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Journal Articles

ATM germ line pathogenic variants affect outcomes in children with ataxia-telangiectasia and hematological malignancies

Sarah Elitzur, Ruth Shiloh, Jan L. C. Loeffen, Agata Pastorczak, Masatoshi Takagi, Simon Bomken, Andre Baruchel, Thomas Lehrnbecher, Sarah K. Tasian, Oussama Abla, Nira Arad-Cohen, Itziar Astigarraga, Miriam Ben-Harosh, Nicole Bodmer, Triantafyllia Brozou, Francesco Ceppi, Liliia Chugaeva, Luciano Dalla Pozza, Stephane Ducassou, Gabriele Escherich, Roula Farah, Amber Gibson, Henrik Hasle, Julieta Hoveyan, Elad Jacoby, Janez Jazbec, Stefanie Junk, Alexandra Kolenova, Jelena Lazic, Luca Lo Nigro, Nizar Mahlaoui, Lane Miller, Vassilios Papadakis, Lucie Pecheux, Marta Pillon, Ifat Sarouk, Jan Stary, Eftichia Stiakaki, Marion Strullu, Thai Hoa Tran, Marek Ussowicz, Jaime Verdu-Amoros, Anna Wakulinska, Joanna Zawitkowska, Dominique Stoppa-Lyonnet, A. Malcolm Taylor, Yosef Shiloh, Shai Izraeli, Veronique Minard-Colin, Kjeld Schmiegelow, Ronit Nirel, Andishe Attarbaschi, Arndt Borkhardt

Blood (2024) 144 (11): 1193–1205.

https://doi.org/10.1182/blood.2024024283

Published: 2024

Includes: Supplemental data

Journal Articles

ATM Germline Pathogenic Variants Affect Treatment Outcomes in Children with Acute Lymphoblastic Leukemia/Lymphoma and Ataxia Telangiectasia

Sarah Elitzur, Ruth Shiloh, Jan Loeffen, Agata Pastorczak, Masatoshi Takagi, Simon Bomken, Andre Baruchel, Stephane Ducassou, Nizar Mahlaoui, Marion Strullu, Thomas Lehrnbecher, Kjeld Schmiegelow, Oussama Abla, Liliia Anderzhanova, Nira Arad-Cohen, Itziar Astigarraga, Miriam Ben-Harosh, Francesco Ceppi, Nicole Bodmer, Triantafyllia Brozou, Luciano Dalla-Pozza, Gabriele Escherich, Roula Farah, Amber Gibson, Henrik Hasle, Julieta Hoveyan, Elad Jacoby, Janez Jazbec, Alexandra Kolenova, Jelena Lazic, Luca Lo Nigro, Lane Miller, Vassilios Papadakis, Lucie Pecheux, Marta Pillon, Ifat Sarouk, Jan Stary, Eftichia Stiakaki, Sarah K. Tasian, Thai Hoa Tran, Marek Ussowicz, Jose Jaime Verdu-Amoros, Anna Wakulinska, Joanna Zawitkowska, Dominique Stoppa-Lyonnet, Malcolm Taylor, Yosef Shiloh, Shai Izraeli, Ronit Nirel, Veronique Minard-Colin, Andishe Attarbaschi, Arndt Borkhardt

Blood (2023) 142 (Supplement 1): 520.

https://doi.org/10.1182/blood-2023-179333

Published: 2023

Journal Articles

Identification of Novel Therapeutic Targets in Atm-Deficient Lymphomas Using a Whole Genome CRISPR/CAS-9 Screen

Tatjana Stankovic, MD PhD, Nicholas Davies, PhD, Louise J Tee, Andrew D Beggs, Malcolm Taylor, PhD

Blood (2019) 134 (Supplement_1): 1504.

https://doi.org/10.1182/blood-2019-129974

Published: 2019

Journal Articles

Targeting an RNaseH2 Defect in Chronic Lymphocytic Leukaemia with PARP Inhibitors

Angelo Agathaggelou, Olga Murina, Andrew P Jackson, Paul Moss, MBBS, PhD FRCP, Shankara Paneesha, MD, Grant S Stewart, Malcolm Taylor, PhD, Tatjana Stankovic, MD PhD

Blood (2018) 132 (Supplement 1): 1835.

https://doi.org/10.1182/blood-2018-99-115967

Published: 2018

Journal Articles

BCR Unresponsiveness and 13q14 Duplication Underpin Spontaneous Disease Regression in Chronic Lymphocytic Leukemia

Blood (2017) 130 (Supplement 1): 3004.

https://doi.org/10.1182/blood.V130.Suppl_1.3004.3004

Published: 2017

Journal Articles

ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53 - or ATM -defective chronic lymphocytic leukemia cells

Marwan Kwok, Nicholas Davies, Angelo Agathanggelou, Edward Smith, Ceri Oldreive, Eva Petermann, Grant Stewart, Jeff Brown, Alan Lau, Guy Pratt, Helen Parry, Malcolm Taylor, Paul Moss, Peter Hillmen, Tatjana Stankovic

Blood (2016) 127 (5): 582–595.

https://doi.org/10.1182/blood-2015-05-644872

Published: 2016

Includes: Supplemental data

Journal Articles

A Meta-Analysis Of Hodgkin Lymphoma Reveals 19p13.3 (TCF3) As a Novel Susceptibility Loc

Wendy Cozen, D.O., M.P.H., Dalin Li, M.D., Ph.D., Maria Timofeeva, Ph.D., Arjan Diepstra, MD PhD, Dennis Hazelett, Ph.D., Manon Delahaye-Sourdeix, M.S., Christopher K. Edlund, M.S., Klaus Rostgaard, Ph.D., David J. Van Den Berg, Ph.D., Lude Franke, Ph.D., Karin Eckstrom Smedby, M.D., Ph.D., Sally L. Glaser, Ph.D., Harm-Jam Westra, Ph.D., Leslie L. Robison, PhD, Thomas M. Mack, M.D., M.P.H., Herve Ghesquieres, MD, PhD, Amie E. Hwang, Ph.D., M.P.H., Alexandra Nieters, Ph.D., Silvia de Sanjosé, M.D., Ph.D., Victoria K. Cortessis, Ph.D., Tracy Lightfoot, Nikolaus Becker, M.D., Ph.D., Marc Maynadie, MD, PhD, Lenka Foretova, Ph.D., Eve Roman, Ph.D., Yolanda Benavente, Ph.D., Bharat N. Nathwani, M.D., Bengt Glimelius, M.D., Ph.D., Anthony Staines, M.D., Ph.D., Paolo Boffetta, M.D., M.P.H., Brian K Link, MD, L. A. Kiemeney, Ph.D., Stephen M Ansell, M.D.Ph.D., Smita Bhatia, Ph.D., Louise C Strong, Ph.D., Pilar Galan, M.D., Lars Vatten, M.D., Ph.D., Thomas M Habermann, MD, Eric J. Duell, Ph.D., M.S., Annette Lake, M.S., Rianne Veenstra, Lydia Visser, PhD, Kevin Urayama, Ph.D., Dorothy Montgomery, Valerie Gaborieau, Lawrence Weiss, M.D, Graham Byrnes, Ph.D., Mark Lathrop, PhD, Hans-Olov Adami, M.D., Ph.D., Mads Melbye, MD, DMSc, James R Cerhan, MD, PhD, Alice Gallagher, M.D., G. Malcolm Taylor, MD, Susan L Slager, PhD, Paul Brennan, Ph.D., David V. Conti, Ph.D., Gerhard Coetzee, Ph.D., Kenan Onel, MD, PhD, Ruth F. Jarrett, M.D., Ph.D., Henrik Hjalgrim, M.D., Ph.D., Anke Van Den Berg, PhD, James D. McKay, Ph.D.

Blood (2013) 122 (21): 626.

https://doi.org/10.1182/blood.V122.21.626.626

Published: 2013

Journal Articles

HLA-DP genetic variation, proxies for early life immune modulation and childhood acute lymphoblastic leukemia risk

Kevin Y. Urayama, Anand P. Chokkalingam, Catherine Metayer, Xiaomei Ma, Steve Selvin, Lisa F. Barcellos, Joseph L. Wiemels, John K. Wiencke, Malcolm Taylor, Paul Brennan, Gary V. Dahl, Priscilla Moonsamy, Henry A. Erlich, Elizabeth Trachtenberg, Patricia A. Buffler

Blood (2012) 120 (15): 3039–3047.

https://doi.org/10.1182/blood-2012-01-404723

Published: 2012

Journal Articles

MHC variation and risk of childhood B-cell precursor acute lymphoblastic leukemia

Fay J. Hosking, Stephen Leslie, Alexander Dilthey, Loukas Moutsianas, Yufei Wang, Sara E. Dobbins, Elli Papaemmanuil, Eamonn Sheridan, Sally E. Kinsey, Tracy Lightfoot, Eve Roman, Julie A. E. Irving, James M. Allan, Malcolm Taylor, Mel Greaves, Gilean McVean, Richard S. Houlston

Blood (2011) 117 (5): 1633–1640.

https://doi.org/10.1182/blood-2010-08-301598

Published: 2011

Includes: Supplemental data

Journal Articles

Genome-wide homozygosity signatures and childhood acute lymphoblastic leukemia risk

Fay J. Hosking, Elli Papaemmanuil, Eammon Sheridan, Sally E. Kinsey, Tracy Lightfoot, Eve Roman, Julie A. E. Irving, James M. Allan, Malcolm Taylor, Ian P. Tomlinson, Mel Greaves, Richard S. Houlston

Blood (2010) 115 (22): 4472–4477.

https://doi.org/10.1182/blood-2009-09-244483

Published: 2010

Includes: Supplemental data

Journal Articles

Genetic variation in the folate metabolic pathway and risk of childhood leukemia

Tracy J. Lightfoot, W. Thomas Johnston, Dan Painter, Jill Simpson, Eve Roman, Chris F. Skibola, Martyn T. Smith, James M. Allan, G. Malcolm Taylor

Blood (2010) 115 (19): 3923–3929.

https://doi.org/10.1182/blood-2009-10-249722

Published: 2010

Journal Articles

Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood

Rashmi B. Prasad, Fay J. Hosking, Jayaram Vijayakrishnan, Elli Papaemmanuil, Rolf Koehler, Mel Greaves, Eamonn Sheridan, Andreas Gast, Sally E. Kinsey, Tracy Lightfoot, Eve Roman, Malcolm Taylor, Kathy Pritchard-Jones, Martin Stanulla, Martin Schrappe, Claus R. Bartram, Richard S. Houlston, Rajiv Kumar, Kari Hemminki

Blood (2010) 115 (9): 1765–1767.

https://doi.org/10.1182/blood-2009-09-241513

Published: 2010

Journal Articles

Risk of EBV-Positive Hodgkin Lymphoma Varies Over 30-Fold by HLA Class I Genotype and History of Infectious Mononucleosis.

Blood (2009) 114 (22): 269.

https://doi.org/10.1182/blood.V114.22.269.269

Published: 2009

Journal Articles

Increased Frequency of Constitutional Pathogenic ATM Mutations in CLL Patients Compared to Control Individuals Suggests An Aetiological Role.

Tatjana Stankovic, MD.PhD, Belinda Austen, Guy Pratt, Anna Skowronska, David Oscier, Martin JS Dyer, Estella Matutes, MD, PhD, Malcolm Taylor, Paul Moss, MBBS, PhD, FRCP

Blood (2009) 114 (22): 1250.

https://doi.org/10.1182/blood.V114.22.1250.1250

Published: 2009

Journal Articles

Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response

Eliot Marston, Victoria Weston, Jennifer Jesson, Esther Maina, Carmel McConville, Angelo Agathanggelou, Anna Skowronska, Katie Mapp, Katrin Sameith, Judith E. Powell, Sarah Lawson, Pamela Kearns, Francesco Falciani, Malcolm Taylor, Tatjana Stankovic

Blood (2009) 113 (1): 117–126.

https://doi.org/10.1182/blood-2008-03-142950

Published: 2009

Includes: Supplemental data

Journal Articles

Defect in DNA Double Strand Break Response in Paediatric ALL Is Caused by Upregulation of Multiple Pro-Survival Pathways That Can Serve as Therapeutic Targets.

Tatjana Stankovic, MD., PhD, Eliot Marston, Victoria Weston, Angelo Agathanggelou, Katie Mapp, Pamela Kearns, Francesco Falciani, Paul Moss, MBBS, PhD, FRCP, Malcolm Taylor

Blood (2008) 112 (11): 3344.

https://doi.org/10.1182/blood.V112.11.3344.3344

Published: 2008

Journal Articles

The Novel PARP Inhibitor, AZD2281, Targets Apoptotic Resistant ATM Mutant CLL Tumours for Cellular Killing.

Victoria Weston, PhD, Claire Baker, BSc, Belinda Austen, BMBCh, Malcolm Taylor, PhD, Paul Moss, PhD, Tanja Stankovic, PhD

Blood (2006) 108 (11): 2110.

https://doi.org/10.1182/blood.V108.11.2110.2110

Published: 2006

Journal Articles

Identification of ATM Mutations in Multiple Myeloma Tumours.

Belinda Austen, BMBCH, Maria Podinovskaia, BSc, Jane Starcynski, PhD, Giancarlo Barone, BSc, Anne Reiman, BM, Phil Byrd, PhD, Guy Pratt, PhD, Malcolm Taylor, PhD, Tanja Stankovic, PhD

Blood (2005) 106 (11): 1562.

https://doi.org/10.1182/blood.V106.11.1562.1562

Published: 2005

Journal Articles

Impact of tumor Epstein-Barr virus status on presenting features and outcome in age-defined subgroups of patients with classic Hodgkin lymphoma: a population-based study

Ruth F. Jarrett, Gail L. Stark, Jo White, Brian Angus, Freda E. Alexander, Andrew S. Krajewski, June Freeland, G. Malcolm Taylor, Penelope R. A. Taylor, for the Scotland and Newcastle Epidemiology of Hodgkin Disease Study Group

Blood (2005) 106 (7): 2444–2451.

https://doi.org/10.1182/blood-2004-09-3759

Published: 2005

Journal Articles

Molecular tracking of leukemogenesis in a triplet pregnancy

Ana Teresa Maia, Anthony M. Ford, G. Reza Jalali, Christine J. Harrison, G. Malcolm Taylor, Osborn B. Eden, Mel F. Greaves

Blood (2001) 98 (2): 478–482.

https://doi.org/10.1182/blood.V98.2.478

Published: 2001

NARROW

ATM germ line pathogenic variants affect outcomes in children with ataxia-telangiectasia and hematological malignancies

ATM Germline Pathogenic Variants Affect Treatment Outcomes in Children with Acute Lymphoblastic Leukemia/Lymphoma and Ataxia Telangiectasia

Identification of Novel Therapeutic Targets in Atm-Deficient Lymphomas Using a Whole Genome CRISPR/CAS-9 Screen

Targeting an RNaseH2 Defect in Chronic Lymphocytic Leukaemia with PARP Inhibitors

BCR Unresponsiveness and 13q14 Duplication Underpin Spontaneous Disease Regression in Chronic Lymphocytic Leukemia

ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53 - or ATM -defective chronic lymphocytic leukemia cells

A Meta-Analysis Of Hodgkin Lymphoma Reveals 19p13.3 (TCF3) As a Novel Susceptibility Loc

HLA-DP genetic variation, proxies for early life immune modulation and childhood acute lymphoblastic leukemia risk

MHC variation and risk of childhood B-cell precursor acute lymphoblastic leukemia

Genome-wide homozygosity signatures and childhood acute lymphoblastic leukemia risk

Genetic variation in the folate metabolic pathway and risk of childhood leukemia

Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood

Risk of EBV-Positive Hodgkin Lymphoma Varies Over 30-Fold by HLA Class I Genotype and History of Infectious Mononucleosis.

Increased Frequency of Constitutional Pathogenic ATM Mutations in CLL Patients Compared to Control Individuals Suggests An Aetiological Role.

Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response

Defect in DNA Double Strand Break Response in Paediatric ALL Is Caused by Upregulation of Multiple Pro-Survival Pathways That Can Serve as Therapeutic Targets.

The Novel PARP Inhibitor, AZD2281, Targets Apoptotic Resistant ATM Mutant CLL Tumours for Cellular Killing.

Identification of ATM Mutations in Multiple Myeloma Tumours.

Impact of tumor Epstein-Barr virus status on presenting features and outcome in age-defined subgroups of patients with classic Hodgkin lymphoma: a population-based study

Molecular tracking of leukemogenesis in a triplet pregnancy

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