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Emma M. Groarke
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Journal Articles

Clonal landscape and clinical outcomes of telomere biology disorders: somatic rescuing and cancer mutations

Fernanda Gutierrez-Rodrigues, Emma M Groarke, Natthakan Thongon, Juan Jose Rodriguez-Sevilla, Luiz Fernando Bazzo Catto, Marena Rebekka Niewisch, Ruba N Shalhoub, Lisa J. McReynolds, Diego V Clé, Bhavisha A. Patel, Xiaoyang Ma, Dalton Hironaka, Flavia S Donaires, Nina R Spitofsky, Barbara A. Santana, Tsung-Po Lai, Lemlem Alemu, Sachiko Kajigaya, Ivana Darden, Weiyin Zhou, Paul V. Browne, Subrata Paul, Justin Lack, David J. Young, Courtney D. DiNardo, Abraham Aviv, Feiyang Ma, Michel Michels de Oliveira, Ana Paula de Azambuja, Cynthia E. Dunbar, Malgorzata Olszewska, Emmanuel Olivier, Eirini P Papapetrou, Neelam Giri, Blanche P. Alter, Carmem M.S. Bonfim, Colin O. Wu, Guillermo Garcia-Manero, Sharon A Savage, Neal S. Young, Simona Colla, Rodrigo T. Calado
Journal: Blood
Blood blood.2024025023.
https://doi.org/10.1182/blood.2024025023
Published: 2024
Includes: Supplemental data
Journal Articles

Venous and arterial thrombosis in patients with VEXAS syndrome

Clinical Trials & Observations
Yael Kusne, Atefeh Ghorbanzadeh, Alina Dulau-Florea, Ruba Shalhoub, Pedro E. Alcedo, Khanh Nghiem, Marcela A. Ferrada, Alexander Hines, Kaitlin A. Quinn, Sumith R. Panicker, Amanda K. Ombrello, Kaaren Reichard, Ivana Darden, Wendy Goodspeed, Jibran Durrani, Lorena Wilson, Horatiu Olteanu, Terra Lasho, Daniel L. Kastner, Kenneth J. Warrington, Abhishek Mangaonkar, Ronald S. Go, Raul C. Braylan, David B. Beck, Mrinal M. Patnaik, Neal S. Young, Katherine R. Calvo, Ana I. Casanegra, Peter C. Grayson, Matthew J. Koster, Colin O. Wu, Yogendra Kanthi, Bhavisha A. Patel, Damon E. Houghton, Emma M. Groarke
Journal: Blood
Blood (2024) 143 (21): 2190–2200.
https://doi.org/10.1182/blood.2023022329
Published: 2024
Includes: Supplemental data
Journal Articles

Early Initiation of Oral Therapy with Cyclosporine and Eltrombopag for Treatment Naïve Severe Aplastic Anemia: Interim Results of a Phase II Trial

Bhavisha A. Patel, Emma M. Groarke, Ruba Shahloub, Jennifer Lotter, Jeanine Superata, Joelle Khoriaty, Kimberly McKernan, Uzoamaka Okeke, Olga Rios, Colin O. Wu, Neal S. Young
Journal: Blood
Blood (2023) 142 (Supplement 1): 2711.
https://doi.org/10.1182/blood-2023-181071
Published: 2023
Journal Articles

Clinical Manifestations Are Evolving and Progressive in Patients with Vexas Syndrome

Bhavisha A. Patel, Marcela Ferrada, Kaitlin Quinn, Kristy Freeman, Ivana Darden, Wendy Goodspeed, Lisa Duncan, Roxanne Merkel, Alice Fike, Peter C Grayson, Neal S. Young, Emma M. Groarke
Journal: Blood
Blood (2023) 142 (Supplement 1): 703.
https://doi.org/10.1182/blood-2023-187454
Published: 2023
Journal Articles

Clonal Bone Marrow Plasma Cells Are Common in Patients with Vexas Syndrome

Alina Dulau-Florea, Raul C. Braylan, Yanna Ding, Nisha Patel, Katherine Calvo, Elizabeth Hill, Emma M. Groarke, Neal S. Young, Bhavisha A. Patel
Journal: Blood
Blood (2023) 142 (Supplement 1): 4681.
https://doi.org/10.1182/blood-2023-186736
Published: 2023
Journal Articles

Characterization of Hematopoietic Stem and Progenitor Cells of PNH Patients Using Single-Cell RNA Sequencing Analysis

Hiroki Mizumaki, Shouguo Gao, Zhijie Wu, Emma M. Groarke, Lemlem Alemu, Diego Quinones Raffo, Olga Rios, Sachiko Kajigaya, Bhavisha A. Patel, Neal S. Young
Journal: Blood
Blood (2023) 142 (Supplement 1): 4085.
https://doi.org/10.1182/blood-2023-181078
Published: 2023
Journal Articles

Distinct Immune and Molecular Profiles of Hepatitis-Associated Aplastic Anemia

Roma V. Rajput, Dalton Hironaka, Ruba Shalhoub, Lemlem Alemu, Emma M. Groarke, Jennifer Lotter, Olga Rios, Ivana Darden, Colin O. Wu, Fernanda Gutierrez-Rodrigues, Xingmin Feng, Neal S. Young, Bhavisha A. Patel
Journal: Blood
Blood (2023) 142 (Supplement 1): 1340.
https://doi.org/10.1182/blood-2023-180902
Published: 2023
Journal Articles

Spectrum of clonal hematopoiesis in VEXAS syndrome

CME
Fernanda Gutierrez-Rodrigues, Yael Kusne, Jenna Fernandez, Terra Lasho, Ruba Shalhoub, Xiaoyang Ma, Hugh Alessi, Christy Finke, Matthew J. Koster, Abhishek Mangaonkar, Kenneth J. Warrington, Kebede Begna, Zhuoer Xie, Amanda K. Ombrello, David Viswanatha, Marcela Ferrada, Lorena Wilson, Ronald Go, Taxiarchis Kourelis, Kaaren Reichard, Horatiu Olteanu, Ivana Darden, Dalton Hironaka, Lemlem Alemu, Sachiko Kajigaya, Sofia Rosenzweig, Rodrigo T. Calado, Emma M. Groarke, Daniel L. Kastner, Katherine R. Calvo, Colin O. Wu, Peter C. Grayson, Neal S. Young, David B. Beck, Bhavisha A. Patel, Mrinal M. Patnaik
Journal: Blood
Blood (2023) 142 (3): 244–259.
https://doi.org/10.1182/blood.2022018774
Published: 2023
Includes: Supplemental data
Journal Articles

Differential diagnosis of bone marrow failure syndromes guided by machine learning

Fernanda Gutierrez-Rodrigues, Eric Munger, Xiaoyang Ma, Emma M. Groarke, Youbao Tang, Bhavisha A. Patel, Luiz Fernando B. Catto, Diego V. Clé, Marena R. Niewisch, Raquel M. Alves-Paiva, Flávia S. Donaires, André Luiz Pinto, Gustavo Borges, Barbara A. Santana, Lisa J. McReynolds, Neelam Giri, Burak Altintas, Xing Fan, Ruba Shalhoub, Christopher M. Siwy, Carrie Diamond, Diego Quinones Raffo, Kathleen Craft, Sachiko Kajigaya, Ronald M. Summers, Paul Liu, Lea Cunningham, Dennis D. Hickstein, Cynthia E. Dunbar, Ricardo Pasquini, Michel Michels De Oliveira, Elvira D. R. P. Velloso, Blanche P. Alter, Sharon A. Savage, Carmem Bonfim, Colin O. Wu, Rodrigo T. Calado, Neal S. Young
Journal: Blood
Blood (2023) 141 (17): 2100–2113.
https://doi.org/10.1182/blood.2022017518
Published: 2023
Includes: Supplemental data
Journal Articles

Efficacy of JAK1/2 inhibition in murine immune bone marrow failure

Emma M. Groarke, Xingmin Feng, Nidhi Aggarwal, Ash Lee Manley, Zhijie Wu, Shouguo Gao, Bhavisha A. Patel, Jichun Chen, Neal S. Young
Journal: Blood
Blood (2023) 141 (1): 72–89.
https://doi.org/10.1182/blood.2022015898
Published: 2023
Includes: Supplemental data
Journal Articles

Eosinophilia in Vexas Syndrome: Expanding Hematologic Phenotype

Ashvind Anand Prabahran, Fernanda Gutierrez-Rodrigues, Serene Ahmad, Edward W Cowen, Ivana Darden, Emma M. Groarke, Marcela Ferrada, Peter C. Grayson, Amy D Klion, Katherine R. Calvo, Irina Maric, Neal S. Young, Bhavisha A. Patel
Journal: Blood
Blood (2022) 140 (Supplement 1): 2607–2608.
https://doi.org/10.1182/blood-2022-160287
Published: 2022
Journal Articles

Thrombotic Manifestations in Patients with Vexas Syndrome

Pedro E. Alcedo Andrade, Ruba Shalhoub, Alina Dulau-Florea, Khanh Nghiem, Marcela Ferrada, Lorena Wilson, Ivana Darden, Wendy Goodspeed, Katherine R. Calvo, David B. Beck, Daniel L. Kastner, Peter C. Grayson, Neal S. Young, Colin O. Wu, Yogendra Kanthi, Bhavisha A. Patel, Emma M. Groarke
Journal: Blood
Blood (2022) 140 (Supplement 1): 2788–2789.
https://doi.org/10.1182/blood-2022-163608
Published: 2022
Journal Articles

Ruxolitinib Stimulates Expansion of Regulatory T Cells in Murine Immune Bone Marrow Failure

Nidhi Aggarwal, Ash Lee Manley, Jichun Chen, Emma M. Groarke, Xingmin Feng, Neal S. Young
Journal: Blood
Blood (2022) 140 (Supplement 1): 5786–5787.
https://doi.org/10.1182/blood-2022-157206
Published: 2022
Journal Articles

Alemtuzumab and Eltrombopag Combination for Patients with Refractory or Relapsed Severe Aplastic Anemia

Ash Lee Manley, Jennifer Lotter, Emma M. Groarke, Olga Rios, Neal S. Young, Bhavisha A. Patel
Journal: Blood
Blood (2022) 140 (Supplement 1): 10851–10852.
https://doi.org/10.1182/blood-2022-163825
Published: 2022
Journal Articles

The Role of Heterozygous Variants in SAMD9/9L and Recessive Bone Marrow Failure-Related Genes in Adults with Severe Aplastic Anemia

Dalton Hironaka, Xiaoyang Ma, Bhavisha A. Patel, Emma M. Groarke, Jennifer Lotter, Olga Rios, Juan L Coelho-Silva, Colin O. Wu, Jorg Cammenga, Fernanda Gutierrez-Rodrigues, Neal S. Young
Journal: Blood
Blood (2022) 140 (Supplement 1): 479–480.
https://doi.org/10.1182/blood-2022-162886
Published: 2022
Journal Articles

Predictors, Risk Factors and Outcomes of Patients with SAA with Anti-HLA Class I Antibodies Treated with Immunosuppressive Therapy

Jibran Durrani, Leonard Chen, Ruba Shalhoub, Nu Ri Cha, Xiaoyang Ma, Jennifer Lotter, Olga Rios, Colin O. Wu, Willy A. Flegel, Neal S. Young, Bhavisha A. Patel, Emma M. Groarke
Journal: Blood
Blood (2022) 140 (Supplement 1): 77–78.
https://doi.org/10.1182/blood-2022-163442
Published: 2022
Journal Articles

Granulocyte Transfusions As an Adjunctive Therapy in Severe Aplastic Anemia

Roma V. Rajput, Vaani Shah, Ruba Shalhoub, Kamille West-Mitchell, Cathy Conry-Cantilena, David J. Young, Cynthia E. Dunbar, Bhavisha A. Patel, Richard W. Childs, Neal S. Young, Colin O. Wu, Emma M. Groarke, Shelley S. Kalsi
Journal: Blood
Blood (2022) 140 (Supplement 1): 8556–8557.
https://doi.org/10.1182/blood-2022-162595
Published: 2022
Journal Articles

JAK 1/2 Inhibition Preserves Hematopoietic Progenitor and Stem Cells, Prevents Aplasia, Inhibits Pro-Inflammatory Cytokines, and Prolongs Survival in Murine Immune Bone Marrow Failure

Emma M. Groarke, Xingmin Feng, Nidhi Aggarwal, Ash Lee Manley, Zhijie Wu, Shouguo Gao, Bhavisha A. Patel, Jichun Chen, Neal S. Young
Journal: Blood
Blood (2022) 140 (Supplement 1): 471–472.
https://doi.org/10.1182/blood-2022-159733
Published: 2022
Journal Articles

Characterizing Immunodeficiency in Patients with Telomere Biology Disorders

Nidhi Aggarwal, Xiaoyang Ma, Fernanda Gutierrez-Rodrigues, Ruba Shalhoub, Ivana Darden, Bhavisha A. Patel, Colin O. Wu, Neal S. Young, Emma M. Groarke
Journal: Blood
Blood (2022) 140 (Supplement 1): 5826–5827.
https://doi.org/10.1182/blood-2022-163264
Published: 2022
Journal Articles

Clonal Hematopoiesis in Vexas Syndrome

Bhavisha A. Patel, Fernanda Gutierrez-Rodrigues, Yael Kusne, Jenna A. Fernandez, Terra Lasho, Ruba Shalhoub, Xiaoyang Ma, Hugh Alessi, Christy Finke, Matthew Koster, Abhishek A. Mangaonkar, Kenneth Warrington, Kebede H. Begna, Zhuoer Xie, Amanda Ombrello, David S. Viswanatha, Marcela Ferrada, Lorena Wilson, Ronald Go, Taxiarchis Kourelis, Kaaren K. Reichard, Horatiu Olteanu, Emma M. Groarke, Ivana Darden, Dalton Hironaka, Sofia Rosenzweig, Daniel L. Kastner, Katherine R. Calvo, Colin O. Wu, Peter C. Grayson, David B. Beck, Mrinal M.M. Patnaik, Neal S. Young
Journal: Blood
Blood (2022) 140 (Supplement 1): 5745–5746.
https://doi.org/10.1182/blood-2022-160263
Published: 2022