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Journal Articles

Combined Pharmacologic Inhibition of Bcl-Xl/Bcl-2 and mTORC1/2 Survival Signals Trigger Apoptosis in BCR-ABL1 + in Vitro Models of Blast Crisis Chronic Myelogenous Leukemia (CML-BC), and Primary CD34 + /CD38 − Stem and CD34 + progenitor Cells From CML-BC Patients

Jason G Harb, Ph.D, Paolo Neviani, PhD, Claudia S Huettner, PhD, Guido Marcucci, MD, Danilo Perrotti, MD, Ph.D

Blood (2011) 118 (21): 2738.

https://doi.org/10.1182/blood.V118.21.2738.2738

Published: 2011

Journal Articles

Leukemia-Induced Alterations in Bone Marrow Cytokine and Chemokine Levels Contribute to Altered Stem Cell Lodgment and Impairment of Normal Stem Cell Growth in CML

Bin Zhang, Yin Wei Ho, Tessa L. Holyoake, PhD, FRCP, FRCPath, Claudia S Huettner, PhD, Ravi Bhatia, MD

Blood (2011) 118 (21): 962.

https://doi.org/10.1182/blood.V118.21.962.962

Published: 2011

Journal Articles

Blockade of interleukin-23 signaling results in targeted protection of the colon and allows for separation of graft-versus-host and graft-versus-leukemia responses

Rupali Das, Richard Komorowski, Martin J. Hessner, Hariharan Subramanian, Claudia S. Huettner, Daniel Cua, William R. Drobyski

Blood (2010) 115 (25): 5249–5258.

https://doi.org/10.1182/blood-2009-11-255422

Published: 2010

Journal Articles

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

Mirle Schemionek, Christian Elling, Ulrich Steidl, Nicole Bäumer, Ashley Hamilton, Tilmann Spieker, Joachim R. Göthert, Martin Stehling, Amy Wagers, Claudia S. Huettner, Daniel G. Tenen, Lara Tickenbrock, Wolfgang E. Berdel, Hubert Serve, Tessa L. Holyoake, Carsten Müller-Tidow, Steffen Koschmieder

Blood (2010) 115 (16): 3185–3195.

https://doi.org/10.1182/blood-2009-04-215376

Published: 2010

Journal Articles

Loss of Bcl-x in Ph + B-ALL increases cellular proliferation and does not inhibit leukemogenesis

Jason G. Harb, Brenda I. Chyla, Claudia S. Huettner

Blood (2008) 111 (7): 3760–3769.

https://doi.org/10.1182/blood-2007-08-108803

Published: 2008

Journal Articles

Loss of Bcl-x Does Not Ameliorate Chronic Myeloid Leukemia in an Inducible Murine Model System.

Brenda J. Chyla, PhD, Jason G. Harb, Ph.D., Claudia S. Huettner, Ph.D.

Blood (2007) 110 (11): 1000.

https://doi.org/10.1182/blood.V110.11.1000.1000

Published: 2007

Journal Articles

Reversible Transplantable Chronic Phase CML-Like Disease in SCLtTA/BCR-ABL Transgenic Mice.

Mirle Schemionek, Jörg Stypmann, MD, Sven Hermann, MD, Christian Elling, Nicole Bäumer, PhD, Tilmann Spieker, MD, Joachim R. Göthert, MD, Martin Stehling, PhD, Claudia S. Huettner, PhD, Michael Schäfers, MD, Daniel G. Tenen, MD, Wolfgang E. Berdel, MD, Tessa L. Holyoake, MD, Carsten Müller-Tidow, MD, Hubert Serve, MD, Steffen Koschmieder, MD

Blood (2007) 110 (11): 1002.

https://doi.org/10.1182/blood.V110.11.1002.1002

Published: 2007

Journal Articles

A Novel Role for Bcl-x L in the Context of p210 BCR/ABL B Cell Acute Lymphoblastic Leukemia (B-ALL).

Jason G. Harb, PhD, Brenda I. Chyla, PhD, Claudia S. Huettner, PhD

Blood (2007) 110 (11): 156.

https://doi.org/10.1182/blood.V110.11.156.156

Published: 2007

Journal Articles

Genetic Deletion of Bcl-x Reveals a Potential Role in Governing Stem Cell Homeostasis.

Brenda J. Chyla, PhD, Jason G. Harb, Ph.D., Claudia S. Huettner, Ph.D.

Blood (2006) 108 (11): 1349.

https://doi.org/10.1182/blood.V108.11.1349.1349

Published: 2006

Journal Articles

Decitabine and Vitamin D3 Differentially Increase C-Jun, PU.1, and Sp1 Hematopoietic Transcription Factors To Induce Monocytic Differentiation.

Steffen Koschmieder, MD, Shuchi Agrawal, Hanna S. Radomska, PhD, Claudia S. Huettner, PhD, Daniel G. Tenen, MD, Oliver G. Ottmann, MD, Wolfgang E. Berdel, MD, Hubert L. Serve, MD, Carsten Mueller-Tidow, MD

Blood (2006) 108 (11): 2223.

https://doi.org/10.1182/blood.V108.11.2223.2223

Published: 2006

Journal Articles

KLF4 suppresses transformation of pre-B cells by ABL oncogenes

Michael G. Kharas, Isharat Yusuf, Vanessa M. Scarfone, Vincent W. Yang, Julia A. Segre, Claudia S. Huettner, David A. Fruman

Blood (2006) 109 (2): 747–755.

https://doi.org/10.1182/blood-2006-03-011106

Published: 2006

Journal Articles

Bcl-x Is Indispensable for the Development of Natural Killer Cells.

Jason G. Harb, PhD, Malarkannan Subramaniam, PhD, Claudia S. Huettner, PhD

Blood (2005) 106 (11): 340.

https://doi.org/10.1182/blood.V106.11.340.340

Published: 2005

Journal Articles

CD34 expression by mast cells: of mice and men

Erin Drew, Claudia S. Huettner, Daniel G. Tenen, Kelly M. McNagny

Blood (2005) 106 (5): 1885–1887.

https://doi.org/10.1182/blood-2005-03-1291

Published: 2005

Journal Articles

Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation

Hiromi Iwasaki, Chamorro Somoza, Hirokazu Shigematsu, Estelle A. Duprez, Junko Iwasaki-Arai, Shin-ichi Mizuno, Yojiro Arinobu, Kristin Geary, Pu Zhang, Tajhal Dayaram, Maris L. Fenyus, Shannon Elf, Susan Chan, Philippe Kastner, Claudia S. Huettner, Richard Murray, Daniel G. Tenen, Koichi Akashi

Blood (2005) 106 (5): 1590–1600.

https://doi.org/10.1182/blood-2005-03-0860

Published: 2005

Includes: Supplemental data

Journal Articles

Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis

Steffen Koschmieder, Berthold Göttgens, Pu Zhang, Junko Iwasaki-Arai, Koichi Akashi, Jeffery L. Kutok, Tajhal Dayaram, Kristin Geary, Anthony R. Green, Daniel G. Tenen, Claudia S. Huettner

Blood (2005) 105 (1): 324–334.

https://doi.org/10.1182/blood-2003-12-4369

Published: 2005

Journal Articles

Reversible Expansion of Hematopoietic Stem Cells (HSC) and CML-Like Disease in Transgenic Mice Expressing BCR-ABL under the Control of the SCL 3′ Enhancer.

Steffen Koschmieder, MD, Berthold Goettgens, PHD, Pu Zhang, MD, Tajhal Dayaram, Kristin Geary, Anthony R. Green, MD, PHD, Daniel G. Tenen, MD, Claudia S. Huettner, PHD

Blood (2004) 104 (11): 715.

https://doi.org/10.1182/blood.V104.11.715.715

Published: 2004

Journal Articles

Inducible expression of BCR/ABL using human CD34 regulatory elements results in a megakaryocytic myeloproliferative syndrome

Claudia S. Huettner, Steffen Koschmieder, Hiromi Iwasaki, Junko Iwasaki-Arai, Hanna S. Radomska, Koichi Akashi, Daniel G. Tenen

Blood (2003) 102 (9): 3363–3370.

https://doi.org/10.1182/blood-2003-03-0768

Published: 2003

Journal Articles

Transgenic targeting with regulatory elements of the human CD34 gene

Hanna S. Radomska, David A. Gonzalez, Yutaka Okuno, Hiromi Iwasaki, Andras Nagy, Koichi Akashi, Daniel G. Tenen, Claudia S. Huettner

Blood (2002) 100 (13): 4410–4419.

https://doi.org/10.1182/blood-2002-02-0355

Published: 2002

Journal Articles

Distal elements are critical for human CD34 expression in vivo

Yutaka Okuno, Claudia S. Huettner, Hanna S. Radomska, Victoria Petkova, Hiromi Iwasaki, Koichi Akashi, Daniel G. Tenen

Blood (2002) 100 (13): 4420–4426.

https://doi.org/10.1182/blood-2002-03-0788

Published: 2002

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Combined Pharmacologic Inhibition of Bcl-Xl/Bcl-2 and mTORC1/2 Survival Signals Trigger Apoptosis in BCR-ABL1 + in Vitro Models of Blast Crisis Chronic Myelogenous Leukemia (CML-BC), and Primary CD34 + /CD38 − Stem and CD34 + progenitor Cells From CML-BC Patients

Leukemia-Induced Alterations in Bone Marrow Cytokine and Chemokine Levels Contribute to Altered Stem Cell Lodgment and Impairment of Normal Stem Cell Growth in CML

Blockade of interleukin-23 signaling results in targeted protection of the colon and allows for separation of graft-versus-host and graft-versus-leukemia responses

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

Loss of Bcl-x in Ph + B-ALL increases cellular proliferation and does not inhibit leukemogenesis

Loss of Bcl-x Does Not Ameliorate Chronic Myeloid Leukemia in an Inducible Murine Model System.

Reversible Transplantable Chronic Phase CML-Like Disease in SCLtTA/BCR-ABL Transgenic Mice.

A Novel Role for Bcl-x L in the Context of p210 BCR/ABL B Cell Acute Lymphoblastic Leukemia (B-ALL).

Genetic Deletion of Bcl-x Reveals a Potential Role in Governing Stem Cell Homeostasis.

Decitabine and Vitamin D3 Differentially Increase C-Jun, PU.1, and Sp1 Hematopoietic Transcription Factors To Induce Monocytic Differentiation.

KLF4 suppresses transformation of pre-B cells by ABL oncogenes

Bcl-x Is Indispensable for the Development of Natural Killer Cells.

CD34 expression by mast cells: of mice and men

Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation

Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis

Reversible Expansion of Hematopoietic Stem Cells (HSC) and CML-Like Disease in Transgenic Mice Expressing BCR-ABL under the Control of the SCL 3′ Enhancer.

Inducible expression of BCR/ABL using human CD34 regulatory elements results in a megakaryocytic myeloproliferative syndrome

Transgenic targeting with regulatory elements of the human CD34 gene

Distal elements are critical for human CD34 expression in vivo

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