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Journal Articles

AZA + Glutaminase Inhibition with Telaglenastat (CB-839) for Advanced MDS: An Updated Interim Analysis

Blood (2020) 136 (Supplement 1): 31–32.

https://doi.org/10.1182/blood-2020-137266

Published: 2020

Journal Articles

PU.1-Dependent Enhancer Decommissioning Drives Transformation of Tet2 deficient Hematopoietic Stem and Progenitor Cells

Maria M. Aivalioti, MS., Tushar D Bhagat, PhD, Aditi Paranjpe, MS., Boris Bartholdy, PhD, Kith Pradhan, PhD, Mario Pujato, PhD, Amit Verma, MBBS, Britta Will, PhD

Blood (2020) 136 (Supplement 1): 40.

https://doi.org/10.1182/blood-2020-142070

Published: 2020

Journal Articles

SF3B1 Mutations Induce Oncogenic IRAK4 Isoforms and Activate Targetable Innate Immune Pathways in MDS and AML

Blood (2019) 134 (Supplement_1): 4224.

https://doi.org/10.1182/blood-2019-124458

Published: 2019

Journal Articles

ASXL1 Mutations Are Associated with Widespread and Distinct DNA Methylation Alterations

Nora E Rahmani, MD, Nandini Ramachandra, Tushar D Bhagat, PhD, Shanisha Gordon, Kith Pradhan, PhD, Bianca Rivera Pena, Mohammad Kazemi, Orsi Giricz, PhD, Shahina Maqbool, Raul Olea, Hamid Dolatshad, Vickram Tittrea, Dharamveer Tatwavedi, Shalini Singh, Andrea Pellagatti, Jacqueline Boultwood, Amit Verma, MBBS

Blood (2019) 134 (Supplement_1): 2989.

https://doi.org/10.1182/blood-2019-126850

Published: 2019

Journal Articles

Clinical ALK5 Inhibitor, Vactosertib, Reverses TGFβ-1 Stimulated Smad-2 Driven Ineffective Hematopoiesis in MDS

Srinivas Aluri, Kimo Bachiashvili, MD, Anjali Budhathoki, MD, Tushar D Bhagat, PhD, Gaurav S Choudhary, PhD, Shanisha Gordon, Nandini Ramachandra, Kith Pradhan, PhD, Shahina Maqbool, Aditi Shastri, MD, Jung Im Huh, Sunjin Hwang, Kim Seong-Jin, PhD, Hui Zhang, Britta Will, PhD, Amittha Wickrema, PhD, Ulrich G. Steidl, MD PhD, Amit Verma, MBBS

Blood (2019) 134 (Supplement_1): 2990.

https://doi.org/10.1182/blood-2019-127561

Published: 2019

Journal Articles

High Burden of Clonal Hematopoiesis in First Responders Exposed to the World Trade Center Disaster

Blood (2019) 134 (Supplement_1): 3720.

https://doi.org/10.1182/blood-2019-129276

Published: 2019

Journal Articles

North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies

Blood (2018) 132 (14): 1507–1518.

https://doi.org/10.1182/blood-2018-01-824607

Published: 2018

Includes: Supplemental data

Journal Articles

Role of Glutamine in Metabolic and Epigenetic Reprogramming in AML

Juliana Vélez Luján, PhDCandidate, Niki Zacharias, PhD, Dinesh Rakheja, MD, Tushar D Bhagat, PhD, Jaehyuk Lee, PhD, Prasanta Dutta, PhD, Doriann Gonzalez, MDStudent, Michael Andreeff, MD PhD, Pratip K Bhattacharya, PhD, Amit Verma, M.B.,B.S., Marina Konopleva, MD PhD

Blood (2015) 126 (23): 2559.

https://doi.org/10.1182/blood.V126.23.2559.2559

Published: 2015

Journal Articles

Colony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21

Cristina I. Caescu, Xingyi Guo, Lydia Tesfa, Tushar D. Bhagat, Amit Verma, Deyou Zheng, E. Richard Stanley

Blood (2015) 125 (8): e1–e13.

https://doi.org/10.1182/blood-2014-10-608000

Published: 2015

Includes: Supplemental data

Journal Articles

Efficacy of Dual Inhibition of p38 Mitogen Activated Protein Kinase (MAPK) and Tie-2 Kinase in Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)

Blood (2014) 124 (21): 4628.

https://doi.org/10.1182/blood.V124.21.4628.4628

Published: 2014

Journal Articles

Exome Sequencing of Familial MDS Reveals Novel Mutations and High Rates of False Positive Mutations in MLL3 Due to Pseudogene Effects

Timothy Geoffrey Bowler, PhD MBBS, Matthias Bartenstein, MD, Kerry A. Morrone, MD, Mersedeh Rohanizadegan, MD, Rachel M. Kessel, MD, Lauren Hooda, Ishan Datt, Orsolya Giricz, PhD, Tushar D. Bhagat, PhD, Bartlomiej P Przychodzen, Simrit Parmar, Jonathan B. Gill, MD, Yiting Yu, PhD, Jaroslaw P. Maciejewski, MD PhD, Ulrich Steidl, MDPhD, Amit Verma, MD

Blood (2014) 124 (21): 4591.

https://doi.org/10.1182/blood.V124.21.4591.4591

Published: 2014

Journal Articles

Targeting of MDS and AML Stem Cells Via Inhibition of STAT3 By Pyrimethamine

Aditi Shastri, MD, Carolina Schinke, MD, Asya Varshavsky Yanovsky, MD PhD, Tushar D. Bhagat, PhD, Orsolya Giricz, Laura Barreyro, M.Sc., Jacqueline Boultwood, PhD, Andrea Pellagati, Yiting Yu, PhD, Jennifer R. Brown, MD PhD, David A. Frank, MD PhD, Bhaskar Das, PhD, Suman Kambhampati, MD, Britta Will, PhD, Ulrich Steidl, MDPhD, Amit Verma, MD

Blood (2014) 124 (21): 3602.

https://doi.org/10.1182/blood.V124.21.3602.3602

Published: 2014

Journal Articles

Myelodysplastic Syndrome Marrow Stroma Shows Widespread Aberrant Hypermethylation That Is Abrogated By Treatment with Dnmt Inhibitors

Tushar D Bhagat, PhD, Matthias Bartenstein, MD, Yiting Yu, PhD, A. Mario Q. Marcondes, MD PhD, Britta Will, PhD, Orsolya Giricz, PhD, Davendra P. Sohal, MD MPH, Ioannis Mantzaris, MD, Amittha Wickrema, PhD, Christine Mcmahon, MD, Yeung Cecilia, MD, John Greally, MB, PhD, Siddhartha Mukherjee, MD PhD, Ulrich Steidl, MD PhD, H. Joachim Deeg, MD, Amit Verma, MD

Blood (2014) 124 (21): 4379.

https://doi.org/10.1182/blood.V124.21.4379.4379

Published: 2014

Journal Articles

Inhibition Of Erythropoiesis By Iron Overload Is Mediated Through TGFβ Signaling

Krishna Gundabolu, MD, Huiyong Chen, Huihui Li, MS, Lohith Shakaladevanapura, Tushar D. Bhagat, Nishant Vallumsetla, Yelena Ginzburg, MD, Amit Verma

Blood (2013) 122 (21): 2787.

https://doi.org/10.1182/blood.V122.21.2787.2787

Published: 2013

Journal Articles

Inhibition Of CXCR2 As a Therapeutic Strategy In AML and MDS

Carolina Schinke, Orsolya Giricz, Shanisha A. K. Gordon, Laura Barreyro, M.Sc., Tushar D. Bhagat, Andrea Pellagatti, Jacqueline Boultwood, Yiting Yu, Ulrich Steidl, MD PhD, Amit Verma

Blood (2013) 122 (21): 484.

https://doi.org/10.1182/blood.V122.21.484.484

Published: 2013

Journal Articles

miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling

Blood (2013) 121 (15): 2875–2881.

https://doi.org/10.1182/blood-2011-12-397067

Published: 2013

Includes: Supplemental data

Journal Articles

Aberrant Expression of DOCK4 Leads to Disruption of the F-Actin Skeleton and Altered Membrane Stability in MDS Erythroblasts and Mature Erythrocytes

Sriram Sundaravel, MS, Tushar D. Bhagat, MS, Carolina Schinke, M.D., David Ebenezer, Hui Liu, MS, Yiting Yu, PhD, Andrea Pellagatti, PhD, Jacqueline Boultwood, MD, Vijay Yajnik, MD, Ph.D, Andrew Artz, MD MS, Amit Verma, Amittha Wickrema, PhD

Blood (2012) 120 (21): 924.

https://doi.org/10.1182/blood.V120.21.924.924

Published: 2012

Journal Articles

Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations

Blood (2012) 120 (10): 2076–2086.

https://doi.org/10.1182/blood-2011-12-399683

Published: 2012

Includes: Supplemental data

Journal Articles

Mir-21 Mediates Hematopoietic Suppression in MDS by Activating TGF-b Signaling,

Tushar D. Bhagat, M.S., Li Zhou, PhD, Lubomir Sokol, MD, PhD, Ioannis Mantzaris, MD, Krishna Gundabolu, MD, Shanisha A. K. Gordon, Yiting Yu, PhD, Sangeeta Nischal, Ph.D., Rahul Polineni, MD, Carolina Schinke, M.D., Grigorios Chrysofakis, M.D., Amittha Wickrema, PhD, Andrea Pellagatti, Jacqueline Boultwood, PhD, Ulrich G Steidl, MD, PhD, Gang Liu, MD., Ph.D., Alan F List, MD, Markus Bitzer, M.D., Amit Verma, MD

Blood (2011) 118 (21): 3813.

https://doi.org/10.1182/blood.V118.21.3813.3813

Published: 2011

Journal Articles

MDS Marrow Stroma Is Characterized by Distinct Epigenetic Alterations

Tushar D Bhagat, Emily Spaulding, Davendra Sohal, Yongkai Mo, Mario Marcondes, Li Zhou, Reid Thompson, John Greally, H. Joachim Deeg, Amit Verma

Blood (2008) 112 (11): 3635.

https://doi.org/10.1182/blood.V112.11.3635.3635

Published: 2008

NARROW

AZA + Glutaminase Inhibition with Telaglenastat (CB-839) for Advanced MDS: An Updated Interim Analysis

PU.1-Dependent Enhancer Decommissioning Drives Transformation of Tet2 deficient Hematopoietic Stem and Progenitor Cells

SF3B1 Mutations Induce Oncogenic IRAK4 Isoforms and Activate Targetable Innate Immune Pathways in MDS and AML

ASXL1 Mutations Are Associated with Widespread and Distinct DNA Methylation Alterations

Clinical ALK5 Inhibitor, Vactosertib, Reverses TGFβ-1 Stimulated Smad-2 Driven Ineffective Hematopoiesis in MDS

High Burden of Clonal Hematopoiesis in First Responders Exposed to the World Trade Center Disaster

North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies

Role of Glutamine in Metabolic and Epigenetic Reprogramming in AML

Colony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21

Efficacy of Dual Inhibition of p38 Mitogen Activated Protein Kinase (MAPK) and Tie-2 Kinase in Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)

Exome Sequencing of Familial MDS Reveals Novel Mutations and High Rates of False Positive Mutations in MLL3 Due to Pseudogene Effects

Targeting of MDS and AML Stem Cells Via Inhibition of STAT3 By Pyrimethamine

Myelodysplastic Syndrome Marrow Stroma Shows Widespread Aberrant Hypermethylation That Is Abrogated By Treatment with Dnmt Inhibitors

Inhibition Of Erythropoiesis By Iron Overload Is Mediated Through TGFβ Signaling

Inhibition Of CXCR2 As a Therapeutic Strategy In AML and MDS

miR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling

Aberrant Expression of DOCK4 Leads to Disruption of the F-Actin Skeleton and Altered Membrane Stability in MDS Erythroblasts and Mature Erythrocytes

Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations

Mir-21 Mediates Hematopoietic Suppression in MDS by Activating TGF-b Signaling,

MDS Marrow Stroma Is Characterized by Distinct Epigenetic Alterations

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American Society of Hematology

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ASH Publications

American Society of Hematology

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