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Journal Articles

Inhibition of PIM Kinases Targets Synthetic Vulnerabilities and Enhances Antigen Presentation in B-Cell Lymphoma

Patrizia Mondello, MD PhD MSc, Chiara Tarantelli, PhD, Luciano Cascione, PhD, Alberto Arribas, PhD, Andrea Rinaldi, Anas Younes, MD, Francesco Bertoni, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2858.
https://doi.org/10.1182/blood-2019-125123
Published: 2019
Journal Articles

A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance Via Blocking Receptor Auto-Induction and BIM/Bmf Expression in ALL

Jianping Li, MD, Catalina Troche, PhD, Julia Hlavka Zhang, BS, Jonathan Shrimp, PhD, Jacob S. Roth, PhD, Duohui Jing, PhD, Alok Swaroop, PhD, Marta Kulis, Jon Oyer, PhD, Christine Will, MS, Daphne Dupere-Richer, PhD, Alberto Riva, PhD, Crissandra Pipe, LATG, Amin Sobn, PhD, Sharon Norton, MS, Richard Lynn Bennett, PhD, Min Shen, PhD, Matthew D. Hall, PhD, Richard B. Lock, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3758.
https://doi.org/10.1182/blood-2019-126910
Published: 2019
Journal Articles

Staurosporine Induces Caspase-Dependent Proteolysis of MEF2D-Fusion Protein and Cell Death Selective to MEF2D-Fusion-Positive ALL Cells

Naoyuki Tange, MD, Fumihiko Hayakawa, MD, PhD, Takahiko Yasuda, MD, PhD, Hideyuki Yamamoto, MD, Daiki Hirano, MD, PhD, Shinobu Tsuzuki, MD,PhD, Hitoshi Kiyoi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1349.
https://doi.org/10.1182/blood-2019-123602
Published: 2019
Journal Articles

A High-Throughput Screening Approach to Identify Therapeutics for the Treatment of Diamond-Blackfan Anaemia

Lorena Nunez Villacis, Sheren J Al-Obaidi, Piyush Madhamshettiwar, PhD, Nadine Hein, PhD, Jun Chen, MD PhD, Priscilla Soo, Perlita Poh, Megan Pavy, Kaylene J Simpson, PhD, Thomas John Gonda, PhD BSc, Richard B Pearson, PhD, Johan Flygare, MD PhD, Katherine M Hannan, PhD, Amee J George, PhD, Ross Hannan, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3859.
https://doi.org/10.1182/blood-2018-99-114303
Published: 2018
Journal Articles

A Safety Study of the Addition of Omacetaxine to the Standard-of-Care Induction Regimen of Cytarabine and Idarubicin in Newly-Diagnosed AML Patients

Sonia Christian, MD, Kelley E. Kozma, DO, Stephanie Barath, Ardaman Shergill, MD, Damiano Rondelli, MD, David Peace, MD, Santosh L. Saraf, MD, Annie Lee Oh, MD, Karen Sweiss, PharmD, Irum Khan, MBBS, Pritesh Patel, MD, Arkadiusz Dudek, MD PhD, John G. Quigley
Journal: Blood
Blood (2018) 132 (Supplement 1): 5218.
https://doi.org/10.1182/blood-2018-99-111412
Published: 2018
Journal Articles

Enhanced Selective Inhibition of KRAS Mutant Hematopoietic Progenitor Cell Expansion By MEK and Bcl-2 Inhibition

Huan-Ting Lin, PhD, Kenji Kubara, Kazuto Yamazaki, PhD, Masatoshi Takagi, MD PhD, Takuya Naruto, MD PhD, Tomohiro Morio, MD PhD, Takashi Okumura, PhD, Makoto Otsu, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1278.
https://doi.org/10.1182/blood-2018-99-117889
Published: 2018
Journal Articles

A Yoda1-Based Approach to Investigate Piezo1 Channels in Red Blood Cells Using Automated Patch Clamp Technology

Maria Giustina Rotordam, BSc, MSc, Elisa Fermo, PhD, Nadine Becker, PhD, Wilma Barcellini, MD, Andrea Brüggemann, PhD CSO, Niels Fertig, PhD CEO, Stéphane Egée, PhD, Markus Rapedius, PhD, Paola Bianchi, BSc, PhD, Lars Kaestner, Dr. rer. nat.
Journal: Blood
Blood (2018) 132 (Supplement 1): 1031.
https://doi.org/10.1182/blood-2018-99-118043
Published: 2018
Journal Articles

Discovery of DNA G-Quadruplexes As a New Target for B-Cell Receptor Signaling Inhibition in Diffuse Large B-Cell Lymphoma

Ying-Zhi Xu, PhD, Thomas Raney, Samantha L. Kendrick, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3502.
https://doi.org/10.1182/blood-2018-99-116793
Published: 2018
Journal Articles

Interferon-Gamma Pathway Regulates Emergence of Engraftable Hematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells

Ryohichi Sugimura, MD PhD, Clara Soria Valles, George Q. Daley, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2426.
https://doi.org/10.1182/blood.V130.Suppl_1.2426.2426
Published: 2017
Journal Articles

Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma

Sophia Gayle, Sean Landrette, Neil Beeharry, Chris Conrad, Marylens Hernandez, Paul Beckett, Shawn M. Ferguson, Talya Mandelkern, Meiling Zheng, Tian Xu, Jonathan Rothberg, Henri Lichenstein
Journal: Blood
Blood (2017) 129 (13): 1768–1778.
https://doi.org/10.1182/blood-2016-09-736892
Published: 2017
Includes: Supplemental data
Journal Articles

Targeting Pre-Leukemic Stem Cells in T-Acute Lymphoblastic Leukemia

Bastien Gerby, PhD, Diogo F.T Veiga, PhD, Jana Krosl, PhD, Julianne Ouellette, André Haman, Geneviève Lavoie, PhD, Iman Fares, MSc, Mathieu Tremblay, PhD, Véronique Litalien, Elizabeth Ottoni, Milena Kosic, Dominique Geoffrion, Joël Ryan, Paul Maddox, PhD, Jalila Chagraoui, PhD, Anne Marinier, PhD, Josée Hébert, MD, Guy Sauvageau, MD, PhD, Benjamin H Kwok, PhD, Philippe P Roux, PhD, Trang Hoang, PhD
Journal: Blood
Blood (2016) 128 (22): 527.
https://doi.org/10.1182/blood.V128.22.527.527
Published: 2016
Journal Articles

Identification of Novel Immune-Checkpoint Molecules on Multiple Myeloma Cells Using a High-Throughput Discovery Platform

Valentina Volpin, Till Michels, Antonio Sorrentino, Dirk Hose, Anthony D. Ho, MD, Hartmut Goldschmidt, MD, Philipp Beckhove, Mathias Witzens-Harig, MD
Journal: Blood
Blood (2016) 128 (22): 380.
https://doi.org/10.1182/blood.V128.22.380.380
Published: 2016
Journal Articles

Rearrangements in Nucleoporin Family of Genes in Childhood Acute Myeloid Leukemia: A Report from Children Oncology Group and NCI/COG Target AML Initiative

Fabiana Ostronoff, MD, Rhonda E. Ries, MA, Robert B. Gerbing, MA, Marco A Marra, PhD, Ma Yussanne, William Long, PhD, Stuart Zong, Karen Mungall, PhD, Andrew Andrew, Daniela S. Gerhard, PhD, Malcolm A. Smith, MD PhD, Gesuwan Patee, Tanja M. Davidsen, PhD, Leandro C. Hermida, Jason E. Farrar, MD, Jaime Guidry Auvil, Susana C. Raimondi, PhD, Betsy A. Hirsch, PhD, E. Anders Kolb, MD, Alan S. Gamis, MD MPH, Todd A. Alonzo, PhD, Soheil Meshinchi, MD PhD
Journal: Blood
Blood (2015) 126 (23): 169.
https://doi.org/10.1182/blood.V126.23.169.169
Published: 2015
Journal Articles

Identification of a Small Molecule Inhibitor of RAD52 to Induce Synthetic Lethality in BRCA-Deficient Leukemias

Katherine Sullivan, Kimberly Cramer-Morales, Daniel L McElroy, David Ostrov, Kimberly Haas, Margaret Nieborowska-Skorska, Wayne Childers, Alexander Mazin, Robert A Hromas, Richard Pomerantz, Tomasz Skorski
Journal: Blood
Blood (2015) 126 (23): 4434.
https://doi.org/10.1182/blood.V126.23.4434.4434
Published: 2015
Journal Articles

Chemoresistant Leukemia-Initiating Cell Expansion Is Inhibited By Targeting Oncogenic Self-Renewal

John M. Perry, PhD, Anuradha Roy, Xiuling Lu, PhD, Xi C. He, MD, Fang Tao, Meng Zhao, PhD, Pengxu Qian, PhD, Linheng Li, PhD
Journal: Blood
Blood (2015) 126 (23): 1860.
https://doi.org/10.1182/blood.V126.23.1860.1860
Published: 2015
Journal Articles

First-in-Class ROR1 Small Molecule Inhibitor (KAN0439834) Downregulated Wnt-Canonical and Non-Canonical Signaling Pathways and Induced Apoptosis of CLL Cells

Mohammad Hojjat-Farsangi, PhD, Ali Moshfegh, PhD, Amir Hossein Daneshmanesh, MD PhD, Jan Vågberg, Byström Styrbjörn, Johan Schultz, Elisabeth Olsson, Charlotta Löfberg, Carina Norström, Martin Norin, Thomas Olin, PhD, Anders Österborg, MD PhD, Håkan Mellstedt, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2912.
https://doi.org/10.1182/blood.V126.23.2912.2912
Published: 2015
Journal Articles

Structure-Guided Design of DOT1L Methyltransferase Inhibitors By a Novel, Label Free Assay Platform

Joanna S. Yi, MD, Alex Federation, Jun Qi, PhD, Sirano Dhe-Paganon, PhD, Michael Hadler, MSc, Xiang Xu, PhD, Anthony Varca, Roodolph St. Pierre, Scott A. Armstrong, MD PhD, James E. Bradner
Journal: Blood
Blood (2014) 124 (21): 4811.
https://doi.org/10.1182/blood.V124.21.4811.4811
Published: 2014
Journal Articles

Metformin Suppresses the GRP78-Dependent Delivery of Aggresomes to Autophagosomes to Enhance the Anti-Myeloma Benefit of Proteasome Inhibition

Sajjeev Jagannathan, MS, Nikhil Vad, PhD, Mohamed A.Y. Abdel Malek, MD, Ehsan Malek, MD, James J. Driscoll, MD PhD
Journal: Blood
Blood (2014) 124 (21): 433.
https://doi.org/10.1182/blood.V124.21.433.433
Published: 2014
Journal Articles

Development of a High-Throughput Screening Assay with Nurse-like Cell-Based Microenviroment in Chronic Lymphoid Leukemia Cells.

Daniel Primo, PhD, Javier De la Serna, MD PhD, Joaquin Martinez, MD, Marcos González, MD, Javier Lopez, Abelardo Bárez, Macarena Ortiz, MD, Javier Loscertales, MD, Julian Vidán, MD, Alicia Rodriguez, MD, Marta Polo, MD, Sandra Irhaeta, MD, Jose Maria Alonso, MD, Jose Antonio Queizan, MD, Jose Angel Hernandez Rivas, MD, María Jesus Peñarrubia, MD, Julian Gorrochategui, Ana Belen Espinosa, PhD, Elena Arroyo, Melanie Oates, PhD, Andrew R Pettit, FRCP, PhD, Joan Ballesteros, PhD, Pilar Hernandez, PhD
Journal: Blood
Blood (2014) 124 (21): 3639.
https://doi.org/10.1182/blood.V124.21.3639.3639
Published: 2014
Journal Articles

Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay

e-blood
Marie Lordkipanidzé, Gillian C. Lowe, Nicholas S. Kirkby, Melissa V. Chan, Martina H. Lundberg, Neil V. Morgan, Danai Bem, Shaista P. Nisar, Vincenzo C. Leo, Matthew L. Jones, Stuart J. Mundell, Martina E. Daly, Andrew D. Mumford, Timothy D. Warner, Steve P. Watson
Journal: Blood
Blood (2014) 123 (8): e11–e22.
https://doi.org/10.1182/blood-2013-08-520387
Published: 2014
Includes: Supplemental data