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Journal Articles

Talazoparib Treatment Preferentially Depletes Cohesin-Mutant Clones in New In Vivo M odels of Cohesin-Mutant Myeloid Diseases

Mounica Vallurupalli, MD, Rebecca Gorelov, BS, Jacqueline S Garcia, MD, Elizabeth A Morgan, MD, Benjamin Ebert, MD, Zuzana Tothova, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 560.
https://doi.org/10.1182/blood-2019-130308
Published: 2019
Journal Articles

Anti-Leukemic Efficacy of Talazoparib and APE1 Inhibitor III Combined with Decitabine in Myeloid Malignancies

Vanessa Kohl, MSc, Susanne Brendel, MTA, Johanna Flach, PhD, Helga Kleiner, MTA, Christel Weiss, PhD, Wolfgang Seifarth, PhD, Daniel Nowak, MD, Wolf-Karsten Hofmann, MD PhD, Alice Fabarius, PhD, Henning D. Popp
Journal: Blood
Blood (2019) 134 (Supplement_1): 5056.
https://doi.org/10.1182/blood-2019-122672
Published: 2019
Journal Articles

High Expression of BCAT1 promotes Acute Myeloid Leukemia Progression and Sensitize to PARP Inhibitor

Jie Jin, PhD, Jie Jin, PhD, Jiajia Pan, Yungui Wang, PhD, Shujuan Huang, Shihui Mao, Qing Ling, Jinghan Wang, MD PhD, Chenying Li
Journal: Blood
Blood (2019) 134 (Supplement_1): 5041.
https://doi.org/10.1182/blood-2019-125221
Published: 2019
Journal Articles

STAG2 Loss Gives Rise to Therapeutically Targetable DNA Damage Repair Defects and Altered Replication Fork Dynamics in Acute Myeloid Leukaemia

Harmony Estelle Black, BSc, Satpal Jhujh, Grant S Stewart, BSc, PhD, Kienan I Savage, PhD, Ken I Mills, PhD FRCPath, BSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 1255.
https://doi.org/10.1182/blood-2019-129828
Published: 2019
Journal Articles

DNA Methyltransferase Inhibitors Promote Homologous Recombination Deficiency through Induction of Immune Signaling, Sensitizing Acute Myeloid Leukemia Cells to PARP Inhibitors

Aksinija A Kogan, BS, MS, Lena J Mclaughlin, BS, Maria R. Baer, MD, Stephen Baylin, MD, Michael Topper, BS, Feyruz V. Rassool, BSc, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3763.
https://doi.org/10.1182/blood-2019-129535
Published: 2019
Journal Articles

Addition of the PARP Inhibitor, Talazoparib, to Gemtuzumab Ozogamicin Significantly Enhances Anti-Leukemic Activity in Human CD33+ Acute Myeloid Leukemia

Scott M. Portwood, MBA, MS, Marianna C Cantella, BE, Tara L. Cronin, BA, Eunice S. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1371.
https://doi.org/10.1182/blood-2019-130427
Published: 2019
Journal Articles

High PARP-1 expression Predicts Poor Survival in Acute Myeloid Leukemia and PARP-1 Inhibitor and SAHA-Bendamustine Hybrid Inhibitor Combination Treatment Synergistically Enhances Anti-Tumor Effects

Xia Li, Chenying Li, Jingrui Jin, Jinghan Wang, Jie Jin, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5252.
https://doi.org/10.1182/blood-2018-99-114344
Published: 2018
Journal Articles

STAG2 Mutations Alter Cohesin Ring Function and Provide Therapeutic Vulnerabilities in Acute Myeloid Leukemia

Zuzana Tothova, MD PhD, John M. Krill-Burger, MS, Daniel S. Day, PhD, J. Erika Haydu, MD PhD, Brian J. Abraham, PhD, Catherine C. Landers, BA, Edyta Malolepsza, PhD, Christina R. Hartigan, BS, Amie Holmes, PhD, Melanie Donahue, BS, Katerina D. Popova, BA, Sebastian Koochaki, MS, Jeanne Rivera, BSc, Michael Seiler, PhD, Denes Hnisz, PhD, Edwin Chen, PhD, Silvia Buonamici, PhD, Monica Schenone, PhD, Alan D. D'Andrea, MD, Steven A. Carr, PhD, Richard A. Young, PhD, Benjamin L. Ebert, MDPhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 940.
https://doi.org/10.1182/blood-2018-99-117480
Published: 2018
Journal Articles

Absence of NKG2D Ligands Defines Human Acute Myeloid Leukaemia Stem Cells and Mediates Their Immune Evasion

Anna M Paczulla, PhD, Kathrin Rothfelder, PhD, Simon Raffel, MD, Martina Konantz, PhD, Julia Steinbacher, PhD, Hui Wang, PhD, Marcelle Ndoh Mbarga, Thorsten Schaefer, PhD, Daniela Dörfel, MD, Mattia Falcone, Eva Nievergall, PhD, Claudia Tandler, MSc, Christoph Lutz, Pontus Lundberg, PhD, Lothar Kanz, Leticia Quintanilla-Martinez, MD, Alexander Steinle, Andreas Trumpp, Prof, PhD, Helmut R. Salih, MD, Claudia Lengerke, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 769.
https://doi.org/10.1182/blood-2018-99-118047
Published: 2018
Journal Articles

Synergistic Anti-Leukemic Activity of PARP Inhibition Combined with IMGN632, an Anti-CD123 Antibody-Drug Conjugate in Acute Myeloid Leukemia Models

Claire Fritz, Scott M. Portwood, MS, MBA, Julie Adams, BS, Tara Cronin, BA, Linda Lutgen-Dunckley, Brandon L Martens, BS, Callum M. Sloss, PhD, Krystal Watkins, Yelena Kovtun, PhD, Sharlene Adams, PhD, Eunice S. Wang, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2647.
https://doi.org/10.1182/blood-2018-99-117214
Published: 2018
Journal Articles

PARP1 Inhibitors Eliminated Imatinib-Refractory Chronic Myeloid Leukemia Cells in Bone Marrow Microenvironment Conditions

Margaret Nieborowska-Skorska, Paulina Podszywalow-Bartnicka, Silvia Maifrede, Bac Viet Le, Monika Toma, Peter Valent, Tomasz Sliwinski, Wayne Childers, Katarzyna Piwocka, Alexei Tulin, Tomasz Skorski, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3000.
https://doi.org/10.1182/blood-2018-99-115041
Published: 2018
Journal Articles

Multiplex CRISPR/Cas9-Based Genome Editing of Mouse Hematopoietic Stem Cells Recapitulates Acute Erythroid Leukemia and Identifies Therapeutic Targets

Ilaria Iacobucci, PhD, Elena Varotto, MD, Chunxu Qu, PhD, Laura Janke, DVM, PhD, Aman Seth, PhD, Anang Shelat, PhD, Burgess Freeman, PhD, James Kennedy, Adam S Sperling, MD PhD, R. Coleman Lindsley, MD PhD, Kirsten Dickerson, BS, Debbie Payne-Turner, Sarah M Morris, Nina Ghosn, Benjamin L. Ebert, MDPhD, Charles G. Mullighan, MBBS, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5.
https://doi.org/10.1182/blood-2018-99-118817
Published: 2018
Journal Articles

DNA Demethylating Agents Generate a Brcaness Effect in Multiple Sporadic Tumor Types: Prediction for Sensitivity to PARP Inhibitors in AML

Aksinija A Kogan, BS, MS, Lena J Mclaughlin, BS, Michael Topper, BS, Nidal Muvarak, PhD, Lora Stojanovic, BS, T Michael Creed, BS, MS, Soren Bentzen, PhD DMSc, Curt I. Civin, MD, Maria R. Baer, MD, Tami J Kingsbury, PhD, Stephen Baylin, MD, Feyruz V. Rassool, BSc, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3347.
https://doi.org/10.1182/blood.V130.Suppl_1.3347.3347
Published: 2017
Journal Articles

Ruxolitinib-Induced Defects in DNA Repair Cause Sensitivity to PARP Inhibitors in Myeloproliferative Neoplasms

Margaret Nieborowska-Skorska, Silvia Maifrede, Yashodhara Dasgupta, Katherine Sullivan, Bac Viet Le, Martyna Solecka, Lucia Kubovcakova, Morgan Nawrocki, Martin Kirschner, MD, Huaqing Zhao, Josef T. Prchal, MD, Katarzyna Piwocka, Alison R. Moliterno, MD, Steffen Koschmieder, Anthony R Green, PhD FRCP, FRCPath, FMedSci, Radek C. Skoda, MD, Tomasz Skorski
Journal: Blood
Blood (2017) 130 (Supplement 1): 2938.
https://doi.org/10.1182/blood.V130.Suppl_1.2938.2938
Published: 2017
Journal Articles

Tyrosine Kinase Inhibitor-Induced Defects in DNA Repair Sensitize FLT3(ITD)-Positive Acute Myeloid Leukemia Quiescent and Proliferative Cells to PARP Inhibitors

Silvia Maifrede, Margaret Nieborowska-Skorska, Katherine Sullivan, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Bac Viet Le, Martyna Solecka, Zhaorui Lian, Marcin M Machnicki, Huaqing Zhao, Jaroslav Jelinek, Katarzyna Piwocka, Tomasz Stoklosa, Thomas Fischer, Stephen M. Sykes, Steffen Koschmieder, Lars Bullinger, MD, Peter Valent, MD, Jian Huang, Tomasz Skorski
Journal: Blood
Blood (2017) 130 (Supplement 1): 2635.
https://doi.org/10.1182/blood.V130.Suppl_1.2635.2635
Published: 2017
Journal Articles

IGH/MYC Translocation in Burkitt Lymphoma Is Associated with BRCA2 Deficiency and Synthetic Lethality By PARP1 Inhibitors

Silvia Maifrede, Kayla Martin, Paulina Podszywalow-Bartnicka, PhD, Sullivan Katherine, Samantha Langer, Reza Nejati, Yashodhara Dasgupta, Daniel Gritsyuk, Margaret Nieborowska-Skorska, Lena Lupey, Katarzyna Piwocka, Mariusz A Wasik, MD, Italo Tempera, Tomasz Skorski
Journal: Blood
Blood (2016) 128 (22): 4111.
https://doi.org/10.1182/blood.V128.22.4111.4111
Published: 2016