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Journal Articles

CRISPR-Cas13d functional transcriptomics reveals widespread isoform-selective cancer dependencies on lncRNAs

Open Access
Eugenio Morelli, Anil Aktas Samur, Domenico Maisano, Claire Gao, Vanessa Katia Favasuli, Dimitrios Papaioannou, Giovanni De Nola, Jonathan E Henninger, Na Liu, Marcello Turi, Pietro Folino, Laure Vreux, Michela Cumerlato, Liang Chen, Iannis Aifantis, Mariateresa Fulciniti, Kenneth C. Anderson, Abigail KR Lytton-Jean, Annamaria Gulla, Richard Young, Mehmet K. Samur, Nikhil C. Munshi
Journal: Blood
Blood blood.2025028746.
https://doi.org/10.1182/blood.2025028746
Published: 2025
Includes: Supplemental data
Journal Articles

Loss of BCL7A Permits IRF4 Transcriptional Activity and Cellular Growth in Multiple Myeloma

Available to Purchase
Chandraditya Chakraborty, Srikanth Talluri, Moritz Binder, Eugenio Morelli, Jessica Encinas Mayoral, Sanika Derebail, Anil Aktas Samur, Charles B. Epstein, Kenneth C. Anderson, Masood A Shammas, Mehmet K. Samur, Mariateresa Fulciniti, Nikhil C. Munshi
Journal: Blood
Blood blood.2024026588.
https://doi.org/10.1182/blood.2024026588
Published: 2025
Includes: Supplemental data
Journal Articles

Genetic and epigenetic mechanisms of GPRC5D loss after anti-GPRC5D CAR T-cell therapy in multiple myeloma

Available to Purchase
Sha Ma, Jieyun Xia, Miao Zhang, Wenyu Li, Meng Xiao, Yuqian Sha, Wenya Wang, Jianteng Zhou, Ying Wang, Kunming Qi, Chunling Fu, Zengtian Sun, Dian Zhou, Qian Sun, Tingting Qiu, Zhiling Yan, Feng Zhu, Wei Chen, Hai Cheng, Wei Sang, Jiang Cao, Depeng Li, Zhenyu Zhen Li, Mariateresa Fulciniti, Yao Yao, Kailin Xu, Mingshan Niu
Journal: Blood
Blood blood.2024026622.
https://doi.org/10.1182/blood.2024026622
Published: 2025
Includes: Supplemental data
Journal Articles

Heme fuels venetoclax resistance in multiple myeloma

Free
Mariateresa Fulciniti
Journal: Blood
Blood (2025) 145 (7): 658–660.
https://doi.org/10.1182/blood.2024027671
Published: 2025
Journal Articles

Development of hyperdiploidy starts at an early age and takes a decade to complete

Available to Purchase
Brief Report
Mehmet K. Samur, Anil Aktas Samur, Parth Shah, Joseph S. Park, Mariateresa Fulciniti, Masood Shammas, Jill Corre, Kenneth C. Anderson, Giovanni Parmigiani, Hervé Avet-Loiseau, Nikhil C. Munshi
Journal: Blood
Blood (2025) 145 (5): 520–525.
https://doi.org/10.1182/blood.2024025250
Published: 2025
Includes: Supplemental data
Journal Articles

Synergistic Induction of Senescence-Driven Immune Responses and Myeloma Cell Cytotoxicity By CDK4/6 Inhibitors and Daratumumab Combination Therapy

Free
Shiyi Xie, Zhen Yu, Mu Hao, Lu-Gui Qiu, Mariateresa Fulciniti, Nikhil C. Munshi, Yan Xu
Journal: Blood
Blood (2024) 144 (Supplement 1): 1410.
https://doi.org/10.1182/blood-2024-200479
Published: 2024
Journal Articles

Analysis of Alternative Splicing in Waldenstrom's Macroglobulinemia Reveals Novel Targets, Insights into IgM Production and Improved Gene Level Expression Estimates

Free
Zachary R Hunter, Nickolas Tsakmaklis, Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Shirong Liu, Abigail Peachey, Andres Felipe Ramirez Gamero, John M Hatcher, Catherine A. Flynn, Kirsten Meid, Christopher J Patterson, Mariateresa Fulciniti, Mehmet K. Samur, Kenneth C. Anderson, Nikhil C. Munshi, Shayna R Sarosiek, Jorge J. Castillo, Steven P. Treon
Journal: Blood
Blood (2024) 144 (Supplement 1): 2986.
https://doi.org/10.1182/blood-2024-212123
Published: 2024
Journal Articles

PKMYT1 Kinase Is an Actionable Synthetically Lethal Target for Del17p Myeloma

Free
Anais Schavgoulidze, Mariateresa Fulciniti, Giulia Giorgetti, Sabrina Maheo, Shuhui Deng, Vanessa Favasuli, Srikanth Talluri, Masood A. Shammas, Luka Pavageau, Anil Aktas-Samur, Mehmet K. Samur, Herve Avet-Loiseau, Jill Corre, Nikhil C. Munshi
Journal: Blood
Blood (2024) 144 (Supplement 1): 764.
https://doi.org/10.1182/blood-2024-199692
Published: 2024
Journal Articles

A TCR-like CAR T Cell Therapy for the Treatment of MZB1 Positive Multiple Myeloma and Other B-Cell Malignancies

Free
Elena Maroto Martin, Yingjie Zhao, Sara Mangesh Kolhatkar, Roberto Garcia-Vicente, Mubin Tarannum, Mehmet K. Samur, Mariateresa Fulciniti, Rizwan Romee, Jianzhu Chen, Nikhil C. Munshi
Journal: Blood
Blood (2024) 144 (Supplement 1): 4800.
https://doi.org/10.1182/blood-2024-208607
Published: 2024
Journal Articles

Enhancing CAR-T Cell Therapy for Non-Hodgkin Lymphoma through Gut Microbiota and Butyrate

Free
Roberto Garcia-Vicente, Alba Rodríguez García, Raquel Ancos-Pintado, Andrés Arroyo Barea, Adriana Ortega-Hernandez, Irene Bragado-Garcia, Eva Castellano, Alejandra Ortiz-Ruiz, Miguel Angel Navarro-Aguadero, Javier Modrego, Alejandra Leivas, José Sanchez-Pina, Rafael Alonso Fernandez, Maria Hernandez-Sanchez, Mariateresa Fulciniti, Cecilia Carpio, Pere Barba, Diego Carbonell, Mi Kwon, Mariana Bastos-Oreiro, Alejandro Martín García-Sancho, Ana Jiménez Ubieto, Antonio Valeri, Dulcenombre Gomez-Garre, Joaquín Martínez-Lopez, María Linares
Journal: Blood
Blood (2024) 144 (Supplement 1): 3414.
https://doi.org/10.1182/blood-2024-205005
Published: 2024
Journal Articles

A Novel Ribonuclease Targeting Small Molecule RNA-Degrader (MYC-RiboTAC) Overcomes MYC Dependency in Multiple Myeloma

Free
Domenico Maisano, Tenghui Wang, Yuquan Tong, Vanessa Favasuli, Na Liu, Claire Gao, Chandraditya Chakraborty, Giulia Giorgetti, Francesco Ladisa, Marcello Turi, Francesca Barello, Michela Cumerlato, Anil Aktas-Samur, Mehmet K. Samur, Michael Cameron, Filip Garbicz, Ruben D. Carrasco, Mariateresa Fulciniti, Annamaria Gulla, Jessica Childs-Disney, Matthew D. Disney, Eugenio Morelli, Nikhil C. Munshi
Journal: Blood
Blood (2024) 144 (Supplement 1): 3268.
https://doi.org/10.1182/blood-2024-205528
Published: 2024
Journal Articles

Isoform-Level Long Noncoding RNA Dependencies in Multiple Myeloma

Free
Eugenio Morelli, Anil Aktas-Samur, Domenico Maisano, Claire Gao, Vanessa Favasuli, Dimitrios Papaioannou, Na Liu, Marcello Turi, Pietro Folino, Laure Vreux, Michela Cumerlato, Liang Cheng, Iannis Aifantis, Mariateresa Fulciniti, Kenneth C. Anderson, Annamaria Gulla, Mehmet K. Samur, Nikhil C. Munshi
Journal: Blood
Blood (2024) 144 (Supplement 1): 4130.
https://doi.org/10.1182/blood-2024-209546
Published: 2024
Journal Articles

Differentiating between MM like Smoldering Myeloma (SMM) and Non-Progressor SMM

Free
Anil Aktas-Samur, Mariateresa Fulciniti, Parth Shah, Sanika Derebail, Raphael E. Szalat, Jill Corre, Kenneth C. Anderson, Giovanni Parmigiani, Herve Avet-Loiseau, Mehmet K. Samur, Nikhil C. Munshi
Journal: Blood
Blood (2024) 144 (Supplement 1): 1018.
https://doi.org/10.1182/blood-2024-211235
Published: 2024
Journal Articles

Loss of GABARAP mediates resistance to immunogenic chemotherapy in multiple myeloma

Available to Purchase
Annamaria Gulla, Eugenio Morelli, Megan Johnstone, Marcello Turi, Mehmet K. Samur, Cirino Botta, Selma Cifric, Pietro Folino, Delaney Vinaixa, Francesca Barello, Cole Clericuzio, Vanessa Katia Favasuli, Domenico Maisano, Srikanth Talluri, Rao Prabhala, Giada Bianchi, Mariateresa Fulciniti, Kenneth Wen, Keiji Kurata, Jiye Liu, Johany Penailillo, Alberto Bragoni, Anna Sapino, Paul G. Richardson, Dharminder Chauhan, Ruben D. Carrasco, Teru Hideshima, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2024) 143 (25): 2612–2626.
https://doi.org/10.1182/blood.2023022777
Published: 2024
Includes: Supplemental data
Journal Articles

Venetoclax Resistance Results in Broad Resistance to Majority of Anti-MM Agents Due to the Suppression of Apoptosis but Can be Overcome By BCMA-Targeted Immunotherapy

Free
Mariateresa Fulciniti, Shuhui Deng, Sanika Dereibal, Vera Joy Weiler, Madhumouli Chatterjee, Jessica Ng Fong, Chandraditya Chakraborty, Rao Prabhala, Masood A. Shammas, Anil Aktas-Samur, Mehmet K. Samur, Annamaria Gulla, Kenneth C. Anderson, Nikhil C Munshi
Journal: Blood
Blood (2023) 142 (Supplement 1): 3311.
https://doi.org/10.1182/blood-2023-187374
Published: 2023
Journal Articles

CRISPR-Based Functional Transcriptomics Defines the Tumor-Dependency and Molecular Determinants of Long Noncoding RNAs in Multiple Myeloma

Free
Eugenio Morelli, Anil Aktas-Samur, Domenico Maisano, Claire Gao, Na Liu, Vanessa Favasuli, Marcello Turi, Pietro Folino, Mariateresa Fulciniti, Annamaria Gulla, Kenneth C. Anderson, Mehmet K. Samur, Nikhil C Munshi
Journal: Blood
Blood (2023) 142 (Supplement 1): 640.
https://doi.org/10.1182/blood-2023-185523
Published: 2023
Journal Articles

Atypical Stem Cell, Pre-B-Cell, T-Cell and Myeloid Gene Expression Characterizes Early Waldenstrom's Macroglobulinemia Clones Which Diminishes with Advancing Disease and Has Therapeutic Implications

Free
Zachary R Hunter, Maria Luisa Guerrera, Ruben D. Carrasco, Nickolas Tsakmaklis, Kris Richardson, Amanda Kofides, Xia Liu, Shirong Liu, Catherine A. Flynn, Kirsten Meid, Joshua Gustine, Christopher J Patterson, Mariateresa Fulciniti, Mehmet K. Samur, Tomasz Sewastianik, Kenneth C. Anderson, Nikhil C Munshi, Shayna R Sarosiek, Jorge J. Castillo, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 756.
https://doi.org/10.1182/blood-2023-190685
Published: 2023
Journal Articles

Novel Isoforms Identified By Isoseq Analysis Drive Expression Differences in Key Genes That Delineate the Subtypes of Waldenstrom's Macroglobulinemia

Free
Kris Richardson, Nickolas Tsakmaklis, Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Shirong Liu, Catherine A. Flynn, Kirsten Meid, Christopher J Patterson, Mariateresa Fulciniti, Mehmet K. Samur, Kenneth C. Anderson, Nikhil C Munshi, Shayna R Sarosiek, Jorge J. Castillo, Zachary R Hunter, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 1946.
https://doi.org/10.1182/blood-2023-190631
Published: 2023
Journal Articles

Changes in Methylation and Chromatin Accessibility Underlie Subtype Classification and Disease Evolution in Waldenström's Macroglobulinemia

Free
Zachary R Hunter, Nickolas Tsakmaklis, Kris Richardson, Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Shirong Liu, Catherine A. Flynn, Kirsten Meid, Christopher J Patterson, Mariateresa Fulciniti, Mehmet K. Samur, Kenneth C. Anderson, Nikhil C Munshi, Shayna R Sarosiek, Jorge J. Castillo, Ari M Melnick, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 755.
https://doi.org/10.1182/blood-2023-190825
Published: 2023
Journal Articles

Higher CD56 Expression on Multiple Myeloma Cells Increases CD38 Expression, Reduces Intracellular NAD+ Levels, and Enhances the Efficacy of Daratumumab-Based Treatment Strategies

Free
Giulia Giorgetti, Pamela Becherini, Elena Maroto-Martin, Daniela Fenoglio, Debora Soncini, Claudia Martinuzzi, Santina Bruzzone, Andrea Benzi, Aimable Nahimana, Chiara Rosa Maria Uras, Anaïs Schavgoulidze, Jessica Ng Fong, Roberto M. Lemoli, Nikhil C Munshi, Mariateresa Fulciniti, Michele Cea
Journal: Blood
Blood (2023) 142 (Supplement 1): 1951.
https://doi.org/10.1182/blood-2023-189439
Published: 2023