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Issue Archive

Volume 9, Issue 19
October 14 2025
Blood Advances Cover Image for Volume 9, Issue 19

Table of Contents

INSIDE BLOOD ADVANCES

Age and sex influence bleeding score in mild VWF deficiency
Giancarlo Castaman
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Reading between the (long) lines: one-stop F8 gene analysis?
Julie A. Majerus,Juliana Perez Botero
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Extravascular hemolysis in PNH
Clinical Trials & Observations
Jeff Szer
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Moving the needle on chronic GVHD of the lung
Clinical Trials & Observations
Julie R. Boiko,Kenneth R. Cooke
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Point-of-care CAR T-cell therapy: toward broader access
Clinical Trials & Observations
Susana Rives
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Toward eRASing the challenge of CMML heterogeneity
Hasse M. Addinsell,Daniel H. Wiseman
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ADVANCES VIEWPOINT

Advances and updates in pediatric anaplastic large cell lymphoma
Lianna J. Marks,Eric Lowe,Kala Kamdar
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CLINICAL TRIALS AND OBSERVATIONS

Long-term follow-up of venetoclax monotherapy in previously treated patients with Waldenström macroglobulinemia
Clinical Trials & Observations
Jorge J. Castillo,Alberto Guijosa,John N. Allan,Tanya Siddiqi,Ranjana H. Advani,Catherine A. Flynn,Kirsten Meid,Nina Budano,Julia Nguyen,Andres Ramirez-Gamero,Nicholas Tsakmaklis,Zachary R. Hunter,Christopher J. Patterson,Steven P. Treon,Shayna Sarosiek
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Characterizing clinically significant extravascular hemolysis in adults with PNH on ravulizumab or eculizumab treatment
Clinical Trials & Observations
Austin G. Kulasekararaj,Jong Wook Lee,Christopher J. Patriquin,Caroline I. Piatek,Alexander Röth,Wilma Barcellini,Robert A. Brodsky,Jun-ichi Nishimura,Ji Yu,Mohammed Mahdi,Régis Peffault de Latour
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Supplemental data
Extravascular hemolysis in PNH
Clinical Trials & Observations
Jeff Szer
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Tocilizumab prophylaxis for patients with multiple myeloma treated with bispecific antibodies
Clinical Trials & Observations
Andrew Kowalski,Jill Lykon,Benjamin Diamond,David Coffey,Marcella Kaddoura,Francesco Maura,James Hoffman,Abhishek Pandey,Dickran Kazandjian,Ola Landgren
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Pirfenidone for the treatment of bronchiolitis obliterans syndrome related to chronic graft-versus-host disease
Clinical Trials & Observations
Husham Sharifi,Carson Tyler Moss,Zayan Musa,Alexander Bell,Christian O’Donnell,Carlos Hernandez Borges,Efthymia Iliana Matthaiou,Laura Johnston,Craig J. Galban,Ajay Sheshadri,Gregory Yanik,Guang-Shing Cheng,Joe L. Hsu
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Supplemental data
Moving the needle on chronic GVHD of the lung
Clinical Trials & Observations
Julie R. Boiko,Kenneth R. Cooke
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HEMATOPOIESIS AND STEM CELLS

Immune cells display an abnormal maturation and a proinflammatory profile in telomere biology disorders
Willian R. Gomes,Shan Hama,Giorgio Napolitani,Amandine Tan,Luiz Fernando B. Catto,Flávia S. Donaires,Bárbara A. Santana,Vinícius S. Carvalho,Edson Z. Martinez,Antonio Condino-Neto,Mohammad M. Karimi,Ghulam J. Mufti,Rodrigo T. Calado
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Supplemental data
Single-cell proteomics characterization of bone marrow hematopoiesis with distinct Ras pathway lesions
Laila Karra,Anna-Marie Finger,Lauren Shechtman,Milana Krush,Rita Meng-Yao Huang,Morgan Prinz,Iliana Tennvooren,Kriti Bahl,Lisiena Hysienaj,Paulina G. Gonzalez,Alexis J. Combes,Hugo Gonzalez,Rafael J. Argüello,Matthew H. Spitzer,Jeroen P. Roose
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Supplemental data
Antibiotic treatment limits survival of peripheral and bone marrow B-cell populations
Lila S. Sanning,Forrest C. Walker,Arushana A. Maknojia,Leran Wang,Haina Jin,Gowri Kalugotla,Crystal Lovato,Katherine Y. King,Megan T. Baldridge
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Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Characterization and prediction of prolonged severe neutropenia in pediatric patients receiving tisagenlecleucel
Swati Naik,Subodh Selukar,Aimee C. Talleur,Samira Deshpande,Gabriela Llaurador Caraballo,Vanessa A. Fabrizio,Rayne H. Rouce,Xiaopei L. Zeng,Anant Vatsayan,Jenna Rossoff,Holly L. Pacenta,Samuel John,Christine L. Phillips,Julie-An Talano,Amy Moskop,Michael R. Verneris,Gary D Myers,Erin Hall,Nicole Karras,Challice L. Bonifant,Muna Qayed,Emily Bakinowski,Amy K. Keating,Susanne H. C. Baumeister,Emily Tomilson,Michelle L. Hermiston,Prakash Satwani,Christa Krupski,Vasant Chinnabhandar,Heather E. Stefanski,Emily Egeler,Kevin J. Curran,Theodore W. Laetsch,Crystal L. Mackall,Snehit Prabhu,Khanh P. Nguyen,Christina Baggott,Liora Michal Schultz,Kevin O. McNerney
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Supplemental data
Point-of-care fresh CAR T cells for pediatric or young adult BCP-ALL that is relapsed/refractory or in very-high-risk first relapse
Clinical Trials & Observations
Francesca Del Bufalo,Marco Becilli,Chiara Rosignoli,Pietro Merli,Mattia Algeri,Daria Pagliara,Federica Galaverna,Michele Massa,Valeria Paganelli,Maria Giuseppina Cefalo,Linda Hanssens,Valentina Bertaina,Giuseppina Li Pira,Giovanna Leone,Matilde Sinibaldi,Stefano Di Cecca,Laura Iaffaldano,Valentina Fustaino,Biagio De Angelis,Concetta Quintarelli,Franco Locatelli
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Supplemental data
Point-of-care CAR T-cell therapy: toward broader access
Clinical Trials & Observations
Susana Rives
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LYMPHOID NEOPLASIA

BH3 mimetic drugs overcome the microenvironment-induced resistance to crizotinib in ALK+ anaplastic large cell lymphoma
Claudia Pignataro,Pietro Zoppoli,Luca Vincenzo Cappelli,Liron Yoffe,Marta Moretti,Mariapaola Izzo,Selene Mallia,Clarisse Kayembe,Abigail Taylor,Gianluca Petrillo,Alessandra Affinito,Cristina Quintavalle,Giada De Luca,Martina Mascolo,Sara Verde,Aurelia Fraticelli,Alessia Ciarrocchi,Paolo Salerno,Enrico De Smaele,Antonio Francesco Campese,Valentina Fragliasso,Robin Foà,Giuseppe Merla,Giorgio Inghirami,Gerolama Condorelli,Danilo Fiore
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Supplemental data
Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma
Patrick Nylund,Berta Garrido-Zabala,Stefania Iliana Tziola,Tabassom Mohajershojai,Hanna Berglund,Catharina Muylaert,Lien Ann Van Hemelrijck,Alba Atienza Párraga,Louella Vasquez,Jim Jacob,Eric Bergquist,José Ignacio Martín-Subero,Fredrik Öberg,Torbjörn Karlsson,Marika Nestor,Elke De Bruyne,Antonia Kalushkova,Helena Jernberg Wiklund
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Supplemental data
Tafasitamab plus lenalidomide as salvage therapy in diffuse large B-cell lymphoma: real-world experience from GELTAMO
Antonio Gutierrez,Izaskun Zeberio,Francisco Javier Peñalver,Pilar Martinez-Barranco,Sandra Perez,Daniel Morillo,Xabier Martin,Concepcion Nicolas,Ainara Ferrero,Ana Jimenez-Ubieto,Mariana Bastos-Oreiro,Julio Davila-Valls,Maria Victoria Calle,María Perez,Guillermo Rodriguez,Aranzazu Alonso,Ana Garcia-Noblejas,Diana Sanchez Argüello,Teresa Knight,Ángeles Fernandez,Javier Lopez,Jaime Perez De Oteyza,Sonia González de Villambrosia,Elena Perez,Alejandro Marin,Maria Belen Navarro,Ruben Fernandez,Pilar Gomez,José Antonio Hueso,Maria Jesus Peñarrubia Ponce,Pilar Bravo,Daniel Garcia-Belmonte,Haridian De La Nuez,Sara Nistal,Pau Abrisqueta,Fernanda Ibañez,Luis Palomera,Eva Donato,Andrea Provencio,Maria Stefania Infante,Eva Gonzalez-Barca
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YX0798 is a highly potent, selective, and orally effective CDK9 inhibitor for treating aggressive lymphoma
Vivian Jiang,Yu Xue,Hong Kim,Qingsong Cai,Tianci Zhang,Lei Nie,Joseph McIntosh,Yang Liu,Haiying Chen,Jia Zhou,Michael Wang
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Supplemental data
Estimating efficacy of favezelimab plus pembrolizumab relative to pembrolizumab in anti–PD-1–refractory Hodgkin lymphoma
Clinical Trials & Observations
Philippe Armand,Pier Luigi Zinzani,John Timmerman,Nathalie A. Johnson,David Lavie,Kannan Thiagarajan,Brian G. Topp,Pallavi Pillai,Alex F. Herrera
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Supplemental data
In vivo CRISPR screening reveals cooperation of KMT2D and TP53 deficiencies in B-cell lymphomagenesis
Kentaro Yamaguchi,Junji Koya,Kota Mizuno,Yosuke Mizukami,Kota Yoshifuji,Yuki Saito,Mariko Tabata,Sumito Shingaki,Mitsuhiro Yuasa,Yuta Ito,Kazutaka Nakashima,Kostiantyn Dreval,Ryan D. Morin,Kenichi Chiba,Ai Okada,Yuichi Shiraishi,Koichi Murakami,Yasunori Kogure,Koichi Ohshima,Keisuke Kataoka
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Supplemental data

MYELOID NEOPLASIA

Targeting bone marrow mesenchymal stromal cell–derived IL-6 to overcome acute myeloid leukemia chemoresistance
Diyu Hou,Danni Cai,Wei Dai,Xinai Liao,Maoqing Tan,Xiaoming Zheng,Liuhuan Wang,Jingru Liu,Jin Wang,Xiaoting Wang,Qiang Fu,Huifang Huang
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Supplemental data
Utility of IDH1/2 mutations as biomarkers for detection of measurable residual disease in acute myeloid leukemia
Emma L. Boertjes,Christian M. Vonk,François G. Kavelaars,Marie Engvall,Sofia Nordin,Lisanne Beugelink,Melissa Rijken,Jolinda M. L. Konijnenburg,Jurjen Versluis,Bob Löwenberg,Peter J. M. Valk
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Supplemental data
Landscape and clinicopathologic features of RAS pathway mutations in chronic myelomonocytic leukemia
Guillermo Montalban-Bravo,Sanam Loghavi,Ziyi Li,Kelly Chien,Rashmi Kanagal-Shamanna,Alex Bataller,Anuya Natu,Mark Gurney,Alexandre Bazinet,Danielle Hammond,Koji Sasaki,Gautam Borthakur,Mahesh Swaminathan,Courtney DiNardo,Tapan Kadia,Farhad Ravandi,Naval Daver,Nicholas Short,Naveen Pemmaraju,Ghayas Issa,Terra L. Lasho,Christy M. Finke,Aref Al-Kali,Clifford Csizmar,Hassan Alkhateeb,Naseema Gangat,Abhishek A. Mangaonkar,Carlos Bueso-Ramos,Ayalew Tefferi,Hagop Kantarjian,Guillermo Garcia-Manero,Mrinal M. Patnaik
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Supplemental data
Toward eRASing the challenge of CMML heterogeneity
Hasse M. Addinsell,Daniel H. Wiseman
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RED CELLS, IRON, AND ERYTHROPOIESIS

Prospective cohort study of eDiary acute pain assessments in sickle cell disease during third trimester and postpartum
Eugenia V. Asare,William K. Ghunney,John B. Ayete-Nyampong,Enoch A. Mensah,Alim Swarray-Deen,Edeghonghon Olayemi,Theodore Boafor,Jude Jonassaint,Charles R. Jonassaint,Mark Rodeghier,Samuel A. Oppong,Michael R. DeBaun
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THROMBOSIS AND HEMOSTASIS

Effect of age on ISTH-BAT scores and low VWF diagnosis in the Zimmerman Program
Ferdows Atiq,Pamela A. Christopherson,Dearbhla Doherty,Anne-Marije Hulshof,Sandra L. Haberichter,Veronica H. Flood,Michelle Lavin,Niamh M. O’Connell,Kevin Ryan,Mary Byrne,Julie Grabell,Paula D. James,David Lillicrap,Robert R. Montgomery,Jorge Di Paola,James S. O’Donnell
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Supplemental data
Age and sex influence bleeding score in mild VWF deficiency
Giancarlo Castaman
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Multipopulation GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish
Brooke N. Wolford,Queena Yakun Zhao,Kuan-Han H. Wu,Xinge Yu,Catherine E. Richter,Laxmi Bhatta,Ben M. Brumpton,Karl C. Desch,Florian Thibord,Derek Klarin,Andrew D. Johnson,David-Alexandre Trégouët,Scott M. Damrauer,Nicholas L. Smith,Valeria Lo Faro,Kristin Tsuo,Mark J. Daly,Benjamin M. Neale,Wei Zhou,Cristen J. Willer,Jordan A. Shavit,Ida Surakka
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Supplemental data
Outcomes and survival prediction in adults with sickle cell disease treated with extracorporeal membrane oxygenation
Alison Grazioli,Michael Plazak,Kate Willsey,Joseph Rabin,Raymond P. Rector,Leonid Belyayev,Allison S. Lankford,Thomas M. Scalea,Aakash Shah,Bradley S. Taylor,Mark T. Gladwin
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Supplemental data
Hybridization capture long-read sequencing and de novo assembly of homologous haplotypes: a comprehensive hemophilia test
Boyan Liu,Ruixia Xu,Siqian Ma,Mengnan Gu,Lingyin Kong,Lu Zhou,Haoning Liu,Shujin Chen,Yuyan Yang,Ziqiang Yu,Bo Liang,Miao Jiang
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Supplemental data
Reading between the (long) lines: one-stop F8 gene analysis?
Julie A. Majerus,Juliana Perez Botero
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Dietary tryptophan augments cancer-associated venous thrombogenicity mitigated by indoleamine 2,3-dioxygenase 1 inhibition
Saran Lotfollahzadeh,Asha Jose,Xiaosheng Yang,Tanvi Bathla,Adam Lazowski,Isaac Hoekstra,Kashvi Sethuraman,Sowmya Potluri,Karlynn N Dulberger,Jennifer La,Nathanael R Fillmore,Maria Del Carmen Piqueras,Norman Lee,Howard Cabral,Katya Ravid,Vipul C. Chitalia
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TRANSPLANTATION

A simple and efficient method for the robust expansion of human ILC2s to prevent acute GVHD
Danny W. Bruce,Sonia J. Laurie,Yan Xing,Heather E. Stefanski,Keli L. Hippen,Alec D. Wilkinson,Mark G. Woodcock,James M. Coghill, Jr.,Karen P. McKinnon,Bruce R. Blazar,Jonathan S. Serody
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RESEARCH LETTERS

Dose-reduced apixaban for secondary prophylaxis in patients with severe obesity: a single center analysis
Clinical Trials & Observations
Eliot A. Rapoport,Noelle W. Townsend,Nadine Farhat,Parth Patel,Henny H. Billett
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The efficacy of teclistamab in patients with multiple myeloma and secondary plasma cell leukemia
Asis Shrestha,Sharmilan Thanendrarajan,Aishee Bag,Binod Dhakal,Maurizio Zangari,Samer Al-Hadidi,Frits van Rhee,Anita D’Souza,Nishi Shah,Mansi R. Shah,Meera Mohan,Carolina Schinke
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Ibrutinib increases miR-181a/b in leukemic cells from patients with chronic lymphocytic leukemia
Alice Ramassone,Sara Pagotto,Mirco Di Marco,Mohammad Mamunur Rashid,Carola Di Camillo,Fabiana Palmiero,Idanna Innocenti,Francesco Autore,Annamaria Tomasso,Luca Laurenti,Rosa Visone
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Supplemental data
Long-term follow-up of patients with AL amyloidosis treated on a phase 1 trial of CAEL-101
Clinical Trials & Observations
Michael Sang Hughes,Samuel Pan,Rajshekhar Chakraborty,Jayant Raikhelkar,Mathew S. Maurer,Markus Y. Mapara,Andrew Eisenberger,Suzanne Lentzsch,Divaya Bhutani
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Supplemental data
The IL7 receptor and the RAG complex are required for the onset of B-cell acute lymphoblastic leukemia
Audrey Dauba,Emmanuelle Näser,Antoine Nouhaud,Eric Delabesse,Bastien Gerby,Ahmed Amine Khamlichi
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Supplemental data
Targeting Siglec–sialic acid checkpoint to reverse immune dysfunction mediated by plasmacytoid dendritic cells in myeloma
Arghya Ray,Leutz Buon,Xueping Wan,Ting Du,Yan Song,Sindhu C. Pillai,Md Abu Musa,Teng Fang,Minxing Wang,Kenneth C. Anderson
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LETTER TO THE EDITOR

R-CHOP and R-cytarabine for transplant-ineligible MCL
Clinical Trials & Observations
Pavel Klener,Liliana Tušková,Petra Blahovcová,Marek Trněný
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ERRATUM

Linhares Y, Freytes CO, Cherry M, et al. OUTREACH: phase 2 study of lisocabtagene maraleucel as outpatient or inpatient treatment at community sites for R/R LBCL. Blood Adv. 2024;8(23):6114-6126.
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  • Cover Image

    Cover Image

    issue cover

    Nylund and Garrido-Zabala et al. report that co-inhibition of G9a (EHMT2) and DNA methyltransferases (DNMTs) synergistically reprograms the H3K9me1/2- and DNA methylation–driven onco-epigenome in multiple myeloma, promoting therapeutic response both in vitro and in vivo. The cover image depicts a network of proteins functionally and/or physically associated to G9a, highlighting the interdependency between the activity of this H3K9-specific histone methyltransferase and that of DNA methyltransferases.

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