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Journal Articles

TET family dioxygenases and the TET activator vitamin C in immune responses and cancer

Xiaojing Yue, Anjana Rao
Journal: Blood
Blood (2020) 136 (12): 1394–1401.
https://doi.org/10.1182/blood.2019004158
Published: 2020
Journal Articles

Germline TET2 loss of function causes childhood immunodeficiency and lymphoma

Jarmila Stremenova Spegarova, Dylan Lawless, Siti Mardhiana Binti Mohamad, Karin R. Engelhardt, Gina Doody, Jennifer Shrimpton, Anne Rensing-Ehl, Stephan Ehl, Frederic Rieux-Laucat, Catherine Cargo, Helen Griffin, Aneta Mikulasova, Meghan Acres, Neil V. Morgan, James A. Poulter, Eamonn G. Sheridan, Philip Chetcuti, Sean O'Riordan, Rashida Anwar, Clive R. Carter, Stefan Przyborski, Kevin Windebank, Andrew J. Cant, Majlinda Lako, Chris M. Bacon, Sinisa Savic, Sophie Hambleton
Journal: Blood
Blood (2020) 136 (9): 1055–1066.
https://doi.org/10.1182/blood.2020005844
Published: 2020
Includes: Supplemental data
Journal Articles

The AHR: adaptive evolution or one-off?

Michael H. Kroll
Journal: Blood
Blood (2019) 134 (26): 2337–2338.
https://doi.org/10.1182/blood.2019003943
Published: 2019
Journal Articles

KDM6B Overexpression and TET2 Deficiency Cooperatively Drive Development of Myelodysplastic Syndrome and Chronic Myelomonocytic Leukemia-like Phenotype in Mice

Yue Wei, PhD, Hong Zheng, Naran Bao, Rashmi Kanagal-Shamanna, MD, Caleb Class, PhD, Hui Yang, PhDMD, Guillermo Montalban Bravo, MD, Irene Ganan-Gomez, PhD, Kelly Soltysiak, PhD, Kim-Ann Do, Simona Colla, PhD, Carlos E. Bueso-Ramos, MD PhD, Guillermo Garcia-Manero, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 562.
https://doi.org/10.1182/blood-2019-122574
Published: 2019
Journal Articles

Recipient Signaling through the Cannabinoid Type 2 Receptor Regulates IL-6 Independent Neuroinflammation during Graft Versus Host Disease

Alison Moe, PhD, Garrett Sauber, BS, Vivian Zhou, PhD, Anissa Lapitz, BS, Cecilia Hillard, PhD, William R. Drobyski, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 195.
https://doi.org/10.1182/blood-2019-122746
Published: 2019
Journal Articles

R-2HG/KDM2B/RIPK1 Signaling Mediates Necroptosis in Myelodysplastic Syndromes

Shuanghong Zhu, Chen Mei, Hongyan Tong, Jie Jin, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5049.
https://doi.org/10.1182/blood-2019-125482
Published: 2019
Journal Articles

High Expression of BCAT1 promotes Acute Myeloid Leukemia Progression and Sensitize to PARP Inhibitor

Jie Jin, PhD, Jie Jin, PhD, Jiajia Pan, Yungui Wang, PhD, Shujuan Huang, Shihui Mao, Qing Ling, Jinghan Wang, MD PhD, Chenying Li
Journal: Blood
Blood (2019) 134 (Supplement_1): 5041.
https://doi.org/10.1182/blood-2019-125221
Published: 2019
Journal Articles

Comprehensive DNA 5-Hydroxymethylation Landscapes in Myelodysplastic Syndromes (MDS)

Jia Li, PhD, Yue Wei, PhD, Minjung Lee, MS, Caleb Class, PhD, Hui Yang, PhDMD, Deqiang Sun, PhD, Guillermo Garcia-Manero, MD, Yun Huang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2996.
https://doi.org/10.1182/blood-2019-128599
Published: 2019
Journal Articles

Reversible TET Inhibitor As a Hematopoietic Stem Cell Booster: A Novel Strategy to Improve Stem Cell Function

Sunisa Kongkiatkamon, Yihong Guan, PhD, Anand Tiwari, Phillip J Maciejewski, Dale Grabowski, BS, Sergei Vatolin, PhD, Vera Adema, PhD, Cassandra M Kerr, MS, Yasunobu Nagata, MD PhD, Milo Co, Christina Snider, Hassan Awada, Jibran Durrani, Yvonne Parker, Daniel J. Lindner, Mikkael A. Sekeres, MD MS, Valeria Visconte, PhD, James G Phillips, PhD, Jaroslaw P. Maciejewski, MD PhD, Babal K. Jha, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2472.
https://doi.org/10.1182/blood-2019-129056
Published: 2019
Journal Articles

Mechanisms of Tolerance Induction through T Regulatory Cells during Chemotherapy-Mediated Immunogenic Cell Death in Acute Myeloid Leukemia

Darina Ocadlikova, PhD, Serenella Casella, Ines Pintao, Elena Adinolfi, Sabina Sangaletti, PhD, Elena De Marchi, Anna Pegoraro, Elisa Orioli, Mario Paolo Colombo, Francesco Di Virgilio, Michele Cavo, Antonio Curti, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2332.
https://doi.org/10.1182/blood-2019-126478
Published: 2019
Journal Articles

Myelodysplastic Syndromes-Associated Gene Mutations Lead to Pseudohypoxia Condition and Epigenome Hyper-Methylation in Mouse Genetic Models

Asumi Yokota, PhD, Lulu Zhang, PhD, Jianhua Feng, Xiaomin Feng, MD PhD, Xiaomei Yan, MD PhD, Gang Huang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1696.
https://doi.org/10.1182/blood-2019-126799
Published: 2019
Journal Articles

TET Dioxygenase Inhibition As a Therapeutic Strategy in TET2 Mutant Myeloid Neoplasia

Yihong Guan, PhD, Anand D. Tiwari, PhD, James G Phillips, PhD, Metis Hasipek, PhD, Dale Grabowski, BS, Cassandra M Kerr, MS, Vera Adema, PhD, Yasunobu Nagata, MD PhD, Valeria Visconte, PhD, Tomas Radivoyevitch, PhD, Daniel Lindner, MD PhD, Manja Meggendorfer, PhD, Mohamed Abazeed, Mikkael A. Sekeres, MD MS, Torsten Haferlach, MD, Jaroslaw P. Maciejewski, MD PhD, Babal K. Jha, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 880.
https://doi.org/10.1182/blood-2019-131920
Published: 2019
Journal Articles

Indoleamine 2,3-Dioxygenase-1 Expressing Dendritic Cell Populations Are Associated with Tumor-Induced Immune Tolerance & Aggressive Disease Biology in Chronic Myelomonocytic Leukemia

Abhishek A. Mangaonkar, MD, Kaaren K. Reichard, MD, April Chiu, MD, Matthew T Howard, MD, Rebecca L King, MD, Ryan M. Carr, MD, PhD, Bonnie M Alver, Keith D. Robertson, Margot Cousin, PhD, Jose C Villasboas, Martin E. Fernandez-Zapico, MD, Terra L. Lasho, PhD, Naseema Gangat, MBBS, Aref Al-Kali, MD, Michelle A. Elliott, MD, William J. Hogan, MBBCh, Mark R. Litzow, MD, Animesh Pardanani, MBBS, PhD, Eric Solary, MD PhD, Ayalew Tefferi, MD, Mrinal M. Patnaik, MD MBBS
Journal: Blood
Blood (2018) 132 (Supplement 1): 4344.
https://doi.org/10.1182/blood-2018-99-113881
Published: 2018
Journal Articles

Lessons from Nature: A Novel Class of TET Inhibitors for TET2 Mutant Associated Diseases

Yihong Guan, Anand D. Tiwari, PhD, Metis Hasipek, PhD, Dale Grabowski, BS, Yvonne Parker, Cassandra M. Hirsch, Amy C Graham, BS, MS, Yasunobu Nagata, Bartlomiej P. Przychodzen, Aziz Nazha, Daniel Lindner, MD PhD, Tomas Radivoyevitch, PhD, James G Phillips, PhD, Jaroslaw P. Maciejewski, Babal K. Jha
Journal: Blood
Blood (2018) 132 (Supplement 1): 4345.
https://doi.org/10.1182/blood-2018-99-117186
Published: 2018
Journal Articles

Modulation of TET2 Activity By Ascorbic Acid and Factors Affecting Lysine Acetylation

Yihong Guan, Edward F Greenberg, MD, Metis Hasipek, PhD, Cassandra M. Hirsch, Amy C Graham, BS, MS, Tomas Radivoyevitch, PhD, Shi Chen, Xiaochen Liu, Valeria Visconte, PhD, Dewen You, PhD, Eiju Negoro, MD PhD, Bartlomiej P. Przychodzen, Hideki Makishima, MD PhD, Aziz Nazha, Daniel Gackowski, PhD, Ewelina Zarakowska, Mridul Mukherji, D.Phil., Mikkael A. Sekeres, MD MS, Mingjiang Xu, MD PhD, Ryszard Ólinski, Professor, Jaroslaw P. Maciejewski, Babal K. Jha
Journal: Blood
Blood (2018) 132 (Supplement 1): 4346.
https://doi.org/10.1182/blood-2018-99-119712
Published: 2018
Journal Articles

Vector Integration and Efficacy of CD19-Directed CAR T Cell Therapy in Acute Lymphoblastic Leukemia (ALL) and Chronic Lymphocytic Leukemia (CLL)

Christopher L Nobles, PhD, John K Everett, Shantan Reddy, Joseph A Fraietta, PhD, David L. Porter, MD, Noelle V. Frey, MD, Stephan A. Grupp, MD PhD, Don L. Siegel, MD PhD, Simon F Lacey, PhD BS, Carl H June, MD, Frederic D Bushman, PhD, J. Joseph Melenhorst, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4548.
https://doi.org/10.1182/blood-2018-99-117034
Published: 2018
Journal Articles

The Effect of TET Mutations on DNA Methyltransferase Cytotoxicity and ERV Induction in B and T Cell Malignancies

Juan Carlos Nogues, BS, Zi Michael Wang, BS, Sarah School Chisholm, MA, Mitcell Smith, MD PhD, Eduardo Sotomayor, MD, Katherine Chiappinelli, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5157.
https://doi.org/10.1182/blood-2018-99-120281
Published: 2018
Journal Articles

Disruption of TET2 Dioxygenase Enhances Antitumor Efficiency in CD8+ Tumor Infiltrating Lymphocytes

Minjung Lee, MS, Hongxiang Zeng, PhD, Jia Li, PhD, Wei Han, MS, Deqiang Sun, PhD, Yun Huang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 860.
https://doi.org/10.1182/blood-2018-99-115405
Published: 2018
Journal Articles

Antibiotics Treatment Ameliorates TET2 Loss of Function Associated Hematological Malignancies

Hongxiang Zeng, PhD, Hailan He, MS, Jia Li, PhD, Wei Han, MS, Anna Guzman, Deqiang Sun, PhD, Katherine Y. King, MD PhD, Margaret A. Goodell, PhD, Yun Huang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2610.
https://doi.org/10.1182/blood-2018-99-116424
Published: 2018
Journal Articles

Predictive Response Biomarkers for BET Inhibitors in AML

Joseph J Saad, MSc, BSc, Juho Miettinen, PhD, Dimitrios Tsallos, BSc(Hons),MSc, Samuli Eldfors, PhD, Mika Kontro, MD, Krister Wennerberg, PhD, Olli Kallioniemi, MD PhD, Kimmo Porkka, MD PhD, Jing Tang, PhD, Caroline A Heckman, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2749.
https://doi.org/10.1182/blood-2018-99-118363
Published: 2018