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Issue Archive

Volume 4, Issue 5
March 10 2020
Issue Cover

Table of Contents

BLOOD ADVANCES TALK

The changing landscape of anticoagulation in cancer-associated thrombosis
Clinical Trials & Observations
Agnes Y. Y. Lee
View Articletitled, The changing landscape of anticoagulation in cancer-associated thrombosis
Supplemental data

EXCEPTIONAL CASE REPORTS

Successful treatment of thrombocytopenia with daratumumab after allogeneic transplant: a case report and literature review
Clinical Trials & Observations
Yazan Migdady,Asiri Ediriwickrema,Ryan Patrick Jackson,Wendy Kadi,Ridhi Gupta,Francisco Socola,Sally Arai,Beth A. Martin
View Articletitled, Successful treatment of thrombocytopenia with daratumumab after allogeneic transplant: a case report and literature review
Total knee replacement with and without emicizumab: a unique comparison of perioperative management
Clinical Trials & Observations
Matthew S. Evans,Charles Davis, III,M. Elaine Eyster
View Articletitled, Total knee replacement with and without emicizumab: a unique comparison of perioperative management

STIMULUS REPORTS

Monoallelic loss-of-function THPO variants cause heritable thrombocytopenia
Naomi Cornish,M. Riyaad Aungraheeta,Lucy FitzGibbon,Kate Burley,Dominic Alibhai,Janine Collins,Daniel Greene,Kate Downes,NIHR BioResource,Sarah K. Westbury,Ernest Turro,Andrew D. Mumford
View Articletitled, Monoallelic loss-of-function THPO variants cause heritable thrombocytopenia
Supplemental data
Identification of germline variants in adults with hemophagocytic lymphohistiocytosis
Peter G. Miller,Abhishek Niroula,John J. Ceremsak,Christopher J. Gibson,Martin S. Taylor,Sebastian Birndt,Florian Perner,Jon Arnason,Adam S. Sperling,Mridul Agrawal,Alison M. Schram,Sarah Nikiforow,German Pihan,Robert P. Hasserjian,Jon C. Aster,Paul La Rosée,Elizabeth A. Morgan,Nancy Berliner,Benjamin L. Ebert
View Articletitled, Identification of germline variants in adults with hemophagocytic lymphohistiocytosis
Supplemental data

REVIEW ARTICLE

Clinical developments in epigenetic-directed therapies in acute myeloid leukemia
Darren Pan,Raajit Rampal,John Mascarenhas
View Articletitled, Clinical developments in epigenetic-directed therapies in acute myeloid leukemia

SYSTEMATIC REVIEW

Patient values and preferences regarding VTE disease: a systematic review to inform American Society of Hematology guidelines
Itziar Etxeandia-Ikobaltzeta,Yuan Zhang,Francesca Brundisini,Ivan D. Florez,Wojtek Wiercioch,Robby Nieuwlaat,Housne Begum,Carlos A. Cuello,Yetiani Roldan,Ru Chen,Chengyi Ding,Rebecca L. Morgan,John J. Riva,Yuqing Zhang,Rana Charide,Arnav Agarwal,Sara Balduzzi,Gian Paolo Morgano,Juan José Yepes-Nuñez,Yasir Rehman,Ignacio Neumann,Nicole Schwab,Tejan Baldeh,Cody Braun,María Francisca Rodríguez,Holger J. Schünemann
View Articletitled, Patient values and preferences regarding VTE disease: a systematic review to inform American Society of Hematology guidelines
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Assessment of minimal residual disease using multiparametric flow cytometry in patients with AL amyloidosis
Clinical Trials & Observations
Andrew Staron,Eric J. Burks,John C. Lee,Shayna Sarosiek,J. Mark Sloan,Vaishali Sanchorawala
View Articletitled, Assessment of minimal residual disease using multiparametric flow cytometry in patients with AL amyloidosis

IMMUNOBIOLOGY AND IMMUNOTHERAPY

CLL intraclonal fractions exhibit established and recently acquired patterns of DNA methylation
Boris A. Bartholdy,Xiahoua Wang,Xiao-Jie Yan,Marién Pascual,Manxia Fan,Jacqueline Barrientos,Steven L. Allen,Jose Angel Martinez-Climent,Kanti R. Rai,Nicholas Chiorazzi,Matthew D. Scharff,Sergio Roa
View Articletitled, CLL intraclonal fractions exhibit established and recently acquired patterns of DNA methylation
Supplemental data
A novel C2 domain binding CD33xCD3 bispecific antibody with potent T-cell redirection activity against acute myeloid leukemia
Priyanka Nair-Gupta,Michael Diem,Dara Reeves,Weirong Wang,Robert Schulingkamp,Katrin Sproesser,Bethany Mattson,Bradley Heidrich,Mark Mendonça,Jocelin Joseph,Jocelyn Sendecki,Brad Foulk,Gerald Chu,Damien Fink,Qun Jiao,Sheng-Jiun Wu,Kathryn Packman,Yusri Elsayed,Ricardo Attar,François Gaudet
View Articletitled, A novel C2 domain binding CD33xCD3 bispecific antibody with potent T-cell redirection activity against acute myeloid leukemia
Supplemental data

LYMPHOID NEOPLASIA

Copanlisib synergizes with conventional and targeted agents including venetoclax in B- and T-cell lymphoma models
Chiara Tarantelli,Martin Lange,Eugenio Gaudio,Luciano Cascione,Filippo Spriano,Ivo Kwee,Alberto J. Arribas,Andrea Rinaldi,Thibaud Jourdan,Melanie Berthold,Andrea Sturz,Carolyn Sperl,Francesco Margheriti,Lorenzo Scalise,Giuseppe Gritti,Davide Rossi,Anastasios Stathis,Ningshu Liu,Emanuele Zucca,Oliver Politz,Francesco Bertoni
View Articletitled, Copanlisib synergizes with conventional and targeted agents including venetoclax in B- and T-cell lymphoma models
Supplemental data
Integrative analysis of the genomic and transcriptomic landscape of double-refractory multiple myeloma
Bachisio Ziccheddu,Giulia Biancon,Filippo Bagnoli,Chiara De Philippis,Francesco Maura,Even H. Rustad,Matteo Dugo,Andrea Devecchi,Loris De Cecco,Marialuisa Sensi,Carolina Terragna,Marina Martello,Tina Bagratuni,Efstathios Kastritis,Meletios A. Dimopoulos,Michele Cavo,Cristiana Carniti,Vittorio Montefusco,Paolo Corradini,Niccolo Bolli
View Articletitled, Integrative analysis of the genomic and transcriptomic landscape of double-refractory multiple myeloma
Supplemental data
Rituximab/bendamustine and rituximab/cytarabine induction therapy for transplant-eligible mantle cell lymphoma
Clinical Trials & Observations
Reid W. Merryman,Natasha Edwin,Robert Redd,Jad Bsat,Matthew Chase,Ann LaCasce,Arnold Freedman,Caron Jacobson,David Fisher,Samuel Ng,Jennifer Crombie,Austin Kim,Oreofe Odejide,Matthew S. Davids,Jennifer R. Brown,Heather Jacene,Amanda Cashen,Nancy L. Bartlett,Neha Mehta-Shah,Armin Ghobadi,Brad Kahl,Robin Joyce,Philippe Armand,Eric Jacobsen
View Articletitled, Rituximab/bendamustine and rituximab/cytarabine induction therapy for transplant-eligible mantle cell lymphoma
Supplemental data
Progression of AITL-like tumors in mice is driven by Tfh signature proteins and T-B cross talk
Mariko Witalis,Jinsam Chang,Ming-Chao Zhong,Yasser Bouklouch,Vincent Panneton,Joanna Li,Thorsten Buch,Seok Jin Kim,Won Seog Kim,Young Hyeh Ko,André Veillette,Woong-Kyung Suh
View Articletitled, Progression of AITL-like tumors in mice is driven by Tfh signature proteins and T-B cross talk
Supplemental data
The application of RNA sequencing for the diagnosis and genomic classification of pediatric acute lymphoblastic leukemia
Lauren M. Brown,Andrew Lonsdale,Andrea Zhu,Nadia M. Davidson,Breon Schmidt,Anthony Hawkins,Elise Wallach,Michelle Martin,Francoise M. Mechinaud,Seong Lin Khaw,Ray C. Bartolo,Louise E. A. Ludlow,Jackie Challis,Ian Brooks,Vida Petrovic,Nicola C. Venn,Rosemary Sutton,Ian J. Majewski,Alicia Oshlack,Paul G. Ekert
View Articletitled, The application of RNA sequencing for the diagnosis and genomic classification of pediatric acute lymphoblastic leukemia
Supplemental data

MYELOID NEOPLASIA

Molecular pathogenesis of progression to myeloid leukemia from TET-insufficient status
Raksha Shrestha,Mamiko Sakata-Yanagimoto,Koichiro Maie,Motohiko Oshima,Masatomo Ishihara,Yasuhito Suehara,Kota Fukumoto,Yaeko Nakajima-Takagi,Hirotaka Matsui,Takayasu Kato,Hideharu Muto,Tatsuhiro Sakamoto,Manabu Kusakabe,Yasuhito Nannya,Hideki Makishima,Hiroo Ueno,Ryunosuke Saiki,Seishi Ogawa,Kenichi Chiba,Yuichi Shiraishi,Satoru Miyano,Enguerran Mouly,Olivier A. Bernard,Toshiya Inaba,Haruhiko Koseki,Atsushi Iwama,Shigeru Chiba
View Articletitled, Molecular pathogenesis of progression to myeloid leukemia from TET-insufficient status
Supplemental data
Clonal hematopoiesis predicts development of therapy-related myeloid neoplasms post–autologous stem cell transplantation
Clinical Trials & Observations
Johannes Frasez Soerensen,Anni Aggerholm,Gitte Birk Kerndrup,Marcus Celik Hansen,Ina Kathrine Lykke Ewald,Marie Bill,Lene Hyldahl Ebbesen,Carina Agerbo Rosenberg,Peter Hokland,Maja Ludvigsen,Anne Stidsholt Roug
View Articletitled, Clonal hematopoiesis predicts development of therapy-related myeloid neoplasms post–autologous stem cell transplantation
Supplemental data
Single-cell mutational profiling enhances the clinical evaluation of AML MRD
Clinical Trials & Observations
Asiri Ediriwickrema,Alexey Aleshin,Johannes G. Reiter,M. Ryan Corces,Thomas Köhnke,Melissa Stafford,Michaela Liedtke,Bruno C. Medeiros,Ravindra Majeti
View Articletitled, Single-cell mutational profiling enhances the clinical evaluation of AML MRD
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Bleeding in patients with sickle cell disease: a population-based study
Clinical Trials & Observations
Nisha Hariharan,Ann Brunson,Anjlee Mahajan,Theresa H. M. Keegan,Ted Wun
View Articletitled, Bleeding in patients with sickle cell disease: a population-based study
Supplemental data

TRANSFUSION MEDICINE

Human megakaryocytic microparticles induce de novo platelet biogenesis in a wild-type murine model
Christian Escobar,Chen-Yuan Kao,Samik Das,Eleftherios T. Papoutsakis
View Articletitled, Human megakaryocytic microparticles induce de novo platelet biogenesis in a wild-type murine model
Supplemental data

ERRATUM

Bennewitz MF, Tutuncuoglu E, Gudapati S, et al. P-selectin–deficient mice to study pathophysiology of sickle cell disease. Blood Adv. 2020;4(2):266-273.
View Articletitled, Bennewitz MF, Tutuncuoglu E, Gudapati S, et al. P-selectin–deficient mice to study pathophysiology of sickle cell disease. <em>Blood Adv.</em> 2020;4(2):266-273.
  • Cover Image

    Cover Image

    issue cover

    COVER FIGURE
    Coculture of human megakaryocytic microparticles (huMkMPs) with murine hematopoietic stem and progenitor cells (muHSPCs) promotes murine megakaryopoiesis. muHSPCs were cocultured with huMkMPs without any thrombopoietin supplementation for 5 days. At day 5, cells were harvested, fixed, and stained for expression of von Willebrand factor (red), β-tubulin I (green), and the nucleus (4′,6-diamidino-2-phenylindole [DAPI]; blue). Cells were visualized via confocal and bright-field microscopies. An individual megakaryocyte is shown. Color was enhanced for better visualization. See the article by Escobar et al.

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