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Journal Articles

Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia

Blood (2020) 136 (10): 1161–1168.

https://doi.org/10.1182/blood.2020005064

Published: 2020

Includes: Supplemental data

Journal Articles

Increased Risk of Early Hematologic Toxicity during Maintenance Therapy in Acute Lymphoblastic Leukemia Patients of South Indian Origin Carrying NUDT15*3 Allele

Sunitha Kodidela, PhD, Dorababu Patchva, PhD, Dimpal Thakkar:, PhD, Biswajit Dubashi, DM, Rajan Sundaram, M.Sc, Ravi Prasad Nidanapu, PhD, Muralidharan Nivedita, PhD, Anil Aribandi, MD MRCP, FRCPath, Suresh Chandra Pradhan, MD, Chakradhara RS Uppugunduri, PhD

Blood (2019) 134 (Supplement_1): 5059.

https://doi.org/10.1182/blood-2019-129967

Published: 2019

Journal Articles

Pralatrexate-Resistant Cell Lines Show Intact Internalization Via RFC1 but Collateral Sensitivity to Nucleoside Analogs

Kana Oiwa, MD, Naoko Hosono, MD, Rie Nishi, PhD, Takanori Ueda, MD PhD, Luigi Scott, PhD, Owen A. O'Connor, MD, PhD, Takahiro Yamauchi, MD PhD

Blood (2018) 132 (Supplement 1): 3961.

https://doi.org/10.1182/blood-2018-99-110147

Published: 2018

Journal Articles

Methotrexate-Loaded Biodegradable Polymeric Micelles for Lymphoma Therapy in Mouse Model

Mengyao Wang, MD, Ying Qu, PhD, Zhiyong Qian, PhD, Ting Niu, MD PhD

Blood (2018) 132 (Supplement 1): 4181.

https://doi.org/10.1182/blood-2018-99-119151

Published: 2018

Journal Articles

A Novel Bcma-Specific, Centyrin-Based CAR-T Product for the Treatment of Multiple Myeloma

David L. Hermanson, PhD, Burton Earle Barnett, PhD, Srinivas Rengarajan, M.S., Rebecca Codde, B.S., Xinxin Wang, PhD, Yening Tan, B.S., Christopher E. Martin, PhD, Jenessa Barbara Smith, PhD, Jin He, M.S., Rohit Mathur, PhD, Jing Yan, PhD, Sattva S. Neelapu, MD, Eric M. Osertag, MD PhD, Devon J. Shedlock, PhD

Blood (2016) 128 (22): 2127.

https://doi.org/10.1182/blood.V128.22.2127.2127

Published: 2016

Journal Articles

Trafficking of Plasmodium Falciparum Proteins: A Novel Anti-Malaria Drug Target?

Theresa L. Coetzer, PhD, Alisje Churchyard, BSc Hons, Melanie Wepener, MSc

Blood (2016) 128 (22): 2443.

https://doi.org/10.1182/blood.V128.22.2443.2443

Published: 2016

Journal Articles

Effect of Intrathecal Methotrexate on CSF and RBC Folate Levels in Children Receiving Treatment for Acute Lymphoblastic Leukemia

Keith J. August, MD MS, Leon van Haandel, PhD, J. Steven Leeder, PharmD, PhD

Blood (2015) 126 (23): 2486.

https://doi.org/10.1182/blood.V126.23.2486.2486

Published: 2015

Journal Articles

A Prospective, Self-Controlled and Randomized Study about the Optimal Timing of Leucovorin Rescue after High Dose Methotrexate Management

Tongyu Lin, Xueying Li, Tingzhi Liu, He Huang, Huangming Hong, Chengcheng Guo, Xiaohong Fu, Xiaojie Fang, Zhao Wang, Zhongjun Xia, MD, Xiaoting Lin

Blood (2015) 126 (23): 3956.

https://doi.org/10.1182/blood.V126.23.3956.3956

Published: 2015

Journal Articles

Schedule-Dependent Synergy Between Belinostat and Pralatrexate in T-and B-Cell Lymphoma Cells in Vitro

Godefridus Peters, FHA van Gemert, I Kathmann, Saskia AGM Cillessen, MSc, G Jansen, Guru Reddy

Blood (2015) 126 (23): 5128.

https://doi.org/10.1182/blood.V126.23.5128.5128

Published: 2015

Journal Articles

High Dose (5mg) Daily Folic Acid Supplement in Healthy Brazilian Volunteers Increases Mononuclear TNF-Î± Expression and Reduces NK Cell Number and Activity

Juliano Bertinato, PhDstudent, Clovis Paniz, PhDstudent, Maylla Rodrigues Lucena, Msc student, Patrícia Mendonça da Silva Amorim, Msc student, Guilherme Wataru Gomes, Msc student, Maria Stella Figueiredo, MDPhD, Ralph Green, MD PhD, Elvira Maria Guerra Shinohara

Blood (2015) 126 (23): 4531.

https://doi.org/10.1182/blood.V126.23.4531.4531

Published: 2015

Journal Articles

Elevated Serum Folic Acid Concentrations Were Associated with Higher mRNA Expression of DHFR Gene in Patients with Hereditary Spherocytosis

Clovis Paniz, PhDstudent, Maylla Rodrigues Lucena, Msc student, Juliano Felix Bertinato, PhDstudent, Patricia Mendonça da Silva Amorim, Msc student, Guilherme Wataru Gomes, Msc student, Maria Stella Figueiredo, MD PhD, Ralph Green, MD PhD, Rodolfo Cancado, MD PhD, Claudia R Bonini Domingos, PhD, Vera Bláia-D'Avila, MD PhD, Marcelo Cliquet, MD PhD, Elvira Maria Guerra-Shinohara, PhD

Blood (2014) 124 (21): 4005.

https://doi.org/10.1182/blood.V124.21.4005.4005

Published: 2014

Journal Articles

High-Throughput Drug Screening Identifies Pyrimethamine As a Potent and Selective Inhibitor of Acute Myeloid Leukemia

Amit Sharma, PhD, Nidhi Jyotsana, Courteney K. Lai, BSc, Anuhar Chaturvedi, PhD, Kerstin Görlich, Cecilia Murphy, Jan E. Blanchard, Arnold Ganser, Eric Brown, John A. Hassell, R. Keith Humphries, MD PhD, Michael A Morgan, PhD, Michael Heuser, MD

Blood (2014) 124 (21): 2304.

https://doi.org/10.1182/blood.V124.21.2304.2304

Published: 2014

Journal Articles

Influence of Dihydrofolate Reducatse (DHFR) Gene Polymorphisms on Outcome of Methotrexate Maintenance Therapy in Patients with Acute Lymphoblastic Leukemia

Dubashi Biswajit, MBBS, MD DM (MDcal Oncology), Sunitha Kodidela, Suresh Chandra Pradhan, Debdatta Basu, Professor, Ravi Prasad, Umamaheswaran Gurusamy

Blood (2014) 124 (21): 3661.

https://doi.org/10.1182/blood.V124.21.3661.3661

Published: 2014

Journal Articles

Pre-Clinical Analysis Of The Novel Antifolate Pralatrexate In Multiple Myeloma Reveals Functional Biomarkers Correlated With Response

Michael Mangone, PhD, Anna H Mei, BA, Luigi Scotto, PhD, Michele Visentin, PhD, Enrica Marchi, MD, PhD, I. David Goldman, MD, Constantine S. Mitsiades, MD, PhD, Owen A. O'Connor, MD, PhD, Hearn J. Cho, MD, PhD

Blood (2013) 122 (21): 4430.

https://doi.org/10.1182/blood.V122.21.4430.4430

Published: 2013

Journal Articles

Pralatrexate Has Potent Activity Against Multiple Myeloma In Vitro and In Vivo , and Activity Correlates with Tumor RFC-1 and DHFR Expression

Michael Mangone, AB, Luigi Scotto, Ph.D., Enrica Marchi, MD, Ph.D., Owen A. O'Connor, MD, PhD, Hearn J. Cho, MD, PhD

Blood (2011) 118 (21): 1831.

https://doi.org/10.1182/blood.V118.21.1831.1831

Published: 2011

Journal Articles

Cyclin-Dependent Kinase Inhibitors Enhance Sensitivity to Methotrexate In Human T-Cell Leukemia Jurkat Cells

Hitoji Uchiyama, MD, PhD, Yoshihiro Sowa, PhD, Miki Wakada, Mayumi Yogosawa, Ryoko Nakanishi, MSc, Mano Horinaka, PhD, Chihiro Shimazaki, MD, PhD, Masafumi Taniwaki, MD, PhD, Toshiyuki Sakai, MD, PhD

Blood (2010) 116 (21): 3976.

https://doi.org/10.1182/blood.V116.21.3976.3976

Published: 2010

Journal Articles

Dihydrofolate Reductase Deficiency Is Caused by a Homozygous DHFR Mutation and Leads to Congenital Megaloblastic Anemia and Cerebral Folate Deficiency

Holger Cario, MD, Desiree E.C. Smith, PhD, Henk J. Blom, PhD, Harald Bode, MD, Nenad Blau, PhD, Karlheinz Holzmann, PhD, Ulrich Pannicke, Elisabeth Kohne, MD, Klaus-Michael Debatin, MD, Yvo M. Smulders, MD, Klaus Schwarz

Blood (2010) 116 (21): 1006.

https://doi.org/10.1182/blood.V116.21.1006.1006

Published: 2010

Journal Articles

Up-Regulation of Genes Involved in Folate Metabolism Characterize Late but Not Early Relapse in Childhood Acute Lymphoblastic Leukemia.

Laura Hogan, MD, Deepa Bhojwani, MD, Jinhua Wang, PhD, Debra Morrison, PhD, Jun J Yang, PhD, Yutong Zhang, Jiri Zavadil, PhD, Gregory Condos, Stephen P Hunger, MD, Cheryl L. Willman, MD, Mary V. Relling, PharmD, Elizabeth Raetz, MD, William L. Carroll, MD

Blood (2009) 114 (22): 1733.

https://doi.org/10.1182/blood.V114.22.1733.1733

Published: 2009

Journal Articles

Identification of AML1-ETO modulators by chemical genomics

Steven M. Corsello, Giovanni Roti, Kenneth N. Ross, Kwan T. Chow, Ilene Galinsky, Daniel J. DeAngelo, Richard M. Stone, Andrew L. Kung, Todd R. Golub, Kimberly Stegmaier

Blood (2009) 113 (24): 6193–6205.

https://doi.org/10.1182/blood-2008-07-166090

Published: 2009

Includes: Supplemental data

Journal Articles

Histone Deacetylase Inhibitors Induce FPGS mRNA Expression and Intracellular Accumulation of Long-Chain Methotrexate Polyglutamates in Childhood Acute Lymphoblastic Leukemia: Implications for Combination Therapy

Guy J Leclerc, Ph.D., Caihong Mou, M.D., Gilles M Leclerc, Ph.D., Abdul M Mian, Ph.D., Julio C Barredo, M.D.

Blood (2008) 112 (11): 2923.

https://doi.org/10.1182/blood.V112.11.2923.2923

Published: 2008

NARROW

Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia

Increased Risk of Early Hematologic Toxicity during Maintenance Therapy in Acute Lymphoblastic Leukemia Patients of South Indian Origin Carrying NUDT15*3 Allele

Pralatrexate-Resistant Cell Lines Show Intact Internalization Via RFC1 but Collateral Sensitivity to Nucleoside Analogs

Methotrexate-Loaded Biodegradable Polymeric Micelles for Lymphoma Therapy in Mouse Model

A Novel Bcma-Specific, Centyrin-Based CAR-T Product for the Treatment of Multiple Myeloma

Trafficking of Plasmodium Falciparum Proteins: A Novel Anti-Malaria Drug Target?

Effect of Intrathecal Methotrexate on CSF and RBC Folate Levels in Children Receiving Treatment for Acute Lymphoblastic Leukemia

A Prospective, Self-Controlled and Randomized Study about the Optimal Timing of Leucovorin Rescue after High Dose Methotrexate Management

Schedule-Dependent Synergy Between Belinostat and Pralatrexate in T-and B-Cell Lymphoma Cells in Vitro

High Dose (5mg) Daily Folic Acid Supplement in Healthy Brazilian Volunteers Increases Mononuclear TNF-Î± Expression and Reduces NK Cell Number and Activity

Elevated Serum Folic Acid Concentrations Were Associated with Higher mRNA Expression of DHFR Gene in Patients with Hereditary Spherocytosis

High-Throughput Drug Screening Identifies Pyrimethamine As a Potent and Selective Inhibitor of Acute Myeloid Leukemia

Influence of Dihydrofolate Reducatse (DHFR) Gene Polymorphisms on Outcome of Methotrexate Maintenance Therapy in Patients with Acute Lymphoblastic Leukemia

Pre-Clinical Analysis Of The Novel Antifolate Pralatrexate In Multiple Myeloma Reveals Functional Biomarkers Correlated With Response

Pralatrexate Has Potent Activity Against Multiple Myeloma In Vitro and In Vivo , and Activity Correlates with Tumor RFC-1 and DHFR Expression

Cyclin-Dependent Kinase Inhibitors Enhance Sensitivity to Methotrexate In Human T-Cell Leukemia Jurkat Cells

Dihydrofolate Reductase Deficiency Is Caused by a Homozygous DHFR Mutation and Leads to Congenital Megaloblastic Anemia and Cerebral Folate Deficiency

Up-Regulation of Genes Involved in Folate Metabolism Characterize Late but Not Early Relapse in Childhood Acute Lymphoblastic Leukemia.

Identification of AML1-ETO modulators by chemical genomics

Histone Deacetylase Inhibitors Induce FPGS mRNA Expression and Intracellular Accumulation of Long-Chain Methotrexate Polyglutamates in Childhood Acute Lymphoblastic Leukemia: Implications for Combination Therapy

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American Society of Hematology

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American Society of Hematology

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