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Journal Articles

Temporal Dynamics of Tumor-Microenvironment Interaction and Treatment Responses Revealed through Time-Lapse Compartment-Specific Bioluminescence Imaging: Translational implications

Eugen Dhimolea, PhD, Emily King, Efstathios Kastritis, MD, Douglas W. McMillin, PhD, Jake E. Delmore, B.Sc., Joseph M. Negri, B.Sc., Hannah M. Jacobs, B.Sc., Catriona A. Hayes, MD, Michal Sheffer, PhD, Yiguo Hu, PhD, Subhashis Sarkar, PhD, Richard W.J. Groen, PhD, Megan A. Bariteau, B.Sc., Blake T. Aftab, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2014) 124 (21): 276.
https://doi.org/10.1182/blood.V124.21.276.276
Published: 2014
Journal Articles

Cell Non-Autonomous Modulation Of Tumor Cell Responses To Pharmacological Inhibition Of The Proteasome

Eugen Dhimolea, PhD, Richard W.J. Groen, PhD, Catriona A. Hayes, MD, Jana Jakubikova, PhD, Bariteau Megan, Jake E. Delmore, Hannah M. Jacobs, Julio-Cesar Marin, Gregory Della Penna, Douglas W. McMillin, PhD, Ana Acuna, Panisinee Lawasut, MD, Nancy Kohl, PhD, Constantine S. Mitsiades, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4454.
https://doi.org/10.1182/blood.V122.21.4454.4454
Published: 2013
Journal Articles

Cells of the Osteoblast Lineage Confer Myeloma Cell Resistance to Established and Investigational Therapeutic Agents

Catriona A. Hayes, MD, Paul Dowling, PhD, Richard W.J. Groen, PhD, Douglas W. McMillin, PhD, Jake E. Delmore, Hannah M. Jacobs, Niels W.C.J. van de Donk, MD, PhD, Eugen Dhimolea, PhD, Paul G. Richardson, MD, Kenneth C. Anderson, MD, Martin Clynes, PhD, Peter O'Gorman, M.D., Constantine S. Mitsiades, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3995.
https://doi.org/10.1182/blood.V120.21.3995.3995
Published: 2012
Journal Articles

Tumor Cell-Dependent Differences in Stroma-Induced Changes to Bortezomib Sensitivity.

Eugen Dhimolea, PhD, Jana Jakubikova, PhD, Richard W.J. Groen, PhD, Jake E. Delmore, Hannah M. Jacobs, Douglas W. McMilllin, Ana Acuña-Villaorduña, MD, Catriona A. Hayes, MD, Panisinee Lawasut, MD, Constantine S. Mitsiades, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2468.
https://doi.org/10.1182/blood.V120.21.2468.2468
Published: 2012
Journal Articles

Proteomic Characterization of An Isogenic Multiple Myeloma Cell Line Model of Bortezomib Resistance

*Catriona A. Hayes, MD, *Paul Dowling, PhD, Joseph Negri, Michael Henry, Leutz Buon, Jana Jakubikova, PhD, Jake E Delmore, Douglas W. McMillin, PhD, Steffen Klippel, PhD, Hannah M. Jacobs, Niels W.C.J. van de Donk, MD, PhD, Eugen Dhimolea, PhD, Panisinee Lawasut, MD, MSc, Paul G. Richardson, MD, Kenneth C. Anderson, MD, Martin Clynes, PhD, *Peter O Gorman, MD, PhD, *Constantine S. Mitsiades, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 1820.
https://doi.org/10.1182/blood.V118.21.1820.1820
Published: 2011
Journal Articles

In Vitro Anti-Myeloma Activity of the Multitargeted Kinase Inhibitor Midostaurin in the Context of Heterotypic Cocultures of Myeloma Cells with Nonmalignant Microenvironmental Accessory Cells

Panisinee Lawasut, MD, Hannah M. Jacobs, Jake E Delmore, Joseph Negri, Douglas W. McMillin, PhD, Ellen L Weisberg, Ph.D., James D. Griffin, MD, Paul G. Richardson, MD, Kenneth C Anderson, MD, Constantine S. Mitsiades, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 2923.
https://doi.org/10.1182/blood.V118.21.2923.2923
Published: 2011
Journal Articles

Inhibition of c-Myc Expression and Function in Hematologic Malignancies

Ghayas C Issa, MD, Jake E Delmore, Michael R McKeown, Madeleine E Lemieux, Peter B Rahl, Hannah M. Jacobs, Efstathios Kastritis, MD, Timothy Gilpatrick, Ronald M Paranal, Jun Qi, Junwei Shi, Marta Chesi, Anna C. Schinzel, PhD, Christopher R. Vakoc, M.D., Ph.D., P.Leif Bergsagel, MD, Paul G. Richardson, MD, Richard Young, PhD, William C. Hahn, MD, PhD, Irene M. Ghobrial, MD, Kenneth C Anderson, MD, Andrew L. Kung, MD, PhD, Constantine S. Mitsiades, MD, PhD, James E Bradner, MD
Journal: Blood
Blood (2011) 118 (21): 1409.
https://doi.org/10.1182/blood.V118.21.1409.1409
Published: 2011
Journal Articles

Preclinical Studies of Salinomycin In Multiple Myeloma (MM) Models: Targeting of Side Population (SP) Cells In the Context of Tumor – Microenvironment Interactions.

Efstathios Kastritis, Jana Jakubikova, Jake Delmore, Steffen Klippel, Douglas W. McMillin, Melissa Ooi, Hannah M. Jacobs, Jacob P. Laubach, Paul G Richardson, Kenneth C. Anderson, Andrew L. Kung, Constantine S. Mitsiades, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 1574.
https://doi.org/10.1182/blood.V116.21.1574.1574
Published: 2010
Journal Articles

Jun N-terminal kinase promotes proliferation of immature erythroid cells and erythropoietin-dependent cell lines

Sarah M. Jacobs-Helber, Stephen T. Sawyer
Journal: Blood
Blood (2004) 104 (3): 696–703.
https://doi.org/10.1182/blood-2003-05-1754
Published: 2004
Journal Articles

Stat5 expression is critical for mast cell development and survival

Christopher P. Shelburne, Margaret E. McCoy, Roland Piekorz, Veronica Sexl, Kwan-Ho Roh, Sarah M. Jacobs-Helber, Sheila R. Gillespie, Daniel P. Bailey, Paria Mirmonsef, Meredith N. Mann, Mohit Kashyap, Harry V. Wright, Hey Jin Chong, L. Andrew Bouton, Brian Barnstein, Carlos D. Ramirez, Kevin D. Bunting, Steven Sawyer, Chris S. Lantz, John J. Ryan
Journal: Blood
Blood (2003) 102 (4): 1290–1297.
https://doi.org/10.1182/blood-2002-11-3490
Published: 2003
Journal Articles

Tumor necrosis factor-alpha expressed constitutively in erythroid cells or induced by erythropoietin has negative and stimulatory roles in normal erythropoiesis and erythroleukemia

Sarah M. Jacobs-Helber, Kwan-ho Roh, Daniel Bailey, Emmanuel N. Dessypris, John J. Ryan, Jingchun Chen, Amittha Wickrema, Dwayne L. Barber, Paul Dent, Stephen T. Sawyer
Journal: Blood
Blood (2003) 101 (2): 524–531.
https://doi.org/10.1182/blood-2001-11-0084
Published: 2003
Journal Articles

Phosphatase inhibition promotes antiapoptotic but not proliferative signaling pathways in erythropoietin-dependent HCD57 cells

Amy E. Lawson, Haifeng Bao, Amittha Wickrema, Sarah M. Jacobs-Helber, Stephen T. Sawyer
Journal: Blood
Blood (2000) 96 (6): 2084–2092.
https://doi.org/10.1182/blood.V96.6.2084
Published: 2000
Journal Articles

JNK and p38 are activated by erythropoietin (EPO) but are not induced in apoptosis following EPO withdrawal in EPO-dependent HCD57 cells

Sarah M. Jacobs-Helber, John J. Ryan, Stephen T. Sawyer
Journal: Blood
Blood (2000) 96 (3): 933–940.
https://doi.org/10.1182/blood.V96.3.933
Published: 2000
Journal Articles

Protein Kinase B (c-Akt), Phosphatidylinositol 3-Kinase, and STAT5 Are Activated by Erythropoietin (EPO) in HCD57 Erythroid Cells But Are Constitutively Active in an EPO-Independent, Apoptosis-Resistant Subclone (HCD57-SREI Cells)

Haifeng Bao, Sarah M. Jacobs-Helber, Amy E. Lawson, Kalyani Penta, Amittha Wickrema, Stephen T. Sawyer
Journal: Blood
Blood (1999) 93 (11): 3757–3773.
https://doi.org/10.1182/blood.V93.11.3757
Published: 1999
Journal Articles

The Suprapharmacologic Dosing of Antithrombin Concentrate for Staphylococcus Aureus -Induced Disseminated Intravascular Coagulation in Guinea Pigs: Substantial Reduction in Mortality and Morbidity

Craig M. Kessler, ZhaoCheng Tang, Helena M. Jacobs, Linda M. Szymanski
Journal: Blood
Blood (1997) 89 (12): 4393–4401.
https://doi.org/10.1182/blood.V89.12.4393
Published: 1997
Journal Articles

Randomized prospective trial comparing the native prothrombin antigen with the prothrombin time for monitoring oral anticoagulant therapy

B Furie, CF Diuguid, M Jacobs, DL Diuguid, BC Furie
Journal: Blood
Blood (1990) 75 (2): 344–349.
https://doi.org/10.1182/blood.V75.2.344.344
Published: 1990