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Markus Muschen, MDPhD
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Journal Articles

Autoimmunity Checkpoints As Therapeutic Targets in B- and T-Cell Malignancies

Zhengshan Chen, MDPhD, Anna Hecht, MD, Markus Muschen, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 718.
https://doi.org/10.1182/blood.V130.Suppl_1.718.718
Published: 2017
Journal Articles

CD25 Enables Oncogenic BCR-Signaling and Represents a Therapeutic Target in B Cell Malignancies

Jaewoong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Kadriye Nehir Nehir Cosgun, PhD, Francesca Zammarchi, PhD, Patrick Van Berkel, PhD, Ari Melnick, MD, Elisabeth Paietta, PhD, Markus Muschen, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3834.
https://doi.org/10.1182/blood.V130.Suppl_1.3834.3834
Published: 2017
Journal Articles

Stat5 Feedback Control Switches MYC- and BCL6-Dependent Cell Fates in Normal and Transformed B Cells

Zhengshan Chen, MDPhD, Lai N Chan, Huimin Geng, PhD, Merja Heinäniemi, PhD, Olli Lohi, MD PhD, Cheryl L. Willman, MD, Markus Muschen, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1440.
https://doi.org/10.1182/blood.V130.Suppl_1.1440.1440
Published: 2017
Journal Articles

Targeting of Quiescent and Proliferating CML Stem Cells By DNA Repair Inhibitors

Katherine Sullivan, Elisabeth Bolton-Gillespie, Margaret Nieborowska-Skorska, Sabine Cerny-Reiterer, DVM, Peter Valent, MD, Markus Muschen, MDPhD, Richard Pomerantz, Alexander Mazin, Tomasz Skorski
Journal: Blood
Blood (2015) 126 (23): 50.
https://doi.org/10.1182/blood.V126.23.50.50
Published: 2015
Journal Articles

B-Lymphoid Transcription Factors Restrict Glycolytic Energy Supply for Oncogenic Signaling

Lai N Chan, PhD, Zhengshan Chen, PhDMD, Daniel Braas, PhD, Huimin Geng, PhD, Christian Hurtz, PhD, Seyedmehdi Shojaee, PhD, Valeria Cazzaniga, PhD, Carina Ng, Thomas Ernst, MD, Andreas Hochhaus, MD, Steven M Kornblau, PhD, Giovanni Cazzaniga, PhD, Grace Liu, PhD, Thomas Milne, PhD, H. Phillip Koeffler, MD, Scott A. Armstrong, MD PhD, Ross Alexander Dickins, PhD, Keith R Yamamoto, PhD, Thomas G Graeber, PhD, Markus Muschen, MDPhD
Journal: Blood
Blood (2015) 126 (23): 1255.
https://doi.org/10.1182/blood.V126.23.1255.1255
Published: 2015
Journal Articles

Circadian Clock Protein CRY Controls B-Cell Intrinsic Tolerance

Qi Cao, doctor, Xuan Zhao, Doctor, Sigal Gery, Doctor, Zhengshan Chen, PhDMD, Ruishu Deng, MD PhD, Haibo Sun, Doctor, De-chen Lin, Doctor, Zhiqiang Zhao, Doctor, Jonathan W Said, MD, Quan-zhen Li, Doctor, Markus Muschen, MDPhD, Ronald M. Evans, PhD, H. Phillip Koeffler, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1029.
https://doi.org/10.1182/blood.V126.23.1029.1029
Published: 2015
Journal Articles

Extrafollicular CD4 + T and B Interaction Induces Chronic Gvhd in the Absence of Germinal Center Formation

Ruishu Deng, MD PhD, Christian Hurtz, PhD, Chanyu Yue, PhD, Gang Xiao, PhD, Hua Yu, PhD, Markus Muschen, MDPhD, Stephen J. Forman, MD, Paul J. Martin, MD, Defu Zeng, MD
Journal: Blood
Blood (2015) 126 (23): 1875.
https://doi.org/10.1182/blood.V126.23.1875.1875
Published: 2015
Journal Articles

Combined Targeting of JAK2 with a Type II JAK2 Inhibitor and mTOR with a TOR Kinase Inhibitor Constitutes Synthetic Activity in JAK2-Driven Ph-like Acute Lymphoblastic Leukemia

Ce Shi, PhD, Lina Han, PhD, Qi Zhang, Kathryn G. Roberts, Eugene Park, Yoko Tabe, MD PhD, Rodrigo Omar Jacamo, PhD, Hong Mu, MD PhD, Shuo-Chieh Wu, Jin Zhou, Helen Ma, Zhihong Zeng, MD, Nitin Jain, MD, Elias J Jabbour, MD, Markus Muschen, MDPhD, Sarah K Tasian, MD, Charles G. Mullighan, MBBS, MSc, MD, David M. Weinstock, David Fruman, PhD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2529.
https://doi.org/10.1182/blood.V126.23.2529.2529
Published: 2015
Journal Articles

Identification of BCL6 As a Therapeutic Target in RAS -Driven Acute Lymphoblastic Leukemia

Qiang Li, PhD, Christian Hurtz, PhD, Seyedmehdi Shojaee, PhD, Zhengshan Chen, MDPhD, Huimin Geng, PhD, Gang Xiao, PhD, Mignon L. Loh, MD, B. Hilda Ye, PhD, Ari Melnick, MD, Markus Muschen, MDPhD
Journal: Blood
Blood (2015) 126 (23): 556.
https://doi.org/10.1182/blood.V126.23.556.556
Published: 2015
Journal Articles

PP2A Is Required for B Cell Survival and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia

Xiao Gang, PhD, Huimin Geng, PhD, Lai N Chan, PhD, Zhengshan Chen, MDPhD, Xiaoyan Jiang, MDPhD, Markus Muschen, MDPhD
Journal: Blood
Blood (2015) 126 (23): 902.
https://doi.org/10.1182/blood.V126.23.902.902
Published: 2015
Journal Articles

FOXM1 Mediates Drug-Resistance and Represents a Therapeutic Target in Pre-B Acute Lymphoblastic Leukemia

Maike Buchner, PhD, Eugene Park, Lars Klemm, Huimin Geng, PhD, Dragana Kopanja, Pradip Raychaudhuri, PhD, Markus Muschen, MDPhD
Journal: Blood
Blood (2014) 124 (21): 790.
https://doi.org/10.1182/blood.V124.21.790.790
Published: 2014
Journal Articles

Harnessing Negative B Cell Selection to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia

Zhengshan Chen, MD PhD, Seyedmehdi Shojaee, PhD, Huimin Geng, PhD, Jae-Woong Lee, PhD, Maike Buchner, PhD, Lars Klemm, Clifford A. Lowell, MD PhD, Elisabeth Paietta, PhD, Cheryl L. Willman, MD, William L. Carroll, MD, Ari Melnick, MD, Jae U. Jung, PhD, Hassan Jumaa, PhD, John E. Coligan, PhD, Silvia Bolland, PhD, Tak W. Mak, OC, PhD DSc, FRSC, FRS, Markus Muschen, MDPhD
Journal: Blood
Blood (2014) 124 (21): 792.
https://doi.org/10.1182/blood.V124.21.792.792
Published: 2014
Journal Articles

Lineage-Specific Metabolic Reprogramming Reveals LKB1 as Therapeutic Target in Acute Lymphoblastic Leukemia

Lai N Chan, PhD, Daniel Braas, Christian Hurtz, PhD, Seyedmehdi Shojaee, PhD, Behzad Kharabi Masouleh, MD, Huimin Geng, PhD, Thomas Ernst, MD, Andreas Hochhaus, MD, Thomas Graeber, PhD, Markus Muschen, MDPhD
Journal: Blood
Blood (2014) 124 (21): 783.
https://doi.org/10.1182/blood.V124.21.783.783
Published: 2014
Journal Articles

IFITM3 (CD225) Regulates CD19 Surface Expression and CD19-Mediated Activation of PI3K Signaling in Pre-B Acute Lymphoblastic Leukemia Cells

Jae-Woong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MD PhD, Eugene Park, Angela Park, Lars Klemm, Charles Bailey, Markus Muschen, MDPhD
Journal: Blood
Blood (2014) 124 (21): 1070.
https://doi.org/10.1182/blood.V124.21.1070.1070
Published: 2014
Journal Articles

BACH2 promotes Lineage-Specific Fate Decisions in BCR-ABL1 -Driven Leukemia

Eugene Park, Srividya Swaminathan, PhD, Mohammed Firas Sadiyah, PhD, Kazuhiko Igarashi, PhD, Ari Melnick, MD, Markus Muschen, MDPhD
Journal: Blood
Blood (2014) 124 (21): 513.
https://doi.org/10.1182/blood.V124.21.513.513
Published: 2014
Journal Articles

Erk and Stat5 Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia

Shojaee Seyedmehdi, PhD, Zhengshan Chen, MD PhD, Maike Buchner, PhD, Christian Hurtz, PhD, Huimin Geng, PhD, Hilde Schjerven, PhD, Lai N Chan, PhD, Phillip Koeffler, MD, Cheryl L. Willman, MD, Stephen Hunger, MD, Sinisa Dovat, MD,PhD, Elisabeth Paietta, PhD, Wolf-Karsten Hofmann, Ari M Melnick, MD, Warren S. Alexander, Steven M. Kornblau, MD, Markus Muschen, MDPhD
Journal: Blood
Blood (2014) 124 (21): 787.
https://doi.org/10.1182/blood.V124.21.787.787
Published: 2014
Journal Articles

IL2RA (CD25) Recruits Inhibitory Phosphatases to the Cell Membrane and Mediates Negative Feedback Control of STAT5 Signaling in Acute Lymphoblastic Leukemia

Huimin Geng, PhD, Jae-Woong Lee, PhD, Zhengshan Chen, MD PhD, Behzad Kharabi Masouleh, MD, Christian Hurtz, PhD, Eugene Park, Gang Xiao, PhD, Samir Parekh, MD, Steven M. Kornblau, MD, Ari Melnick, MD, Elisabeth Paietta, PhD, Markus Muschen, MDPhD
Journal: Blood
Blood (2014) 124 (21): 788.
https://doi.org/10.1182/blood.V124.21.788.788
Published: 2014