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Journal Articles

Venetoclax plus gilteritinib is effective in preclinical models of FLT3 -mutant BCL11B-a lineage-ambiguous leukemia

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Brief Report
Lindsey E. Montefiori, Ilaria Iacobucci, Qingsong Gao, Jamila Moore, William C. Wright, Huimei Wei, Pradyumna Baviskar, Surbhi Sona, Hongjian Jin, Amit Budhraja, Josi Lott, Qi Zhang Tatarata, Zhongshan Cheng, Tanya Khan, Emily A. Backhaus Wagner, Melissa Johnson, Cyrus M. Mehr, Burgess Freeman, Laura Janke, Torsten Haferlach, Paul Geeleher, Paul E. Mead, Marina Konopleva, Joseph T. Opferman, Charles G. Mullighan
Journal: Blood
Blood (2025) 146 (19): 2350–2356.
https://doi.org/10.1182/blood.2025028985
Published: 2025
Includes: Supplemental data
Journal Articles

UBTF tandem duplications generate a nuclear export signal motif that drives an XPO1 dependency in leukemia

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Juan Barajas, Aaron Phillips, Jina Wang, Melvin Thomas, Lisett Contreras, Masayuki Umeda, Ryan Hiltenbrand, Guangchun Song, Mike Walsh, Lauren Ezzell, Elizabeth Caldwell, Kelly Churion, Tamara Westover, Emily Xiong, Chandra Rolle, Jamila Moore, Josi Lott, Sandi Radko-Juettner, Amit Kumar, Wenjie Qi, Beisi Xu, Evangelia Papachristou, Clive D'Santos, Jing Ma, Burgess Freeman, Laura Janke, Richard Kriwacki, Jeffery Klco
Journal: Blood
Blood (2025) 146 (Supplement 1): 986.
https://doi.org/10.1182/blood-2025-986
Published: 2025
Journal Articles

Multiplex CRISPR/Cas9-Based Genome Editing of Mouse Hematopoietic Stem Cells Recapitulates Acute Erythroid Leukemia and Identifies Therapeutic Targets

Free
Ilaria Iacobucci, PhD, Elena Varotto, MD, Chunxu Qu, PhD, Laura Janke, DVM, PhD, Aman Seth, PhD, Anang Shelat, PhD, Burgess Freeman, PhD, James Kennedy, Adam S Sperling, MD PhD, R. Coleman Lindsley, MD PhD, Kirsten Dickerson, BS, Debbie Payne-Turner, Sarah M Morris, Nina Ghosn, Benjamin L. Ebert, MDPhD, Charles G. Mullighan, MBBS, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5.
https://doi.org/10.1182/blood-2018-99-118817
Published: 2018
Journal Articles

PI3K and MEK Inhibition in Hypodiploid Acute Lymphoblastic Leukemia

Free
Evan Comeaux, PhD, Wenwei Lin, PhD, Taosheng Chen, PhD, Burgess Freeman, III, PharmD, Charles G. Mullighan, MBBS, MSc, PhD
Journal: Blood
Blood (2016) 128 (22): 1635.
https://doi.org/10.1182/blood.V128.22.1635.1635
Published: 2016
Journal Articles

A Phase I/II Trial of the KSP Inhibitor ARRY-520 In Relapsed/Refractory Multiple Myeloma

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Jatin J Shah, MD, Jeffrey A. Zonder, MD, Adam Cohen, Donna Weber, MD, Sheeba Thomas, MD, Michael Wang, MD, Jonathan L. Kaufman, MD, Steven Michael Burt, Duncan Walker, Burgess Freeman, Selena Armistead Rush, BS, Ann Ptaszynski, Robert Z. Orlowski, MD, PhD, Sagar Lonial, MD
Journal: Blood
Blood (2010) 116 (21): 1959.
https://doi.org/10.1182/blood.V116.21.1959.1959
Published: 2010
Journal Articles

A Phase 1 Dose-Escalation Study of the Novel KSP Inhibitor ARRY-520 in Advanced Leukemias.

Free
Guillermo Garcia-Manero, MD, H. Jean Khoury, MD, Gautam Borthakur, MD, Farhad Ravandi, MD, Tapan Kadia, MD, Zeev Estrov, MD, Elias Jabbour, MD, Maria Cielo Foudray, RN, Martha Arellano, Amelia Langston, MD, Beverly Bethelmie-Bryan, Selena Rush, Burgess Freeman, Heidi Simmons, PhD, Mieke Ptaszynski, Hagop Kantarjian, MD
Journal: Blood
Blood (2009) 114 (22): 2047.
https://doi.org/10.1182/blood.V114.22.2047.2047
Published: 2009