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Journal Articles

A Phase 1b/2 Study of TAK-981, a First-in-Class Sumoylation Inhibitor, in Combination with Rituximab in Patients with Relapsed/Refractory (r/r) CD20-Positive Non-Hodgkin Lymphoma (NHL)

Sarit Assouline, MD, Amitkumar Mehta, MD, Paolo F Caimi, MD, Bingxia Wang, PhD, Chirag Patel, Mi-Sook Kim, Dennis Huszar, Allison J Berger, PhD, Sharon Friedlander, Alejandro Gomez-Pinillos, Igor Proscurshim

Blood (2019) 134 (Supplement_1): 1593.

https://doi.org/10.1182/blood-2019-128773

Published: 2019

Journal Articles

Sumoylation of Pyruvate Kinase M2 Inhibits Myeloid Differentiation in Hematopoietic Cells

Li Xia, PhD, Xin-Ran Wang, MA, Ran Wei, BA, Jin-Song Yan, MD PhD, Guo-Qiang Chen, PhD, Ying Lu, PhD

Blood (2018) 132 (Supplement 1): 3919.

https://doi.org/10.1182/blood-2018-99-117899

Published: 2018

Journal Articles

SIRT3 Sumoylation Contributes to Chemoresistance in AML

Jiao MA, PhD, Bin Liu, MSc, Dan Yu, BSc, Wayne Tam, MD PhD, Jianmin Yang, PhD, Jinke Cheng, PhD

Blood (2018) 132 (Supplement 1): 3929.

https://doi.org/10.1182/blood-2018-99-110898

Published: 2018

Journal Articles

Biology of Acute Myeloid Leukemia (AML) with Monosomy of Chromosome 7 or Loss of 7q. a Study on 487 Patients Analyzed By Gene Expression Profile (GEP), Single Nucleotide Polymorphism (SNP) Arrays and Metabolomics

Blood (2018) 132 (Supplement 1): 2748.

https://doi.org/10.1182/blood-2018-99-118183

Published: 2018

Journal Articles

GFI1B Splice Variants Differentially Regulate Transcription and Megakaryocyte/Erythrocyte Fate in Hematopoiesis

David McClellan, BS, Jason Singer, PhD, Matthew Velinder, PhD, Diana Bareyan, MS, Mattie Casey, BA, Helena Lucente, BS, Alexis Weston, BS, Sunil Sharma, MD, Michael Engel, MD PhD

Blood (2017) 130 (Supplement 1): 2430.

https://doi.org/10.1182/blood.V130.Suppl_1.2430.2430

Published: 2017

Journal Articles

Averted NFATc1 Sumoylation in Alloreactive T Cells Ameliorates Acute GvHD

Musga Qureischi, MSc, Lena Dietz, PhD, Martin Vaeth, PhD, Andreas Beilhack, MD, Friederike Berberich-Siebelt, PD PhD

Blood (2016) 128 (22): 809.

https://doi.org/10.1182/blood.V128.22.809.809

Published: 2016

Journal Articles

SUMOylation-disrupting WAS mutation converts WASp from a transcriptional activator to a repressor of NF-κB response genes in T cells

Koustav Sarkar, Sanjoy Sadhukhan, Seong-Su Han, Yatin M. Vyas

Blood (2015) 126 (14): 1670–1682.

https://doi.org/10.1182/blood-2015-05-646182

Published: 2015

Includes: Supplemental data

Journal Articles

ATL response to arsenic/interferon therapy is triggered by SUMO/PML/RNF4-dependent Tax degradation

Zeina Dassouki, Umut Sahin, Hiba El Hajj, Florence Jollivet, Youmna Kfoury, Valérie Lallemand-Breitenbach, Olivier Hermine, Hugues de Thé, Ali Bazarbachi

Blood (2015) 125 (3): 474–482.

https://doi.org/10.1182/blood-2014-04-572750

Published: 2015

Includes: Supplemental data

Journal Articles

Myc Commands an Aurora Kinase – Sumoylation Circuit Required for B Cell Lymphoma Growth and Survival

Alexander Hoellein, MD, Stephanie Schoeffmann, Fallahi Mohammad, PhD, John L Cleveland, PhD, Johannes Gloeckner, PhD, Marius Ueffing, PhD, Martina Rudelius, MD, Christian Peschel, MD, Ulrich Keller, MD

Blood (2014) 124 (21): 3107.

https://doi.org/10.1182/blood.V124.21.3107.3107

Published: 2014

Journal Articles

Sumoylation Sustains the Stability of NPM-ALK Oncogenic Protein and Facilitates Its Nuclear Accumulation in T-Cell Anaplastic Large-Cell Lymphoma

Deeksha Vishwamitra, BS, MS, Choladda V. Curry, MD, Serhan Alkan, MD, Ping Shi, PhD, Hesham M. Amin, MD MSc

Blood (2014) 124 (21): 3586.

https://doi.org/10.1182/blood.V124.21.3586.3586

Published: 2014

Journal Articles

Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma

Alexander Hoellein, Mohammad Fallahi, Stephanie Schoeffmann, Sabine Steidle, Franz X. Schaub, Martina Rudelius, Iina Laitinen, Lisa Nilsson, Andrei Goga, Christian Peschel, Jonas A. Nilsson, John L. Cleveland, Ulrich Keller

Blood (2014) 124 (13): 2081–2090.

https://doi.org/10.1182/blood-2014-06-584524

Published: 2014

Includes: Supplemental data

Journal Articles

Activated Sumoylation Is a Hallmark Of Burkitt's Lymphoma and MYC Driven Cancer Leading To Synthetic Lethal Interactions With Sumoylation Inhibitors

Alexander Hoellein, MD, Sabine Steidle, MD, Mohammad Fellahi, PhD, Stephanie Schoeffmann, Martina Rudelius, MD, Christian Peschel, John L Cleveland, Ulrich Keller

Blood (2013) 122 (21): 3783.

https://doi.org/10.1182/blood.V122.21.3783.3783

Published: 2013

Journal Articles

Notch Alters Sumoylation To Govern GFI1 Protein Stability and Support Its Transcriptional Repression Function

Jason Singer, PhD, Daniel Andrade, PhD, Diana Bareyan, MS, David McClellan, BS, Helena Lucente, BS, Matthew Velinder, BS, Mahesh Chandrasekharan, PhD, Emily Theisen, BS, Fang Liu, PhD, Sunil Sharma, MD, Luke Maese, DO, Michael E Engel, MD, PhD

Blood (2013) 122 (21): 3793.

https://doi.org/10.1182/blood.V122.21.3793.3793

Published: 2013

Journal Articles

Discovery and Characterization of Chemical Inhibitors of UBC13.

Charitha Madiraju, PhD, Shu-ichi Matsuzawa, PhD, Robert Ardecky, PhD, Ian Pass, PhD, Tram Ngo, Yasuko Matsuzawa, Carina Wimer, Michael Cuddy, Paul Diaz, PhD, Correa Ricardo, PhD, Craig Tamble, PhD, Chih-Wen Shu, PhD, Anthony Pinkerton, PhD, Eduard Sergienko, PhD, Chris Hassig, PhD, Thomas Chung, PhD, John C. Reed, MD, PhD

Blood (2012) 120 (21): 2950.

https://doi.org/10.1182/blood.V120.21.2950.2950

Published: 2012

Journal Articles

SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ

Andreas Begitt, Mathias Droescher, Klaus-Peter Knobeloch, Uwe Vinkemeier

Blood (2011) 118 (4): 1002–1007.

https://doi.org/10.1182/blood-2011-04-347930

Published: 2011

Includes: Supplemental data

Journal Articles

Sumoylation of CCAAT/enhancer–binding protein α promotes the biased primitive hematopoiesis of zebrafish

Hao Yuan, Jun Zhou, Min Deng, Yong Zhang, Yi Chen, Yi Jin, Jiang Zhu, Sai Juan Chen, Hugues de The, Zhu Chen, Ting Xi Liu, Jun Zhu

Blood (2011) 117 (26): 7014–7020.

https://doi.org/10.1182/blood-2010-12-325712

Published: 2011

Includes: Supplemental data

Journal Articles

MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation

Eugene Chang, Kyung-Sun Heo, Chang-Hoon Woo, Hakjoo Lee, Nhat-Tu Le, Tamlyn N. Thomas, Keigi Fujiwara, Jun-ichi Abe

Blood (2011) 117 (8): 2527–2537.

https://doi.org/10.1182/blood-2010-08-302281

Published: 2011

Includes: Supplemental data

Journal Articles

Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome

Youmna Kfoury, Niclas Setterblad, Marwan El-Sabban, Alessia Zamborlini, Zeina Dassouki, Hiba El Hajj, Olivier Hermine, Claudine Pique, Hugues de Thé, Ali Saïb, Ali Bazarbachi

Blood (2011) 117 (1): 190–199.

https://doi.org/10.1182/blood-2010-05-285742

Published: 2011

Includes: Supplemental data

Journal Articles

The sumoylation pathway is dysregulated in multiple myeloma and is associated with adverse patient outcome

James J. Driscoll, Dheeraj Pelluru, Konstantinos Lefkimmiatis, Mariateresa Fulciniti, Rao H. Prabhala, Philip R. Greipp, Bart Barlogie, Yu-Tzu Tai, Kenneth C. Anderson, John D. Shaughnessy, Jr, Christina M. Annunziata, Nikhil C. Munshi

Blood (2010) 115 (14): 2827–2834.

https://doi.org/10.1182/blood-2009-03-211045

Published: 2010

Includes: Supplemental data

Journal Articles

Differences in BCL11A SUMOylation Are Associated with Differences in γ-Globin Expression in Primary Erythroid Cells.

Tatiana Kouznetsova, Kestis Vaitkus, Vinzon Ibanez, Joseph DeSimone, Donald Lavelle

Blood (2009) 114 (22): 458.

https://doi.org/10.1182/blood.V114.22.458.458

Published: 2009

NARROW

A Phase 1b/2 Study of TAK-981, a First-in-Class Sumoylation Inhibitor, in Combination with Rituximab in Patients with Relapsed/Refractory (r/r) CD20-Positive Non-Hodgkin Lymphoma (NHL)

Sumoylation of Pyruvate Kinase M2 Inhibits Myeloid Differentiation in Hematopoietic Cells

SIRT3 Sumoylation Contributes to Chemoresistance in AML

Biology of Acute Myeloid Leukemia (AML) with Monosomy of Chromosome 7 or Loss of 7q. a Study on 487 Patients Analyzed By Gene Expression Profile (GEP), Single Nucleotide Polymorphism (SNP) Arrays and Metabolomics

GFI1B Splice Variants Differentially Regulate Transcription and Megakaryocyte/Erythrocyte Fate in Hematopoiesis

Averted NFATc1 Sumoylation in Alloreactive T Cells Ameliorates Acute GvHD

SUMOylation-disrupting WAS mutation converts WASp from a transcriptional activator to a repressor of NF-κB response genes in T cells

ATL response to arsenic/interferon therapy is triggered by SUMO/PML/RNF4-dependent Tax degradation

Myc Commands an Aurora Kinase – Sumoylation Circuit Required for B Cell Lymphoma Growth and Survival

Sumoylation Sustains the Stability of NPM-ALK Oncogenic Protein and Facilitates Its Nuclear Accumulation in T-Cell Anaplastic Large-Cell Lymphoma

Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma

Activated Sumoylation Is a Hallmark Of Burkitt's Lymphoma and MYC Driven Cancer Leading To Synthetic Lethal Interactions With Sumoylation Inhibitors

Notch Alters Sumoylation To Govern GFI1 Protein Stability and Support Its Transcriptional Repression Function

Discovery and Characterization of Chemical Inhibitors of UBC13.

SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ

Sumoylation of CCAAT/enhancer–binding protein α promotes the biased primitive hematopoiesis of zebrafish

MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation

Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome

The sumoylation pathway is dysregulated in multiple myeloma and is associated with adverse patient outcome

Differences in BCL11A SUMOylation Are Associated with Differences in γ-Globin Expression in Primary Erythroid Cells.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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