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Douglas McMillin
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Journal Articles

The Interaction of Bortezomib with P-Gp, MRP-1 and BCRP Drug Transporters: Implications for Therapeutic Applications of Bortezomib in Advanced Multiple Myeloma and Other Neoplasias.

Melissa G Ooi, M.D., Robert O'Connor, Ph.D, Jana Jakubikova, Ph.D, Justine Meiller, Diploma, in, Biochemistry, Degre, Steffen Klippel, Ph.D, Jake Delmore, Efstathios Kastritis, M.D, Douglas McMillin, Ph.D, Martin Clynes, Ph.D, Paul Richardson, M.D., Constantine S. Mitsiades, M.D., Ph.D, Peter O'Gorman, M.D., Kenneth C. Anderson, M.D.
Journal: Blood
Blood (2009) 114 (22): 1729.
https://doi.org/10.1182/blood.V114.22.1729.1729
Published: 2009
Journal Articles

Methyljasmonate, An Inhibitor of Glycolytic Energy Production, Displays Pre-Clinical Activity against Multiple Myeloma Cells.

Steffen Klippel, Jana Jakubikova, Jake Delmore, Melissa G. Ooi, Douglas McMillin, Efstathios Kastritis, Jacob Laubach, Paul G. Richardson, Kenneth C. Anderson, Constantine S. Mitsiades
Journal: Blood
Blood (2009) 114 (22): 1741.
https://doi.org/10.1182/blood.V114.22.1741.1741
Published: 2009
Journal Articles

The Transcriptional Signature of Kinases Inhibited by the Multi-Targeted Kinase Inhibitor AS703569 Is Associated with Clinical Outcome in Multiple Myeloma (MM): Anti-MM Activity of AS703569 in Preclinical Studies.

Jake Delmore, David N. Cervi, Douglas McMillin, Efstathios Kastritis, Jana Jakubikova, Melissa G. Ooi, Steffen Klippel, Joseph M. Negri, Leutz Buon, Jacob Laubach, Luca Rastelli, Ann Clark, Samantha M. Sarno, Paul G. Richardson, Kenneth C. Anderson, Constantine S. Mitsiades, M.D., Ph.D
Journal: Blood
Blood (2009) 114 (22): 730.
https://doi.org/10.1182/blood.V114.22.730.730
Published: 2009
Journal Articles

Targeting the Clonogenic Side Population of Multiple Myeloma by Immunomodulatory Drugs (IMiDs) in the Context of Stromal Cell Microenvironment: Pathophysiologic and Clinical Implications.

Jana Jakubikova, David N. Cervi, John F. Daley, Danka Cholujova, Melissa G. Ooi, Steffen Klippel, Simona Blotta, Merav Leiba, Jake Delmore, Douglas McMillin, Efstathios Kastritis, Jacob Laubach, Paul Richardson, Jan Sedlak, Kenneth C. Anderson, Constantine S. Mitsiades, M.D., Ph.D
Journal: Blood
Blood (2009) 114 (22): 954.
https://doi.org/10.1182/blood.V114.22.954.954
Published: 2009
Journal Articles

Microenvironment-Dependent Synthetic Lethality: Implications for Tumor Pathophysiology and Anti-Cancer Drug Discovery.

Douglas McMillin, Jake Delmore, Ellen Weisberg, Joseph M. Negri, Steffen Klippel, Nicholas Mitsiades, Nikhil C. Munshi, James D Griffin, Paul G. Richardson, Kenneth C. Anderson, Andrew L. Kung, Constantine S. Mitsiades
Journal: Blood
Blood (2009) 114 (22): 1722.
https://doi.org/10.1182/blood.V114.22.1722.1722
Published: 2009
Journal Articles

Hedgehog Pathway as a Potential Therapeutic Target in Multiple Myeloma.

Simona Blotta, MD, Joeseph Negri, Purushothama Nanjappa, Anne-Sophie Moreau, MD, Rao Prabhala, PhD, Masood Shammas, PhD, Dheeraj Pelluru, PhD, Douglas McMillin, PhD, Yu-Tzu Tai, PhD, Pierfrancesco Tassone, MD, Kenneth C. Anderson, MD, Constantine Mitsiades, MD, PhD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2007) 110 (11): 672.
https://doi.org/10.1182/blood.V110.11.672.672
Published: 2007
Journal Articles

Targeting PKC in Multiple Myeloma: In Vitro and In Vivo Effects of the Novel, Orally Available Small-Molecule Inhibitor Enzastaurin (LY317615.HCl).

Marc S. Raab, MD, Klaus Podar, MD, PhD, Jing Zhang, MSc, Douglas McMillin, PhD, Iris Breitkreutz, MD, Yu-Tzu Tai, PhD, Boris Lin, MD, PhD, Irene Ghobrial, MD, Nikhil Munshi, MD, Teru Hideshima, MD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2006) 108 (11): 3466.
https://doi.org/10.1182/blood.V108.11.3466.3466
Published: 2006
Journal Articles

The Combination of the mTOR Inhibitor Rapamycin and Proteasome Inhibitor Bortezomib Is Synergistic In Vitro in Multiple Myeloma.

Garrett O’Sullivan, Xavier Leleu, MD, Xiaoying Jia, Evdoxia Hatjiharisi, MD, Hai Ngo, Anne-Sophie Moreau, MD, Yu-Tsu Tai, PhD, Douglas McMillin, Constantine Mitsiades, MD, Noopur Raje, MD, Teru Hideshima, MD, Robert Schlossman, MD, Paul Richardson, MD, Nikhil Munshi, MD, Kenneth Anderson, MD, Irene Ghobrial, MD
Journal: Blood
Blood (2006) 108 (11): 3495.
https://doi.org/10.1182/blood.V108.11.3495.3495
Published: 2006
Journal Articles

The Proteasome Inhibitor NPI-0052 in Combination with Bortezomib Induces Antitumor Activity in Waldenstrom Macroglobulinemia.

Xiaoying Jia, Xavier Leleu, MD, Anne-Sophie Moreau, MD, Evdoxia Hatjiharisi, MD, Hai Ngo, Garrett O’Sullivan, Douglas McMillin, PhD, Steven Treon, MD, Constantine Mitsiades, MD, Teru Hideshima, MD, Michael Palladino, Kenneth Anderson, MD, Dharminder Chauhan, PhD, Irene Ghobrial, MD
Journal: Blood
Blood (2006) 108 (11): 4746.
https://doi.org/10.1182/blood.V108.11.4746.4746
Published: 2006
Journal Articles

Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl)

Klaus Podar, Marc S. Raab, Jing Zhang, Douglas McMillin, Iris Breitkreutz, Yu-Tzu Tai, Boris K. Lin, Nikhil Munshi, Teru Hideshima, Dharminder Chauhan, Kenneth C. Anderson
Journal: Blood
Blood (2006) 109 (4): 1669–1677.
https://doi.org/10.1182/blood-2006-08-042747
Published: 2006
Includes: Supplemental data