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Katharina S. Götze
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Journal Articles

Mesenchymal Stromal Cells from Individuals with DNMT3A mut Clonal Hematopoiesis Instruct Young Healthy Hematopoietic Stem/Progenitor Cells Towards a Myeloid-Biased Aging Phenotype Resembling That of Patients with Clonal Cytopenia of Undetermined Significance (CCUS)

Anna Navarro Figueredo, Wencke Walter, Jennifer Rivière, Marit Leilich, Siddhi Pawar, Michèle Buck, Judith S. Hecker, Marta Benegas Coll, Carolina Monzó, Maki Sakuma, Priyansh Srivastava, Ana Conesa, Torsten Haferlach, Mark Van Der Garde, Katharina S. Götze
Journal: Blood
Blood (2023) 142 (Supplement 1): 2703.
https://doi.org/10.1182/blood-2023-188781
Published: 2023
Journal Articles

Flipping the switch in the stem cell niche

Katharina S. Götze
Journal: Blood
Blood (2023) 142 (5): 404–406.
https://doi.org/10.1182/blood.2023021286
Published: 2023
Journal Articles

Targeting FLT3 with a new-generation antibody-drug conjugate in combination with kinase inhibitors for treatment of AML

Maike Roas, Binje Vick, Marc-André Kasper, Marina Able, Harald Polzer, Marcus Gerlach, Elisabeth Kremmer, Judith S. Hecker, Saskia Schmitt, Andreas Stengl, Verena Waller, Natascha Hohmann, Moreno Festini, Alexander Ludwig, Lisa Rohrbacher, Tobias Herold, Marion Subklewe, Katharina S. Götze, Christian P. R. Hackenberger, Dominik Schumacher, Jonas Helma-Smets, Irmela Jeremias, Heinrich Leonhardt, Karsten Spiekermann
Journal: Blood
Blood (2023) 141 (9): 1023–1035.
https://doi.org/10.1182/blood.2021015246
Published: 2023
Includes: Supplemental data
Journal Articles

Autophagy in mesenchymal progenitors protects mice against bone marrow failure after severe intermittent stress

Theresa Landspersky, Mehmet Saçma, Jennifer Rivière, Judith S. Hecker, Franziska Hettler, Erik Hameister, Katharina Brandstetter, Rouzanna Istvánffy, Sandra Romero Marquez, Romina Ludwig, Marilena Götz, Michèle Buck, Martin Wolf, Matthias Schiemann, Jürgen Ruland, Dirk Strunk, Akiko Shimamura, Kasiani Myers, Terry P. Yamaguchi, Matthias Kieslinger, Heinrich Leonhardt, Florian Bassermann, Katharina S. Götze, Hartmut Geiger, Christina Schreck, Robert A. J. Oostendorp
Journal: Blood
Blood (2022) 139 (5): 690–703.
https://doi.org/10.1182/blood.2021011775
Published: 2022
Includes: Supplemental data
Journal Articles

Midostaurin Plus Intensive Chemotherapy for Younger and Older Patients with Acute Myeloid Leukemia and FLT3 Internal Tandem Duplications

Hartmut Döhner, Daniela Weber, Julia Krzykalla, Walter Fiedler, Gerald Wulf, Helmut R. Salih, Michael Lübbert, Michael W.M. Kühn, Thomas Schroeder, Hans Salwender, Katharina S. Götze, Jörg Westermann, Lars Fransecky, Karin Mayer, Bernd Hertenstein, Mark Ringhoffer, Hans-Joachim Tischler, Sigrid Machherndl-Spandl, Anika Schrade, Peter Paschka, Verena I Gaidzik, Frauke Theis, Felicitas R Thol, Michael Heuser, Richard F. Schlenk, Lars Bullinger, Maral Saadati, Axel Benner, Konstanze Döhner, Arnold Ganser
Journal: Blood
Blood (2021) 138 (Supplement 1): 692.
https://doi.org/10.1182/blood-2021-147256
Published: 2021
Journal Articles

CHIP and hips: clonal hematopoiesis is common in patients undergoing hip arthroplasty and is associated with autoimmune disease

Brief Report
Judith S. Hecker, Luise Hartmann, Jennifer Rivière, Michèle C. Buck, Mark van der Garde, Maja Rothenberg-Thurley, Luise Fischer, Susann Winter, Bianka Ksienzyk, Frank Ziemann, Maria Solovey, Martina Rauner, Elena Tsourdi, Katja Sockel, Marie Schneider, Anne S. Kubasch, Martin Nolde, Dominikus Hausmann, Alexander C. Paulus, Jörg Lützner, Andreas Roth, Florian Bassermann, Karsten Spiekermann, Carsten Marr, Lorenz C. Hofbauer, Uwe Platzbecker, Klaus H. Metzeler, Katharina S. Götze
Journal: Blood
Blood (2021) 138 (18): 1727–1732.
https://doi.org/10.1182/blood.2020010163
Published: 2021
Includes: Supplemental data
Journal Articles

Impact of gemtuzumab ozogamicin on MRD and relapse risk in patients with NPM1 -mutated AML: results from the AMLSG 09-09 trial

Clinical Trials & Observations
Silke Kapp-Schwoerer, Daniela Weber, Andrea Corbacioglu, Verena I. Gaidzik, Peter Paschka, Jan Krönke, Frauke Theis, Frank G. Rücker, Maria-Veronica Teleanu, Ekaterina Panina, Nikolaus Jahn, Julia Herzig, Lena Kubanek, Anika Schrade, Gudrun Göhring, Walter Fiedler, Thomas Kindler, Thomas Schroeder, Karin T. Mayer, Michael Lübbert, Mohammed Wattad, Katharina S. Götze, Heinz A. Horst, Elisabeth Koller, Gerald Wulf, Jan Schleicher, Martin Bentz, Jürgen Krauter, Lars Bullinger, Julia Krzykalla, Axel Benner, Richard F. Schlenk, Felicitas Thol, Michael Heuser, Arnold Ganser, Hartmut Döhner, Konstanze Döhner
Journal: Blood
Blood (2020) 136 (26): 3041–3050.
https://doi.org/10.1182/blood.2020005998
Published: 2020
Includes: Supplemental data
Journal Articles

A Molecular-Based Response Prediction Model to Romiplostim in Patients with Lower-Risk Myelodysplastic Syndrome and Severe Thrombocytopenia

Anne Sophie Kubasch, Aristoteles Giagounidis, Georgia Metzgeroth, Anna Jonasova, MD PhD, Regina Herbst, MD, Jose Miguel Torregrosa Diaz, Benoit De Renzis, MD, Katharina S. Götze, Marie-Luise Huetter-Kroenke, MD, Marie-Pierre Gourin, Bohrane Slama, MD, Sophie Dimicoli-Salazar, MD, Pascale Cony-Makhoul, MD, Kamel Laribi, MD, Sophie Park, MD PhD, Katja Jersemann, Dorothea Schipp, Klaus H. Metzeler, MD, Oliver Tiebel, MD, Katja Sockel, MD, Silke Gloaguen, Msc, Anna Mies, Fatiha Chermat, Christian Thiede, MD, Rosa Sapena, Richard F. Schlenk, Pierre Fenaux, MD PhD, Uwe Platzbecker, Lionel Ades, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 44–45.
https://doi.org/10.1182/blood-2020-139291
Published: 2020
Journal Articles

Activity of Decitabine (DAC) Combined with All-Trans Retinoic Acid (ATRA) in Oligoblastic AML: Subgroup Analysis of a Randomized 2x2 Phase II Trial

Michael Luebbert, MD PhD, Olga Grishina, Claudia Schmoor, Martina Crysandt, Edgar Jost, Felicitas Thol, Michael Heuser, Katharina S. Götze, Richard F. Schlenk, Konstanze Döhner, Helmut R. Salih, Marcus M. Schittenhelm, Gerhard Heil, Carsten Schwaenen, Carsten Mueller-Tidow, MD, Wolfram Brugger, Andrea Kündgen, Ulrich Germing, Maike de Wit, Stephan Kremers, Aristoteles Giagounidis, Sebastian Scholl, Andreas Neubauer, Professor Dr, Jürgen Krauter, Gesine Bug, Ralph Wäsch, Heiko Becker, Christoph Rummelt, Annette M. May, Justus Duyster, Arnold Ganser, Björn Hackanson, Hartmut Döhner
Journal: Blood
Blood (2020) 136 (Supplement 1): 9–10.
https://doi.org/10.1182/blood-2020-140664
Published: 2020
Journal Articles

Mutational Landscape of Relapsed Core-Binding Factor Acute Myeloid Leukemia (CBF-AML)

Anna Dolnik, Nikolaus Jahn, MD, Eric Sträng, PhD, Sibylle Cocciardi, PhD, Frank G. Rücker, MD, Ekaterina Panina, MD, Tamara J. Blätte, PhD, Julia Katharina Herzig, PhD, Andrea Corbacioglu, PhD, Daniela Weber, MSc, Anika Schrade, PhD, Verena I Gaidzik, MD, Sabrina Skambraks, Katharina S. Götze, Michael Luebbert, MD PhD, Walter Fiedler, MD, Thomas Schroeder, Corinna Hahn, Felicitas Thol, Michael Heuser, Arnold Ganser, Peter Paschka, MD, Hartmut Döhner, Konstanze Döhner, Lars Bullinger, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 42.
https://doi.org/10.1182/blood-2020-142392
Published: 2020
Journal Articles

A Phase 1, Open Label Dose Escalation Trial Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of Orally Administered CA-4948 in Patients with Acute Myelogenous Leukemia or Myelodysplastic Syndrome

Guillermo Garcia-Manero, MD, Uwe Platzbecker, Stefano R. Tarantolo, MD, Stefanie Gropper, Chetasi Talati, MD, Katharina S. Götze, James Dugan, MD, Eric S. Winer, MD, Elizabeth Martinez, PhD DHSC, MSN, Christopher Lieberman, Reinhard von Roemeling, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16.
https://doi.org/10.1182/blood-2020-140889
Published: 2020
Journal Articles

Impact of Genetic Abnormalities and Measurable Residual Disease Levels on Outcome in Patients with MDS/AML Pre-Emptively Treated with Azacitidine: Correlative Results of the Prospective RELAZA2 Trial

Sabine Kayser, MD, Jan Moritz Middeke, MD, Michael Kramer, Katja Sockel, MD, Sebastian Stasik, PhD, Regina Herbst, MD, Lars R. Fransecky, MD, Dominik Wolf, Univ. Prof. Dr., Schumacher Martin, MD, Alwin Krämer, MD, Richard Noppeney, MD, Juergen Novotny, MD, Gesine Bug, Katharina S. Götze, Karsten Spiekermann, MD, Matthias Stelljes, MD, Jan-Henrik Mikesch, PD, MD, Marion Subklewe, MD, Antje Schubert, Anke Mütherig, MD, Tilmann Bochtler, MD, Marika Mende, MD, Friedrich Stoelzel, PD, MD, Anne Kubasch, MD, Malte Von Bonin, MD, Mathias Haenel, MD, Ulrich Duehrsen, MD, Johannes Schetelig, MDMSc, Christoph Rollig, MD MSC, Claudia D Baldus, MD, Gerhard Ehninger, MD, Carsten Müller-Tidow, MD, Hubert Serve, MD PhD, Martin Bornhäuser, MD, Uwe Platzbecker, Christian Thiede, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10–11.
https://doi.org/10.1182/blood-2020-138427
Published: 2020
Journal Articles

Efficacy and Safety of Bemcentinib in Patients with Myelodysplastic Syndromes or Acute Myeloid Leukemia Failing Hypomethylating Agents

Anne Sophie Kubasch, Pierre Peterlin, MD, Thomas Cluzeau, MD PhD, Katharina S. Götze, Katja Sockel, MD, Raphael Teipel, MD, Madlen Jentzsch, MD, Sabine Kayser, MD, Habiba Attalah, Fatiha Chermat, Silke Gloaguen, Msc, Katja Jersemann, Dorothea Schipp, Aristoteles Giagounidis, Stuart McPherson, BSc, Irene Tirado-González, Arjan van de Loosdrecht, MD PhD, Pierre Fenaux, MD PhD, Uwe Platzbecker, Hind Medyouf, Lionel Ades, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-140240
Published: 2020
Journal Articles

Development and Exploitation of a Fully Human and Modular Organotypic Bone Marrow Niche Model to Study the Role of Stroma-Produced Factors in Human MDS

Alexander Schaeffer, Ewelina Czlonka, Irene Tirado-González, Thomas Böse, Jennifer Beauvarlet, Ivan Kur, Aline Bözec, Halvard Bönig, Christian H. Brandts, MD, Uwe Platzbecker, Katharina S. Götze, Hind Medyouf
Journal: Blood
Blood (2020) 136 (Supplement 1): 23.
https://doi.org/10.1182/blood-2020-142782
Published: 2020
Journal Articles

Next-Generation Sequencing (NGS)-Based Measurable Residual Disease (MRD) Monitoring in Acute Myeloid Leukemia with FLT3 Internal Tandem Duplication ( FLT3 -ITD + AML) Treated with Additional Midostaurin

Julia K. Herzig, PhD, Frank G. Rücker, MD, Laura K. Schmalbrock, MD, Tamara J. Blätte, PhD, Daniela Weber, MSc, Sabrina Skambraks, Silke Kapp-Schwoerer, MD, Andrea Corbacioglu, PhD, Verena I Gaidzik, MD, Peter Paschka, MD, Ekaterina Panina, MD, Nikolaus Jahn, MD, Anika Schrade, PhD, Frauke Theis, MD, Sibylle Cocciardi, PhD, Walter Fiedler, MD, Helmut R. Salih, Gerald Wulf, MD, Hans Salwender, MD, Thomas Schroeder, Katharina S. Götze, Thomas Kindler, MD, Michael Luebbert, Richard F. Schlenk, Felicitas Thol, Michael Heuser, Arnold Ganser, Hartmut Döhner, Lars Bullinger, MD, Konstanze Döhner
Journal: Blood
Blood (2020) 136 (Supplement 1): 21–22.
https://doi.org/10.1182/blood-2020-137568
Published: 2020
Journal Articles

Phase 3 Study of Lenalidomide (LEN) Vs Placebo in Non-Transfusion Dependent (TD) Low Risk Del(5q) MDS Patients - Interim Analysis of the European Sintra-REV Trial

Félix López Cadenas, MD, Eva Lumbreras, Blanca Xicoy, MD, Joaquín Sánchez, MD, Rosa Coll, MD, Bohrane Slama, MD, Jose Angel Hernandez-Rivas, MD PhD, Sylvain Thepot, MD, Teresa Bernal, MD PhD, Beatriz Arrizabalaga, MD PhD, Agnès Guerci-Bresler, MD PhD, Guillermo F Sanz, MD PhD, Joan Bargay, MD, Maria Luz Amigo, MD, Raquel de Paz, MD, Benet Nomdedeu, MD, Aristoteles Giagounidis, Uwe Platzbecker, Stefan Wickenhauser, Katharina S. Götze, Ali Arar, Jesus María Hernández Rivas, MD PhD, Pierre Fenaux, MD PhD, Consuelo Del Cañizo, MDPhD, Maria Diez-Campelo, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-140339
Published: 2020
Journal Articles

Midostaurin added to chemotherapy and continued single-agent maintenance therapy in acute myeloid leukemia with FLT3 -ITD

Clinical Trials & Observations
Richard F. Schlenk, Daniela Weber, Walter Fiedler, Helmut R. Salih, Gerald Wulf, Hans Salwender, Thomas Schroeder, Thomas Kindler, Michael Lübbert, Dominik Wolf, Jörg Westermann, Doris Kraemer, Katharina S. Götze, Heinz-August Horst, Jürgen Krauter, Michael Girschikofsky, Mark Ringhoffer, Thomas Südhoff, Gerhard Held, Hans-Günter Derigs, Roland Schroers, Richard Greil, Martin Grießhammer, Elisabeth Lange, Alexander Burchardt, Uwe Martens, Bernd Hertenstein, Lore Marretta, Michael Heuser, Felicitas Thol, Verena I. Gaidzik, Wolfgang Herr, Julia Krzykalla, Axel Benner, Konstanze Döhner, Arnold Ganser, Peter Paschka, Hartmut Döhner
Journal: Blood
Blood (2019) 133 (8): 840–851.
https://doi.org/10.1182/blood-2018-08-869453
Published: 2019
Includes: Supplemental data
Journal Articles

Sorafenib As Maintenance Therapy Post Allogeneic Stem Cell Transplantation for FLT3-ITD Positive AML: Results from the Randomized, Double-Blind, Placebo-Controlled Multicentre Sormain Trial

Andreas Burchert, MD, Gesine Bug, Jürgen Finke, MD, Matthias Stelljes, MD, Christoph Rollig, MD MSC, Ralph Wäsch, MD, Martin Bornhäuser, Tobias Berg, MD, Fabian Lang, MD, Gerhard Ehninger, MD, Hubert Serve, MD, Robert Zeiser, MD, Eva-Maria Wagner, MD, Nicolaus Kroeger, Christine Wolschke, MD, Michael Schleuning, MD, Ahmet Elmaagacli, Katharina S. Götze, MD, Christoph Schmid, MD, Edgar Jost, MD, Dominik Wolf, Alexandra Böhm, MD, Christian Thiede, MD, Torsten Haferlach, MD, Wolfgang Bethge, MD, Susanne Harnisch, Dipl. Humanbiol., Michael Wittenberg, PhD, Susanne Rospleszcz, Andreas Neubauer, Markus Brugger, Konstantin Strauch, PhD, Carmen Schade-Brittinger, Stephan K Metzelder, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 661.
https://doi.org/10.1182/blood-2018-99-112614
Published: 2018
Journal Articles

Data Driven Computational Modeling of Hematopoiesis in Myelodysplastic Syndromes Unveils Differences in Hematopoietic Stem Cell Kinetics Compared to Age-Matched Healthy Controls

Michèle Kyncl, MSc, Lisa Bast, MSc, Lynette Henkel, Fabian Theis, PhD, Robert A.J. Oostendorp, PhD, Carsten Marr, PhD, Katharina S. Götze, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4354.
https://doi.org/10.1182/blood-2018-99-115942
Published: 2018
Journal Articles

Phase 3 Study of Lenalidomide (LEN) Vs Placebo in Non-Transfusion Dependent (TD) Low Risk Del(5q) MDS Patients with Del(5q) — Preliminary Blinded Analysis of the European Sintra-REV Trial

Félix López Cadenas, MD, Eva Lumbreras, Blanca Xicoy, Joaquin Sanchez-Garcia, MD PhD, Pierre Fenaux, MD PhD, Rosa Coll, Borhane Slama, MD, Jose Angel Hernandez-Rivas, MD, Sylvain Thepot, MD, Teresa Bernal, MD, Beatriz Arrizabalaga, MD PhD, Agnès Guerci, Guillermo Sanz, Joan Bargay, MD PhD, Maria Luz Amigo, Raquel de Paz, Aristoteles Giagounidis, Uwe Platzbecker, Benet Nomdedeu, Eric Jourdan, MD, Katharina S. Götze, MD, Ali Arar, Jesús María Hernández-Rivas, MD PhD, Consuelo Del Cañizo, MDPhD, María Díez-Campelo
Journal: Blood
Blood (2018) 132 (Supplement 1): 468.
https://doi.org/10.1182/blood-2018-99-119430
Published: 2018