokines with Celmod Agents: Implications for CRS with T-Cell Engagers (TCEs)

Danny V Jeyaraju, Maryam Alapa, Aimee O'Donohue, Ross La Motte-Mohs, Isaac W. Boss, Patrick Hagner, Michael Pourdehnad, Michael R. Burgess, William E. Pierceall, Anjan Thakurta

Blood (2022) 140 (Supplement 1): 7070–7071.

https://doi.org/10.1182/blood-2022-157927

Published: 2022

Journal Articles

Investigations into the Mechanisms and Clinical Implications of Modulation of Hepcidin Levels By Luspatercept in TD MDS and TD b-Thalassemia

Aarif Ahsan, Wei Fang, Manuel Ugidos, Danny V Jeyaraju, Pierre Fenaux, Uwe Platzbecker, Olivier Hermine, John B. Porter, Rajasekhar N.V.S. Suragani, Sadanand Vodala, Anita K. Gandhi

Blood (2022) 140 (Supplement 1): 8188–8189.

https://doi.org/10.1182/blood-2022-166559

Published: 2022

Journal Articles

Low Exposure Extended Dosing Mimicking Clinical Exposures of the Oral Formulation of Azacitidine Results in a Sustained Hypomethylation and Targets Leukemic Stem Cells

Danny V Jeyaraju, Maryam Alapa, Ann Polonskaia, Alberto Risueño, Aarif Ahsan, Chao Wang, Prakash Subramanyam, Jammula Sriganesh, Amit Anand, Gaurav Jain, Madhusudhan Reddy, Kaushik Ghosh, Charalampos Kyriakopoulos, Nathalie Lailler, Christopher Hartl, Daniel Lopes de Menezes, Patrick Hagner, Anjan Thakurta

Blood (2021) 138 (Supplement 1): 3355.

https://doi.org/10.1182/blood-2021-153523

Published: 2021

Journal Articles

CC-486 Mechanism Imparted By Extended Exposure of Azacitidine Upregulates Myeloid Differentiation Markers and Induces Cell Death in AML Cells

Diana R. Dunshee, Yumin Dai, Jessica C. Jang, Alberto Risueño, Danny V Jeyaraju, Patrick Hagner, PhD, Wendy L. See, Kyle MacBeth, Xiaomin Wang, Ignazia La Torre, Barry Skikne, MD, C.L. Beach, PharmD, Keshava Kumar, PhD, Anjan Thakurta, Daniel Lopes de Menezes, PhD

Blood (2020) 136 (Supplement 1): 33–34.

https://doi.org/10.1182/blood-2020-137606

Published: 2020

Journal Articles

Mitochondrial carrier homolog 2 is necessary for AML survival

Blood (2020) 136 (1): 81–92.

https://doi.org/10.1182/blood.2019000106

Published: 2020

Includes: Supplemental data

Journal Articles

ZFP91 Regulates Multiple Myeloma Cell Proliferation through IL-1β Mediated IL-6 Secretion in the Tumor Microenvironment

Danny V Jeyaraju, Ekta Kumari, Michael Amatangelo, Chad C. Bjorklund, Chih-Chao Hsu, Anjan Thakurta

Blood (2019) 134 (Supplement_1): 4406.

https://doi.org/10.1182/blood-2019-129181

Published: 2019

Journal Articles

Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism

Blood (2018) 132 (Supplement 1): 1339.

https://doi.org/10.1182/blood-2018-99-111015

Published: 2018

Journal Articles

The Thymidine Dideoxynucleoside Analogue, Alovudine, Inhibits the Mitochondrial DNA Polyermase, POLG, Impairs Oxidative Phosphorylation and Promotes Monocytic Differentiation in AML

Dana Yehudai-Ofir, MD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Rose Hurren, BSc, Marcela Gronda, MSc, Danny V. Jeyaraju, PhD, Xiaoming Wang, Thirushi Siriwardena, Yulia Jitkova, PhD, Aaron D. Schimmer, MDPhD, Biljana Rizoska, PhD, Paul Targett-Adams, PhD, Mark Albertella, PhD

Blood (2017) 130 (Supplement 1): 2524.

https://doi.org/10.1182/blood.V130.Suppl_1.2524.2524

Published: 2017

Journal Articles

TAK-243 Is a Selective UBA1 Inhibitor That Displays Preclinical Activity in Acute Myeloid Leukemia (AML)

Samir H. Barghout, BSPharm, MSc, Parasvi Patel, BSc (Hons), Xiaoming Wang, G. Wei Xu, Simon Kavanagh, Marcela Gronda, MSc, Rose Hurren, BSc, Danny V. Jeyaraju, PhD, Neil MacLean, Marc Hyer, PhD, Allison Berger, PhD, Tary Traore, Michael Sintchak, Michael Milhollen, Mark D. Minden, MD PhD, Razq Hakem, PhD, Aaron D. Schimmer, MDPhD

Blood (2017) 130 (Supplement 1): 814.

https://doi.org/10.1182/blood.V130.Suppl_1.814.814

Published: 2017

Journal Articles

Tafazzin (TAZ) Regulates the Differentiation of AML Cells By Reducing Levels of the Phospholipid Phosphatidylethanolamine

Blood (2017) 130 (Supplement 1): 788.

https://doi.org/10.1182/blood.V130.Suppl_1.788.788

Published: 2017

Journal Articles

Mitochondrial Carrier Homolog 2 (MTCH2) Regulates the Differentiation of AML Cells By Controlling Pyruvate Entry into the Mitochondria, Nuclear Localization of Pyruvate Dehydrogenase Complex and H3 and H4 Histone Acetylation

Dilshad H. Khan, Michael Mullokandov, Yan Wu, Marcela Gronda, MSc, Rose Hurren, BSc, Xiaoming Wang, Neil MacLean, Danny V. Jeyaraju, PhD, G. Wei Xu, Rob C. Laister, PhD, Zachary Blatman, Troy Ketela, Mark D. Minden, MD PhD, Atan Gross, PhD, Aaron D. Schimmer, MDPhD

Blood (2017) 130 (Supplement 1): 299.

https://doi.org/10.1182/blood.V130.Suppl_1.299.299

Published: 2017

Journal Articles

Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells

Danny V. Jeyaraju, PhD, Veronique Voisin, Changjiang Xu, Samir H. Barghout, BSPharm, MSc, Dilshad H. Khan, Rose Hurren, BSc, Marcela Gronda, MSc, Xiaoming Wang, Yulia Jitkova, PhD, David Sharon, PhD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Joelle Soriano, Eric R. Lechman, PhD, Neil MacLean, Mark D. Minden, MD PhD, Steven M. Chan, MDPhD, John E. Dick, PhD, Gary D Bader, Aaron D. Schimmer, MDPhD

Blood (2017) 130 (Supplement 1): 881.

https://doi.org/10.1182/blood.V130.Suppl_1.881.881

Published: 2017

Journal Articles

Inhibition of the Mitochondrial Protein Import Machinery Is Selectively Cytotoxic to Acute Myeloid Leukemia (AML) Cells and Stem Cells

Danny V Jeyaraju, Veronique Voisin, Changjiang Xu, Rose Hurren, Marcela Gronda, Xiaoming Wang, Yulia Jitkova, Joelle Soriano, Neil MacLean, Gary D Bader, Aaron D. Schimmer, MD PhD

Blood (2016) 128 (22): 1572.

https://doi.org/10.1182/blood.V128.22.1572.1572

Published: 2016

Journal Articles

A Novel Isoflavone, ME-344, Targets the Cytoskeleton in Acute Myeloid Leukemia

Danny V Jeyaraju, Rose Hurren, Xiaoming Wang, Neil MacLean, Marcela Gronda, Craig T Jordan, PhD, Mark D. Minden, MD PhD, Guri Giaever, Aaron D. Schimmer, MD PhD

Blood (2015) 126 (23): 3682.

https://doi.org/10.1182/blood.V126.23.3682.3682

Published: 2015

Journal Articles

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

Blood (2015) 125 (13): 2120–2130.

https://doi.org/10.1182/blood-2014-08-594408

Published: 2015

Includes: Supplemental data

NARROW

Fedratinib Induces Cytokine Changes Correlating with Clinical Response in Ruxolitinib Exposed Myelofibrosis Patients: Biomarker Analysis from the Freedom Trial

Suppression of Myeloid Cell-Derived Proinflammatory Cytokines with Celmod Agents: Implications for CRS with T-Cell Engagers (TCEs)

Investigations into the Mechanisms and Clinical Implications of Modulation of Hepcidin Levels By Luspatercept in TD MDS and TD b-Thalassemia

Low Exposure Extended Dosing Mimicking Clinical Exposures of the Oral Formulation of Azacitidine Results in a Sustained Hypomethylation and Targets Leukemic Stem Cells

CC-486 Mechanism Imparted By Extended Exposure of Azacitidine Upregulates Myeloid Differentiation Markers and Induces Cell Death in AML Cells

Mitochondrial carrier homolog 2 is necessary for AML survival

ZFP91 Regulates Multiple Myeloma Cell Proliferation through IL-1β Mediated IL-6 Secretion in the Tumor Microenvironment

Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism

The Thymidine Dideoxynucleoside Analogue, Alovudine, Inhibits the Mitochondrial DNA Polyermase, POLG, Impairs Oxidative Phosphorylation and Promotes Monocytic Differentiation in AML

TAK-243 Is a Selective UBA1 Inhibitor That Displays Preclinical Activity in Acute Myeloid Leukemia (AML)

Tafazzin (TAZ) Regulates the Differentiation of AML Cells By Reducing Levels of the Phospholipid Phosphatidylethanolamine

Mitochondrial Carrier Homolog 2 (MTCH2) Regulates the Differentiation of AML Cells By Controlling Pyruvate Entry into the Mitochondria, Nuclear Localization of Pyruvate Dehydrogenase Complex and H3 and H4 Histone Acetylation

Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells

Inhibition of the Mitochondrial Protein Import Machinery Is Selectively Cytotoxic to Acute Myeloid Leukemia (AML) Cells and Stem Cells

A Novel Isoflavone, ME-344, Targets the Cytoskeleton in Acute Myeloid Leukemia

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

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American Society of Hematology

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ASH Publications

American Society of Hematology

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