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Jaroslav Čermák
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Journal Articles

Accelerated Progression in Lower-Risk Myelodysplastic Neoplasms: Attenuated Cell Cycle, DNA Damage Response, and Augmented Oncogenic Transcriptome Signatures

Monika Kaisrlikova, Zuzana Lenertová, Pavla Koralkova, Iva Trsová, David Kundrat, Michaela Dostalova Merkerova, Hana Votavova, Zdenek Krejcik, Anna Jonasova, Jaroslav Cermak, Vladimir Divoky, Monika Belickova
Journal: Blood
Blood (2023) 142 (Supplement 1): 6454.
https://doi.org/10.1182/blood-2023-180496
Published: 2023
Journal Articles

Different Mutations in SF3B1 Gene Have Specific Transcriptomic Characteristics in Myelodysplastic Neoplasms

Iva Trsová, Andrea Hrustincova, Monika Belickova, Monika Kaisrlikova, Zuzana Lenertová, David Kundrat, Zdenek Krejcik, Jitka Vesela, Jaroslav Cermak, Anna Jonasova, Michaela Dostalova Merkerova
Journal: Blood
Blood (2023) 142 (Supplement 1): 3218.
https://doi.org/10.1182/blood-2023-179068
Published: 2023
Journal Articles

Patient-Reported Outcomes (PROs) in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Treated with Crovalimab and Eculizumab: Results from the Phase III Randomized COMMODORE 2 and COMMODORE 1 Trials

Jens Panse, Jaroslav Cermak, Olena Kyselova, Akihiko Gotoh, Fahri Sahin, Hubert Schrezenmeier, Alice C. Chang, Brittany Gentile, Marianne Uguen, Bing Han
Journal: Blood
Blood (2023) 142 (Supplement 1): 4090.
https://doi.org/10.1182/blood-2023-177584
Published: 2023
Journal Articles

Molecular Mechanisms Underlying Abnormal Activation of T Cells in Idiopathic Aplastic Anemia and Hypoplastic Myelodysplastic Neoplasms

Zuzana Lenertová, Monika Kaisrlikova, David Kundrat, Hana Votavova, Jitka Vesela, Iva Trsová, Sarka Ransdorfova, Iuri Marinov, Tomas Prochazka, Daniel Lysak, Anna Jonasova, Jaroslav Čermák, Monika Belickova
Journal: Blood
Blood (2023) 142 (Supplement 1): 1342.
https://doi.org/10.1182/blood-2023-181713
Published: 2023
Journal Articles

Somatic Mutations and DNA Hypermethylation at Enhancers and Promoters Identify Distinct Subtypes within Lower-Risk Myelodysplastic Syndromes

David Rombaut, Tobias Tekath, Sarah Sandmann, Simon Crouch, Aniek O. de Graaf, Olivier Kosmider, Magnus Tobiasson, Andreas Lennartsson, Bert A. Van der Reijden, Sophie Park, Maud D'Aveni, Bohrane Slama, Emmanuelle Clappier, Pierre Fenaux, Lionel Ades, Arjan A. van de Loosdrecht, Saskia MC Langemeijer, Argiris S. Symeonidis, Jaroslav Čermák, Claude Preudhomme, Aleksandar Savic, Ulrich Germing, Reinhard Stauder, David T. Bowen, Corine J. Van Marrewijk, Elsa Bernard, Alexandra Smith, Daniel Painter, Theo J.M. de Witte, Eva Hellstrom Lindberg, Julian Varghese, Martin Dugas, Joost H.A. Martens, Luca Malcovati, Joop H. Jansen, Michaela Fontenay
Journal: Blood
Blood (2023) 142 (Supplement 1): 4587.
https://doi.org/10.1182/blood-2023-180071
Published: 2023
Journal Articles

Changes of Transcriptomic Landscape in Blasts of Responding and Refractory Acute Myeloid Leukemia Patients after Chemotherapy

Ela Cerovska, Cyril Salek, David Kundrat, Zdenek Krejcik, Monika Belickova, Jaroslav Cermak, Hana Remesova
Journal: Blood
Blood (2022) 140 (Supplement 1): 9130–9131.
https://doi.org/10.1182/blood-2022-162176
Published: 2022
Journal Articles

Aging-Related Gene Expression Signatures Define Likelihood of Disease Progression in Patients with Lower-Risk Myelodysplastic Syndromes

Monika Kaisrlikova, Iva Trsová, Zuzana Lenertova, Jitka Vesela, David Kundrat, Hana Votavova, Michaela Dostalova Merkerova, Zdenek Krejcik, Martin Vostry, Jaroslav Cermak, Monika Belickova
Journal: Blood
Blood (2022) 140 (Supplement 1): 4020–4021.
https://doi.org/10.1182/blood-2022-168503
Published: 2022
Journal Articles

Dynamics of Mortality and Transformation Risk within Different Risk Groups of Patients with Myelodysplastic Syndromes Stratified According to the IPSS-R - Comparison of Treated and Untreated Patients and Consequences for the Description of Risk Categories

Michael Pfeilstocker, Heinz Tuechler, Lionel Ades, Jaroslav Cermak, Fatiha Chermat, Matteo G. Della Porta, Pierre Fenaux, Guillermo Garcia-Manero, Ulrich Germing, Detlef Haase, Andrea Kuendgen, Michael Luebbert, Silvia Maria Meira Magalhaes, Luca Malcovati, Yasushi Miyazaki, Guillermo Sanz, Valeria Santini, Mikkael A. Sekeres, Matthew J Walter, Peter Valent, Peter L Greenberg
Journal: Blood
Blood (2022) 140 (Supplement 1): 6976–6978.
https://doi.org/10.1182/blood-2022-158671
Published: 2022
Journal Articles

Upregulation of ZEB1 -Derived Circular RNAs Is Associated with SF3B1 -Mutated Myelodysplastic Neoplasms

Iva Trsová, Monika Belickova, Andrea Hrustincova, Monika Kaisrlikova, Zuzana Lenertova, David Kundrat, Zdenek Krejcik, Jitka Vesela, Jiri Klema, Petr Ryšavý, Jaroslav Cermak, Michaela Dostalova Merkerova
Journal: Blood
Blood (2022) 140 (Supplement 1): 4005–4006.
https://doi.org/10.1182/blood-2022-159466
Published: 2022
Journal Articles

Risk Assessment in Patients with Myelodysplastic Neoplasms Using the Molecular International Prognostic Scoring System: A Single-Center Study from the Czech Republic

Jitka Vesela, Hana Votavova, Monika Kaisrlikova, Zuzana Lenertova, David Kundrat, Iva Trsová, Sarka Ransdorfova, Dana Mikulenkova, Jaroslav Cermak, Monika Belickova
Journal: Blood
Blood (2022) 140 (Supplement 1): 4098–4099.
https://doi.org/10.1182/blood-2022-165903
Published: 2022
Journal Articles

Management of MDS with Isolated Del(5q) Patients in the European MDS (EUMDS) Registry: A Report on 197 Cases

Inga Mandac Smoljanovic, Adele Taylor, Pierre Fenaux, Agnès Guerci-Bresler, Raphael Itzykson, Argiris Symeonidis, Ioannis Kotsianidis, Moshe Mittelman, Guillermo Sanz, Dominic J. Culligan, Jaroslav Cermak, Reinhard Stauder, Eva Hellström-Lindberg, Luca Malcovati, Saskia M.C. Langemeijer, Ulrich Germing, Krzysztof Madry, Howard S. Oster, Alexandra Smith, Corine van Marrewijk, Theo M de Witte, David Bowen
Journal: Blood
Blood (2022) 140 (Supplement 1): 9802–9803.
https://doi.org/10.1182/blood-2022-167716
Published: 2022
Journal Articles

Management of MDS with Isolated Del(5q) Patients in the European MDS (EUMDS) Registry, a Unique Prospective Real-World Dataset

David Bowen, Adele Taylor, Pierre Fenaux, Agnes Guerci-Bresler, Raphael Itzykson, Argiris Symeonidis, Ioannis Kotsianidis, Moshe Mittelman, Guillermo Sanz, Dominic J. Culligan, Jaroslav Cermak, Reinhard Stauder, Eva Hellstrom Lindberg, Luca Malcovati, Saskia M. C. Langemeijer, Ulrich Germing, Howard S. Oster, Krzysztof Madry, Mette Skov Holm, Alexandra Smith, Corine van Marrewijk, Theo M de Witte
Journal: Blood
Blood (2021) 138 (Supplement 1): 4671.
https://doi.org/10.1182/blood-2021-150322
Published: 2021
Journal Articles

Circular RNAs in Myelodysplastic Syndromes and Impact of SF3B1 Mutations on Their Expression

Michaela Dostalova Merkerova, David Kundrat, Zdenek Krejcik, Andrea Hrustincova, Iva Trsova, Katarina Szikszai, Monika Kaisrlikova, Jitka Vesela, Jiri Klema, Jaroslav Cermak, Monika Belickova
Journal: Blood
Blood (2021) 138 (Supplement 1): 2590.
https://doi.org/10.1182/blood-2021-149633
Published: 2021
Journal Articles

Mutation Profiles Identify Distinct Clusters of Lower Risk Myelodysplastic Syndromes with Unique Clinical and Biological Features and Clinical Endpoints

Luca Malcovati, MD, Simon Crouch, PhD BA, MA, MSc, Aniek O. De Graaf, PhD, Sarah Sandmann, Magnus Tobiasson, MD, Olivier Kosmider, PharmD, PhD, Bert A. van der Reijden, PhD, Daniel Painter, BSc, Arjan A. Van de Loosdrecht, MD PhD, Argiris Symeonidis, MD PhD, Jaroslav Cermak, MD PhD, Emmanuelle Clappier, PharmD,PhD, Claude Preudhomme, MD PhD, Reinhard Stauder, MD MSc, Moshe Mittelman, MD, Ulrich Germing, David Bowen, MD, Pierre Fenaux, MD PhD, Corine Van Marrewijk, PhD, Alexandra Smith, PhD, Martin Dugas, Eva Hellstrom Lindberg, MD PhD, Theo M de Witte, MD, Michaela Fontenay, Joop Jansen, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29.
https://doi.org/10.1182/blood-2020-138549
Published: 2020
Journal Articles

The QUAZAR AML-001 Maintenance Trial: Results of a Phase III International, Randomized, Double-Blind, Placebo-Controlled Study of CC-486 (Oral Formulation of Azacitidine) in Patients with Acute Myeloid Leukemia (AML) in First Remission

Andrew H. Wei, MBBS, FRACP, FRCPA, PhD, Hartmut Döhner, MD, Christopher Pocock, MBBS, Pau Montesinos, MD PhD, Boris Afanasyev, MD DSci, Hervé Dombret, MD, Farhad Ravandi, MD, Hamid Sayar, MD MSc, Jun Ho Jang, MD PhD, Kimmo Porkka, MD, Dominik Selleslag, MD, Irwindeep Sandhu, MD, Mehmet Turgut, MD, Valentina Giai, MD, Yishai Ofran, MD, Merih Kizil Cakar, MD, Aida Botelho de Sousa, MD, Justyna Rybka, MD PhD, Chiara Frairia, MD, Lorenza Borin, MD, Germana Beltrami, MD, Jaroslav Cermak, MD PhD, Gert J. Ossenkoppele, MD PhD, Ignazia La Torre, MD, Barry Skikne, MD, Keshava Kumar, PhD, Qian Dong, DrPH, CL Beach, PharmD, Gail J. Roboz, MD
Journal: Blood
Blood (2019) 134 (Supplement_2): LBA-3.
https://doi.org/10.1182/blood-2019-132405
Published: 2019
Journal Articles

Malignancies and MDS in Patients with Diamond-Blackfan Anemia (DBA) from the Czech National DBA Registry

Dagmar Pospisilova, Prof MD PhD, Jaroslav Cermak, Monika Belickova, PhD, Monika Horvathova, MSc, PhD, Jana Volejnikova, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5017.
https://doi.org/10.1182/blood-2019-126187
Published: 2019
Journal Articles

Arsenic Trioxide Upregulates Cereblon mRNA Expression and Potentiates Sensitivity of SKM-1 and MDS-L Cells to Lenalidomide

Radka Bokorová, Ota Fuchs, PhD, Denisa Myslivcova, PhD, Jaroslav Cermak
Journal: Blood
Blood (2019) 134 (Supplement_1): 5397.
https://doi.org/10.1182/blood-2019-126443
Published: 2019
Journal Articles

Circulating Small Noncoding RNAs As Novel Semi-Invasive Markers of Patient Survival in Myelodysplastic Syndromes

Michaela Dostalova Merkerova, PhD MSc, Andrea Hrustincova, Zdenek Krejcik, David Kundrat, Katarina Szikszai, PhD, Jaroslav Cermak, Jitka Vesela, Monika Hruba, Monika Belickova, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3004.
https://doi.org/10.1182/blood-2019-126520
Published: 2019
Journal Articles

I-Care for MDS: Development of Guidelines-Based Indicators for Appropriate Care in Adult Patients with Myelodysplastic Syndromes

Kristina Stojkov, BSc, MSc Pharm, Tobias Silzle, MD, Georg Stussi, MD, David Schwappach, PhD MPH, Juerg Bernhard, PhD, David Bowen, MD, Jaroslav Cermak, Avinash G. Dinmohamed, BSc, MSc, Corien Eeltink, Sabrina Eggmann, PT, MSc, Pierre Fenaux, MD PhD, Ulrich Germing, MD, Manuel Haschke, MD, Eva Hellstrom Lindberg, MD PhD, Monika Heger, Arjan A. Van de Loosdrecht, MD PhD, Jakob R. Passweg, MDMS, Michael Pfeilstocker, MD, Uwe Platzbecker, MD, Luca Malcovati, MD, Antonio Medina De Almeida, MD PhD, Moshe Mittelman, MD, Christine Morgenthaler, David P. Steensma, MD, Valeria Santini, MD, Reinhard Stauder, MD MSc, Argiris Symeonidis, MD PhD, Saemi Schaer, PhD, Charlotte Maddox, DVM, PhD, Theo M de Witte, MD, Julia Bohlius, MD, Nicolas Bonadies, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4752.
https://doi.org/10.1182/blood-2019-122285
Published: 2019
Journal Articles

RUNX1 Mutation Accompanied with Dysregulated Cellular Senescence in Lower-Risk Myelodysplastic Syndrome Patients Is Associated with Disease Progression

Monika Hruba, Jitka Vesela, Hana Votavova, PhD, Michaela Dostalova Merkerova, PhD MSc, David Kundrat, Katarina Szikszai, PhD, Marie Lauermanova, MD, Zuzana Zemanova, PhD, Anna Jonasova, MD PhD, Jaroslav Cermak, MD PhD, Monika Belickova, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4230.
https://doi.org/10.1182/blood-2019-131150
Published: 2019