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Journal Articles

Early BCR-ABL1 kinetics are predictive of subsequent achievement of treatment-free remission in chronic myeloid leukemia

Clinical Trials & Observations
Naranie Shanmuganathan, Ilaria S. Pagani, David M. Ross, Sahee Park, Agnes S. M. Yong, Jodi A. Braley, Haley K. Altamura, Devendra K. Hiwase, David T. Yeung, Dong-Wook Kim, Susan Branford, Timothy P. Hughes
Journal: Blood
Blood (2021) 137 (9): 1196–1207.
https://doi.org/10.1182/blood.2020005514
Published: 2021
Includes: Supplemental data
Journal Articles

The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemic stem cells in CML

Hanyang Lin, Katharina Rothe, Min Chen, Andrew Wu, Artem Babaian, Ryan Yen, Jonathan Zeng, Jens Ruschmann, Oleh I. Petriv, Kieran O'Neill, Tobias Maetzig, David J. H. F. Knapp, Naoto Nakamichi, Ryan Brinkman, Inanc Birol, Donna L. Forrest, Carl Hansen, R. Keith Humphries, Connie J. Eaves, Xiaoyan Jiang
Journal: Blood
Blood (2020) 136 (5): 596–609.
https://doi.org/10.1182/blood.2019003636
Published: 2020
Includes: Supplemental data
Journal Articles

An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia

Tun Kiat Ko, Asif Javed, Kian Leong Lee, Thushangi N. Pathiraja, Xingliang Liu, Simeen Malik, Sheila Xinxuan Soh, Xiu Ting Heng, Naoto Takahashi, Joanna H. J. Tan, Ravi Bhatia, Alexis J. Khng, Wee-Joo Chng, Yee Yen Sia, David A. Fruman, King Pan Ng, Zhu En Chan, Kim Jiajing Xie, Qiangze Hoi, Cheryl Xueli Chan, Audrey S. M. Teo, Oscar Velazquez Camacho, Wee Yang Meah, Chiea Chuen Khor, Chin Thing J. Ong, Wei Jia W. Soon, Patrick Tan, Pauline C. Ng, Charles Chuah, Axel M. Hillmer, S. Tiong Ong
Journal: Blood
Blood (2020) 135 (26): 2337–2353.
https://doi.org/10.1182/blood.2020004834
Published: 2020
Includes: Supplemental data
Journal Articles

Detection of Actionable BCR-ABL1 Kinase Domain (KD) Mutations in Chronic Myeloid Leukemia (CML) Patients with Failure and Warning Response to Tyrosine Kinase Inhibitors (TKIs): Potential Impact of Next-Generation Sequencing (NGS) and Droplet Digital PCR (ddPCR) on Clinical Decision Making

Simona Soverini, PhD, Margherita Martelli, Dr, Luana Bavaro, Dr, Caterina De Benedittis, Alessandra Iurlo, MD PhD, Sara Galimberti, MD PhD, Patrizia Pregno, Massimiliano Bonifacio, MD, Francesca Lunghi, MD, Fausto Castagnetti, MD PhD, Gabriele Gugliotta, MD PhD, Gianantonio Rosti, MD, Mario Tiribelli, Vanessa Velotta, Fabio Stagno, MD, Antonella Russo Rossi, Mariella D'Adda, MD, Claudia Baratè, Monica Crugnola, MD, Luigiana Luciano, Maria Antonella Laginestra, PhD, Adam S Corner, PhD, Dianna Maar, PhD, Antonio Percesepe, MD PhD, Stefano Pileri, MD, Fabrizio Pane, MD, Giuseppe Saglio, MD, Michele Baccarani, MD, Giovanni Martinelli, MD, Michele Cavo
Journal: Blood
Blood (2019) 134 (Supplement_1): 661.
https://doi.org/10.1182/blood-2019-126767
Published: 2019
Journal Articles

Longitudinal Trajectory of Frailty in Blood or Marrow Transplant (BMT) Survivors - a BMT Survivor Study (BMTSS)

Mukta Arora, MD, Yanjun Chen, MS, Jessica Wu, MPH, Lindsey Hageman, MPH, Emily Ness, MPH, Michelle Kung, MA, Liton F. Francisco, BS, Alysia Bosworth, BA, Daniel J. Weisdorf, MD, Stephen J Forman, MD, Wendy Landier, PhD CRNP, Merve - Pamukçuoğlu, MD, Saro H. Armenian, DO, MPH, Lennie Wong, PhD, Smita Bhatia, MDMPH
Journal: Blood
Blood (2019) 134 (Supplement_1): 699.
https://doi.org/10.1182/blood-2019-123344
Published: 2019
Journal Articles

Gene Expression Signature Predicts Deep Molecular Response (DMR) in Chronic Myeloid Leukemia (CML): An Exploratory Biomarker Analysis from ENESTnd

Jerald P. Radich, MD, Richard A. Larson, MD, Hagop M. Kantarjian, MD, Michael W. Deininger, Javier Pinilla Ibarz, MD PhD, Daniel J. DeAngelo, MD PhD, Susan Branford, PhD FFSc (RCPA), Islam Sadek, Shalini Chaturvedi, Manu Sondhi, MD PhD, Matthew Wall, Kaushal Mishra, PhD, Das Purkayastha, PhD, Alok Shrestha, Vanessa Obourn, Brian S. White, Brian J. Druker
Journal: Blood
Blood (2019) 134 (Supplement_1): 665.
https://doi.org/10.1182/blood-2019-124716
Published: 2019
Journal Articles

High-Risk Additional Chromosomal Abnormalities in CML Herald Death By Blast Crisis Already at Low Blast Levels

Rüdiger Hehlmann, MD, Astghik Voskanyan, Michael Lauseker, Markus Pfirrmann, PhD, Lida Kalmanti, Sébastien Rinaldetti, Katharina Kohlbrenner, PhD, Claudia Haferlach, MD, Brigitte Schlegelberger, MD, Alice Fabarius, PhD, Stefan W Krause, MD, Hans-Jochem Kolb, MD, Andreas Neubauer, MD, Dieter K. Hossfeld, MD PhD, Christoph Nerl, MD PhD, Alois Gratwohl, MD, Gabriela M Baerlocher, MD, Andreas Burchert, MD, Tim H Brümmendorf, MD, Andreas Hochhaus, MD, Susanne Saussele, MD, Michele Baccarani, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 666.
https://doi.org/10.1182/blood-2019-127127
Published: 2019
Journal Articles

Patient-Reported Outcome Results from the U.S. Life after Stopping TKIs (LAST) Study in Patients with Chronic Myeloid Leukemia

Kathryn E Flynn, PhD, Kevin P. Weinfurt, PhD, Li Lin, MS, Jerald P. Radich, MD, Charles A. Schiffer, MD, Michael J. Mauro, MD, Javier Pinilla Ibarz, MD PhD, Joseph O. Moore, MD, Richard A. Larson, MD, Vivian G. Oehler, MD, Michael W. Deininger, James E. Thompson, MD, Neil P Shah, MD PhD, Martha Wadleigh, MD, Ellen K. Ritchie, MD, Richard T. Silver, MD, Jorge E. Cortes, MD, Vamsi Kota, Ehab L. Atallah, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 705.
https://doi.org/10.1182/blood-2019-126002
Published: 2019
Journal Articles

Identification of Immunological Parameters Related to Relapse in Patients with Chronic Myeloid Leukemia on Treatment-Free Remission

Valentín Garcia-Gutiérrez, MD PhD, Lorena Vigon, Laura Checa, Alejandro Luna, MD, Miguel Piris-Villaespesa, MD, Sara Rodriguez-Mora, Guiomar Bautista, Juan Luis Steegmann, Prof., MD, Vicente Planelles, Jose Alcamí, Maria Rosa López-Huertas, Maria Teresa Coiras
Journal: Blood
Blood (2019) 134 (Supplement_1): 191.
https://doi.org/10.1182/blood-2019-130017
Published: 2019
Journal Articles

Optimum Imatinib Exposure Have Possibility of Leading to Appropriate Immune Response after Imatinib Discontinuation in CML Patients

Yuki Fujioka, MD PhD, Hiroyoshi Nishikawa, MD PhD, Naoto Takahashi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 192.
https://doi.org/10.1182/blood-2019-130300
Published: 2019
Journal Articles

CD93-Signaling Regulates Self-Renewal and Proliferation of Chronic Myeloid Leukemia Stem Cells in Mice and Humans and Might be a Promising Target for Treatment

Carsten Riether, PhD, Ramin Radpour, PhD, Chantal L. Bachmann, MSc, Christian M Schürch, MD PhD, Miroslav Arambasic, PhD, Gabriela M Baerlocher, MD, Adrian F Ochsenbein, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 187.
https://doi.org/10.1182/blood-2019-127864
Published: 2019
Journal Articles

BCR-ABL1 p190 in CML: A Minor Breakpoint with a Major Impact

Shady Adnan Awad, MD, Helena Hohtari, MD, Komal Kumar Javarappa, PhD, Tania Brandstoetter, Daehong Kim, Swapnil Potdar, MSc, Caroline A Heckman, PhD, Soili Kytölä, PhD, Kimmo Porkka, Eszter Doma, PhD, Veronika Sexl, MD PhD, Matti Kankainen, PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 190.
https://doi.org/10.1182/blood-2019-126584
Published: 2019
Journal Articles

The AHI-1-BCR-ABL-DNM2 Complex Mediates Mitochondrial Dynamics in Drug-Resistant BCR-ABL + Cells

Ryan Yen, BSc, Lambert Yue, BSc, Steven Pelech, PhD, Xiaoyan Jiang, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 189.
https://doi.org/10.1182/blood-2019-128712
Published: 2019
Journal Articles

Repurposing Clofazimine As a Novel Drug for the Treatment of PI-Resistant Stem Cell-like Subclones in Myeloma

Harish Kumar, PhD, Ujjal Kumar Mukherjee, PhD, Suman Mazumder, PhD, Sabyasachi Sanyal, PhD, Brian G. Van Ness, PhD, Amit Kumar Mitra, PhD MSc, BSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 4418.
https://doi.org/10.1182/blood-2019-131596
Published: 2019
Journal Articles

Adjusting BuCy 2 in Allogeneic Hematopoietic Stem Cell Transplantation to Improve Outcomes: Experience of a Limited-Resource Center in a Developing Country

Monica Magdalena Rivera Franco, MDMSc, Eucario Leon Rodriguez, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4480.
https://doi.org/10.1182/blood-2019-122203
Published: 2019
Journal Articles

Development of Reference Control Material for the Evaluation of the Cepheid Prototype * Xpert® BCR-ABL P190 Ultra Assay

Yuanyuan Liu, PhD, Tran Tran, BS, Phat Nguyen, BSc, Huilin Wei, MD PhD, Gwo-Jen Day, PhD, Lin Yuan, MS
Journal: Blood
Blood (2019) 134 (Supplement_1): 5213.
https://doi.org/10.1182/blood-2019-128856
Published: 2019
Journal Articles

Accumulation of DNA Damage and Alteration of the DNA Damage Response in Chronic Myeloid Leukemia

Henning D. Popp, Vanessa Kohl, MSc, Johanna Flach, PhD, Susanne Brendel, MTA, Helga Kleiner, MTA, Wolfgang Seifarth, PhD, Christel Weiss, PhD, Susanne Saussele, MD, Wolf-Karsten Hofmann, MD PhD, Alice Fabarius, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5364.
https://doi.org/10.1182/blood-2019-122698
Published: 2019
Journal Articles

Efficacy of OR21, a Novel Oral Demethylating Agent in Chronic Myeloid Leukemia

Kazuharu Kamachi, MD, Hiroshi Ureshino, MD, Nao Yoshida, MD, Yuki Kurahashi, Tatsuro Watanabe, PhD, Seiji Okada, MD PhD, Shinya Kimura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5365.
https://doi.org/10.1182/blood-2019-125460
Published: 2019
Journal Articles

BCR-ABL and Src Family Kinases Induce YAP Tyrosine Phosphorylation Resulting in Survivin and Cyclin D1 Expression in Chronic Myeloid Leukemia Cells

Toshiyuki Hori, MD PhD, Kenta Moriyama, MS
Journal: Blood
Blood (2019) 134 (Supplement_1): 5366.
https://doi.org/10.1182/blood-2019-124643
Published: 2019
Journal Articles

Determine White Blood Cell Count (WBCC) Limits and ABL Ct Cut-Off with ABL Copy Number (CN) Calibration for the Xpert® BCR-ABL Ultra Assay

Huilin Wei, MD PhD, Krupa Shridhar, Gwo-Jen Day, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5367.
https://doi.org/10.1182/blood-2019-130899
Published: 2019