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Volume 2, Issue 3
August 2025
In Progress
Blood Neoplasia Cover Image for Volume 2, Issue 3

Volume 2 Issue 3 | Blood Neoplasia | American Society of Hematology

CLINICAL TRIALS AND OBSERVATIONS

Clarithromycin, ixazomib, pomalidomide, dexamethasone for relapsed/refractory myeloma: survival and correlative analysis
Clinical Trials & Observations
Aaron S. Rosenberg,Emanual Maverakis,Caitlin Costello,Elizabeth A. Brem,Matthew Joseph Wieduwilt,Guillaume Luxardi,Paul Kaesberg,Keon Abedi,Samantha Herbert,Joseph Tuscano
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Supplemental data
Outcomes of myeloablative allogeneic hematopoietic cell transplantation with omidubicel vs alternative donor sources
Clinical Trials & Observations
Chenyu Lin,Smitha Sivaraman,Gautam Sajeev,Yan Song,Chunyi Xu,Chujun He,James E. Signorovitch,Heayoung Shin,Xiao-Ying Tang,Mei-Jie Zhang,Linda J. Burns,Ronit Simantov,Mitchell E. Horwitz
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Supplemental data
Checkpoint immunotherapy is associated with preferential activation of tumor antigen–specific CD4+ T cells in MDS
Clinical Trials & Observations
Elizabeth A. Griffiths,Pragya Srivastava,Eduardo Cortes Gomez,Junko Matsuzaki,Kunle Odunsi,Laura W. Dillon,Devdeep Mukherjee,Christopher S. Hourigan,Jacqueline Peng,Shovik Bandyopadhyay,Kai Tan,Kristopher M. Attwood,Joseph B. Kuechle,Prashant K. Singh,Jianmin Wang,Michael J. Nemeth
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Supplemental data
Dose escalation study of the HLA-A2-WT1 CD3 bispecific antibody RO7283420 in relapsed/refractory acute myeloid leukemia
Clinical Trials & Observations
Martin Hutchings,Koorosh Korfi,Pau Montesinos,Armando Santoro,Hsin-An Hou,Pilar Martinez-Sanchez,Susana Vives,Sara Galimberti,Tsai-Yun Chen,Marco Frigeni,Sylvain Garciaz,Olga Salamero Garcia,Su-Peng Yeh,Karen Yee,Jordi Esteve,Ashish Bajel,Shaun Fleming,Anne Catherine Bretz,Jan Attig,Min Sun,Sina Nassiri,Tobias Rutishauser,Christian Klein,Y. May Ma,Gabriel Schnetzler,Stephanie Vauleon,Huixin Yu,Teresa Barata,Muriel Richard,Silke Simon,Heather Hinton,Nino Keshelava,Marion Subklewe
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Supplemental data
Gut Faecalibacterium abundance in patients with plasma cell disorders is associated with survival after autologous HSCT
Clinical Trials & Observations
Erin A. Dean,Arkaprava Roy,Rick Y. Lin,Raad Z. Gharaibeh,Derek M. Li,Josee Gauthier,Christian Jobin,John R. Wingard
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Lymphoid Neoplasia

Phase 2 trial of daratumumab, cyclophosphamide, thalidomide, and dexamethasone in newly diagnosed multiple myeloma
Edvan de Queiroz Crusoé,Joanna Suzana Leal Ribeiro dos Santos,Juliana de Andrade Santos,Herbert Henrique de Melo Santos,Allan de Souza Santos,Larissa Ferreira Lucas,Cristiane Almeida Requião de Pinna,Paula Nogueira Caldas Freire,Adriano Araujo de Jesus,Alessandro de Moura Almeida,Daniela Dourado Dutra,Marcos Fonseca Chaves,Jamile Souza Nicanor,Marco Aurelio Salvino,Maria da Gloria Bomfim Arruda,Vania Hungria,on behalf of GBRAM
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Supplemental data
Tumor-associated myeloid cells support murine T-ALL in the central nervous system via integrin signaling
Ryan S. Humphrey,Seohee Nam,Dennis C. Wylie,Lauren I. R. Ehrlich
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Supplemental data
A novel cereblon variant with both exon 8 and 10 deletions in newly diagnosed and relapsed multiple myeloma
Yuan Xiao Zhu,Soumya Dutta,Gregory J. Ahmann,Laura Bruins,Mariano Arribas,Xianfeng Chen,Abhigna Polavarapu,Jonathan Chapman,Isaac Lopez,Marta Chesi,P. Leif Bergsagel,Abhishek Singharoy,Rafael Fonseca,Lisa M. Rimsza
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Supplemental data
Ambroxol induces myeloma cell death by inhibiting autophagy
Yutaka Hattori,Hiromu Sugiyama,Yamato Miyashita,Shinsuke Shibata,Taiga Okaue,Yoshinao Matsumoto,Taketo Yamada,Tomofumi Yamamoto,Takashi Yamaguchi,Kohei Yamazaki,Hisako Kunieda,Hideyuki Saya,Maiko Matsushita
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Supplemental data
Outcomes at a single institution with MTR induction and consolidation in the management of primary CNS lymphoma
Nikita K. Dave,Veronica Carvajal,Alex C. Watts,Jordan S. Carter,Michael Cook,Colin Thomas,Donald E. Tsai,Stephen J. Schuster,James N. Gerson,Stefan K. Barta,Jakub Svoboda,Elise A. Chong,Wei-Ting Hwang,Daniel J. Landsburg,Sunita D. Nasta
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Supplemental data
Belantamab mafodotin in patients with relapsed/refractory multiple myeloma: a real-world experience
Malin Hultcrantz,Andriy Derkach,Hani Hassoun,Neha Korde,Kylee Maclachlan,Sham Mailankody,Dhwani Patel,Urvi A. Shah,Carlyn R. Tan,David J. Chung,Oscar B. Lahoud,Heather J. Landau,Michael Scordo,Gunjan L. Shah,David Nemirovsky,Ross S. Firestone,Theresia Akhlaghi,Tala Shekarkhand,Sergio A. Giralt,Alexander M. Lesokhin,Saad Z. Usmani
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Outcomes and factors influencing survival in patients with diffuse large B-cell lymphoma: a population-based analysis
Inna Y. Gong,Michael Crump,Anca Prica,Andrew Calzavara,Ning Liu,Tiana Kordbacheh,Danielle Rodin,David Hodgson,Lee Mozessohn,Matthew C. Cheung,John Kuruvilla
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Supplemental data
An antibody-drug conjugate targeting VpreB1 for the treatment of B-cell acute lymphoblastic leukemia
Peter M. Gordon,Robin L. Williams,Jason Ostergaard,Keegan C. Lee,Hannah N. Bui,Joseph M. Muretta,Bridget S. Wilson,Thomas Beder,Claudia D. Baldus,Luke Lambert,Benjamin E. Deonovic,Timothy Singleton,Sarah K. Tasian,Stuart S. Winter
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MYELOID NEOPLASIA

Phase 1 trial of venetoclax with cladribine, cytarabine, G-CSF, and mitoxantrone for AML and high-grade myeloid neoplasm
Suravi Raychaudhuri,Ted A. Gooley,Allegra Rasmussen,Kim Quach,Eva Gill,Anna B. Halpern,Jacob S. Appelbaum,Cristina M. Ghiuzeli,Paul C. Hendrie,Ryan D. Cassaday,Roland B. Walter,Mary-Elizabeth M. Percival
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Supplemental data
TYK2 is essential for the therapeutic effect of IFN-α in Jak2V617F-induced murine myeloproliferative neoplasms
Yuki Tahira,Kotaro Shide,Takuro Kameda,Taisuke Uchida,Ayako Kamiunten,Keiichi Akizuki,Yoko Kubuki,Masayoshi Karasawa,Ryoma Ikeda,Kengo Matsumoto,Jie Bai,Minoru Terashima,Koji Kato,Tomofumi Uto,Tomohiro Fukaya,Shuya Mitoma,Katsuaki Sato,Yudai Uehira,Hiroaki Ueno,Goro Sashida,Hideki Yamaguchi,Kazuya Shimoda
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Quality of life, fatigue, depression, attention deficits, and pain after childhood Langerhans cell histiocytosis
Malin Sveijer,Désirée Gavhed,Helena Hertzberg,Eric Zander,Jan-Inge Henter,Tatiana von Bahr Greenwood
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Supplemental data
Targeting HASPIN kinase disrupts SR protein–mediated RNA splicing and synergizes with BCL-2 inhibitor venetoclax in AML
Mengdan Liu,Ming Yan,Amanda G. Davis,Samuel A. Stoner,Edward D. Ball,Dong-Er Zhang
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Supplemental data
The oral CDK9 inhibitor voruciclib combined with venetoclax for patients with relapsed/refractory acute myeloid leukemia
Yesid Alvarado-Valero,Rachel J. Cook,Shira N. Dinner,Michael Keng,Kebede H. Begna,Nathalie Javidi-Sharifi,Sameem Abedin,Monzr M. Al Malki,Vijaya Raj Bhatt,Prabhu Rajagopalan,Min Tang,Sandra E. Wiley,Richard G. Ghalie,Matthew S. Davids
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Supplemental data
Replication of a GWAS signal near HLA-DQA2 with AML using a disease-only cohort and external population-based controls
Rose Laflamme,Véronique Lisi,Josée Hébert,Guy Sauvageau,Sébastien Lemieux,Vincent-Philippe Lavallée,Guillaume Lettre
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Supplemental data
PPARγ-induced upregulation of fatty acid metabolism confers resistance to venetoclax and decitabine therapy in AML
Kotoko Yamatani,Tatsuro Watanabe,Kaori Saito,Abdullah Khasawneh,Abhishek Maiti,Zhihong Zeng,Kala Hayes,Shinya Kimura,Courtney D. DiNardo,Xiaoping Su,Shuko Nojiri,Yasushi Okazaki,Michael Andreeff,Marina Konopleva,Yoko Tabe
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RESEARCH LETTER

Reduced CD20 expression yields inferior survival in patients with B-cell lymphoma treated with CD20×CD3 antibodies
Emil Ramsø Kyvsgaard,Trine Lønbo Grantzau,Mia Dahl Sørensen,Michael Boe Møller,Lene Dissing Sjø,Morten Grauslund,Trine Trab,Linea Cecilie Melchior,Lærke Sloth Andersen,Caroline Riley,Carsten U. Niemann,Jacob Haaber,Thomas Stauffer Larsen,Michael Roost Clausen,Kirsten Grønbæk,Martin Hutchings,Simon Husby
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Supplemental data
Risk factors and clinical impact of cytomegalovirus DNAemia in patients with multiple myeloma treated with teclistamab
Charles Pei,Zeinab El Boghdadly,Lisa Blackburn,Nidhi Sharma,Naresh Bumma,Abdullah M. Khan,Srinivas Devarakonda,Elvira Umyarova,Don Benson,Ashley Rosko,Francesca Cottini
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Supplemental data
Magnetic resonance spectroscopy–based detection of response to therapy targeting glutaminolysis in lymphoma
Kavindra Nath,Pradeep K. Gupta,Shengchun Wang,Alexander A. Shestov,Neil Sen,Shilpa Rao,Stepan Orlovskiy,Cosimo Lobello,David Rushmore,Fernando Arias-Mendoza,Johnvesly Basappa,David S. Nelson,Mariusz A. Wasik
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Temporal clonal relatedness between myeloid neoplasm and nodal T-follicular helper cell lymphoma: a retrospective study
Mingfei Yan,Robert Stuver,Kai Shiang Lin,William T. Johnson,Steven M. Horwitz,Ahmet Dogan,Wenbin Xiao
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TRANSLATIONAL RESEARCH

Activity of STAMP inhibitors in ABL2 rearranged acute lymphoblastic leukemia is dependent on the Abl2 SH3 domain
Elias Lagonik,Elyse C. Page,John B. Bruning,Laura N. Eadie,Susan L. Heatley,Matthew Greenwood,Chun Y. Fong,Andrew S. Moore,David T. Yeung,Timothy P. Hughes,Deborah L. White
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BASIC MECHANISMS OF NEOPLASIA

Prognostic impact of extranodal disease on PET/CT in follicular lymphoma: results from a validation study with ECOG 2408
Frederique St-Pierre,Stephen M. Broski,Zequn Sun,Masha Kocherginsky,Betsy LaPlant,Matthew J. Maurer,Andrew Quon,Lucia Baratto,Hatice Savas,Lale Kostakoglu,Jane N. Winter,Thomas E. Witzig,Brad Kahl,Andrew M. Evens,Leo I. Gordon
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