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Maria E. Figueroa, MD
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Journal Articles

Analysis of the Global Methylation Profile of Accelerated and Blast Phase Myeloproliferative Neoplasms and Its Association with Response to Decitabine-Based Therapy

Raajit K. Rampal, MD PhD, Qin Yang, Richard P. Koche, PhD, Erin McGovern, BA, Christopher Famulare, MS, Rona Singer Weinberg, PhD, John Mascarenhas, MD, Ross L. Levine, MD, Ronald Hoffman, MD, Maria E. Figueroa, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–20.
https://doi.org/10.1182/blood-2020-139505
Published: 2020
Journal Articles

EP300 Suppresses Leukemia Development in Myelodysplastic Syndrome through Myb Repression

Na Man, Gloria Mas Martin, PhD, Daniel Karl, PhD, Jun Sun, PhD, Fan Liu, PhD, Miguel Torres-Martin, PhD, Hidehiro Itonaga, MD PhD, Concepcion Martinez, B.S., Shi Chen, Stephanie Duffort, Pierre-Jacques Hamard, PhD, Ye Xu, PhD, Luisa Cimmino, PhDBSc, Feng-Chun Yang, MD PhD, Philip A. Cole, MD PhD, Mingjiang Xu, MD PhD, Maria E. Figueroa, MD, Stephen Nimer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 561.
https://doi.org/10.1182/blood-2019-130507
Published: 2019
Journal Articles

Loss of KLF6 Recapitulates Molecular and Functional Changes Associated with Aging in Human Hematopoietic Stem and Progenitor Cells

Alejandro Roisman, PhD, Emmalee R. Adelman, BA, Hsuan-Ting Huang, PhD, Dean Wade, Daniel Bilbao, Maria E. Figueroa, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 447.
https://doi.org/10.1182/blood-2019-130800
Published: 2019
Journal Articles

The Lysine-Specific Demethylase 1 (LSD1) Inhibitor Tranylcypromine (TCP) in Combination with ATRA Is Tolerable and Has Anti-Leukemic Activity in Adult Patients with Relapsed/Refractory AML and MDS

Justin M Watts, MD, Terrence J Bradley, MD, Amber Thomassen, MA, MSN, Yvonne Trang Dinh, BS, Dalissa Tejera, MSN, Kristen Englund, Sorab Boga, MPH, Randy Astaiza, BS, Charles J Chen, MPH, Malika Abdur-Rahman, BS, MSED, Marinescu Ion, CCRC, FMG, Aymee Perez, PhD, Masoumeh Tayari, PhD, Lluis Morey, PhD, Maria E. Figueroa, MD, Ramin Shiekhattar, PhD, Arthur Zelent, PhD, Ronan Swords, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2721.
https://doi.org/10.1182/blood-2018-99-115411
Published: 2018
Journal Articles

Dysregulation of RUNX3 in Aged Human HSPCs May Contribute to Perturbations in Erythropoiesis and Balanced Lineage Output

Peter Balogh, Brian Capaldo, PhD, Sandeep Singh, PhD, Kamaleldin Elagib, MBBS, PhD, Hui Li, PhD, Eli Zunder, PhD, Maria E. Figueroa, MD, Wendy Pang, MD, Adam Goldfarb, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2553.
https://doi.org/10.1182/blood-2018-99-115245
Published: 2018
Journal Articles

Integrative Epigenetic and Single-Cell RNA-Seq Profiling of Human Hematopoietic Stem Cells Reveals Epigenetic Reprogramming of Enhancer and Regulatory Elements during Normal Aging

Emmalee Adelman, BA, André Olsson, MSc, PhD, Tingting Qin, PhD, R. Coleman Lindsley, MD PhD, Rafael Bejar, MD PhD, Nathan Salomonis, PhD, Lee Grimes, Maria E. Figueroa, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 770.
https://doi.org/10.1182/blood.V130.Suppl_1.770.770
Published: 2017
Journal Articles

DNA Methylation in Cancer and Development: An Evolving Paradigm

Maria E. Figueroa, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): SCI-50.
https://doi.org/10.1182/blood.V130.Suppl_1.SCI-50.SCI-50
Published: 2017
Journal Articles

Differentiation Response to Quizartinib, a Potent 2 nd Generation FLT3 Inhibitor, in Relapsed FLT3 -Mutant AML Patients Correlates with Specific DNA Methylation Signature Prior to Therapy

Miguel Torres Martin, PhD, Grace Jeschke, PhD, Alexander E. Perl, MD, Martin Carroll, MD, Maria E. Figueroa, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3922.
https://doi.org/10.1182/blood.V130.Suppl_1.3922.3922
Published: 2017
Journal Articles

Lineage Deconvolution Using Chromatin Accessibility and DNA Methylation Shows a Spectrum of Lineage Characteristics and Differentiation States across Acute Leukemias

Jacob L Glass, MDPhD, Alyson J Palia, Francine E. Garrett-Bakelman, MDPhD, Richard Koche, PhD, Ross L. Levine, MD, Martin S. Tallman, MD, Richard James Dillon, MA, PhD MRCP, FRCPath, David Grimwade, Adolfo A. Ferrando, MD PhD, Peter J.M. Valk, PhD, Ruud Delwel, PhD, Maria E. Figueroa, MD, Ari Melnick, MD, Olivier Elemento, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1208.
https://doi.org/10.1182/blood.V130.Suppl_1.1208.1208
Published: 2017
Journal Articles

Hyperactive Nras and Dose Reduction of Tet2 Collaborate to Dys-Regulate Hematopoietic Stem Cells and Promote Leukemogenesis

Xi Jin, PhD, Tingting Qin, PhD, Nathanael G Bailey, MD, Meiling Zhao, MS, Kevin B Yang, Victor Ng, MS, Lu Liu, PhD, Rosemary Coolon, MS, Gina Ney, MD PhD, Maria E Figueroa, MD, Qing Li, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1204.
https://doi.org/10.1182/blood.V128.22.1204.1204
Published: 2016
Journal Articles

Aldehyde Dehydrogenase Activity in the Leukemic Stem Cell Compartment Uncovers Opposing Methylation Patterns of Leukemia Stem Cells in AML

Lauren Suarez, Tingting Qin, PhD, Kristen Meldi, PhD, Manjusha Thakar, Sarah Sakoian, Gabriel Ghiaur, MD PhD, Jonathan M. Gerber, MD, Hetty E. Carraway, MD MBA, Maria E Figueroa, MD, Steven D. Gore, MD
Journal: Blood
Blood (2016) 128 (22): 3925.
https://doi.org/10.1182/blood.V128.22.3925.3925
Published: 2016
Journal Articles

Aging Human Hematopoietic Stem Cells Manifest Massive Epigenetic Reprogramming and Altered Gene Splicing of Key Hematopoietic Gene Sets

Emmalee R Adelman, Jian Shi, Maria E Figueroa, MD
Journal: Blood
Blood (2016) 128 (22): 885.
https://doi.org/10.1182/blood.V128.22.885.885
Published: 2016
Journal Articles

RNA Binding Protein Syncrip Regulates the Leukemia Stem Cell Program

Ly P. Vu, PhD, Camila Prieto, Elianna Amin, PhD, Gerard Minuesa, PhD, Sagar Chhangawala, Maria J Vidal, PhD, Andrei V. Krivtsov, PhD, Tim Chou, Trevor Barlowe, BA, James Taggart, BS, Patrick Tivnan, BS, Raquel P. Deering, Mithat Gonen, PhD, Maria E Figueroa, MD, Elisabeth Paietta, PhD, Martin S. Tallman, MD, Ari Melnick, MD, Ross L. Levine, MD, Fatima Al-Shahrour, PhD, Marcus Järås, Lisa Chu, Ralph Garippa, PhD, Christopher Lengner, PhD, Scott A. Armstrong, MD PhD, Glenn Cowley, PhD, David Root, PhD, John G Doench, PhD, Leandro Cerchietti, MD, Christina Leslie, PhD, Benjamin Ebert, Michael G. Kharas, PhD
Journal: Blood
Blood (2016) 128 (22): 739.
https://doi.org/10.1182/blood.V128.22.739.739
Published: 2016
Journal Articles

Next-Generation Bisulfite Sequencing of Aml Reveals Widespread Acquisition of Epigenetic Abnormalities in Leukemic Stem Cells That Are Stably Retained in More Mature Leukemic Cell Fractions

Lauren Suarez, Tingting Qin, PhD, Kristen Meldi, PhD, Manjusha Thakar, Sarah Sakoian, Jonathan M. Gerber, MD, Gabriel Ghiaur, MD PhD, Hetty E. Carraway, MD MBA, Maria E Figueroa, MD, Steven D. Gore, MD
Journal: Blood
Blood (2015) 126 (23): 2429.
https://doi.org/10.1182/blood.V126.23.2429.2429
Published: 2015
Journal Articles

Cellular Reprogramming Erases Aberrant DNA Methylation and the Malignant Phenotype in Chronic Myeloid Leukemia

Giovanni Amabile, PhD, Annalisa Di Ruscio, MDPhD, Fabian Muller, PhD, Robert S Welner, PhD, Henry Yang, PhD, Alexander K Ebralidze, PhD, Hong Zhang, PhD, Lihua Qi, PhD, Giovanni Martinelli, MD, Thijn Brummelkamp, PhD, Michelle M. Le Beau, PhD, Maria E Figueroa, MD, Christoph Bock, PhD, Daniel G Tenen, MD
Journal: Blood
Blood (2014) 124 (21): 4524.
https://doi.org/10.1182/blood.V124.21.4524.4524
Published: 2014
Journal Articles

Genome-Wide DNA Methylation Analysis Reveals Epigenetic Deregulation of Key Biological Pathways in Therapy-Related Myeloid Neoplasms

Orsolya Lautner-Csorba, PhD, Jason Sotzen, Fabiani Emiliano, Fianchi Luana, Stefan Hohaus, MD, Giuseppe Leone, MD, Maria Teresa Voso, Maria E Figueroa, MD
Journal: Blood
Blood (2014) 124 (21): 3542.
https://doi.org/10.1182/blood.V124.21.3542.3542
Published: 2014
Journal Articles

Molecular Determinants of Decitabine Response in Chronic Myelomonocytic Leukemia

Alessia Rossi, Kristen Meldi, PhD, Ana Belen Valencia Martinez, Omar Abdel-Wahab, MD, Jean Baptiste Micol, Qin Tingting, Francesca Buchi, Erico Masala, Alessandro Sanna, Bernardino Allione, Monia Lunghi, MD, Francesco Onida, MD, Antonella Poloni, MD, Emanuele Angelucci, Carlo Finelli, MD, Alessandro Levis, Daniela Gioia, Maria E Figueroa, MD, Valeria Santini, MD
Journal: Blood
Blood (2014) 124 (21): 4644.
https://doi.org/10.1182/blood.V124.21.4644.4644
Published: 2014
Journal Articles

DNA Hydroxymethylation Profiling Reveals That WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia

Raajit K. Rampal, MD PhD, Altuna Alkalin, Jozef Madzo, PhD, Aparna Vasanthakumar, BSc, MSc, PhD, Elodie Pronier, PhD, Jay P. Patel, Yushan Li, Jihae Ahn, BS, Omar Abdel-Wahab, MD, Alan H. Shih, MDPhD, Chao Lu, Patrick Ward, Jennifer J Tsai, MD, Todd Hricik, Jacob Tallman, Valeria Tosello, PhD, Xinyang Zhao, PhD, Danette Daniels, Qing Dai, Luisa Ciminio, Iannis Aifantis, PhD, Chuan He, PhD, François Fuks, Martin S. Tallman, MD, Adolfo A. Ferrando, MD PhD, Stephen Nimer, MD, Elisabeth Paietta, PhD, Craig B. Thompson, MD, Jonathan D. Licht, MD, Christopher E Mason, PhD, Lucy A Godley, MD PhD, Ari M Melnick, MD, Maria E Figueroa, MD, Ross L Levine, MD
Journal: Blood
Blood (2014) 124 (21): 365.
https://doi.org/10.1182/blood.V124.21.365.365
Published: 2014
Journal Articles

Dynamic Changes Of DNA Methylation and a Functional Role For TET2 DNA Dioxygenase In Human Erythroid Differentiation

Jie Li, MD, PhD, Papoin Julien, Chao An, Jingpin Hu, Ari Melnick, MD, Narla Mohandas, D.Sc., Maria E. Figueroa, MD, Xiuli An, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3415.
https://doi.org/10.1182/blood.V122.21.3415.3415
Published: 2013
Journal Articles

Lineage, Fusion Partner and Age Differences in the Methylome of MLL-r Leukemias

Eric S Schafer, MD, Rumen Kostadinov, PhD, Peter Murakami, MSc, Sandeep S. Negi, PhD, Maria E Figueroa, MD, Ari Melnick, MD, Patrick Brown, MD
Journal: Blood
Blood (2012) 120 (21): 3506.
https://doi.org/10.1182/blood.V120.21.3506.3506
Published: 2012