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James S O’Donnell
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Journal Articles

The interleukin-33 receptor (ST2) is a novel therapeutic target to attenuate the progression of hemophilic arthropathy

Open Access
Heike C. Hawerkamp, Aoife Yeow, Ciara M. Byrne, Anne Chevalier, Laura Matarazzo, Alexander Lawrence, Daniel Ivers, Tatenda Murangi, Niamh O’Dowd, Anne-Marije Hulshof, Ferdows Atiq, Jamie M. O'Sullivan, Vincent P. Kelly, Conor M. Finlay, Henry J. McSorley, Bagirath Gangadharan, Birgit M. Reipert, James S. O'Donnell, Peter L. Turecek, Padraic G. Fallon
Journal: Blood
Blood (2025) 146 (16): 1979–1990.
https://doi.org/10.1182/blood.2024027578
Published: 2025
Includes: Supplemental data
Journal Articles

Clinical phenotype and pathophysiological mechanisms underlying qualitative low VWF

Open Access
CME Clinical Trials & Observations
Ferdows Atiq, Robin Blok, Calvin B. van Kwawegen, Anne-Marije Hulshof, Dearbhla Doherty, Michelle Lavin, Johanna G. van der Bom, Niamh M. O’Connell, Joke de Meris, Kevin Ryan, Saskia E. M. Schols, Waander L. van Heerde, Mairead Doyle, Mary Byrne, Floor C. J. I. Heubel-Moenen, Karin P. M. van Galen, Roger J. S. Preston, Marjon H. Cnossen, Karin Fijnvandraat, Ross I. Baker, Karina Meijer, Paula James, Jorge Di Paola, Jeroen Eikenboom, Frank W. G. Leebeek, James S. O’Donnell
Journal: Blood
Blood (2025) 146 (3): 369–381.
https://doi.org/10.1182/blood.2024028035
Published: 2025
Includes: Supplemental data
Journal Articles

Enhanced α2-3–linked sialylation determines the extended half-life of CHO-rVWF

Open Access
Brief Report
Ciara Byrne, Soracha Ward, Jamie O’Sullivan, Alain Chion, Patricia Lopes, Bogdan Baci, Caoimhe Dowd, Darragh Jordan, Ross Baker, Roger J. S. Preston, Marco Monopoli, Peter L. Turecek, Maximilianos Kotsias, Jack Cheeseman, Alan B. Moran, Richard A. Gardner, Daniel I. R. Spencer, Ferdows Atiq, James S. O’Donnell
Journal: Blood
Blood (2025) 145 (23): 2768–2773.
https://doi.org/10.1182/blood.2024027038
Published: 2025
Includes: Supplemental data
Journal Articles

The aptamer BT200 blocks interaction of K1405-K1408 in the VWF-A1 domain with macrophage LRP1

Free
Alain Chion, Ciara Byrne, Ferdows Atiq, Dearbhla Doherty, Sonia Aguila, Judicael Fazavana, Patricia Lopes, Ellie Karampini, Aamir Amin, Roger J. S. Preston, Ross I. Baker, Thomas A. J. McKinnon, Shuhao Zhu, James C. Gilbert, Jonas Emsley, Bernd Jilma, James S. O’Donnell
Journal: Blood
Blood (2024) 144 (13): 1445–1456.
https://doi.org/10.1182/blood.2024024055
Published: 2024
Includes: Supplemental data
Journal Articles

Novel functions for von Willebrand factor

Free
Ferdows Atiq, James S. O’Donnell
Journal: Blood
Blood (2024) 144 (12): 1247–1256.
https://doi.org/10.1182/blood.2023021915
Published: 2024
Includes: Supplemental data
Journal Articles

Type 1 VWD classification revisited: novel insights from combined analysis of the LoVIC and WiN studies

Free
Ferdows Atiq, Robin Blok, Calvin B. van Kwawegen, Dearbhla Doherty, Michelle Lavin, Johanna G. van der Bom, Niamh M. O'Connell, Joke de Meris, Kevin Ryan, Saskia E. M. Schols, Mary Byrne, Floor C. J. I. Heubel-Moenen, Karin P. M. van Galen, Roger J. S. Preston, Marjon H. Cnossen, Karin Fijnvandraat, Ross I. Baker, Karina Meijer, Paula James, Jorge Di Paola, Jeroen Eikenboom, Frank W. G. Leebeek, James S. O'Donnell
Journal: Blood
Blood (2024) 143 (14): 1414–1424.
https://doi.org/10.1182/blood.2023022457
Published: 2024
Includes: Supplemental data
Journal Articles

Age Regulates Desmopressin Responses in Patients with Low Von Willebrand Factor and Type 1 Von Willebrand Disease in the Lovic and Win Studies

Free
Ferdows Atiq, Robin Blok, Calvin Van Kwawegen, Dearbhla Doherty, Michelle Lavin, Johanna G. Van Der Bom, Niamh O'Connell, Joke De Meris, Kevin Ryan, Saskia Schols, Mary Byrne, Floor Moenen, Karin PM Van Galen, Roger J.S Preston, Karin Fijnvandraat, Ross Baker, Karina Meijer, Paula James, Jorge Di Paola, Jeroen Eikenboom, James S. O'Donnell, Frank W.G. Leebeek
Journal: Blood
Blood (2023) 142 (Supplement 1): 510.
https://doi.org/10.1182/blood-2023-184734
Published: 2023
Journal Articles

The Relationship between Low Von Willebrand Factor, Type 1 Von Willebrand Disease and Ageing - Novel Insights from the Lovic and Win Cohort Studies

Free
Ferdows Atiq, Robin Blok, Calvin Van Kwawegen, Dearbhla Doherty, Michelle Lavin, Johanna G. Van Der Bom, Niamh O'Connell, Joke De Meris, Kevin Ryan, Saskia Schols, Mary Byrne, Floor Moenen, Karin PM Van Galen, Roger J.S Preston, Karin Fijnvandraat, Ross Baker, Karina Meijer, Paula James, Jorge Di Paola, Jeroen Eikenboom, Frank W.G. Leebeek, James S. O'Donnell
Journal: Blood
Blood (2023) 142 (Supplement 1): 509.
https://doi.org/10.1182/blood-2023-181603
Published: 2023
Journal Articles

How I treat bleeding disorder of unknown cause

Free
Ross I. Baker, James S. O’Donnell
Journal: Blood
Blood (2021) 138 (19): 1795–1804.
https://doi.org/10.1182/blood.2020010038
Published: 2021
Journal Articles

Bleeding Outcomes in People with Von Willebrand Disease Receiving Antithrombotic Therapy

Free
Aisling Barrett, Catherine Bergin, Mary Byrne, Kevin Ryan, Niamh M O'Connell, James S O'Donnell, Michelle Lavin
Journal: Blood
Blood (2021) 138 (Supplement 1): 3196.
https://doi.org/10.1182/blood-2021-152919
Published: 2021
Journal Articles

The relationship between ABO blood group, von Willebrand factor, and primary hemostasis

Free
Soracha E. Ward, Jamie M. O’Sullivan, James S. O’Donnell
Journal: Blood
Blood (2020) 136 (25): 2864–2874.
https://doi.org/10.1182/blood.2020005843
Published: 2020
Journal Articles

von Willebrand factor promotes wound healing

Free
James S. O’Donnell, Jamie M. O’Sullivan
Journal: Blood
Blood (2019) 133 (24): 2553–2555.
https://doi.org/10.1182/blood.2019001175
Published: 2019
Journal Articles

Increased galactose expression and enhanced clearance in patients with low von Willebrand factor

Free
Sonia Aguila, Michelle Lavin, Niall Dalton, Sean Patmore, Alain Chion, George D. Trahan, Kenneth L. Jones, Catriona Keenan, Teresa M. Brophy, Niamh M. O’Connell, Kevin Ryan, Mary Byrne, Margaret Nolan, Anjali Patel, Roger J. S. Preston, Paula James, Jorge Di Paola, Jamie M. O’Sullivan, James S. O’Donnell
Journal: Blood
Blood (2019) 133 (14): 1585–1596.
https://doi.org/10.1182/blood-2018-09-874636
Published: 2019
Includes: Supplemental data
Journal Articles

Blood group alters platelet binding kinetics to von Willebrand factor and consequently platelet function

Free
Eimear Dunne, Qin M. Qi, Eric S. Shaqfeh, Jamie M. O’Sullivan, Ingmar Schoen, Antonio J. Ricco, James S. O’Donnell, Dermot Kenny
Journal: Blood
Blood (2019) 133 (12): 1371–1377.
https://doi.org/10.1182/blood-2018-06-855528
Published: 2019
Includes: Multimedia, Supplemental data
Journal Articles

How I treat low von Willebrand factor levels

Free
Michelle Lavin, James S. O’Donnell
Journal: Blood
Blood (2019) 133 (8): 795–804.
https://doi.org/10.1182/blood-2018-10-844936
Published: 2019
Journal Articles

The Irish Personalized Approach to the Treatment of Haemophilia (iPATH) - Determinants of Inter-Individual Variation in FVIII Pharmacokinetics

Free
Michelle Lavin, MB, PhD FRCPath, Niamh Larkin, Anjali Patel, Evelyn Singleton, Mary Byrne, Kevin Ryan, MB, FRCPath, Niamh M O'Connell, MB, PhD FRCPath, Birgit M Reipert, Steven Pipe, Peter L Turecek, PhD, James S O'Donnell, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1190.
https://doi.org/10.1182/blood-2018-99-112850
Published: 2018
Journal Articles

Defining the Molecular Mechanisms through Which the Macrophage Galactose Lectin (MGL) Receptor Regulates Von Willebrand Factor Clearance

Free
Soracha E Ward, BSc, Jamie M O'Sullivan, Sonia Aguila Martinez, BSc, PhD, Clive Drakeford, BSc, Thomas Anthony Jude McKinnon, BSc, PhD, Alain Chion, BSc, PhD, James S O'Donnell, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 980.
https://doi.org/10.1182/blood-2018-99-114775
Published: 2018
Journal Articles

The Low Von Willebrand Factor in Ireland Cohort Study - Defining Optimal Management for Procedures in Patients with Low VWF (30-50 IU/dL)

Free
Dearbhla Doherty, MB, MRCPI, Anjali Patel, Margaret Nolan, Mary Byrne, Sonia Aguila, PhD, Jamie M O'Sullivan, Kevin Ryan, MB, FRCPath, Niamh M O'Connell, MB, PhD FRCPath, Michelle Lavin, MB, PhD FRCPath, James S O'Donnell, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1178.
https://doi.org/10.1182/blood-2018-99-115946
Published: 2018
Journal Articles

Younger Age at Diagnosis Is Associated with an Increased Risk of Venous Thromboembolism in Multiple Myeloma

Free
Aisling Barrett, John Quinn, MD PhD, Siobhan Glavey, MD PhD, Jeremy Sargent, FRCPath, Michelle Lavin, MB, PhD FRCPath, Patrick Thornton, MB, FRCPath, James S O'Donnell, MD PhD, Philip Murphy, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1223.
https://doi.org/10.1182/blood-2018-99-116148
Published: 2018
Journal Articles

Site-Directed Pegylation at Specific Sites Significantly Prolongs the Half-Life of A1A2A3-VWF By Markedly Attenuating LRP1-Mediated Clearance

Free
Jamie M O'Sullivan, Judicael Fazavana, PhD, Alain Chan, PhD, Niamh Cooke, PhD, Virginie Terraube, Justin Cohen, PhD, Debra D Pittman, MS, Orla Cunningham, PhD, Matthew Lambert, James S O'Donnell, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1165.
https://doi.org/10.1182/blood-2018-99-114966
Published: 2018