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Journal Articles

Single Chain Variable Fragment Linker Length Regulates CAR Biology and T Cell Efficacy

Nathan Singh, MD, Noelle V. Frey, MD, Boris Engels, PhD, David M. Barrett, Olga Shestova, PhD, Pranali Ravikumar, MS, Amy Shyu, Steven Highfill, PhD, Linlin Zhao, Liaomin Peng, Brian Granda, Melissa Ramones, Xeuqing Maggie Lu, David A Christian, PhD, Jessica Perazzelli, Simon F Lacey, PhD, Nathan Roy, Janis K Burkhardt, PhD, Florent Colomb, Mohamed Abdel-Mohsen, Regina M Young, PhD, Jennifer Brogdon, PhD, Stephan Grupp, MD PhD, Carl H June, MD, Shannon L. Maude, MD PhD, Saar I. Gill, MD PhD, Marco Ruella, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 247.
https://doi.org/10.1182/blood-2019-131024
Published: 2019
Journal Articles

Generation of a Highly Sensitive CD22 CAR

Evangelia K Kokalaki, Biao Ma, PhD, Thomas Grothier, MSc, Warren Hazelton, MSc, Eren Costu, BSc, Somayya Manzoor, MSc, Ram Jha, MSc, Simon Thomas, PhD, Shimobi Onuoha, PhD, Shaun P Cordoba, PhD, Martin Pule, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5747.
https://doi.org/10.1182/blood-2019-128002
Published: 2019
Journal Articles

Neddylation Pathway Regulates Treg Differentiation and T Cell Function in Chronic Lymphocytic Leukemia (CLL) Ex Vivo and Murine In Vivo Studies

Scott R Best, BS, Vi Lam, Nur Bruss, BS, Taylor Hashiguchi Rowland, BS, Adam S. Kittai, MD, Tingting Liu, Allison J Berger, PhD, Alexey Danilov, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4313.
https://doi.org/10.1182/blood-2019-123600
Published: 2019
Journal Articles

Investigation of Cell-Contact Dependent Alterations in Immune Synapse Formation between T Cells and BCP-ALL Cells

Britta Wenske, PhD, Lothar Marischen, PhD, Julia Welzenbach, André Heimbach, PhD, Per Hoffmann, PhD, Selim Corbacioglu, MD, David A Williams, MD, Anja Troeger, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2754.
https://doi.org/10.1182/blood-2019-128835
Published: 2019
Journal Articles

Modulation of T-Cell Function in the Microenvironment of Emu-TCL1 CLL Bearing Mice By Btki Appears Independent of ITK

Mark-Alexander Schwarzbich, MD, Arantxa Romero-Toledo, MSc, Melanie Frigault, PhD, John G. Gribben
Journal: Blood
Blood (2018) 132 (Supplement 1): 3139.
https://doi.org/10.1182/blood-2018-99-116444
Published: 2018
Journal Articles

Wave-Complex-Dependent Actin Dynamics Controls Hematopoietic Stem Cell Bone Marrow Retention and Orderly Differentiation into Mature Hematopoietic Lineages

Eliza Wiercinska, PhD, David de Gorter, PhD, Eva Danner, Sabine Harenkamp, Andre Gorgens, PhD, Anja Schwiebs, PhD, Theresia Stradal, PhD, Halvard Bonig, MD MA
Journal: Blood
Blood (2017) 130 (Supplement 1): 2417.
https://doi.org/10.1182/blood.V130.Suppl_1.2417.2417
Published: 2017
Journal Articles

Mir-181c Modulates T Cell Function By Regulating the Expression of BRK1

Shok Ping Lim, Donal McLornan, MB, Bch (Hons), PhD MRCP, FRCPath, Nikolaos Ioannou, David Darling, Alan G. Ramsay, PhD, Joop Gäken, PhD, Ghulam J Mufti, MBBS, DM, FRCP, FRCPath
Journal: Blood
Blood (2016) 128 (22): 132.
https://doi.org/10.1182/blood.V128.22.132.132
Published: 2016
Journal Articles

Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration

Marta Pasikowska, Elisabeth Walsby, Benedetta Apollonio, Kirsty Cuthill, Elizabeth Phillips, Eve Coulter, Maria Serena Longhi, Yun Ma, Deborah Yallop, Linda D. Barber, Piers Patten, Chris Fegan, Alan G. Ramsay, Chris Pepper, Stephen Devereux, Andrea G. S. Buggins
Journal: Blood
Blood (2016) 128 (4): 563–573.
https://doi.org/10.1182/blood-2016-01-683128
Published: 2016
Includes: Supplemental data
Journal Articles

The Rac activator DOCK2 regulates natural killer cell–mediated cytotoxicity in mice through the lytic synapse formation

Yusuke Sakai, Yoshihiko Tanaka, Toyoshi Yanagihara, Mayuki Watanabe, Xuefeng Duan, Masao Terasawa, Akihiko Nishikimi, Fumiyuki Sanematsu, Yoshinori Fukui
Journal: Blood
Blood (2013) 122 (3): 386–393.
https://doi.org/10.1182/blood-2012-12-475897
Published: 2013
Includes: Supplemental data
Journal Articles

FcRL4 acts as an adaptive to innate molecular switch dampening BCR signaling and enhancing TLR signaling

Hae Won Sohn, Peter D. Krueger, Randall S. Davis, Susan K. Pierce
Journal: Blood
Blood (2011) 118 (24): 6332–6341.
https://doi.org/10.1182/blood-2011-05-353102
Published: 2011
Includes: Multimedia, Supplemental data
Journal Articles

Lenalidomide Treatment Enhances Immunological Synapse Formation of Cord Blood Natural Killer Cells with B Cells Derived From Chronic Lymphocytic Leukemia

Dongxia Xing, Ph. D., Alan G. Ramsay, PhD, Simon Robinson, PhD, Catherine M. Bollard, MD, Nina Shah, MD, Richard Champlin, MD, John G. Gribben, MD, DSc, Elizabeth J Shpall, MD
Journal: Blood
Blood (2011) 118 (21): 1794.
https://doi.org/10.1182/blood.V118.21.1794.1794
Published: 2011
Journal Articles

Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming

Gerben Bouma, Ariadna Mendoza-Naranjo, Michael P. Blundell, Elena de Falco, Kathryn L. Parsley, Siobhan O. Burns, Adrian J. Thrasher
Journal: Blood
Blood (2011) 118 (9): 2492–2501.
https://doi.org/10.1182/blood-2011-03-340265
Published: 2011
Includes: Multimedia, Supplemental data
Journal Articles

Functional Screening Studies Identify Combinational Activity of PD-L1 and CD200 In Mediating Dysfunctional T Cell Immunological Synapse Formation In Chronic Lymphocytic Leukemia

Alan G. Ramsay, PhD, Andrew James Clear, Alexander Davenport, Rewas Fatah, John G. Gribben, MD, DSc
Journal: Blood
Blood (2010) 116 (21): 696.
https://doi.org/10.1182/blood.V116.21.696.696
Published: 2010
Journal Articles

Impaired Natural Killer Cells Immune Synapse Formation in Acute Myeloid Leukemia.

Dongxia Xing, PhD, Alan G. Ramsay, PhD, William Decker, PhD, Sufang Li, Simon Robinson, Ph.D., Hong Yang, PhD, John G. Gribben, MD, DSc, Elizabeth J. Shpall, MD
Journal: Blood
Blood (2009) 114 (22): 2663.
https://doi.org/10.1182/blood.V114.22.2663.2663
Published: 2009
Journal Articles

Treatment of MCL Cells with Combined Rituximab and Lenalidomide Enhances NK-Mediated Synapse Formation and Cell Killing.

Svetlana Gaidarova, Laura G Corral, Emilia Glezer, Peter H Schafer, Antonia Lopez-Girona
Journal: Blood
Blood (2009) 114 (22): 1687.
https://doi.org/10.1182/blood.V114.22.1687.1687
Published: 2009
Journal Articles

Lenalidomide Alone and in Combination with Rituximab Enhances NK Cell Immune Synapse Formation in Chronic Lymphocytic Leukemia (CLL) Cells in Vitro through Activation of Rho and Rac1 GTPases.

Svetlana Gaidarova, JianWu Li, M.D., Laura G Corral, Emilia Glezer, Peter H Schafer, Weilin Xie, Antonia Lopez-Girona, Bruce D. Cheson, MD, Brydon Bennett
Journal: Blood
Blood (2009) 114 (22): 3441.
https://doi.org/10.1182/blood.V114.22.3441.3441
Published: 2009
Journal Articles

Ex Vivo Expansion of Cord Blood Natural Killer Cells Overcomes Impaired Immune Synapse Formation and Effector Function in Acute Myeloid Leukemia

Dongxia Xing, PhD, Alan G Ramsay, PhD, John G. Gribben, MD, William K Decker, PhD, Jared K Burt, PhD, Sufang Li, Simon N Simon, PhD, Hong Yang, PhD, Laurence Cooper, MD, PhD, John D. McMannis, PhD, Richard E Champlin, MD, PhD, Elizabeth J Shpall, MD, Patrick Zweidler-McKay, MD, PhD, Catherine M. Bollard, MD, FRACP, FRCPA
Journal: Blood
Blood (2008) 112 (11): 2905.
https://doi.org/10.1182/blood.V112.11.2905.2905
Published: 2008
Journal Articles

Lenalidomide Repairs Suppressed T Cell Immunological Synapse Formation in Follicular Lymphoma

Alan G. Ramsay, PhD, Andrew J. Clear, BSc, Rewa Fatah, BSc, John G. Gribben, MD, DSc
Journal: Blood
Blood (2008) 112 (11): 885.
https://doi.org/10.1182/blood.V112.11.885.885
Published: 2008
Journal Articles

Impaired Actin Polymerization Results in Defective Immunological Synapse Formation in T Cells in Chronic Lymphocytic Leukemia.

Alan G. Ramsay, PhD, Abigail M. Lee, MBBS, John G. Gribben, MD DSc
Journal: Blood
Blood (2007) 110 (11): 338.
https://doi.org/10.1182/blood.V110.11.338.338
Published: 2007
Journal Articles

RIAM, a Novel Rap-1 Effector, Is Recruited at the Immunological Synapse and the Lipid Rafts and Links TCR-Mediated Signals to the Actin Cytoskeleton.

Esther M. Lafuente, PhD, Erica M. Constantine, Matthew Salanga, Vassiliki A. Boussiotis, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 3299.
https://doi.org/10.1182/blood.V106.11.3299.3299
Published: 2005