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Journal Articles

Class I PI3K Is Required for HSC Differentiation

Kristina Ames, PhD, Imit Kaur, PhD, Meng Tong, Shayda Hemmati, PhD, Ellen Tein, Shira Glushakow-Smith, Lindsay Gurska, Kira Gritsman, MD PhD

Blood (2019) 134 (Supplement_1): 2461.

https://doi.org/10.1182/blood-2019-123823

Published: 2019

Journal Articles

Comprehensive Analysis of 22 Cases with Blastic Plasmacytoid Dendritic Cell Neoplasm Reveals Mutations in DNA Repair Genes and Two Distinct Subgroups Defined By Differential Gene Expression with Prognostic Impact

Anna Stengel, PhD, Wencke Walter, PhD, Constance Baer, PhD, Manja Meggendorfer, PhD, Wolfgang Kern, MD, Torsten Haferlach, MD, Claudia Haferlach, MD

Blood (2019) 134 (Supplement_1): 1234.

https://doi.org/10.1182/blood-2019-125645

Published: 2019

Journal Articles

DNA Repair Genes' Expression Abnormalities in De Novo Acute Myelogenous Leukemia (AML): Implications for Targeted Treatment

Frieda Kontsioti, PhD, Eirini Maratou, PhD, Anthi Bouhla, MD, Vassiliki Mpakou, PhD, Konstantinos Gkodopoulos, MD, Georgia Stavroulaki, MD, Eirini Glezou, MD, Thomas Thomopoulos, MD, Efthimia Bazani, MD, Sotirios Papageorgiou, MD PhD, Argiris Symeonidis, MD PhD, George Dimitriadis, MD, Vassiliki Pappa, MD

Blood (2019) 134 (Supplement_1): 5176.

https://doi.org/10.1182/blood-2019-127501

Published: 2019

Journal Articles

Pathogenic Germline Variants in Acquired Aplastic Anemia (AA) and Paroxysmal Nocturnal Hemoglobinuria (PNH)

Wenyi Shen, MD, Cassandra M. Hirsch, Bartlomiej P. Przychodzen, Hideki Makishima, MD PhD, Louis Williams, MD MBA, Sudipto Mukherjee, MD PhD MPH, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski

Blood (2018) 132 (Supplement 1): 2583.

https://doi.org/10.1182/blood-2018-99-115228

Published: 2018

Journal Articles

DNA Repair Genes May Influence Cognitive Outcomes in Adult Patients with Hematologic Malignancies (HM) Treated with Blood or Marrow Transplantation (BMT)

Noha Sharafeldin, MBBCh, MSc, PhD, Alysia Bosworth, BA, Yanjun Chen, MS, Purnima Singh, PhD BS, MSc, Sunita Patel, PhD, Xuexia Wang, PhD, Emily Morse, MA, Molly Mather, MS, Can-Lan Sun, PhD, Liton F. Francisco, BS, Stephen J Forman, F. Lennie Wong, PhD, Smita Bhatia, MD MPH

Blood (2018) 132 (Supplement 1): 3411.

https://doi.org/10.1182/blood-2018-99-113043

Published: 2018

Journal Articles

Analysis of Even a Limited Number of Genes Indicates a Strong Inherited Component in Otherwise Typical Sporadic MDS

Cassandra M. Hirsch, Wenyi Shen, MD, Bartlomiej P. Przychodzen, Yasunobu Nagata, Vera Adema, PhD, Teodora Kuzmanovic, BA, Louis Williams, MD MBA, Aziz Nazha, Valeria Visconte, PhD, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski

Blood (2018) 132 (Supplement 1): 3074.

https://doi.org/10.1182/blood-2018-99-116535

Published: 2018

Journal Articles

A Protective Role of DNA Repair Genes Against Acute Graft Versus Host Disease in Children

Patricia Huezo-Diaz, Chakradhara RS Uppugunduri, PhD, Mohamed Aziz Rezgui, MsC, Anuj Tyagi, PhD, Vid Mlakar, PhD, Laurence Lesne, MSc, Tiago Nava, MD, Yves Theoret, PhD, Yves Chalandon, MD PhD, Robbert Bredius, PhD MD, Jean-Hugues Dalle, MD PhD, Peter Bader, MD PhD, Christina Peters, MD, Henrique Bittencourt, MD PhD, Maja Krajinovic, MD PhD, Marc Ansari, MD

Blood (2017) 130 (Supplement 1): 749.

https://doi.org/10.1182/blood.V130.Suppl_1.749.749

Published: 2017

Journal Articles

Transcriptome of DNA Repair Genes in CMML: Rationale for Targeting ERCC1 and CDKN1A As a Synthetic Lethality Approach

Blood (2017) 130 (Supplement 1): 1679.

https://doi.org/10.1182/blood.V130.Suppl_1.1679.1679

Published: 2017

Journal Articles

Rare Variants Affecting the Fanconi Anaemia DNA Repair Genes Associate with Increased Risk for AML

Kyaw Ze Ya Maung, BSc, Paul Leo, PhD, Anna L Brown, PhD, Mahmoud A Bassal, Bsc, BCompSc, Debora A. Casolari, PhD, Adam Ewing, B.A & PhD, Emma Duncan, PhD, Sarah C Bray, PhD, Evgeny Glazov, PhD, Luen Bik To, MBBS, FRACP, FRCPA, PhD, Russell Saal, MMSc, BSMedTech, Ian D Lewis, MBBS, PhD FRACP, FRCPA, Devinder S Gill, MBChB FRCPath MRCP, Paula Marlton, MBBS, FRACP, FRCPA, James X Gray, MD PhD, Thomas J Gonda, PhD, Richard D'Andrea, PhD

Blood (2016) 128 (22): 41.

https://doi.org/10.1182/blood.V128.22.41.41

Published: 2016

Journal Articles

Altered Expression of the Repair Genes in CD34+ Cells May be Responsible for Formation and Accumulation of Mutations in MDS Patients

Jan Valka, MD, Monika Belickova, Jitka Vesela, Eliska Stara, Barbora Pejsova, Anna Jonasova, MD PhD

Blood (2015) 126 (23): 4119.

https://doi.org/10.1182/blood.V126.23.4119.4119

Published: 2015

Journal Articles

Acute Myeloid Leukemia in the Elderly Is Characterized By a Distinct Genetic Landscape

Patricia Silva, Martin Neumann, MD, Sebastian Vosberg, Cornelia Schlee, Konstandina Isaakidis, Michael P Schroeder, Jutta Ortiz-Tánchez, Lars R. Fransecky, Teresa Hartung, Alexander Graf, PhD, Stefan Krebs, PhD, Helmut Blum, PhD, Gerhard Ehninger, Hubert Serve, MD, Wolfgang E Berdel, MD, Philipp A. Greif, Christoph Röllig, MD, Claudia D Baldus, MD

Blood (2015) 126 (23): 804.

https://doi.org/10.1182/blood.V126.23.804.804

Published: 2015

Journal Articles

Characterization of the Mutational Spectrum in Young Patients with Myelodysplastic Syndrome

Cassandra M Hirsch, Bartlomiej Przychodzen, MSc, Tomas Radivoyevitch, PhD, Sean Hobson, Bhumika J. Patel, Swapna Thota, MD, Michael J. Clemente, Hetty E. Carraway, MD MBA, Mikkael A Sekeres, MD MS, Jaroslaw P. Maciejewski, MD PhD

Blood (2015) 126 (23): 5218.

https://doi.org/10.1182/blood.V126.23.5218.5218

Published: 2015

Journal Articles

Deletion of Nono, a Novel Double-Strand Break Repair Factor, Leads to Hematopoietic Stem Cell Defects

Liliana Souza, PharmD PhD, Shuyi Li, MDPhD, Erica Silva, PhD, Zhentian Li, PhD, Shu Feng-jue, PhD, Hairong Xiong, PhD, William S. Dynan, PhD, Morgan L. McLemore, MD

Blood (2014) 124 (21): 478.

https://doi.org/10.1182/blood.V124.21.478.478

Published: 2014

Journal Articles

Hereditary Mutations Are Present As Pathogenic or Predisposition Factors in Otherwise Typical Adult MDS

Bartlomiej P Przychodzen, Hideki Makishima, MD PhD, Brittney Dienes, Tomas Radivoyevitch, PhD, Hetty E. Carraway, MD MBA, Swapna Thota, MD, Bhumika J Patel, MD, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski, MD PhD

Blood (2014) 124 (21): 3233.

https://doi.org/10.1182/blood.V124.21.3233.3233

Published: 2014

Journal Articles

Microsatellite Instability Induced Mutation in DNA Repair Genes, CTiP and Mre11 Confer Hypersensitivity to PARP Inhibitors in Myeloid Malignancies

Terry J Gaymes, DPhil, Rajani Chelliah, BSc, MSc, Austin G Kulasekararaj, Azim M Mohamedali, PhD, Sydney Shall, DPhil, Ghulam J. Mufti, MD

Blood (2011) 118 (21): 276.

https://doi.org/10.1182/blood.V118.21.276.276

Published: 2011

Journal Articles

Targeting DNA Repair Gene, RAD52, Induces Exhaustion of the Proliferating CML-CP Leukemia Stem Cells Carrying Oxidative DNA Damage

Kimberly Cramer, Elisabeth Bolton, Margaret Nieborowska-Skorska, MD, PhD, Sylwia Flis, Tomasz Skorski, MD, PhD

Blood (2011) 118 (21): 447.

https://doi.org/10.1182/blood.V118.21.447.447

Published: 2011

Journal Articles

Dysfunctional Double-Strand DNA Break Repair In Primary t-AML/t-MDS Myeloblasts.

Meagan A Jacoby, MD/PhD, Rigoberto de Jesus, Matthew J. Walter, MD

Blood (2010) 116 (21): 3366.

https://doi.org/10.1182/blood.V116.21.3366.3366

Published: 2010

Journal Articles

Microsatellite Instability (MSI) In High Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukaemia (AML) Cells Promotes Frameshift Mutations In DNA Repair Genes: Indications for PARP Inhibitor Therapy.

Terry J Gaymes, DPhil, Azim Mohamedali, PHD, Austin G Kulasekararaj, Sydney Shall, DPhil, Ghulam J. Mufti, DM, FRCP, FRCPath

Blood (2010) 116 (21): 1194.

https://doi.org/10.1182/blood.V116.21.1194.1194

Published: 2010

Journal Articles

Novel SIRT1 Agonists, SRT501 and SRT2183, Induce Expression of DNA Repair Genes and Apoptosis of Ph − Acute Lymphoblastic Leukemia Cells Alone and in Combination with the HDAC Inhibitor LBH589..

Anna Scuto, Mark Kirschbaum, MD, Jennifer M Cermak, Peter Atadja, Richard Jove

Blood (2009) 114 (22): 3083.

https://doi.org/10.1182/blood.V114.22.3083.3083

Published: 2009

Journal Articles

Association Between Genetic Polymorphism in DNA Repair Genes and Acute Myeloid Leukemia.

Hee Nam Kim, PhD, Nan young Kim, Li Yu, Huong Thi Thanh Tran, Yeo-Kyeoung Kim, Il-Kwon Lee, Deok-Hwan Yang, Je-Jung Lee, Hee-Je Kim, Woo-Sung Min, Moo-Rim Park, Deog Yeon Jo, Jong Ho Won, Jae-Yong Kwak, Hyeoung-Joon Kim

Blood (2009) 114 (22): 4131.

https://doi.org/10.1182/blood.V114.22.4131.4131

Published: 2009

NARROW

Class I PI3K Is Required for HSC Differentiation

Comprehensive Analysis of 22 Cases with Blastic Plasmacytoid Dendritic Cell Neoplasm Reveals Mutations in DNA Repair Genes and Two Distinct Subgroups Defined By Differential Gene Expression with Prognostic Impact

DNA Repair Genes' Expression Abnormalities in De Novo Acute Myelogenous Leukemia (AML): Implications for Targeted Treatment

Pathogenic Germline Variants in Acquired Aplastic Anemia (AA) and Paroxysmal Nocturnal Hemoglobinuria (PNH)

DNA Repair Genes May Influence Cognitive Outcomes in Adult Patients with Hematologic Malignancies (HM) Treated with Blood or Marrow Transplantation (BMT)

Analysis of Even a Limited Number of Genes Indicates a Strong Inherited Component in Otherwise Typical Sporadic MDS

A Protective Role of DNA Repair Genes Against Acute Graft Versus Host Disease in Children

Transcriptome of DNA Repair Genes in CMML: Rationale for Targeting ERCC1 and CDKN1A As a Synthetic Lethality Approach

Rare Variants Affecting the Fanconi Anaemia DNA Repair Genes Associate with Increased Risk for AML

Altered Expression of the Repair Genes in CD34+ Cells May be Responsible for Formation and Accumulation of Mutations in MDS Patients

Acute Myeloid Leukemia in the Elderly Is Characterized By a Distinct Genetic Landscape

Characterization of the Mutational Spectrum in Young Patients with Myelodysplastic Syndrome

Deletion of Nono, a Novel Double-Strand Break Repair Factor, Leads to Hematopoietic Stem Cell Defects

Hereditary Mutations Are Present As Pathogenic or Predisposition Factors in Otherwise Typical Adult MDS

Microsatellite Instability Induced Mutation in DNA Repair Genes, CTiP and Mre11 Confer Hypersensitivity to PARP Inhibitors in Myeloid Malignancies

Targeting DNA Repair Gene, RAD52, Induces Exhaustion of the Proliferating CML-CP Leukemia Stem Cells Carrying Oxidative DNA Damage

Dysfunctional Double-Strand DNA Break Repair In Primary t-AML/t-MDS Myeloblasts.

Microsatellite Instability (MSI) In High Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukaemia (AML) Cells Promotes Frameshift Mutations In DNA Repair Genes: Indications for PARP Inhibitor Therapy.

Novel SIRT1 Agonists, SRT501 and SRT2183, Induce Expression of DNA Repair Genes and Apoptosis of Ph − Acute Lymphoblastic Leukemia Cells Alone and in Combination with the HDAC Inhibitor LBH589..

Association Between Genetic Polymorphism in DNA Repair Genes and Acute Myeloid Leukemia.

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American Society of Hematology

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American Society of Hematology

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