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Joseph M. Negri
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Journal Articles

Temporal Dynamics of Tumor-Microenvironment Interaction and Treatment Responses Revealed through Time-Lapse Compartment-Specific Bioluminescence Imaging: Translational implications

Eugen Dhimolea, PhD, Emily King, Efstathios Kastritis, MD, Douglas W. McMillin, PhD, Jake E. Delmore, B.Sc., Joseph M. Negri, B.Sc., Hannah M. Jacobs, B.Sc., Catriona A. Hayes, MD, Michal Sheffer, PhD, Yiguo Hu, PhD, Subhashis Sarkar, PhD, Richard W.J. Groen, PhD, Megan A. Bariteau, B.Sc., Blake T. Aftab, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2014) 124 (21): 276.
https://doi.org/10.1182/blood.V124.21.276.276
Published: 2014
Journal Articles

Compartment-specific bioluminescence imaging platform for the high-throughput evaluation of antitumor immune function

e-blood
Douglas W. McMillin, Jake Delmore, Joseph M. Negri, Matthew Vanneman, Shohei Koyama, Robert L. Schlossman, Nikhil C. Munshi, Jacob Laubach, Paul G. Richardson, Glenn Dranoff, Kenneth C. Anderson, Constantine S. Mitsiades
Journal: Blood
Blood (2012) 119 (15): e131–e138.
https://doi.org/10.1182/blood-2011-04-348490
Published: 2012
Includes: Supplemental data
Journal Articles

The Transcriptional Signature of Kinases Inhibited by the Multi-Targeted Kinase Inhibitor AS703569 Is Associated with Clinical Outcome in Multiple Myeloma (MM): Anti-MM Activity of AS703569 in Preclinical Studies.

Jake Delmore, David N. Cervi, Douglas McMillin, Efstathios Kastritis, Jana Jakubikova, Melissa G. Ooi, Steffen Klippel, Joseph M. Negri, Leutz Buon, Jacob Laubach, Luca Rastelli, Ann Clark, Samantha M. Sarno, Paul G. Richardson, Kenneth C. Anderson, Constantine S. Mitsiades, M.D., Ph.D
Journal: Blood
Blood (2009) 114 (22): 730.
https://doi.org/10.1182/blood.V114.22.730.730
Published: 2009
Journal Articles

Microenvironment-Dependent Synthetic Lethality: Implications for Tumor Pathophysiology and Anti-Cancer Drug Discovery.

Douglas McMillin, Jake Delmore, Ellen Weisberg, Joseph M. Negri, Steffen Klippel, Nicholas Mitsiades, Nikhil C. Munshi, James D Griffin, Paul G. Richardson, Kenneth C. Anderson, Andrew L. Kung, Constantine S. Mitsiades
Journal: Blood
Blood (2009) 114 (22): 1722.
https://doi.org/10.1182/blood.V114.22.1722.1722
Published: 2009
Journal Articles

Compartment-Specific Bioluminescence Imaging (CS-BLI) High- Throughput Assays Provide Comparative Insights into the Impact of Osteoclasts Vs. Stromal Cells on Activity of Anti-Myeloma Therapeutics

Melissa G. Ooi, Douglas W. McMillin, Joseph M. Negri, Jake Delmore, Steffen Klippel, Nicholas Mitsiades, Paul G. Richardson, Kenneth C. Anderson, Constantine S. Mitsiades
Journal: Blood
Blood (2008) 112 (11): 219.
https://doi.org/10.1182/blood.V112.11.219.219
Published: 2008
Journal Articles

Interactions of the Mdm2/p53 and Proteasome Pathways: Implications for Combination Strategies to Enhance the Anti-Myeloma Activity of Bortezomib

Melissa G. Ooi, Patrick J. Hayden, Douglas W. McMillin, Joseph M. Negri, Jake Delmore, Noopur S Raje, Nikhil C. Munshi, Dharminder Chauhan, Teru Hideshima, Paul G. Richardson, Constantine S. Mitsiades, Kenneth C Anderson, Nicholas Mitsiades
Journal: Blood
Blood (2008) 112 (11): 2651.
https://doi.org/10.1182/blood.V112.11.2651.2651
Published: 2008
Journal Articles

The Antidiabetic Biguanide Metformin Induces Growth Arrest in Multiple Myeloma Cells in Vitro, overcoming the Effect of Stromal Cells

Melissa G. Ooi, Douglas W. McMillin, Joseph M. Negri, Jake Delmore, Nikhil C. Munshi, Dharminder Chauhan, Teru Hideshima, Paul G. Richardson, Constantine S. Mitsiades, Kenneth C. Anderson, Nicholas Mitsiades
Journal: Blood
Blood (2008) 112 (11): 2652.
https://doi.org/10.1182/blood.V112.11.2652.2652
Published: 2008
Journal Articles

Activity of CDK1/2 Inhibitor LCQ195 Against Multiple Myeloma Cells.

Douglas W. McMillin, Jake Delmore, Joseph M. Negri, Patrick Hayden, Nicholas Mitsiades, Paul G. Richardson, Robert Schlossman, Nikhil C. Munshi, Kenneth C. Anderson, Constantine S. Mitsiades
Journal: Blood
Blood (2007) 110 (11): 1519.
https://doi.org/10.1182/blood.V110.11.1519.1519
Published: 2007
Journal Articles

In Vitro and In Vivo Anti-Myeloma Activity of PRLX, an Orally-Bioavailable Agent Against Cells with Constitutive Activation of Ras or Its Downstream Pathway.

Steffen Klippel, Jana Jakubikova, Lauren Jenkins, Joseph M. Negri, Yevgenia Tesmenitsky, Melissa Rooney, Jake Delmore, Douglas W. McMillin, R. Selliah, P. Robbins, Nicholas Mitsiades, Robert Schlossman, Sudhir Sahasrabudhe, Kenneth C. Anderson, Paul G. Richardson, Constantine S. Mitsiades
Journal: Blood
Blood (2007) 110 (11): 540.
https://doi.org/10.1182/blood.V110.11.540.540
Published: 2007
Journal Articles

Compartment-Specific Bioluminescence Imaging (CS-BLI): A High-Throughput Approach To Identify Novel Anti-Neoplastic Therapies That Overcome the Protection of Stromal Cells.

Douglas W. McMillin, Joseph M. Negri, Patrick Hayden, Ellen Weisberg, Steffen Klippel, Robert Schlossman, Nikhil C. Munshi, Nicholas Mitsiades, Paul G. Richardson, Kenneth C. Anderson, Constantine S. Mitsiades
Journal: Blood
Blood (2007) 110 (11): 536.
https://doi.org/10.1182/blood.V110.11.536.536
Published: 2007
Journal Articles

Anti-Myeloma Activity of the Dual Akt/p70 S6K Inhibitor EXEL-6075.

Douglas W. McMillin, Joseph M. Negri, Jake Delmore, Melissa Ooi, Patrick Hayden, Nicholas Mitsiades, Paul G. Richardson, Robert Schlossman, Kenneth C. Anderson, Constantine S. Mitsiades
Journal: Blood
Blood (2007) 110 (11): 649.
https://doi.org/10.1182/blood.V110.11.649.649
Published: 2007
Journal Articles

Anti-Myeloma Activity of the Small-Molecule Aurora Kinase Inhibitor VE465.

Joseph M. Negri, Douglas W. McMillin, Nicholas Mitsiades, Teru Hideshima, Dharminder Chauhan, Yu-Tzu Tai, Xavier Leleu, Nikhil C. Munshi, Paul G. Richardson, Carolyn A. Buser-Doepner, John Pollard, Kenneth C. Anderson, Constantine S. Mitsiades
Journal: Blood
Blood (2006) 108 (11): 3468.
https://doi.org/10.1182/blood.V108.11.3468.3468
Published: 2006
Journal Articles

Reversine: A Chemical Probe Providing Insight into Myeloma Biology and Potential Therapeutic Applications.

Douglas W. McMillin, D. Corey Geer, Joseph M. Negri, Nicholas Mitsiades, Teru Hideshima, Dharminder Chauhan, Yu-Tzu Tai, Nikhil C. Munshi, Paul G. Richardson, Kenneth C. Anderson, Constantine S. Mitsiades
Journal: Blood
Blood (2006) 108 (11): 3481.
https://doi.org/10.1182/blood.V108.11.3481.3481
Published: 2006