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Frank G. Rucker
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Journal Articles

Rapid and Reproducible Karyotyping with Nanopore Sequencing in AML Patients

Michael Heuser, Nouraldin Damrah, Razif Gabdoulline, Courteney K. Lai, Eric Sträng, Mustafa Salim, Gudrun Göhring, Yvonne L. Behrens, Ekaterina Jahn, Martin Wichmann, Jens F. Schrezenmeier, Yasmine Alwie, Joerg Westermann, Frederick Damm, Brigitte Schlegelberger, Frank G. Rücker, Hartmut Döhner, Arnold Ganser, Felicitas R. Thol, Olga Blau, Konstanze Döhner, Lars Bullinger, Anna Dolnik
Journal: Blood
Blood (2022) 140 (Supplement 1): 6070–6072.
https://doi.org/10.1182/blood-2022-163035
Published: 2022
Journal Articles

Genomic Landscape and Molecular Risk in Patients with Advanced Myelofibrosis Treated within the Multicenter Phase Ib/II MPNSG0212 (POMINC) Trial

Ekaterina Panina, Steffen Koschmieder, Florian H. Heidel, Andreas Hochhaus, Holger Hebart, Susanne Isfort, Frank G. Rücker, Andreas Reiter, Markus Bangerter, Cornelius Waller, Christoph Scheid, Denise Wolleschak, Joachim R. Goethert, Philippe Schafhausen, Thomas Kindler, Markus P. Radsak, Norbert Gattermann, Robert Möhle, Nikolas von Bubnoff, Tim H Brümmendorf, Hartmut Döhner, Martin Griesshammer, Frank Stegelmann, Konstanze Döhner
Journal: Blood
Blood (2021) 138 (Supplement 1): 4637.
https://doi.org/10.1182/blood-2021-150361
Published: 2021
Journal Articles

Clonal evolution of acute myeloid leukemia with FLT3 -ITD mutation under treatment with midostaurin

Laura K. Schmalbrock, Anna Dolnik, Sibylle Cocciardi, Eric Sträng, Frauke Theis, Nikolaus Jahn, Ekaterina Panina, Tamara J. Blätte, Julia Herzig, Sabrina Skambraks, Frank G. Rücker, Verena I. Gaidzik, Peter Paschka, Walter Fiedler, Helmut R. Salih, Gerald Wulf, Thomas Schroeder, Michael Lübbert, Richard F. Schlenk, Felicitas Thol, Michael Heuser, Richard A. Larson, Arnold Ganser, Hendrik G. Stunnenberg, Saverio Minucci, Richard M. Stone, Clara D. Bloomfield, Hartmut Döhner, Konstanze Döhner, Lars Bullinger
Journal: Blood
Blood (2021) 137 (22): 3093–3104.
https://doi.org/10.1182/blood.2020007626
Published: 2021
Includes: Supplemental data
Journal Articles

Impact of gemtuzumab ozogamicin on MRD and relapse risk in patients with NPM1 -mutated AML: results from the AMLSG 09-09 trial

Clinical Trials & Observations
Silke Kapp-Schwoerer, Daniela Weber, Andrea Corbacioglu, Verena I. Gaidzik, Peter Paschka, Jan Krönke, Frauke Theis, Frank G. Rücker, Maria-Veronica Teleanu, Ekaterina Panina, Nikolaus Jahn, Julia Herzig, Lena Kubanek, Anika Schrade, Gudrun Göhring, Walter Fiedler, Thomas Kindler, Thomas Schroeder, Karin T. Mayer, Michael Lübbert, Mohammed Wattad, Katharina S. Götze, Heinz A. Horst, Elisabeth Koller, Gerald Wulf, Jan Schleicher, Martin Bentz, Jürgen Krauter, Lars Bullinger, Julia Krzykalla, Axel Benner, Richard F. Schlenk, Felicitas Thol, Michael Heuser, Arnold Ganser, Hartmut Döhner, Konstanze Döhner
Journal: Blood
Blood (2020) 136 (26): 3041–3050.
https://doi.org/10.1182/blood.2020005998
Published: 2020
Includes: Supplemental data
Journal Articles

Next-Generation Sequencing (NGS)-Based Measurable Residual Disease (MRD) Monitoring in Acute Myeloid Leukemia with FLT3 Internal Tandem Duplication ( FLT3 -ITD + AML) Treated with Additional Midostaurin

Julia K. Herzig, PhD, Frank G. Rücker, MD, Laura K. Schmalbrock, MD, Tamara J. Blätte, PhD, Daniela Weber, MSc, Sabrina Skambraks, Silke Kapp-Schwoerer, MD, Andrea Corbacioglu, PhD, Verena I Gaidzik, MD, Peter Paschka, MD, Ekaterina Panina, MD, Nikolaus Jahn, MD, Anika Schrade, PhD, Frauke Theis, MD, Sibylle Cocciardi, PhD, Walter Fiedler, MD, Helmut R. Salih, Gerald Wulf, MD, Hans Salwender, MD, Thomas Schroeder, Katharina S. Götze, Thomas Kindler, MD, Michael Luebbert, Richard F. Schlenk, Felicitas Thol, Michael Heuser, Arnold Ganser, Hartmut Döhner, Lars Bullinger, MD, Konstanze Döhner
Journal: Blood
Blood (2020) 136 (Supplement 1): 21–22.
https://doi.org/10.1182/blood-2020-137568
Published: 2020
Journal Articles

Mutational Landscape of Relapsed Core-Binding Factor Acute Myeloid Leukemia (CBF-AML)

Anna Dolnik, Nikolaus Jahn, MD, Eric Sträng, PhD, Sibylle Cocciardi, PhD, Frank G. Rücker, MD, Ekaterina Panina, MD, Tamara J. Blätte, PhD, Julia Katharina Herzig, PhD, Andrea Corbacioglu, PhD, Daniela Weber, MSc, Anika Schrade, PhD, Verena I Gaidzik, MD, Sabrina Skambraks, Katharina S. Götze, Michael Luebbert, MD PhD, Walter Fiedler, MD, Thomas Schroeder, Corinna Hahn, Felicitas Thol, Michael Heuser, Arnold Ganser, Peter Paschka, MD, Hartmut Döhner, Konstanze Döhner, Lars Bullinger, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 42.
https://doi.org/10.1182/blood-2020-142392
Published: 2020
Journal Articles

Functional Classification of TP53 Mutations in Acute Myeloid Leukemia

Sayantanee Dutta, PhD, Gudrun Pregartner, Frank G. Rücker, MD, Ellen Heitzer, PhD, Armin Zebisch, MD, Lars Bullinger, Andrea Berghold, PhD, Konstanze Döhner, Heinz Sill, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2725.
https://doi.org/10.1182/blood-2019-124316
Published: 2019
Journal Articles

Measurable Residual Disease (MRD) Monitoring in Acute Myeloid Leukemia (AML) with t(8;21)(q22;q22.1) RUNX1 - RUNX1T1 Identifies Patients at High Risk of Relapse: Results of the AML Study Group (AMLSG)

Frank G. Rücker, MD, Mridul Agrawal, MDMSc, Andrea Corbacioglu, PhD, Daniela Weber, Silke Kapp-Schwoerer, MD, Verena I. Gaidzik, MD, Nikolaus Jahn, MD, Thomas Schroeder, MD, Mohammad Wattad, MD, Michael Lübbert, Elisabeth Koller, MD, Thomas Kindler, MD, Katharina Götze, Mark Ringhoffer, MD, Jörg Westermann, MD, Walter Fiedler, MD, Heinz A. Horst, MD, Richard Greil, MD, Roland Schroers, Karin Mayer, MD, Thomas Heinicke, MD, Jürgen Krauter, MD, Richard F. Schlenk, MD, Felicitas Thol, MD, Michael Heuser, MD, Arnold Ganser, MD, Lars Bullinger, Peter Paschka, MD, Hartmut Döhner, MD, Konstanze Döhner
Journal: Blood
Blood (2019) 134 (Supplement_1): 2740.
https://doi.org/10.1182/blood-2019-125584
Published: 2019
Journal Articles

Measurable residual disease monitoring in acute myeloid leukemia with t(8;21)(q22;q22.1): results from the AML Study Group

Frank G. Rücker, Mridul Agrawal, Andrea Corbacioglu, Daniela Weber, Silke Kapp-Schwoerer, Verena I. Gaidzik, Nikolaus Jahn, Thomas Schroeder, Mohammed Wattad, Michael Lübbert, Elisabeth Koller, Thomas Kindler, Katharina Götze, Mark Ringhoffer, Jörg Westermann, Walter Fiedler, Heinz A. Horst, Richard Greil, Roland Schroers, Karin Mayer, Thomas Heinicke, Jürgen Krauter, Richard F. Schlenk, Felicitas Thol, Michael Heuser, Arnold Ganser, Lars Bullinger, Peter Paschka, Hartmut Döhner, Konstanze Döhner
Journal: Blood
Blood (2019) 134 (19): 1608–1618.
https://doi.org/10.1182/blood.2019001425
Published: 2019
Includes: Supplemental data
Journal Articles

Prognostic Impact of Insertion Site in Acute Myeloid Leukemia (AML) with FLT3 Internal Tandem Duplication: Results from the Ratify Study (Alliance 10603)

Frank G. Rücker, MD, Ling Du, PhD, Tamara J. Blätte, MSc, Axel Benner, Julia Krzykalla, MSc, Insa Gathmann, Richard A. Larson, MD, Francesco Lo-Coco, MD, Sergio Amadori, MD, Thomas W Prior, MD, Joseph M. Brandwein, MD, Frederick R. Appelbaum, MD, Bruno C. Medeiros, MD, Martin S. Tallman, MD, Michelle Geddes, MD, Jorge Sierra, MD, Eva Tiecke, PhD, Celine Pallaud, PhD, Miguel A. Sanz, MD, Theo M de Witte, MD, Dietger Niederwieser, MD, Gerhard Ehninger, MD, Michael Heuser, MD, Arnold Ganser, MD, Lars Bullinger, MD, Clara D. Bloomfield, MD, Richard M. Stone, MD, Hartmut Döhner, MD, Christian Thiede, MD, Konstanze Dohner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 435.
https://doi.org/10.1182/blood-2018-99-116149
Published: 2018
Journal Articles

Monitoring of FLT3 Phosphorylation and FLT3 Ligand Levels in Patients with FLT3 -ITD Mutated Acute Myeloid Leukemia (AML) Treated with Midostaurin within the AMLSG 16-10 Trial of the German-Austrian Study Group

Frauke Theis, Daniela Weber, MSc, Frank G. Rücker, MD, Peter Paschka, MD, Verena I. Gaidzik, MD, Felicitas Thol, MD, Michael Heuser, MD, Walter Fiedler, MD, Gerald Wulf, MD, Michael Lübbert, MD PhD, Helmut R. Salih, MD, Thomas Michael Schroeder, MD PhD, Katharina S. Götze, MD, Hans Jürgen Salwender, MD, Thomas Kindler, MD, Heinz-August Horst, MD, Mark Ringhoffer, MD, Dominik Wolf‎, MD, Jürgen Krauter, MD, Richard F. Schlenk, MD, Lars Bullinger, MD, Arnold Ganser, MD, Hartmut Döhner, MD, Konstanze Döhner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1501.
https://doi.org/10.1182/blood-2018-99-114588
Published: 2018
Journal Articles

Impact of TP53 Mutated Subclones in Acute Myeloid Leukemia

Gabriel Pabst, Katharina Prochazka, MD, Gudrun Pregartner, Frank G. Rücker, MD, Ellen Heitzer, PhD, Albert Woelfler, MD, Armin Zebisch, MD, Andrea Berghold, PhD, Konstanze Döhner, MD, Heinz Sill, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1483.
https://doi.org/10.1182/blood-2018-99-110667
Published: 2018
Journal Articles

Assessment of Treatment Effects By Measurable Residual Disease Monitoring in NPM1 -Mutated AML Patients Randomized for Gemtuzumab-Ozogamicin (GO) within the AMLSG 09-09 Trial of the German-Austrian AML Study Group (AMLSG)

Silke Kapp-Schwoerer, MD, Daniela Weber, MSc, Andrea Corbacioglu, PhD, Verena I. Gaidzik, MD, Peter Paschka, MD, Jan Krönke, MD, Maria-Veronica Teleanu, MD, Frauke Theis, Frank G. Rücker, MD, Gudrun Göhring, MD, Brigitte Schlegelberger, MD PhD, Walter Fiedler, MD, Thomas Kindler, MD, Thomas Michael Schroeder, MD PhD, Karin Mayer, MD, Michael Lübbert, Mohammed Amen Wattad, MD, Katharina S. Götze, MD, Heinz A. Horst, MD, Elisabeth Koller, MD, Gerald Wulf, MD, Jan Schleicher, MD, Martin Bentz, MD, Jürgen Krauter, MD, Julia Krzykalla, MSc, Axel Benner, Richard F. Schlenk, MD, Felicitas Thol, MD, Michael Heuser, MD, Arnold Ganser, MD, Hartmut Döhner, MD, Konstanze Döhner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 991.
https://doi.org/10.1182/blood-2018-99-114648
Published: 2018
Journal Articles

Assessment of the Genomic Landscape of Intermediate Risk Acute Myeloid Leukemia As Defined By 2010 ELN Risk Classification

Ekaterina Panina, MD, Frank G. Rücker, MD, Lars Bullinger, MD, Anna Dolnik, PhD, Julia Herzig, PhD, Tamara J. Blätte, MSc, Verena I. Gaidzik, MD, Peter Paschka, MD, Maria-Veronica Teleanu, MD, Nikolaus Jahn, MD, Laura K. Schmalbrock, MD, Daniela Weber, MSc, Lena Kubanek, Thomas Kindler, MD, Jörg Westermann, MD, Michael Lubbert, MD PhD, Helmut R. Salih, MD, Felicitas Thol, MD, Michael Heuser, MD, Arnold Ganser, MD, Hartmut Döhner, MD, Konstanze Döhner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 994.
https://doi.org/10.1182/blood-2018-99-114671
Published: 2018
Journal Articles

Somatic TP53 mutations characterize preleukemic stem cells in acute myeloid leukemia

Ridhima Lal, Karin Lind, Ellen Heitzer, Peter Ulz, Kristina Aubell, Karl Kashofer, Jan M. Middeke, Christian Thiede, Eduard Schulz, Angelika Rosenberger, Sybille Hofer, Birgit Feilhauer, Beate Rinner, Vendula Svendova, Michael G. Schimek, Frank G. Rücker, Gerald Hoefler, Konstanze Döhner, Armin Zebisch, Albert Wölfler, Heinz Sill
Journal: Blood
Blood (2017) 129 (18): 2587–2591.
https://doi.org/10.1182/blood-2016-11-751008
Published: 2017
Includes: Supplemental data
Journal Articles

Mutational Landscape of Del(9q) Acute Myeloid Leukemia (AML)

Anna Dolnik, PhD, Sundaram R. Chakkarappan, PhD, Tamara J. Blätte, Sibylle Cocciardi, Jan Krönke, MD, Corbacioglu Andrea, PhD, Karlheinz Holzmann, PhD, Peter Paschka, MD, Frank G. Rücker, MD, Silke Kapp-Schwoerer, MD, Verena I. Gaidzik, MD, Richard F. Schlenk, MD, Hartmut Döhner, Prof. Dr., Konstanze Döhner, MD, Lars Bullinger, MD
Journal: Blood
Blood (2015) 126 (23): 3844.
https://doi.org/10.1182/blood.V126.23.3844.3844
Published: 2015
Journal Articles

Sequential Molecular Characterization Based Delineation of Potential Driver Aberrations in ACUTE Myeloid Leukemia Following Myelodysplastic Syndrome

Frank G. Rücker, MD, Sibylle Cocciardi, Anna Dolnik, PhD, Tamara J. Blätte, Ulrike Wüst, Peter Paschka, MD, Verena I. Gaidzik, MD, Richard F. Schlenk, MD, Hartmut Döhner, Prof. Dr., Lars Bullinger, MD, Konstanze Döhner, MD
Journal: Blood
Blood (2015) 126 (23): 4123.
https://doi.org/10.1182/blood.V126.23.4123.4123
Published: 2015
Journal Articles

Clonal evolution in relapsed NPM1 -mutated acute myeloid leukemia

Jan Krönke, Lars Bullinger, Veronica Teleanu, Florian Tschürtz, Verena I. Gaidzik, Michael W. M. Kühn, Frank G. Rücker, Karlheinz Holzmann, Peter Paschka, Silke Kapp-Schwörer, Daniela Späth, Thomas Kindler, Marcus Schittenhelm, Jürgen Krauter, Arnold Ganser, Gudrun Göhring, Brigitte Schlegelberger, Richard F. Schlenk, Hartmut Döhner, Konstanze Döhner
Journal: Blood
Blood (2013) 122 (1): 100–108.
https://doi.org/10.1182/blood-2013-01-479188
Published: 2013
Includes: Supplemental data
Journal Articles

Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing

e-blood
Anna Dolnik, Julia C. Engelmann, Maren Scharfenberger-Schmeer, Julian Mauch, Sabine Kelkenberg-Schade, Berit Haldemann, Tamara Fries, Jan Krönke, Michael W. M. Kühn, Peter Paschka, Sabine Kayser, Stephan Wolf, Verena I. Gaidzik, Richard F. Schlenk, Frank G. Rücker, Hartmut Döhner, Claudio Lottaz, Konstanze Döhner, Lars Bullinger
Journal: Blood
Blood (2012) 120 (18): e83–e92.
https://doi.org/10.1182/blood-2011-12-401471
Published: 2012
Includes: Supplemental data
Journal Articles

TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome

Frank G. Rücker, Richard F. Schlenk, Lars Bullinger, Sabine Kayser, Veronica Teleanu, Helena Kett, Marianne Habdank, Carla-Maria Kugler, Karlheinz Holzmann, Verena I. Gaidzik, Peter Paschka, Gerhard Held, Marie von Lilienfeld-Toal, Michael Lübbert, Stefan Fröhling, Thorsten Zenz, Jürgen Krauter, Brigitte Schlegelberger, Arnold Ganser, Peter Lichter, Konstanze Döhner, Hartmut Döhner
Journal: Blood
Blood (2012) 119 (9): 2114–2121.
https://doi.org/10.1182/blood-2011-08-375758
Published: 2012
Includes: Supplemental data