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Journal Articles

Phase 1b/2 Study of Escalating Doses of the NEDD8 Activating Enzyme Inhibitor Pevonedistat Administered in Combination with Standard Induction Therapy (Cytarabine and Idarubicin) in Newly Diagnosed High Risk Acute Myeloid Leukemia

Carissa M. Feliciano, Jennifer S. Carew, Hetty E. Carraway, Justin M. Watts, Sharad Khurana, Bhumika J. Patel, Keri Maher, Claudia Espitia, Kaijin Wu, Denice Tsao-Wie, Xuelian Chen, Mikkael A. Sekeres, Stan Louie, Homa Dadrastoussi, Eduardo Fernandez, Julian Olea, Brandon Sookdeo, Steffan T. Nawrocki, George Yaghmour, Kevin R. Kelly
Journal: Blood
Blood (2023) 142 (Supplement 1): 4279.
https://doi.org/10.1182/blood-2023-185481
Published: 2023
Journal Articles

Detection of Cryptic Gene Fusion and Chimeric RNA Variants in Relapsed/Refractory Acute Myeloid Leukemia Patients Diagnosed with KMT2A/Afdn Chromosomal Translocation

Esther G Chong, Bowon Joung, Durga Cherukuri, Yan Liu, Saied Mirshahidi, Jane Xu, Jeffery Xiao, Xi Huang, Cristina Maria Ghiuzeli, David Baylink, Qian Liu, Xuelian Chen, Homa Dadrastoussi, Julian Olea, Kaijin Wu, Kevin R. Kelly, Xi Zhang, Fengzhu Sun, Mojtaba Akhtari, Huynh Cao, Yi Xu
Journal: Blood
Blood (2023) 142 (Supplement 1): 5994.
https://doi.org/10.1182/blood-2023-184951
Published: 2023
Journal Articles

Venetoclax and idasanutlin in relapsed/refractory AML: a nonrandomized, open-label phase 1b trial

Clinical Trials & Observations
Naval G. Daver, Monique Dail, Jacqueline S. Garcia, Brian A. Jonas, Karen W. L. Yee, Kevin R. Kelly, Norbert Vey, Sarit Assouline, Gail J. Roboz, Stefania Paolini, Daniel A. Pollyea, Agostino Tafuri, Joseph M. Brandwein, Arnaud Pigneux, Bayard L. Powell, Pierre Fenaux, Rebecca L. Olin, Giuseppe Visani, Giovanni Martinelli, Maika Onishi, Jue Wang, Weize Huang, Cherie Green, Marion G. Ott, Wan-Jen Hong, Marina Y. Konopleva, Michael Andreeff
Journal: Blood
Blood (2023) 141 (11): 1265–1276.
https://doi.org/10.1182/blood.2022016362
Published: 2023
Includes: Supplemental data
Journal Articles

A Phase 1, Open-Label, Dose-Escalation and Expansion, Multicenter Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of MT-0169 in Patients with Relapsed or Refractory Multiple Myeloma or Non-Hodgkin Lymphoma

Bhagirathbhai Dholaria, Admasu Mamuye, Diana Yurewicz, Kristina Dabovic, Amy Yuet, Rafat Abonour, Kevin R. Kelly, Timothy J. Voorhees, Dickran Kazandjian
Journal: Blood
Blood (2022) 140 (Supplement 1): 12621–12622.
https://doi.org/10.1182/blood-2022-168960
Published: 2022
Journal Articles

Renal Toxicity with Carfilzomib in Multiple Myeloma: Secondary Analysis of SWOG S1304 Comparing Low-Dose Versus High-Dose Carfilzomib

Rajshekhar Chakraborty, Rachael Sexton, Suzanne Lentzsch, Muneer H. Abidi, Peter M. Voorhees, Adam D Cohen, Eric Rohren, Stephen B. Heitner, Kevin R. Kelly, Niklas J Mackler, David M. Baer, Antje Hoering, Brian G.M. Durie, Sikander Ailawadhi, Robert Z. Orlowski
Journal: Blood
Blood (2022) 140 (Supplement 1): 4349–4351.
https://doi.org/10.1182/blood-2022-166609
Published: 2022
Journal Articles

Pathway Analysis Provides Mechanistic Insights into Navtemadlin (KRT-232) Activity and Synergy with Decitabine in Acute Myeloid Leukemia Preclinical Models

Jin Wang, Venu Valmeekam, Kaijin Wu, Jiang F. Zhong, Andres Stucky, Xuelian (Lili) Chen, Alex Duong, Jude Canon, Cecile Marie Krejsa, Kevin R. Kelly
Journal: Blood
Blood (2021) 138 (Supplement 1): 2232.
https://doi.org/10.1182/blood-2021-145364
Published: 2021
Journal Articles

Efficacy and Safety of Bosutinib in Previously Treated Patients with Chronic Myeloid Leukemia: Final Results from the Byond Trial

Carlo Gambacorti-Passerini, Tim H Brümmendorf, Elisabetta Abruzzese, Kevin R. Kelly, Vivian G. Oehler, Valentín Garcia-Gutiérrez, Henrik Hjorth-Hansen, Thomas Ernst, Eric Leip, Simon Purcell, Gerald Luscan, Andrea Viqueira, Frank Giles, Andreas Hochhaus
Journal: Blood
Blood (2021) 138 (Supplement 1): 1475.
https://doi.org/10.1182/blood-2021-150352
Published: 2021
Journal Articles

Pharmacologic Normalization of Altered Transcriptome of SF3B1 Mutant Myeloid Neoplasia

Valeria Visconte, PhD, Vera Adema, PhD, Anand D. Tiwari, PhD, Cassandra M Kerr, MS, Hassan Awada, Bartlomiej Przychodzen, Allison Noe, Rachel Toth, Christina Snider, Yvonne Parker, Yuriy Fedorov, Drew Adams, Hetty E. Carraway, MD MBA, Anjali S. Advani, MD, Kevin R Kelly, MD PhD, Steffan T. Nawrocki, PhD, Jennifer S. Carew, PhD, Heesun J. Rogers, MD PhD, Daniel J. Lindner, Mikkael A. Sekeres, MD MS, James G Phillips, PhD, Jaroslaw P. Maciejewski, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 564.
https://doi.org/10.1182/blood-2019-129189
Published: 2019
Journal Articles

CUL1: Novel Therapeutic Target in Myeloid Neoplasms Harboring -7/Del(7q)

Vera Adema, PhD, Cassandra M Kerr, MS, Sunisa Kongkiatkamon, Jibran Durrani, Hassan Awada, MD, Stephan Hutter, PhD, Kevin Fung, Francesca Gould, Christina A. Snider, BA, Anjali S. Advani, MD, Hetty E. Carraway, MD MBA, Kevin R Kelly, MD PhD, Steffan T. Nawrocki, PhD, Yogenthiran Saunthararajah, MD, Jennifer S. Carew, PhD, Manja Meggendorfer, PhD, James G Phillips, PhD, Mikkael A. Sekeres, MD MS, Michael R. Savona, MD, Torsten Haferlach, MD, Jaroslaw P. Maciejewski, MD PhD, Valeria Visconte, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1281.
https://doi.org/10.1182/blood-2019-129196
Published: 2019
Journal Articles

Updated Results from the Venetoclax (Ven) in Combination with Idasanutlin (Idasa) Arm of a Phase 1b Trial in Elderly Patients (Pts) with Relapsed or Refractory (R/R) AML Ineligible for Cytotoxic Chemotherapy

Naval G. Daver, MD, Jacqueline S Garcia, MD, Brian A Jonas, MD PhD, Kevin R Kelly, MD PhD, Sarit Assouline, MD, Joseph M Brandwein, MD, Pierre Fenaux, MD PhD, Rebecca L. Olin, MD, Giovanni Martinelli, MD, Stefania Paolini, MD PhD, Arnaud Pigneux, Daniel A Pollyea, MD, Bayard L Powell, MD, Gail J. Roboz, MD, Agostino Tafuri, MD, Norbert Vey, MD PhD, Giuseppe Visani, MD, Karen W.L. Yee, MD, Monique Dail, PhD, Cherie Green, BS, Whitney P Kirschbrown, PharmD, PhD, Wan-Jen Hong, MD, Marion G Ott, MD PhD, Maika Onishi, MD, Jue Wang, PhD, Marina Y Konopleva, MD PhD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 229.
https://doi.org/10.1182/blood-2019-123711
Published: 2019
Journal Articles

A Pooled Analysis of Relapsed/Refractory Diffuse Large B-Cell Lymphoma Patients Treated with the Dual PI3K and HDAC Inhibitor Fimepinostat (CUDC-907), Including Patients with MYC-Altered Disease

Daniel J. Landsburg, MD, Radhakrishnan Ramchandren, MD, Petronella J Lugtenburg, MD PhD, Kevin R. Kelly, MD PhD, Anas Younes, MD, Robert Gharavi, PharmD, David P. Tuck, MD, Stefan Klaus Barta, MD MRCP, MS
Journal: Blood
Blood (2018) 132 (Supplement 1): 4184.
https://doi.org/10.1182/blood-2018-99-112527
Published: 2018
Journal Articles

Exploring Disease Biology in Hispanic Versus Non-Hispanic Patients with Diffuse Large B-Cell Lymphoma (DLBCL) to Explain Survival Disparities

Sikander Ailawadhi, Alvaro J. Alencar, MD, Madiha Iqbal, MBBS, Prachi Jani, MD, Salman Ahmed, MD, Aditya Mehta, Ruqin Chen, MD, Leyla Bojanini, MD, Moises Harari Turquie, MD, Kevin R Kelly, MD PhD, Prakash Vishnu, MD, Vivek Roy, MD, Anshika Singh, Abuzar Asif, Shishir David, Imran Siddiqi, MD PhD, Asher A. Chanan-Khan, MD, Taimur Sher, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4867.
https://doi.org/10.1182/blood-2018-99-119494
Published: 2018
Journal Articles

Development of a Novel Class of Agents Targeting the RNA-Splicing Machinery in Myeloid Malignancies

Valeria Visconte, PhD, Bartlomiej P. Przychodzen, Vera Adema, PhD, Cassandra M. Hirsch, Allison Noe, Rachel Toth, Christina Snider, BA, Hassan Awada, MD, Amy C Graham, BS, MS, Yvonne Parker, Yuriy Fedorov, Drew Adams, Hetty E. Carraway, MD MBA, Anjali S. Advani, MD, Tomas Radivoyevitch, Heesun J. Rogers, MD PhD, Kevin R Kelly, MD PhD, Steffan T. Nawrocki, PhD, Jennifer S. Carew, PhD, Daniel Lindner, MD PhD, Richard A Padgett, Mikkael A. Sekeres, MD MS, James G Phillips, PhD, Jaroslaw P. Maciejewski
Journal: Blood
Blood (2018) 132 (Supplement 1): 211.
https://doi.org/10.1182/blood-2018-99-116411
Published: 2018
Journal Articles

Activation of Autophagy in Models of SF3B1 Mutant MDS

Valeria Visconte, PhD, Vera Adema, PhD, Bartlomiej P. Przychodzen, MSc, Allison Noe, Rachel Toth, Yasmine Hirbawi, Cassandra M. Hirsch, BS, Jack Khouri, MD, Elise LeMelle, BS, Suresh K. Balasubramanian, MD, Hetty E. Carraway, MD MBA, Daniel Lindner, MD PhD, Anjali S. Advani, MD, Heesun J. Rogers, MD PhD, James G Phillips, PhD, Tomas Radivoyevitch, Kevin R Kelly, MD PhD, Steffan T. Nawrocki, PhD, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski, PhD MD FACP, Jennifer Carew, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4230.
https://doi.org/10.1182/blood.V130.Suppl_1.4230.4230
Published: 2017
Journal Articles

Preliminary Results from a Phase Ib Study Evaluating BCL-2 Inhibitor Venetoclax in Combination with MEK Inhibitor Cobimetinib or MDM2 Inhibitor Idasanutlin in Patients with Relapsed or Refractory (R/R) AML

Naval Daver, MD, Daniel A. Pollyea, MD, Karen W.L. Yee, MD, Pierre Fenaux, MD PhD, Joseph M. Brandwein, MD FRCPC, Norbert Vey, Giovanni Martinelli, Kevin R Kelly, MD PhD, Gail J. Roboz, MD, Jacqueline S. Garcia, Arnaud Pigneux, MD PhD, Smita Kshirsagar, Monique Dail, Jue Wang, Mehrdad Mobasher, Lin-Chi Chen, Wan-Jen Hong, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 813.
https://doi.org/10.1182/blood.V130.Suppl_1.813.813
Published: 2017
Journal Articles

Racial Differences in Disease Characteristics: Understanding Multiple Myeloma in Hispanics

Tania Jain, MD, Rafael Fonseca, MD, Ruqin Chen, MD, Raj Patel, MD, Prachi Jani, MD, Veronica Gonzalez De La Calle, MD, Zahara Meghji, James E. Hoffman, MD, Alvaro J. Alencar, MD, Kevin R Kelly, MD PhD, Vivek Roy, MD, Taimur Sher, MD, Asher A. Chanan-Khan, MD, Sikander Ailawadhi
Journal: Blood
Blood (2017) 130 (Supplement 1): 864.
https://doi.org/10.1182/blood.V130.Suppl_1.864.864
Published: 2017
Journal Articles

The Presence of Philadelphia Chromosome Does Not Confer Poor Prognosis in Adult Pre-B Acute Lymphoblastic Leukemia in the Tyrosine Kinase Inhibitor Era - a Surveillance, Epidemiology, and End Results Database Analysis

Igwe John Igwe, Dongyun Yang, PhD, Merchant Akil, Noah Merin, George Yaghmour, Kevin R Kelly, MD PhD, Giridharan Ramsingh, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2567.
https://doi.org/10.1182/blood.V130.Suppl_1.2567.2567
Published: 2017
Journal Articles

Oncolytic Reovirus Sensitizes Multiple Myeloma Cells to Anti-PD-L1 Therapy

Kevin R Kelly, MD PhD, Claudia M Espitia, Weiguo Zhao, Kaijin Wu, Valeria Visconte, PhD, Faiz Anwer, MD, Christine M Calton, PhD, Jennifer S. Carew, PhD, Steffan T. Nawrocki, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3137.
https://doi.org/10.1182/blood.V130.Suppl_1.3137.3137
Published: 2017
Journal Articles

Persistent Racial/Ethnic Disparities in Outcomes for Multiple Myeloma: A SEER-Database Update

Kevin R. Kelly, MD PhD, Dongyun Yang, Mayank Sharma, MBBS, Vivek Roy, MD, Asher A. Chanan-Khan, MD, Sikander Ailawadhi, MD
Journal: Blood
Blood (2016) 128 (22): 1191.
https://doi.org/10.1182/blood.V128.22.1191.1191
Published: 2016
Journal Articles

Racial/Ethnic Disparities in NK/T-Cell Non-Hodgkin Lymphomas in the US: A SEER Analysis

Irene Kang, MD, Dongyun Yang, Mi Hee Park, MD, Ann Mohrbacher, MD, Anil Tulpule, MD, Imran N Siddiqi, MD PhD, Sikander Ailawadhi, MD, Kevin R. Kelly, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3612.
https://doi.org/10.1182/blood.V128.22.3612.3612
Published: 2016