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Laura Janke
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Journal Articles

Venetoclax plus gilteritinib is effective in preclinical models of FLT3 -mutant BCL11B-a lineage-ambiguous leukemia

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Brief Report
Lindsey E. Montefiori, Ilaria Iacobucci, Qingsong Gao, Jamila Moore, William C. Wright, Huimei Wei, Pradyumna Baviskar, Surbhi Sona, Hongjian Jin, Amit Budhraja, Josi Lott, Qi Zhang Tatarata, Zhongshan Cheng, Tanya Khan, Emily A. Backhaus Wagner, Melissa Johnson, Cyrus M. Mehr, Burgess Freeman, Laura Janke, Torsten Haferlach, Paul Geeleher, Paul E. Mead, Marina Konopleva, Joseph T. Opferman, Charles G. Mullighan
Journal: Blood
Blood (2025) 146 (19): 2350–2356.
https://doi.org/10.1182/blood.2025028985
Published: 2025
Includes: Supplemental data
Journal Articles

Characterizing the In Vivo impact of inflammation on Samd9l hematopoietic phenotypes.

Free
Melvin Thomas, Emily Xiong, Tamara Westover, Mike Walsh, Jing Ma, Chandra Rolle, Yonghui Ni, Steven Burden, Laura Janke, Stanley Pounds, Jeffery Klco
Journal: Blood
Blood (2025) 146 (Supplement 1): 2055.
https://doi.org/10.1182/blood-2025-2055
Published: 2025
Journal Articles

UBTF tandem duplications generate a nuclear export signal motif that drives an XPO1 dependency in leukemia

Free
Juan Barajas, Aaron Phillips, Jina Wang, Melvin Thomas, Lisett Contreras, Masayuki Umeda, Ryan Hiltenbrand, Guangchun Song, Mike Walsh, Lauren Ezzell, Elizabeth Caldwell, Kelly Churion, Tamara Westover, Emily Xiong, Chandra Rolle, Jamila Moore, Josi Lott, Sandi Radko-Juettner, Amit Kumar, Wenjie Qi, Beisi Xu, Evangelia Papachristou, Clive D'Santos, Jing Ma, Burgess Freeman, Laura Janke, Richard Kriwacki, Jeffery Klco
Journal: Blood
Blood (2025) 146 (Supplement 1): 986.
https://doi.org/10.1182/blood-2025-986
Published: 2025
Journal Articles

Menin inhibition as a new therapeutic option for the myeloproliferative neoplasms

Free
John Crispino, Jeremy Wen, Anitria Cotton, Rashid Mehmood, Amber Broadhurst, Trent Hall, Bridget Marcellino, John Mascarenhas, Ronald Hoffman, Laura Janke, Sandeep Gurbuxani, Gerard McGeehan
Journal: Blood
Blood (2025) 146 (Supplement 1): 67.
https://doi.org/10.1182/blood-2025-67
Published: 2025
Journal Articles

Zoledronic Acid Reduces Osteonecrosis and Anti-Leukemic Efficacy in Murine Models of Acute Lymphoblastic Leukemia Therapy

Free
Laura Janke, DVM, PhD, Jieun Kim, PhD, David Jenkins, BS, Monique A Payton, BS, Mary V Relling, PharmD, Seth E Karol, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4029.
https://doi.org/10.1182/blood-2018-99-112941
Published: 2018
Journal Articles

Expression of TCF3-ZNF384 in Human Hematopoietic Cells Induces Lineage Disruption in Vitro and Acute Leukemia in Vivo

Free
Kirsten Dickerson, BS, Hiroki Yoshihara, MDPhD, Laura Janke, DVM, PhD, Charles G. Mullighan, MBBS, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 550.
https://doi.org/10.1182/blood-2018-99-118855
Published: 2018
Journal Articles

Multiplex CRISPR/Cas9-Based Genome Editing of Mouse Hematopoietic Stem Cells Recapitulates Acute Erythroid Leukemia and Identifies Therapeutic Targets

Free
Ilaria Iacobucci, PhD, Elena Varotto, MD, Chunxu Qu, PhD, Laura Janke, DVM, PhD, Aman Seth, PhD, Anang Shelat, PhD, Burgess Freeman, PhD, James Kennedy, Adam S Sperling, MD PhD, R. Coleman Lindsley, MD PhD, Kirsten Dickerson, BS, Debbie Payne-Turner, Sarah M Morris, Nina Ghosn, Benjamin L. Ebert, MDPhD, Charles G. Mullighan, MBBS, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5.
https://doi.org/10.1182/blood-2018-99-118817
Published: 2018
Journal Articles

Evaluation of Nudt15 -Guided Thiopurine Dose Individualization In Vivo Using CRISPR/Cas9-Edited Mouse Model

Free
Takaya Moriyama, MDPhD, Rina Nishii, Laura Janke, DVM, PhD, Lie Li, Chen Ru, Scott A Brown, PhD, Ting-Nien Lin, Chase Suiter, Kentaro Kihira, MD, Hidemi Toyoda, MD PhD, Motohiro Kato, MD PhD, Atushi Manabe, MD PhD, Katsuyoshi Koh, MD, Masatoshi Takagi, MD PhD, Hiroki Hori, MD PhD, Jun J. Yang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3879.
https://doi.org/10.1182/blood.V130.Suppl_1.3879.3879
Published: 2017
Journal Articles

PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia

Free
Jinjun Dang, Lei Wei, Jeroen de Ridder, Xiaoping Su, Alistair G. Rust, Kathryn G. Roberts, Debbie Payne-Turner, Jinjun Cheng, Jing Ma, Chunxu Qu, Gang Wu, Guangchun Song, Robert G. Huether, Brenda Schulman, Laura Janke, Jinghui Zhang, James R. Downing, Louise van der Weyden, David J. Adams, Charles G. Mullighan
Journal: Blood
Blood (2015) 125 (23): 3609–3617.
https://doi.org/10.1182/blood-2015-02-626127
Published: 2015
Includes: Supplemental data
Journal Articles

Antileukemic Efficacy of Continuous Vs Discontinuous Dexamethasone in Murine Xenografts of Acute Lymphoblastic Leukemia

Free
Laura B. Ramsey, PhD, Laura Janke, DVM, PhD, Monique A. Payton, B.S., Xiangjun Cai, PhD, Sima Jeha, MD, Ching-Hon Pui, MD, William E. Evans, PharmD, Mary V. Relling, PharmD
Journal: Blood
Blood (2014) 124 (21): 3701.
https://doi.org/10.1182/blood.V124.21.3701.3701
Published: 2014
Journal Articles

High Content Screening Identifies Synthetic Lethality Of Retinoid Receptor Agonists In IKZF1 -Mutated BCR-ABL1 positive Acute Lymphoblastic Leukemia

Free
Michelle Churchman, Ph.D., Jonathan Low, Ph.D., Debbie Payne-Turner, Shann-Ching Chen, PhD, Jing Ma, PhD, Mark J. Althoff, Faiyaz Notta, PhD, John E. Dick, PhD, Laura Janke, DVM, PhD, Rodney Kiplin Guy, Ph.D, Taosheng Chen, Ph.D., Charles G. Mullighan, MBBS, MSc, MD, FRACP, FRCPA
Journal: Blood
Blood (2013) 122 (21): 172.
https://doi.org/10.1182/blood.V122.21.172.172
Published: 2013
Journal Articles

Host Thiopurine Methyltransferase Status Affects Mercaptopurine Antileukemic Effectiveness

Free
Laura B. Ramsey, PhD, Laura Janke, DVM, PhD, Mathew Edick, PhD, Cheng Cheng, PhD, Richard T Williams, MBBS, PhD, Charles J. Sherr, MD, PhD, William E. Evans, PharmD, Mary V. Relling, PharmD
Journal: Blood
Blood (2012) 120 (21): 3560.
https://doi.org/10.1182/blood.V120.21.3560.3560
Published: 2012