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Journal Articles

A First-in-Human Phase 1 Trial of NX-2127, a First-in-Class Bruton's Tyrosine Kinase (BTK) Dual-Targeted Protein Degrader with Immunomodulatory Activity, in Patients with Relapsed/Refractory B Cell Malignancies

Alexey Danilov, Michael T. Tees, Krish Patel, William G. Wierda, Manish Patel, Ian W. Flinn, Tahir Latif, Weiyun Ai, Meghan C. Thompson, Michael L. Wang, Clare Sun, Deborah M. Stephens, Michael J Thirman, Melissa Gessner, Johannes Wolff, Amanda Schwab, May Tan, Daniel Chan, Erin Meredith, Adrian Wiestner
Journal: Blood
Blood (2023) 142 (Supplement 1): 4463.
https://doi.org/10.1182/blood-2023-179872
Published: 2023
Journal Articles

Development of Cytokine Release Syndrome Is Associated with Superior Progression-Free Survival in DLBCL Patients Receiving Axi-Cel or Liso-Cel

Matthew A Karr, Michael A Spinner, Sarah Wang, Charalambos Andreadis, Madhav R Seshadri, Lawrence David Kaplan, Weiyun Ai, Siobhan LaRue
Journal: Blood
Blood (2023) 142 (Supplement 1): 7344.
https://doi.org/10.1182/blood-2023-173885
Published: 2023
Journal Articles

A Phase 1b Dose Escalation Trial of Carfilzomib in Combination with Bendamustine and Rituximab in Patients with Relapsed or Refractory Non-Hodgkin Lymphoma

Swetha Kambhampati, MD, Bita Fakhri, MDMPH, Weiyun Ai, MD PhD, Lawrence D Kaplan, MD, Joseph Tuscano, MD, Matthew J. Wieduwilt, MD PhD, Akshay Sudhindra, MD, Jimmy Hwang, PhD, Jesika Reiner, MPH, Michelle Martinelli, Charlie Aoun, BS, Teresa Ta, Diem Le, Michelle Padilla, Erika Crawford, Charalambos Andreadis, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2828.
https://doi.org/10.1182/blood-2019-123279
Published: 2019
Journal Articles

Long Term Follow-up of a Phase 2 Study Examining Intratumoral G100 Alone and in Combination with Pembrolizumab in Patients with Follicular Lymphoma

Christopher R Flowers, MD MS, Carlos Panizo, MD PhD, Iris Isufi, MD, Alex F. Herrera, MD, Craig Okada, MD PhD, Elizabeth H. Cull, MD, Bela Kis, MD, Jorge M. Chaves, MD, Nancy L. Bartlett, MD, Weiyun Ai, MD PhD, Luis de la Cruz-Merino, MD PhD, Locke J. Bryan, MD, Roch Houot, MD PhD, Kim Linton, MBChB PhD, Javier Briones, MD, Ian Chau, MD, Gottfried R. von Keudell, MD PhD, Hailing Lu, PhD, Frank J Hsu, MD, Ahmad S Halwani, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2892.
https://doi.org/10.1182/blood-2018-99-117932
Published: 2018
Journal Articles

Intratumoral G100 Induces Systemic Immunity and Abscopal Tumor Regression in Patients with Follicular Lymphoma: Results of a Phase 1/ 2 Study Examining G100 Alone and in Combination with Pembrolizumab

Christopher Flowers, MD, Carlos Panizo, MD PhD, Iris Isufi, MD, Alex F. Herrera, MD, Craig Okada, MD PhD, Elizabeth H. Cull, MD, Bela Kis, MD, Jorge M. Chaves, MD, Nancy L. Bartlett, MD, Weiyun Ai, MD PhD, Luis de la Cruz-Merino, MD, Locke J. Bryan, MD, Roch Houot, MD PhD, Kim Linton, MBChB PhD, Javier Briones, MD, Ian Chau, MD, Gottfried R. von Keudell, MD PhD, Hailing Lu, PhD, Frank J Hsu, MD, Ahmad S. Halwani, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2771.
https://doi.org/10.1182/blood.V130.Suppl_1.2771.2771
Published: 2017
Journal Articles

A Multicenter Phase I Dose-Finding and Preliminary Efficacy Study of the Histone Deacetylase Inhibitor Romidepsin in Combination with Pegylated Liposomal Doxorubicin for the Treatment of Adults with Relapsed or Refractory Cutaneous and Peripheral T-Cell Lymphomas

Weiyun Ai, MD PhD, Pierluigi Porcu, MD, Wade Berry, Juliana Engleman, Matthew J. Wieduwilt, Jonathan E Brammer, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1544.
https://doi.org/10.1182/blood.V130.Suppl_1.1544.1544
Published: 2017
Journal Articles

High Prevalence and Incidence of Fractures in Patients Treated for Aggressive B-Cell Non-Hodgkin Lymphomas

Li-Wen Huang, MD, Dong Sun, MD PhD, Weiyun Ai, MD PhD, Lawrence D Kaplan, MD, Thomas M Link, MD PhD, Thomas Lang, PhD, Charalambos Andreadis, MD MSCE
Journal: Blood
Blood (2017) 130 (Supplement 1): 4131.
https://doi.org/10.1182/blood.V130.Suppl_1.4131.4131
Published: 2017
Journal Articles

Pathway-Directed High Throughput Drug Screen Identifies PI3K Inhibitors That Synergistically Potentiate Anti-Tumor Activity of HDAC Inhibitors in Mycosis Fungoides and Sezary Syndrome

Weiyun Ai, MD PhD, Chen-Yen Yang, PhD, Razan Faraj, Taha Rakhshandhroo, BSc, Shervin Afghani, BSc, Laura Pincus, MD, Sourav Bandyopadhyay, PhD, Frank McCormick, PhD FRS
Journal: Blood
Blood (2015) 126 (23): 2755.
https://doi.org/10.1182/blood.V126.23.2755.2755
Published: 2015
Journal Articles

Efficacy Of a Pharmacokinetics-Directed IV Busulfan (Bu), Plus Cyclophosphamide (Cy) and Etoposide (E) Preparative Regimen With Autologous Hematopoietic Stem Cell Transplantation For Lymphoma: Final Report Of a Multi-Center Phase 2 Study In North America

Christopher R. Flowers, MD, Michael Lill, M.D., Luciano J Costa, MD, PhD, Tsiporah B. Shore, William Vaughan, MD, Michael Craig, MD, Cesar O. Freytes, MD, Thomas C. Shea, M.D., Mitchell E. Horwitz, MD, Joseph W. Fay, MD, Shin Mineishi, MD, Damiano Rondelli, MD, James Mason, MD, Vijay Reddy, MD, PhD, Ira Braunschweig, MD, Weiyun Ai, MD, PhD, Elizabeth Armstrong, MS, Angela Smith, MS, PA, Cathy Zhao, PhD, Agnes Elekes, MD, Kazunobu Kato, MD, PhD, Edmund K. Waller, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 768.
https://doi.org/10.1182/blood.V122.21.768.768
Published: 2013
Journal Articles

MDM2 phenotypic and genotypic profiling, respective to TP53 genetic status, in diffuse large B-cell lymphoma patients treated with rituximab-CHOP immunochemotherapy: a report from the International DLBCL Rituximab-CHOP Consortium Program

Zijun Y. Xu-Monette, Michael B. Møller, Alexander Tzankov, Santiago Montes-Moreno, Wenwei Hu, Ganiraju C. Manyam, Louise Kristensen, Lei Fan, Carlo Visco, Karen Dybkær, April Chiu, Wayne Tam, Youli Zu, Govind Bhagat, Kristy L. Richards, Eric D. Hsi, William W. L. Choi, J. Han van Krieken, Qin Huang, Jooryung Huh, Weiyun Ai, Maurilio Ponzoni, Andrés J. M. Ferreri, Lin Wu, Xiaoying Zhao, Carlos E. Bueso-Ramos, Sa A. Wang, Ronald S. Go, Yong Li, Jane N. Winter, Miguel A. Piris, L. Jeffrey Medeiros, Ken H. Young
Journal: Blood
Blood (2013) 122 (15): 2630–2640.
https://doi.org/10.1182/blood-2012-12-473702
Published: 2013
Includes: Supplemental data
Journal Articles

Single nucleotide variation in the TP53 3′ untranslated region in diffuse large B-cell lymphoma treated with rituximab-CHOP: a report from the International DLBCL Rituximab-CHOP Consortium Program

Yong Li, Michael W. Gordon, Zijun Y. Xu-Monette, Carlo Visco, Alexander Tzankov, Dehui Zou, Lugui Qiu, Santiago Montes-Moreno, Karen Dybkaer, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L. Richards, Eric D. Hsi, William W. L. Choi, J. Han van Krieken, Qin Huang, Weiyun Ai, Maurilio Ponzoni, Andrés J. M. Ferreri, Jane N. Winter, Ronald S. Go, Miguel A. Piris, Michael B. Møller, Lin Wu, Michael Wang, Kenneth S. Ramos, L. Jeffrey Medeiros, Ken H. Young
Journal: Blood
Blood (2013) 121 (22): 4529–4540.
https://doi.org/10.1182/blood-2012-12-471722
Published: 2013
Includes: Supplemental data
Journal Articles

MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program

CME
Shimin Hu, Zijun Y. Xu-Monette, Alexander Tzankov, Tina Green, Lin Wu, Aarthi Balasubramanyam, Wei-min Liu, Carlo Visco, Yong Li, Roberto N. Miranda, Santiago Montes-Moreno, Karen Dybkaer, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L. Richards, Eric D. Hsi, William W. L. Choi, Xiaoying Zhao, J. Han van Krieken, Qin Huang, Jooryung Huh, Weiyun Ai, Maurilio Ponzoni, Andrés J. M. Ferreri, Fan Zhou, Graham W. Slack, Randy D. Gascoyne, Meifeng Tu, Daina Variakojis, Weina Chen, Ronald S. Go, Miguel A. Piris, Michael B. Møller, L. Jeffrey Medeiros, Ken H. Young
Journal: Blood
Blood (2013) 121 (20): 4021–4031.
https://doi.org/10.1182/blood-2012-10-460063
Published: 2013
Includes: Supplemental data
Journal Articles

CD30 expression defines a novel subgroup of diffuse large B-cell lymphoma with favorable prognosis and distinct gene expression signature: a report from the International DLBCL Rituximab-CHOP Consortium Program Study

Shimin Hu, Zijun Y. Xu-Monette, Aarthi Balasubramanyam, Ganiraju C. Manyam, Carlo Visco, Alexander Tzankov, Wei-min Liu, Roberto N. Miranda, Li Zhang, Santiago Montes-Moreno, Karen Dybkær, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L. Richards, Eric D. Hsi, William W. L. Choi, J. Han van Krieken, Qin Huang, Jooryung Huh, Weiyun Ai, Maurilio Ponzoni, Andrés J. M. Ferreri, Xiaoying Zhao, Jane N. Winter, Mingzhi Zhang, Ling Li, Michael B. Møller, Miguel A. Piris, Yong Li, Ronald S. Go, Lin Wu, L. Jeffrey Medeiros, Ken H. Young
Journal: Blood
Blood (2013) 121 (14): 2715–2724.
https://doi.org/10.1182/blood-2012-10-461848
Published: 2013
Includes: Supplemental data
Journal Articles

Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study

Clinical Trials & Observations
Zijun Y. Xu-Monette, Lin Wu, Carlo Visco, Yu Chuan Tai, Alexander Tzankov, Wei-min Liu, Santiago Montes-Moreno, Karen Dybkær, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L. Richards, Eric D. Hsi, X. Frank Zhao, William W. L. Choi, Xiaoying Zhao, J. Han van Krieken, Qin Huang, Jooryung Huh, Weiyun Ai, Maurilio Ponzoni, Andrés J. M. Ferreri, Fan Zhou, Brad S. Kahl, Jane N. Winter, Wei Xu, Jianyong Li, Ronald S. Go, Yong Li, Miguel A. Piris, Michael B. Møller, Roberto N. Miranda, Lynne V. Abruzzo, L. Jeffrey Medeiros, Ken H. Young
Journal: Blood
Blood (2012) 120 (19): 3986–3996.
https://doi.org/10.1182/blood-2012-05-433334
Published: 2012
Includes: Supplemental data
Journal Articles

The t(14;18)(q32;q21) Characterizes a Subset of Patients with Diffuse Large-B Cell Lymphoma of Germinal Center Origin with Poor Outcome: Report From the International DLBCL Rituximab-CHOP Consortium Program Study

Carlo Visco, MD, Alexander Tzankov, MD, Zijun Y. Xu-Monette, PhD, Roberto N. Miranda, MD, Emanuele S. G. d'Amore, MD, Santiago Montes-Moreno, MD, Karen Dybkaer, PhD, April Chiu, MD, Wayne Tam, MD, PhD, Attilio Orazi, MD, Youli Zu, MD, PhD, Govind Bhagat, MD, Brad S. Kahl, MD, Jane N. Winter, MD, Huan-You Wang, MD, PhD, Cherie H. Dunphy, MD, Eric D. Hsi, MD, Frank X. Zhao, MD, PhD, Ronald S. Go, MD, William W. L. Choi, MD, Fan Zhou, MD, PhD, Magdalena Czader, MD, PhD, Xiaoying Zhao, MD, Joannes H.J.M. Van Krieken, PhD, MD, Qin Huang, MD, PhD, Weiyun Ai, MD, PhD, Joan E. Etzell, MD, Maurilio Ponzoni, MD, Andres J.M. Ferreri, MD, Miguel A. Piris, MD, Michael B. Møller, MD, PhD, Carlos E. Bueso-Ramos, MD, PhD, L. Jeffrey Medeiros, MD, Ken H. Young, MD
Journal: Blood
Blood (2011) 118 (21): 949.
https://doi.org/10.1182/blood.V118.21.949.949
Published: 2011
Journal Articles

Increased Risk of Second Malignancies In Young Patients with Mycosis Fungoides Diagnosed Before 30 Years of Age: A Population-Based Study

Weiyun Ai, MD, PhD, Theresa Keegan, PhD, Kari Fish, MPH, Pincus Laura, MD, Christopher Soon, MD, Youn H. Kim, MD, Ellen Chang, Sc., D
Journal: Blood
Blood (2010) 116 (21): 1994.
https://doi.org/10.1182/blood.V116.21.1994.1994
Published: 2010
Journal Articles

In Situ Vaccination with TLR9 Agonist Combined with Local Radiation In Mycosis Fungoides: Analysis of Phase I/II Study

Youn H. Kim, MD, Dita Gratzinger, MD, PhD, Cameron Harrison, MD, Joshua Brody, MD, Debra Czerwinski, Leon Xing, Anjali Morales, MD, PhD, Weiyun Ai, MD, PhD, Farah Abdulla, MD, Daniel Navi, MD, Robert J. Tibshirani, PhD, Ranjana Advani, MD, Yasodha Natkunam, MD, PhD, Richard T. Hoppe, MD, Ron Levy, MD
Journal: Blood
Blood (2010) 116 (21): 286.
https://doi.org/10.1182/blood.V116.21.286.286
Published: 2010
Journal Articles

Long-Term Outcomes in Patients with Acute Myelogenous Leukemia (AML) Following Allogeneic Stem Cell Transplantation (AlloSCT) for Relapse After Initial Autologous Bone Marrow Transplant (ASCT).

Mary-Elizabeth Percival, MD, Lloyd E. Damon, MD, Thomas Martin, MD, Lawrence Kaplan, MD, Weiyun Ai, MD PhD, Jeffrey L. Wolf, MD, Sanghee Hong, Charles Linker, MD, Curt A. Ries, MD, Charalambos Andreadis, MD MSCE
Journal: Blood
Blood (2009) 114 (22): 2299.
https://doi.org/10.1182/blood.V114.22.2299.2299
Published: 2009
Journal Articles

Phase I Analysis of the Safety and Pharmacodynamics of the Novel Broad Spectrum Histone Deacetylase Inhibitor (HDACi) PCI-24781 in Relapsed and Refractory Lymphoma.

Andrew M Evens, DO, MSc, Weiyun Ai, MD, PhD, Sriram Balasubramanian, PhD, Mint Sirisawad, M.S., Chitra Mani, PhD, Martha Guerra, RN, Nancy Szakacs, BS, MBA, David Loury, PhD, Joseph J Buggy, Ph.D., Ahmed Hamdy, MD, Julie M. Vose, M.D., Nancy L Bartlett, MD
Journal: Blood
Blood (2009) 114 (22): 2726.
https://doi.org/10.1182/blood.V114.22.2726.2726
Published: 2009
Journal Articles

Neither CD68+ Nor CD163+ Macrophages Are Associated with Decreased Survival in Follicular Lymphoma

Di ta Gratzinger, MD, PhD, Weiyun Ai, MD, PhD, Robert Tibshirani, PhD., R. Levy, Y. Natkunam
Journal: Blood
Blood (2008) 112 (11): 3747.
https://doi.org/10.1182/blood.V112.11.3747.3747
Published: 2008