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Journal Articles

How I treat pediatric acute myeloid leukemia

Jeffrey E. Rubnitz, Gertjan J. L. Kaspers

Blood (2021) 138 (12): 1009–1018.

https://doi.org/10.1182/blood.2021011694

Published: 2021

Journal Articles

MLL1 Modulates IgM and Inflammatory Cytokines in Waldenstrom's Macroglobulinemia

Mona Karbalivand, MSc, BSc, Weiguo Han, PhD, Luciana L Almada, PhD, Stephen M Ansell, MD PhD, Martin Fernandez-Zapico, MD, Sherine F Elsawa, PhD

Blood (2019) 134 (Supplement_1): 3966.

https://doi.org/10.1182/blood-2019-125833

Published: 2019

Journal Articles

DYRK1A Is Regulated By Oncogenic KMT2A and Required for Survival of KMT2A -Rearranged Acute Lymphoblastic Leukemia

Christian Hurtz, PhD, Gerald Wertheim, MD, PhD, Rahul S. Bhansali, Anne Lehman, Grace Jeschke, PhD, John D. Crispino, PhD MBA, Thierry Besson, PhD, Sarah K. Tasian, MD, Martin Carroll, MD

Blood (2019) 134 (Supplement_1): 2742.

https://doi.org/10.1182/blood-2019-123475

Published: 2019

Journal Articles

Combined Targeting of the Menin-MLL1 Chromatin Complex and FLT3 As a Novel Therapeutic Concept Against NPM1 Mutant or MLL -Rearranged AML with Mutated FLT3

Margarita M. Dzama, MSc, Martha C. Taubert, MSc, Kerstin Kunz, Johanna Rausch, MD, Chun-Wei David Chen, PhD, Annalisa Mupo, PhD, Patricia Hähnel, PhD, Matthias Theobald, MD PhD, Thomas Kindler, MD, Richard P. Koche, PhD, George S. Vassiliou, FRCPath, MRCP, PhD, Scott A. Armstrong, MD PhD, Michael W.M. Kühn, MD

Blood (2019) 134 (Supplement_1): 1441.

https://doi.org/10.1182/blood-2019-122847

Published: 2019

Journal Articles

Investigation of the Significance of Son Isoform mRNA Expression in Patients with Blood Cytopenias with/without Evidence of Myeloid Neoplasia

Jung-Hyun Kim, PhD, Eun-Young Erin Ahn, PhD, Aliyeh Kennedy, Aaron Dinerman, Thomas W Butler, MD

Blood (2018) 132 (Supplement 1): 5123.

https://doi.org/10.1182/blood-2018-99-120211

Published: 2018

Journal Articles

Menin Is a Therapeutic Target in MN1 High Leukemia

Clara Libbrecht, MD, Simone Stefanie Riedel, PhD, Jessica Haladyna, BA,MS, Kathrin M. Bernt, MD

Blood (2018) 132 (Supplement 1): 758.

https://doi.org/10.1182/blood-2018-99-115551

Published: 2018

Journal Articles

MLL-Menin Inhibition Reverses Pre-Leukemic Progenitor Self-Renewal Induced By NPM1 Mutations and Prevents AML Development

Hannah J. Uckelmann, PhD, Stephanie M. Kim, BA, Noa J. C. Antonissen, Andrei V. Krivtsov, PhD, Charles Hatton, Gerard M. McGeehan, PhD, Ross L. Levine, MD, George S. Vassiliou, Scott A. Armstrong, MD PhD

Blood (2018) 132 (Supplement 1): 546.

https://doi.org/10.1182/blood-2018-99-110851

Published: 2018

Journal Articles

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis

Sara El Ashkar, Juerg Schwaller, Tim Pieters, Steven Goossens, Jonas Demeulemeester, Frauke Christ, Siska Van Belle, Sabine Juge, Nancy Boeckx, Alan Engelman, Pieter Van Vlierberghe, Zeger Debyser, Jan De Rijck

Blood (2018) 131 (1): 95–107.

https://doi.org/10.1182/blood-2017-05-786962

Published: 2018

Includes: Supplemental data

Journal Articles

Investigation of the Significance of Son Isoform mRNA Expression in Patients with Blood Cytopenias with/without Evidence of Myeloid Neoplasia

Aaron Dinerman, Jung-Hyun Kim, PhD, Eun-Young Erin Ahn, PhD, Thomas Butler, MD

Blood (2017) 130 (Supplement 1): 5293.

https://doi.org/10.1182/blood.V130.Suppl_1.5293.5293

Published: 2017

Journal Articles

The Role of MLL1 and MLL2 in MLL Fusion Oncoprotein-Initiated Leukemia

Patricia Ernst, PhD, Konstantinos Anastassiadis, PhD, Andrea Kranz, PhD, A. Francis Stewart, PhD, Kathrin Arndt, PhD, Claudia Waskow, PhD, Akihiko Yokoyama, PhD, Kenneth Jones, PhD, Tobias Neff, MD, Yufei Chen

Blood (2016) 128 (22): 573.

https://doi.org/10.1182/blood.V128.22.573.573

Published: 2016

Journal Articles

MLL Histone Methyltransferase Restrains Effector Differentiation and PD-1 Expression in Human CD8 + T Cells While Promoting Their Proliferation

Janaki Purushe, Hongxin Sun, PhD, Shan He, PhD, Yali Dou, PhD, Yi Zhang, MD, PhD

Blood (2016) 128 (22): 863.

https://doi.org/10.1182/blood.V128.22.863.863

Published: 2016

Journal Articles

Son and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes

Jung-Hyun Kim, PhD, Thomas W. Butler, MD, Eun-Young Erin Ahn, PhD

Blood (2015) 126 (23): 2426.

https://doi.org/10.1182/blood.V126.23.2426.2426

Published: 2015

Journal Articles

The same site on the integrase-binding domain of lens epithelium–derived growth factor is a therapeutic target for MLL leukemia and HIV

Marcelo J. Murai, Jonathan Pollock, Shihan He, Hongzhi Miao, Trupta Purohit, Adam Yokom, Jay L. Hess, Andrew G. Muntean, Jolanta Grembecka, Tomasz Cierpicki

Blood (2014) 124 (25): 3730–3737.

https://doi.org/10.1182/blood-2014-01-550079

Published: 2014

Includes: Supplemental data

Journal Articles

MLL1 and menin: not partners in crime?

Malek Djabali

Blood (2013) 122 (12): 1995.

https://doi.org/10.1182/blood-2013-08-519827

Published: 2013

Journal Articles

Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells

Bin E. Li, Tao Gan, Matthew Meyerson, Terence H. Rabbitts, Patricia Ernst

Blood (2013) 122 (12): 2039–2046.

https://doi.org/10.1182/blood-2013-03-486647

Published: 2013

Includes: Supplemental data

Journal Articles

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia

Aibin Shi, Marcelo J. Murai, Shihan He, George Lund, Thomas Hartley, Trupta Purohit, Gireesh Reddy, Maksymilian Chruszcz, Jolanta Grembecka, Tomasz Cierpicki

Blood (2012) 120 (23): 4461–4469.

https://doi.org/10.1182/blood-2012-05-429274

Published: 2012

Includes: Supplemental data

Journal Articles

Coordinating Self-Renewal and Proliferation via MLL1-HOX Pathways and Beyond

Patricia Ernst, PhD, Erika L. Artinger, Bibhu P. Mishra, Kristin M. Zaffuto, Bin E. Li, Yufei Chen

Blood (2012) 120 (21): SCI-28.

https://doi.org/10.1182/blood.V120.21.SCI-28.SCI-28

Published: 2012

Journal Articles

Targeting Menin-MLL Interaction to Inhibit MLL Fusion Oncoproteins in Leukemia

Jolanta Grembecka, PhD, Shihan He, PhD, Aibin Shi, PhD, Trupta Purohit, Andrew G. Muntean, PhD, Xiaoqin Li, Thomas Hartley, Duxin Sun, PhD, Jay L. Hess, MD, PhD, Tomasz Cierpicki, PhD

Blood (2011) 118 (21): 2497.

https://doi.org/10.1182/blood.V118.21.2497.2497

Published: 2011

Journal Articles

Targeting LEDGF Interactions in MLL Leukemia

Tomasz Cierpicki, PhD, Shihan He, PhD, Trupta Purohit, Marcelo Murai, PhD, Thomas Hartley, Jolanta Grembecka, PhD

Blood (2011) 118 (21): 2500.

https://doi.org/10.1182/blood.V118.21.2500.2500

Published: 2011

Journal Articles

The Trithorax Group Protein Ash1l Is An Essential Epigenetic Regulator of Adult Hematopoietic Stem Cell Maintenance

Morgan Jones, BS, MS, Michelle L Brinkmeier, PhD, Julien Schira, BS, MS, Ann Friedman, BS, Sami Malek, MD, Yali Dou, PhD, Sally A Camper, PhD, Ivan Maillard, MD, PhD

Blood (2011) 118 (21): 387.

https://doi.org/10.1182/blood.V118.21.387.387

Published: 2011

NARROW

How I treat pediatric acute myeloid leukemia

MLL1 Modulates IgM and Inflammatory Cytokines in Waldenstrom's Macroglobulinemia

DYRK1A Is Regulated By Oncogenic KMT2A and Required for Survival of KMT2A -Rearranged Acute Lymphoblastic Leukemia

Combined Targeting of the Menin-MLL1 Chromatin Complex and FLT3 As a Novel Therapeutic Concept Against NPM1 Mutant or MLL -Rearranged AML with Mutated FLT3

Investigation of the Significance of Son Isoform mRNA Expression in Patients with Blood Cytopenias with/without Evidence of Myeloid Neoplasia

Menin Is a Therapeutic Target in MN1 High Leukemia

MLL-Menin Inhibition Reverses Pre-Leukemic Progenitor Self-Renewal Induced By NPM1 Mutations and Prevents AML Development

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis

Investigation of the Significance of Son Isoform mRNA Expression in Patients with Blood Cytopenias with/without Evidence of Myeloid Neoplasia

The Role of MLL1 and MLL2 in MLL Fusion Oncoprotein-Initiated Leukemia

MLL Histone Methyltransferase Restrains Effector Differentiation and PD-1 Expression in Human CD8 + T Cells While Promoting Their Proliferation

Son and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes

The same site on the integrase-binding domain of lens epithelium–derived growth factor is a therapeutic target for MLL leukemia and HIV

MLL1 and menin: not partners in crime?

Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia

Coordinating Self-Renewal and Proliferation via MLL1-HOX Pathways and Beyond

Targeting Menin-MLL Interaction to Inhibit MLL Fusion Oncoproteins in Leukemia

Targeting LEDGF Interactions in MLL Leukemia

The Trithorax Group Protein Ash1l Is An Essential Epigenetic Regulator of Adult Hematopoietic Stem Cell Maintenance

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American Society of Hematology

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American Society of Hematology

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