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Journal Articles

Dimethyl fumarate induces ferroptosis and impairs NF-κB/STAT3 signaling in DLBCL

Anja Schmitt, Wendan Xu, Philip Bucher, Melanie Grimm, Martina Konantz, Heike Horn, Myroslav Zapukhlyak, Philipp Berning, Marc Brändle, Mohamed-Ali Jarboui, Caroline Schönfeld, Karsten Boldt, Andreas Rosenwald, German Ott, Michael Grau, Pavel Klener, Petra Vockova, Claudia Lengerke, Georg Lenz, Klaus Schulze-Osthoff, Stephan Hailfinger
Journal: Blood
Blood (2021) 138 (10): 871–884.
https://doi.org/10.1182/blood.2020009404
Published: 2021
Includes: Supplemental data
Journal Articles

Differential Efficacy of Anti-Sickling and Anti-Inflammatory Mechanisms in a Fluorescent Intravital Microscopy Dorsal Skinfold Vaso-Occlusion Model in Sickle Cell Disease Townes Mice

Sarah Sturtevant, BSc, Alejandra Macias-Garcia, PhD, Sriram Krishnamoorthy, PhD, Arjan van der Flier, PhD, Alexandra Hicks, PhD, Melanie Demers, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2264.
https://doi.org/10.1182/blood-2019-128922
Published: 2019
Journal Articles

Genetic Activation of NRF2 By KEAP1 Inhibition Induces Fetal Hemoglobin Expression and Triggers Anti-Oxidant Stress Response in Erythroid Cells

Dipti Gupta, Samuel Lessard, PhD, Nancy Moore, Jicheng Duan, PhD, Yukio Nakamura, MD PhD, Feng-Chun Yang, MD PhD, Alexandra Hicks, PhD, David R. Light, PhD, Sriram Krishnamoorthy, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 210.
https://doi.org/10.1182/blood-2019-129479
Published: 2019
Journal Articles

Tecfidera Modulates Activation of Malignant B-Cells: Correlative Analysis from a Phase 1 Clinical Trial in Patients with Chronic Lymphocytic Leukemia

Christina Wu, PhD, Emanuela M. Ghia, PhD, Fitzgerald Lao, Minya Pu, PhD, Karen Messer, PhD, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD PhD, Dennis A. Carson, MD, Michael Y. Choi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3143.
https://doi.org/10.1182/blood-2018-99-119292
Published: 2018
Journal Articles

NRF2 Mediates Epigenetic Changes in DNA and Chromatin Structure to Regulate γ-Globin Gene Expression in a Human βYAC Transgenic Mouse Model

Xingguo Zhu, PhD, Alexander H. Ward, PhD, Caixia Xi, PhD, Betty S. Pace, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1053.
https://doi.org/10.1182/blood-2018-99-116438
Published: 2018
Journal Articles

Proteomic Analysis Reveals IRAK4 As a Therapeutic Target in Chronic Lymphocytic Leukemia

Christina Wu, PhD, Ekaterina Vinogradova, PhD, Fitzgerald Lao, Emily Nan, Katie Ta, Karen Messer, PhD, Michael Choi, MD, Benjamin F. Cravatt, PhD, Dennis A. Carson, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3838.
https://doi.org/10.1182/blood.V130.Suppl_1.3838.3838
Published: 2017
Journal Articles

Nrf2 Activation Attenuates Hemolysis but Promotes Pulmonary Vascular Dysfunction in Sickle Mice

Chibueze A. Ihunnah, PhD, Samit Ghosh, PhD, Scott A. Hahn, MS, Adam C Straub, PhD, Solomon F Ofori-Acquah, PhD
Journal: Blood
Blood (2016) 128 (22): 1296.
https://doi.org/10.1182/blood.V128.22.1296.1296
Published: 2016
Journal Articles

Dimethyl fumarate restores apoptosis sensitivity and inhibits tumor growth and metastasis in CTCL by targeting NF-κB

Jan P. Nicolay, Karin Müller-Decker, Anne Schroeder, Markus Brechmann, Markus Möbs, Cyrill Géraud, Chalid Assaf, Sergij Goerdt, Peter H. Krammer, Karsten Gülow
Journal: Blood
Blood (2016) 128 (6): 805–815.
https://doi.org/10.1182/blood-2016-01-694117
Published: 2016
Includes: Supplemental data
Journal Articles

Dimethyl Fumarate Induces Fetal Hemoglobin in Sickle Cell Disease

Sriram Krishnamoorthy, PhD, Dipti Gupta, MS, Sarah Sturtevant, Biaoru Li, PhD, Levi C Makala, DVM, MBA, PhD, William E. Hobbs, MDPhD, David R. Light, PhD, Betty Pace, MD
Journal: Blood
Blood (2015) 126 (23): 410.
https://doi.org/10.1182/blood.V126.23.410.410
Published: 2015
Journal Articles

Pharmacologic Modulation of STAT1 and Wnt Signaling in Chronic Lymphocytic Leukemia

Christina Wu, PhD, Fitzgerald S Lao, BS, Michael Y. Choi, MD, Dennis A. Carson, MD
Journal: Blood
Blood (2015) 126 (23): 4150.
https://doi.org/10.1182/blood.V126.23.4150.4150
Published: 2015
Journal Articles

Dimethyl Fumarate Induces Cytoprotection and Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Mice

John D. Belcher, PhD, Julia Nguyen, Chunsheng Chen, Fuad Abdulla, Phong Nguyen, Minh Nguyen, Ping Zhang, PhD, Pauline Xu, Nicholas J. Slipek, Gregory M. Vercellotti, MD
Journal: Blood
Blood (2014) 124 (21): 219.
https://doi.org/10.1182/blood.V124.21.219.219
Published: 2014
Journal Articles

Inhibition of Wnt Signaling By Dimethyl Fumarate Results in in Vitro and in Vivo Clearance of Chronic Lymphocytic Leukemia Cells and Has Additive Activity with Ibrutinib

Christina C.N. Wu, PhD, Fitzgerald Lao, Hongying Li, PhD, Laura Rassenti, PhD, Thomas J. Kipps, MD, Karen Messer, PhD, Dennis A. Carson, MD, Michael Y. Choi, MD
Journal: Blood
Blood (2014) 124 (21): 4683.
https://doi.org/10.1182/blood.V124.21.4683.4683
Published: 2014
Journal Articles

Monomethylfumarate (MMF), a Novel Inducer Of Fetal Hemoglobin In Human Erythroid Progenitors and Retinal Pigment Epithelial Cells

Levi Makala, PhD, DVM, Wanwisa Promsote, BS, Biaoru Li, PhD, Vadivel Ganapathy, PhD, Martin Pamela, PhD, Betty S. Pace, MD
Journal: Blood
Blood (2013) 122 (21): 317.
https://doi.org/10.1182/blood.V122.21.317.317
Published: 2013
Journal Articles

Large Scale Screening for DNA Damage-Induced Transcription Factors as Potential Targets for Treatment of CLL with p53 Apoptotic Defect.

Victoria Weston, PhD, Paul Moss, MBBS, PhD, FRCP, A. Malcolm R Taylor, PhD, Tatjana Stankovic, MD., PhD
Journal: Blood
Blood (2009) 114 (22): 3439.
https://doi.org/10.1182/blood.V114.22.3439.3439
Published: 2009