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Journal Articles

Analysis of Metformin Effects on Bone Marrow Fibrosis and Disease Progression in Primary Myelofibrosis Patients: Preliminary Results of an Open Label Phase II Trial (FIBROMET)

Paula De Melo Campos, MD, Katia B Pagnano, MD PhD, Rubia Mancuso, Francisco Breno S. Teófilo, Juan L Coelho-Silva, BSc, MSc, Fernanda I Della Via, MSc, Leandro Luiz Lopes Freitas, MD PhD, Hernandes F. Carvalho, PhD, Fernando Ferreira Costa, MD PhD, Fabiola Traina, MD PhD, Sara T Olalla Saad, PhD

Blood (2019) 134 (Supplement_1): 554.

https://doi.org/10.1182/blood-2019-130648

Published: 2019

Journal Articles

Metformin Suppresses Expression of Pre-Fibrotic Enzyme Lysyl-Oxidase Levels through Inhibition of UPR in MPN Cells

Megumi Suzuki, MD, Ichiro Kawashima, Keita Kirito, MD

Blood (2018) 132 (Supplement 1): 3070.

https://doi.org/10.1182/blood-2018-99-113276

Published: 2018

Journal Articles

Metformin Reduces Tumor Burden and Splenomegaly in JAK2 V617F Murine Models

João Agostinho Machado-Neto, BSc, Renata Scopim Ribeiro, BSc, MSc, Juan Luiz Coelho-Silva, BSc, MSc, Christopher A. Eide, Bruna Alves Fenerich, BSc, Jaqueline Cristina Fernandes, BSc, MSc, Ana Paula Nunes Rodrigues Alves, MSc, Priscila S Scheucher, PhD, Cristina E. Tognon, PhD, Lorena Lobo Figueiredo-Pontes, MD PhD, Brian J. Druker, MD, Eduardo Magalhães Rego, MDPhD, Fabiola Traina, MD PhD

Blood (2017) 130 (Supplement 1): 4222.

https://doi.org/10.1182/blood.V130.Suppl_1.4222.4222

Published: 2017

Journal Articles

Therapeutic Effects of Metformin in Follicular Lymphoma (FL) Treated with Rituximab in Combination with Bendamustine

Angel Mier Hicks, MD, Anil Singh, MD, Juan Gu, MD PhD, Ryan Hare, Pallawi Torka, MD, Austin Miller, PhD, Francisco J. Hernandez-Ilizaliturri, MD

Blood (2017) 130 (Supplement 1): 5152.

https://doi.org/10.1182/blood.V130.Suppl_1.5152.5152

Published: 2017

Journal Articles

Multitarget Antileukemic Effects of Metformin in Myeloproliferative Neoplasm Cells: Inhibition of JAK2/STAT Signaling and Mitochondrial Activity

João Agostinho Machado-Neto, PhD, Bruna Alves Fenerich, B.Sc., Renata Scopim-Ribeiro, M.Sc., Carlos Roberto Porto Dechandt, B.Sc., Ana Paula Nunes Rodrigues Alves, M.Sc., Jaqueline Cristina Fernandes, B.Sc., Priscila Santos Scheucher, PhD, Belinda Pinto Simões, MD, PhD, Luciane Carla Alberici, PhD, Lorena Lôbo de Figueiredo Pontes, MD, PhD, Eduardo Magalhães Rego, MD, PhD, Fabiola Traina, MD, PhD

Blood (2016) 128 (22): 1960.

https://doi.org/10.1182/blood.V128.22.1960.1960

Published: 2016

Journal Articles

Effect of the Adition of Metformin on the expressión of Multidrug-Resistance Genes (ABCB1, ABCG2) in Acute Lymphoblastic Leukemia: In Vitro and In Vivo Study

Christian Omar Ramos Peñafiel, MD, Irma Olarte Carrillo, PhD, Rafael Cerón Maldonado, Adrián Santoyo Sánchez, Humberto Baldemar Castellanos Sinco, MD Hematologist, Efreen Montaño Figueroa, Gloria Queipo García, Adolfo Martínez Tovar

Blood (2016) 128 (22): 5142.

https://doi.org/10.1182/blood.V128.22.5142.5142

Published: 2016

Journal Articles

Vitamine B12 Deficiency Presenting As Severe Pancytopenia in Adult Patients. a Monocentric Study of 104 Cases

Zoubida Tazi Mezalek, professor, Wafaa Ammouri, Mouna Maamar, Meriem Bourkia, Hicham Harmouche, Mohammed Adnaoui, Meryem Alaoui, Nisrine Bouigua

Blood (2016) 128 (22): 4812.

https://doi.org/10.1182/blood.V128.22.4812.4812

Published: 2016

Journal Articles

Metformin Therapy and Survival in Multiple Myeloma Among US Veterans with Diabetes Mellitus

Jesse Keller, MD, Kristen M. Sanfilippo, MD MPHS, Suhong Luo, MPH, Brian F. Gage, MDMSc, Kenneth R Carson, MD PhD

Blood (2015) 126 (23): 4502.

https://doi.org/10.1182/blood.V126.23.4502.4502

Published: 2015

Journal Articles

Metformin Inhibits JAK2V617F Activity By Activating AMPK and PP2A Containing B56 Alpha Subunits in MPN Cells

Ichiro Kawashima, MD, Keita Kirito, MD

Blood (2015) 126 (23): 1636.

https://doi.org/10.1182/blood.V126.23.1636.1636

Published: 2015

Journal Articles

Metformin Suppresses the GRP78-Dependent Delivery of Aggresomes to Autophagosomes to Enhance the Anti-Myeloma Benefit of Proteasome Inhibition

Sajjeev Jagannathan, MS, Nikhil Vad, PhD, Mohamed A.Y. Abdel Malek, MD, Ehsan Malek, MD, James J. Driscoll, MD PhD

Blood (2014) 124 (21): 433.

https://doi.org/10.1182/blood.V124.21.433.433

Published: 2014

Journal Articles

Metformin Affects the Proliferation Cell Nuclear Antigen (PCNA) and p21 Protein Interaction Resulting in Direct Anti-Tumor Activity and Enhances the Cytotoxic/Biological Effects of Chemotherapy Agents or Rituximab in Lymphoma in Vitro and in Vivo Pre-Clinical Models

Juan J Gu, PhD, Vivek Yanamadala, Anil Singh, MD, Cory Mavis, MSc, Myron S. Czuczman, MD, Francisco Hernandez, MD

Blood (2014) 124 (21): 1781.

https://doi.org/10.1182/blood.V124.21.1781.1781

Published: 2014

Journal Articles

Metformin Exerts Anti-Leukemic Effects Via Direct Inhibition Of Oncogenic Kinase Activity In Leukemia Cells Derived From Myeloproliferative Neoplasms

Ichiro Kawashima, MD, Keita Kirito, MD, PhD

Blood (2013) 122 (21): 2853.

https://doi.org/10.1182/blood.V122.21.2853.2853

Published: 2013

Journal Articles

Targeting Glycolysis and Compensatory Mitochondrial Metabolism in Multiple Myeloma with FDA Approved Ritonavir and Metformin Via Synthetic Lethality

Kehinde U. A. Adekola, M.B.B.S, Maylyn Martinez, Steven T. Rosen, MD, FRCPA, Mala Shanmugam, PhD

Blood (2012) 120 (21): 4016.

https://doi.org/10.1182/blood.V120.21.4016.4016

Published: 2012

Journal Articles

Safety and Efficacy of Frontline Nilotinib (Nb) for Chronic Phase (CP) Chronic Myeloid Leukemia (CML) in Diabetic Patients (pts)

Mahran Shoukier, Hagop M. Kantarjian, Elias Jabbour, Alfonso Quintas-Cardama, Zeev Estrov, Tapan Kadia, Gautam Borthakur, Guillermo Garcia-Manero, Steven M. Kornblau, Elizabeth M Burton, Susan O'Brien, Jorge E Cortes

Blood (2011) 118 (21): 2764.

https://doi.org/10.1182/blood.V118.21.2764.2764

Published: 2011

Journal Articles

Metformin for Therapeutic Intervention In Acute Myeloid Leukemia

Sarah Scotland, Elizabeth Micklow, Zhu Wang, Helena Boutzen, Christian Récher, MD, Gwenn Danet-Desnoyers, Mary Selak, Martin Carroll, MD, Jean-Emmanuel Sarry

Blood (2010) 116 (21): 4351.

https://doi.org/10.1182/blood.V116.21.4351.4351

Published: 2010

Journal Articles

Modulation of Histone H3K4 and H3K27 Methylation Levels Via Pharmacological Inhibition of LSD1 and Degradation of the EZH2-Containing Polycomb Repressive Complex 2 Stimulates ATRA-Mediated Differentiation of AML Cells.

Kevin R. Petrie, PhD, Tino Schenk, PhD, Manuel Boix Chornet, PhD, Louise Howell, John E Dick, PhD, Victor E Marquez, PhD, Laurence J Marton, MD, Patrick M Woster, PhD, Robert A Casero, Jr., PhD, Arthur Zelent, PhD

Blood (2009) 114 (22): 1046.

https://doi.org/10.1182/blood.V114.22.1046.1046

Published: 2009

Journal Articles

The Antidiabetic Biguanide Metformin Induces Growth Arrest in Multiple Myeloma Cells in Vitro, overcoming the Effect of Stromal Cells

Melissa G. Ooi, Douglas W. McMillin, Joseph M. Negri, Jake Delmore, Nikhil C. Munshi, Dharminder Chauhan, Teru Hideshima, Paul G. Richardson, Constantine S. Mitsiades, Kenneth C. Anderson, Nicholas Mitsiades

Blood (2008) 112 (11): 2652.

https://doi.org/10.1182/blood.V112.11.2652.2652

Published: 2008

NARROW

Analysis of Metformin Effects on Bone Marrow Fibrosis and Disease Progression in Primary Myelofibrosis Patients: Preliminary Results of an Open Label Phase II Trial (FIBROMET)

Metformin Suppresses Expression of Pre-Fibrotic Enzyme Lysyl-Oxidase Levels through Inhibition of UPR in MPN Cells

Metformin Reduces Tumor Burden and Splenomegaly in JAK2 V617F Murine Models

Therapeutic Effects of Metformin in Follicular Lymphoma (FL) Treated with Rituximab in Combination with Bendamustine

Multitarget Antileukemic Effects of Metformin in Myeloproliferative Neoplasm Cells: Inhibition of JAK2/STAT Signaling and Mitochondrial Activity

Effect of the Adition of Metformin on the expressión of Multidrug-Resistance Genes (ABCB1, ABCG2) in Acute Lymphoblastic Leukemia: In Vitro and In Vivo Study

Vitamine B12 Deficiency Presenting As Severe Pancytopenia in Adult Patients. a Monocentric Study of 104 Cases

Metformin Therapy and Survival in Multiple Myeloma Among US Veterans with Diabetes Mellitus

Metformin Inhibits JAK2V617F Activity By Activating AMPK and PP2A Containing B56 Alpha Subunits in MPN Cells

Metformin Suppresses the GRP78-Dependent Delivery of Aggresomes to Autophagosomes to Enhance the Anti-Myeloma Benefit of Proteasome Inhibition

Metformin Affects the Proliferation Cell Nuclear Antigen (PCNA) and p21 Protein Interaction Resulting in Direct Anti-Tumor Activity and Enhances the Cytotoxic/Biological Effects of Chemotherapy Agents or Rituximab in Lymphoma in Vitro and in Vivo Pre-Clinical Models

Metformin Exerts Anti-Leukemic Effects Via Direct Inhibition Of Oncogenic Kinase Activity In Leukemia Cells Derived From Myeloproliferative Neoplasms

Targeting Glycolysis and Compensatory Mitochondrial Metabolism in Multiple Myeloma with FDA Approved Ritonavir and Metformin Via Synthetic Lethality

Safety and Efficacy of Frontline Nilotinib (Nb) for Chronic Phase (CP) Chronic Myeloid Leukemia (CML) in Diabetic Patients (pts)

Metformin for Therapeutic Intervention In Acute Myeloid Leukemia

Modulation of Histone H3K4 and H3K27 Methylation Levels Via Pharmacological Inhibition of LSD1 and Degradation of the EZH2-Containing Polycomb Repressive Complex 2 Stimulates ATRA-Mediated Differentiation of AML Cells.

The Antidiabetic Biguanide Metformin Induces Growth Arrest in Multiple Myeloma Cells in Vitro, overcoming the Effect of Stromal Cells

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American Society of Hematology

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American Society of Hematology

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