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Kimberly Cramer
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Journal Articles

Identification of a Small Molecule Inhibitor of RAD52 to Induce Synthetic Lethality in BRCA-Deficient Leukemias

Katherine Sullivan, Kimberly Cramer-Morales, Daniel L McElroy, David Ostrov, Kimberly Haas, Margaret Nieborowska-Skorska, Wayne Childers, Alexander Mazin, Robert A Hromas, Richard Pomerantz, Tomasz Skorski
Journal: Blood
Blood (2015) 126 (23): 4434.
https://doi.org/10.1182/blood.V126.23.4434.4434
Published: 2015
Journal Articles

Gene Expression and Mutation Analysis (GEMA) –Guided Precision Medicine Targeting PARP1 to Induce Synthetic Lethality in DNA-PK –Deficient Quiescent and BRCA-Deficient Proliferating Leukemia Stem and Progenitor Cells

Margaret Nieborowska-Skorska, MD PhD, Katherine Sullivan, Paulina Podszywalow-Bartnicka, Grazyna Hoser, PhD, Elisabeth Bolton-Gillespie, Kimberly Cramer-Morales, Artur Slupianek, PhD, Chun Zhou, PhD, Sabine Cerny-Reiterer, DVM, Tomasz Stoklosa, MD PhD, Stephen M. Sykes, PhD, Peter Valent, MD, Curt I. Civin, MD, Markus Muschen, MD PhD, Mark D. Minden, MD PhD, Kolja Eppert, PhD, Tomasz Skorski, MD PhD
Journal: Blood
Blood (2014) 124 (21): 480.
https://doi.org/10.1182/blood.V124.21.480.480
Published: 2014
Journal Articles

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile

Kimberly Cramer-Morales, Margaret Nieborowska-Skorska, Kara Scheibner, Michelle Padget, David A. Irvine, Tomasz Sliwinski, Kimberly Haas, Jaewoong Lee, Huimin Geng, Darshan Roy, Artur Slupianek, Feyruz V. Rassool, Mariusz A. Wasik, Wayne Childers, Mhairi Copland, Markus Müschen, Curt I. Civin, Tomasz Skorski
Journal: Blood
Blood (2013) 122 (7): 1293–1304.
https://doi.org/10.1182/blood-2013-05-501072
Published: 2013
Includes: Multimedia, Supplemental data
Journal Articles

RAD52-Dependent Synthetic Lethality Eradicates Leukemia Stem Cells

Kimberly Cramer, Ph.D., Margaret Nieborowska-Skorska, MD, PhD, Artur Slupianek, PhD, Tomasz Sliwinski, David Irvine, Mhairi Copland, PhD, BSc, MRCP, FRCPath, Tomasz Skorski, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3.
https://doi.org/10.1182/blood.V120.21.3.3
Published: 2012
Journal Articles

Rac2-MRC-cIII–generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors

Margaret Nieborowska-Skorska, Piotr K. Kopinski, Regina Ray, Grazyna Hoser, Danielle Ngaba, Sylwia Flis, Kimberly Cramer, Mamatha M. Reddy, Mateusz Koptyra, Tyrone Penserga, Eliza Glodkowska-Mrowka, Elisabeth Bolton, Tessa L. Holyoake, Connie J. Eaves, Sabine Cerny-Reiterer, Peter Valent, Andreas Hochhaus, Timothy P. Hughes, Heiko van der Kuip, Martin Sattler, Wieslaw Wiktor-Jedrzejczak, Christine Richardson, Adrienne Dorrance, Tomasz Stoklosa, David A. Williams, Tomasz Skorski
Journal: Blood
Blood (2012) 119 (18): 4253–4263.
https://doi.org/10.1182/blood-2011-10-385658
Published: 2012
Includes: Supplemental data
Journal Articles

Targeting Rac2 - Mitochondrial Respiratory Chain Complex III Signaling to Prevent Genomic Instability in Leukemia Stem and Progenitor Cells

Margaret Nieborowska-Skorska, MD, PhD, Piotr Kopinski, Regina Ray, Grazyna Hoser, PhD, Danielle Ngaba, Sylwia Flis, Kimberly Cramer, Mamatha M. Reddy, PhD, Mateusz Koptyra, PhD, Tyrone Penserga, Eliza Glodkowska-Mrowka, MD, Magdalena Ambrozek, Ilona Seferynska, MD, PhD, Joanna Niesiobedzka-Krezel, MD, Elisabeth Bolton, Artur Slupianek, PhD, Tessa L. Holyoake, PhD, FRCP, FRCPath, Connie J. Eaves, PhD, Sabine Cerny-Reiterer, D.V.M., Peter Valent, M.D., Andreas Hochhaus, MD, Timothy P. Hughes, MD, MBBS, Heiko van der Kuip, Martin Sattler, PhD, Wieslaw Wiktor-Jedrzejczak, MD, PhD, Christine Richardson, PhD, Adrienne M. Dorrance, PhD, Tomasz Stoklosa, MD, PhD, David A. Williams, MD, Tomasz Skorski, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 2736.
https://doi.org/10.1182/blood.V118.21.2736.2736
Published: 2011
Journal Articles

Targeting DNA Repair Gene, RAD52, Induces Exhaustion of the Proliferating CML-CP Leukemia Stem Cells Carrying Oxidative DNA Damage

Kimberly Cramer, Elisabeth Bolton, Margaret Nieborowska-Skorska, MD, PhD, Sylwia Flis, Tomasz Skorski, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 447.
https://doi.org/10.1182/blood.V118.21.447.447
Published: 2011
Journal Articles

Targeting Phosphotyrosine-315 In RAD51 Recombinase to Prevent BCR-ABL1 - Mediated Unfaithful Homeologous Recombination Repair.

Artur Slupianek, PhD, Yashodhara Dasgupta, Shu-yue Ren, PhD, Kimberly Cramer, Tomasz Skorski, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 1190.
https://doi.org/10.1182/blood.V116.21.1190.1190
Published: 2010
Journal Articles

Targeting BCR/ABL-RAD51 Interaction to Prevent Unfaithful Homeologous Recombination Repair.

Artur Slupianek, PhD, Yashodhara Dasgupta, Shuyue Ren, MD, PhD, Kimberly Cramer, Tomasz Skorski, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 3272.
https://doi.org/10.1182/blood.V114.22.3272.3272
Published: 2009
Journal Articles

BCR/ABL Kinase Elevates ROS-Mediated Oxidative DNA Damage in CML Stem/Progenitor Cells and Affects the Efficiency and Fidelity of DNA Repair To Induce Genetic Instability.

Margaret Nieborowska-Skorska, MD, PhD, Artur Slupianek, PhD, Tomasz Stoklosa, MD, Tomasz Poplawski, PhD, Kimberly Cramer, Tomasz Skorski
Journal: Blood
Blood (2007) 110 (11): 34.
https://doi.org/10.1182/blood.V110.11.34.34
Published: 2007
Journal Articles

BCR/ABL and Other Oncogenic Fusion Tyrosine Kinases (FTKs) Stimulate Single Strand Annealing (SSA), the Rare and Extremely Unfaithful DNA Double-Strand Break Repair Pathway To Facilitate Genomic Instability in Hematologic Malignancies.

Kimberly Cramer, Emir T. Penserga, Akhil Reddy, Jonathan Wosen, Tomasz Skorski
Journal: Blood
Blood (2007) 110 (11): 998.
https://doi.org/10.1182/blood.V110.11.998.998
Published: 2007