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Journal Articles

RNA Polymerase 1 Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Malignancies: Results of a Phase I First in Human Study

Amit Khot, MBBS, MD MRCP, FRCPath, FRACP, Natalie Brajanovski, BSc, Donald P Cameron, BSc, Gretchen Poortinga, PhD, Elaine Sanij, PhD, John Lim, PharmD, John Soong, MD FCAP, Nadine Hein, PhD, Emma Link, DPhil, Richard B Pearson, PhD, Ross Hannan, Grant A. McArthur, MBBS, PhD BSc, FRACP, Simon J. Harrison, MBBS,MRCP,FRCPath,FRACP,PhD

Blood (2017) 130 (Supplement 1): 3835.

https://doi.org/10.1182/blood.V130.Suppl_1.3835.3835

Published: 2017

Journal Articles

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Blood (2017) 129 (21): 2882–2895.

https://doi.org/10.1182/blood-2016-05-718171

Published: 2017

Includes: Supplemental data

Journal Articles

Inhibition Of RNA Polymerase I Transcription By CX-5461 As a Therapeutic Strategy For The Cancer-Specific Activation Of p53 In Highly Refractory Haematological Malignancies

Nadine Hein, PhD, Sean O'Brien, Ph.D., Denis Drygin, PhD, Simon J. Harrison, MBBS MRCP (uk) MRCPath (uk) PhD, Amit Khot, MD, FRCPath, MBBS, MRCP, Carleen Cullinane, PhD, Matthews Geoff, PhD, Marta Chesi, PhD, Peter Leif Bergsagel, MD, Johannes Zuber, MD, Scott W. Lowe, Ph.D., Ricky W Johnstone, PhD, Rick Pearson, PhD, Grant A. McArthur, MD, PhD, FRACP, MBBS, Ross D Hannan, PhD

Blood (2013) 122 (21): 3941.

https://doi.org/10.1182/blood.V122.21.3941.3941

Published: 2013

Journal Articles

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

Jake Shortt, Benjamin P. Martin, Andrea Newbold, Katherine M. Hannan, Jennifer R. Devlin, Adele J. Baker, Rachael Ralli, Carleen Cullinane, Clemens A. Schmitt, Maurice Reimann, Michael N. Hall, Meaghan Wall, Ross D. Hannan, Richard B. Pearson, Grant A. McArthur, Ricky W. Johnstone

Blood (2013) 121 (15): 2964–2974.

https://doi.org/10.1182/blood-2012-08-446096

Published: 2013

Includes: Supplemental data

Journal Articles

Inhibition of RNA Polymerase I Transcription by CX-5461 As a Therapeutic Strategy for the Cancer-Specific Activation of p53 in MLL-Rearranged Acute Myeloid Leukemias

Nadine Hein, PhD, Megan J Bywater, PhD, Kim Stanley, BSc, Inge Verbrugge, PhD, Carlene Cullinane, PhD, Adele Baker, PhD, Hannes Zuber, PhD, Amy Rappaport, PhD, Denis Drygin, PhD, Nanni Huser, PhD, Josh Bliesath, PhD, David M Ryckman, PhD, William G Rice, PhD, Scott W Lowe, PhD, Ricky W Johnstone, PhD, Richard B Pearson, PhD, Grant A. McArthur, MD, PhD, FRACP, MBBS, Ross D Hannan, PhD

Blood (2011) 118 (21): 1548.

https://doi.org/10.1182/blood.V118.21.1548.1548

Published: 2011

Journal Articles

Deregulated Hoxa1 Expression in Murine Bone Marrow Results in An MDS-Like Phenotype

Jean Hendy, BSc, Stewart A Fabb, PhD, Meaghan Wall, MBBS, PhD, FRACP, FRCPA, Lorraine J Gudas, PhD, Grant A. McArthur, MD, PhD, FRACP, MBBS, Louise E Purton, PhD

Blood (2011) 118 (21): 2423.

https://doi.org/10.1182/blood.V118.21.2423.2423

Published: 2011

Journal Articles

ATRA and the RARα Specific Agonist, NRX195183, Have Opposing Effects on the In Vitro Clonogenicity of Pre-Leukemic Murine AML1-ETO Bone Marrow Cells

Lynette C.Y. Chee, FRACP, FRCPA, MBBS, Jean Hendy, BSc, Louise Purton, PhD, Grant A. McArthur, MD, PhD, FRACP, MBBS

Blood (2010) 116 (21): 999.

https://doi.org/10.1182/blood.V116.21.999.999

Published: 2010

Journal Articles

N-Methyl-2-Pyrrolidone Is a Biologically Active Thalidomide Subunit with In Vivo anti-Myeloma Properties

Jake Shortt, FRACP, FRCPA, Andy Hsu, PhD, Geoffrey M Matthews, PhD, Marta Chesi, P.Leif Bergsagel, MD, Grant A. McArthur, MD, PhD, FRACP, MBBS, Paul Neeson, PhD, David Ritchie, MBBS, FRACP, FRCPA, Ricky W Johnstone, PhD

Blood (2010) 116 (21): 4082.

https://doi.org/10.1182/blood.V116.21.4082.4082

Published: 2010

Journal Articles

The Truncated Form of Hoxa1 Regulates Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells.

Jean Hendy, Stewart A Fabb, Meaghan Wall, Paul J Simmons, Lorraine J Gudas, Grant A McArthur, Louise E Purton

Blood (2009) 114 (22): 3654.

https://doi.org/10.1182/blood.V114.22.3654.3654

Published: 2009

Journal Articles

Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation

Meaghan Wall, Gretchen Poortinga, Katherine M. Hannan, Richard B. Pearson, Ross D. Hannan, Grant A. McArthur

Blood (2008) 112 (6): 2305–2317.

https://doi.org/10.1182/blood-2007-09-111856

Published: 2008

Includes: Supplemental data

Journal Articles

Inhibiton of mTOR by RAD001 Restores Normal B Cell Differentiation and Prevents B Cell Lymphomas in Eμ- MYC Mice.

Meaghan Wall, Gretchen Poortinga, Daniela Cardozo, Ricky W. Johnstone, Grant A. McArthur

Blood (2006) 108 (11): 2498.

https://doi.org/10.1182/blood.V108.11.2498.2498

Published: 2006

Journal Articles

Durable responses to imatinib in patients with PDGFRB fusion gene–positive and BCR-ABL –negative chronic myeloproliferative disorders

Blood (2006) 109 (1): 61–64.

https://doi.org/10.1182/blood-2006-05-024828

Published: 2006

Journal Articles

Inhibition of mTOR Reverses the Ability of c-MYC To Block the Differentiation of Murine Granulocytes.

Meaghan Wall, Gretchen Poortinga, Richard B. Pearson, Ross D. Hannan, Grant A. McArthur

Blood (2005) 106 (11): 310.

https://doi.org/10.1182/blood.V106.11.310.310

Published: 2005

Journal Articles

Novel Methods for the Sensitive Detection of c- KIT D816V and Other Exon 17 Mutations in Patients with Mastocytosis.

Angela Y. Tan, PhD, David A. Westerman, MD, Kevin P. Lynch, MD, Grant A. McArthur, MD, PhD, Alexander Dobrovic, PhD

Blood (2005) 106 (11): 3273.

https://doi.org/10.1182/blood.V106.11.3273.3273

Published: 2005

Journal Articles

Identification of the molecular requirements for an RARα-mediated cell cycle arrest during granulocytic differentiation

Carl R. Walkley, Louise E. Purton, Hayley J. Snelling, Yang-Dar Yuan, Hideaki Nakajima, Pierre Chambon, Roshantha A. S. Chandraratna, Grant A. McArthur

Blood (2004) 103 (4): 1286–1295.

https://doi.org/10.1182/blood-2003-07-2391

Published: 2004

Includes: Supplemental data

NARROW

RNA Polymerase 1 Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Malignancies: Results of a Phase I First in Human Study

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Inhibition Of RNA Polymerase I Transcription By CX-5461 As a Therapeutic Strategy For The Cancer-Specific Activation Of p53 In Highly Refractory Haematological Malignancies

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

Inhibition of RNA Polymerase I Transcription by CX-5461 As a Therapeutic Strategy for the Cancer-Specific Activation of p53 in MLL-Rearranged Acute Myeloid Leukemias

Deregulated Hoxa1 Expression in Murine Bone Marrow Results in An MDS-Like Phenotype

ATRA and the RARα Specific Agonist, NRX195183, Have Opposing Effects on the In Vitro Clonogenicity of Pre-Leukemic Murine AML1-ETO Bone Marrow Cells

N-Methyl-2-Pyrrolidone Is a Biologically Active Thalidomide Subunit with In Vivo anti-Myeloma Properties

The Truncated Form of Hoxa1 Regulates Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells.

Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation

Inhibiton of mTOR by RAD001 Restores Normal B Cell Differentiation and Prevents B Cell Lymphomas in Eμ- MYC Mice.

Durable responses to imatinib in patients with PDGFRB fusion gene–positive and BCR-ABL –negative chronic myeloproliferative disorders

Inhibition of mTOR Reverses the Ability of c-MYC To Block the Differentiation of Murine Granulocytes.

Novel Methods for the Sensitive Detection of c- KIT D816V and Other Exon 17 Mutations in Patients with Mastocytosis.

Identification of the molecular requirements for an RARα-mediated cell cycle arrest during granulocytic differentiation

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American Society of Hematology

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American Society of Hematology

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