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François G. Kavelaars
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Journal Articles

Detecting measurable residual disease beyond 10 −4 by an IGHV leader-based NGS approach improves prognostic stratification in CLL

Paul J. Hengeveld, Michèle Y. van der Klift, P. Martijn Kolijn, Frédéric Davi, François G. Kavelaars, Evert de Jonge, Sandra Robrecht, Jorn L. J. C. Assmann, Lina van der Straten, Matthias Ritgen, Peter E. Westerweel, Kirsten Fischer, Valentin Goede, Michael Hallek, Mark-David Levin, Anton W. Langerak
Journal: Blood
Blood (2023) 141 (5): 519–528.
https://doi.org/10.1182/blood.2022017411
Published: 2023
Includes: Supplemental data
Journal Articles

Molecular characterization of mutant TP53 acute myeloid leukemia and high-risk myelodysplastic syndrome

Tim Grob, Adil S. A. Al Hinai, Mathijs A. Sanders, François G. Kavelaars, Melissa Rijken, Patrycja L. Gradowska, Bart J. Biemond, Dimitri A. Breems, Johan Maertens, Marinus van Marwijk Kooy, Thomas Pabst, Okke de Weerdt, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht, Gerwin A. Huls, Jan J. Cornelissen, H. Berna Beverloo, Bob Löwenberg, Mojca Jongen-Lavrencic, Peter J. M. Valk
Journal: Blood
Blood (2022) 139 (15): 2347–2354.
https://doi.org/10.1182/blood.2021014472
Published: 2022
Includes: Supplemental data
Journal Articles

RUNX1 germline variants in RUNX1 -mutant AML: how frequent?

Martijn P. T. Ernst, François G. Kavelaars, Bob Löwenberg, Peter J. M. Valk, Marc H. G. P. Raaijmakers
Journal: Blood
Blood (2021) 137 (10): 1428–1431.
https://doi.org/10.1182/blood.2020008478
Published: 2021
Includes: Supplemental data
Journal Articles

Clonal Evolution of Multiple Myeloma in Patients from Diagnosis to First Relapse, Who Were Treated in Subsequent Clinical Trials

Mark van Duin, Annemiek Broijl, Jasper Koenders, Sonja Zweegman, Monique C. Minnema, Francois G. Kavelaars, Remco Hoogenboezem, Kazem Nasserinejad, Mario Boccadoro, Peter Valk, PhD, Pieter Sonneveld
Journal: Blood
Blood (2019) 134 (Supplement_1): 1798.
https://doi.org/10.1182/blood-2019-130086
Published: 2019
Journal Articles

Archived Bone Marrow Smears Are an Excellent Source for NGS-Based Mutation Detection in Acute Myeloid Leukemia

Adil S.A. Al Hinai, MSc, Francois G. Kavelaars, Melissa Rijken, Tim Grob, MD, Kirsten Gussinklo, Annelieke Zeilemaker, Claudia Erpelinck-Verschueren, B.Sc., Mathijs A. Sanders, PhD, Kirsten van Lom, Peter J.M. Valk, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2783.
https://doi.org/10.1182/blood-2018-99-118066
Published: 2018
Journal Articles

MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML

Mathijs A. Sanders, Edward Chew, Christoffer Flensburg, Annelieke Zeilemaker, Sarah E. Miller, Adil S. al Hinai, Ashish Bajel, Bram Luiken, Melissa Rijken, Tamara Mclennan, Remco M. Hoogenboezem, François G. Kavelaars, Stefan Fröhling, Marnie E. Blewitt, Eric M. Bindels, Warren S. Alexander, Bob Löwenberg, Andrew W. Roberts, Peter J. M. Valk, Ian J. Majewski
Journal: Blood
Blood (2018) 132 (14): 1526–1534.
https://doi.org/10.1182/blood-2018-05-852566
Published: 2018
Includes: Supplemental data
Journal Articles

Prospective Molecular MRD Detection By NGS: A Powerful Independent Predictor for Relapse and Survival in Adults with Newly Diagnosed AML

Mojca Jongen-Lavrencic, MD PhD, Tim Grob, MD, Francois G. Kavelaars, Adil S.A. Al Hinai, Annelieke Zeilemaker, Claudia A.J. Erpelinck-Verschueren, Yvette Norden, Rosa Meijer, PhD, Bart J. Biemond, MD PhD, Carlos Graux, Marinus van Marwijk Kooij, MD PhD, Markus G. Manz, MD, Thomas Pabst, MD PhD, Violaine Havelange, MD PhD, Jakob R. Passweg, MD PhD, Gert J. Ossenkoppele, MD PhD, Gerrit Jan Schuurhuis, PhD, Mathijs A. Sanders, PhD, Bob Löwenberg, MD PhD, Peter J.M. Valk, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): LBA-5.
https://doi.org/10.1182/blood.V130.Suppl_1.LBA-5.LBA-5
Published: 2017
Journal Articles

DNMT3A Mutations Enhance CpG Mutagenesis through Deregulation of the Active DNA Demethylation Pathway

Mathijs A. Sanders, PhD, Annelieke Zeilemaker, Adil al Hinai, Remco Hoogenboezem, François G. Kavelaars, BSc, Melissa Rijken, Eric M.J. Bindels, PhD, Bob Löwenberg, MD PhD, Peter J.M. Valk, PhD
Journal: Blood
Blood (2016) 128 (22): 1076.
https://doi.org/10.1182/blood.V128.22.1076.1076
Published: 2016
Journal Articles

Multiple Myeloma with a Deletion of Chromosome 17p: TP53 Mutations Are Highly Prevalent and Negatively Affect Prognosis

Davine Hofste op Bruinink, MD MSc, Hoogenboezem Remco, MSc, Mathijs A. Sanders, PhD, Christopher P Wardell, PhD, Cody Ashby, PhD, Eric M.J. Bindels, PhD, Claudia Erpelinck-Verschueren, BSc, Paulette van Strien, BSc, Jasper Koenders, BSc, François G. Kavelaars, BSc, Jie He, PhD, Mark Bailey, MSc, Tariq I Mughal, MD FRCP, Kristine Misund, PhD, Berna Beverloo, PhD, Bronno van der Holt, PhD, Ivo Touw, PhD, Anders Waage, MDPhD, Hervé Avet-Loiseau, MD PhD, Graham H Jackson, MD PhD, Gareth J Morgan, MD PhD, Brian A Walker, PhD, Pieter Sonneveld, MDPhD
Journal: Blood
Blood (2016) 128 (22): 3271.
https://doi.org/10.1182/blood.V128.22.3271.3271
Published: 2016
Journal Articles

Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value

Brief Report
Saman Abbas, Sanne Lugthart, François G. Kavelaars, Anita Schelen, Jasper E. Koenders, Annelieke Zeilemaker, Wim J. L. van Putten, Anita W. Rijneveld, Bob Löwenberg, Peter J. M. Valk
Journal: Blood
Blood (2010) 116 (12): 2122–2126.
https://doi.org/10.1182/blood-2009-11-250878
Published: 2010
Includes: Supplemental data