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Issue Archive

Volume 9, Issue 23
December 9 2025
Blood Advances Cover Image for Volume 9, Issue 23

Table of Contents

INSIDE BLOOD ADVANCES

The clot thickens: transverse cables under high shear flow
Yevgeniy Kreinin,Netanel Korin
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Reporting infections in cellular therapies
Clinical Trials & Observations
Gemma K. Reynolds,Monica A. Slavin
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Pharma steps back from Hodgkin lymphoma: now what?
Clinical Trials & Observations
Ryan C. Lynch,Ajay K. Gopal
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A tale of 2 mice
David C. Rees,John S. Gibson
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ADVANCES VIEWPOINT

Harnessing virus-specific T cells: expanding therapeutic strategies across diverse populations
Navid Djassemi,Benjamin Hanisch,Cecilia Motta,Naseem Maghzian,Anant Vatsayan,Jessica R. Durkee-Shock,Michael D. Keller
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Supplemental data

REVIEW ARTICLE

Harmonized immune recovery monitoring after HCT: evidence and practical guidance from the Westhafen Intercontinental Group
Taymour Hammoudi,Silvia Nucera,Alexandre G. Troullioud Lucas,Marc Ansari,Adriana Balduzzi,Alice Bertaina,Jochen Buechner,Selim Corbacioglu,Jean-Hugues Dalle,Krzystof Kalwak,Dean Lee,John E. Levine,Caroline A. Lindemans,Franco Locatelli,Roland Meisel,Stefan Nierkens,Giorgio Ottaviano,Antonio Perez-Martinez,Herbert Pichler,Susan E. Prockop,Michael A. Pulsipher,Julie-An M. Talano,Sanjay Tewari,Kirk R. Schultz,Nirali N. Shah,Michael R. Verneris,Jaap Jan Boelens,on behalf of the Westhafen Intercontinental Group
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SYSTEMATIC REVIEW

Efficacy of eculizumab discontinuation in atypical hemolytic uremic syndrome: a systematic review and meta-analysis
Amy Hockman,Sydney Anuskiewicz,Emily Brennan,Saifur R. Chowdhury,Alexander Coltoff,Jacqueline N. Poston,Charles Greenberg,Benjamin Djulbegovic
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CLINICAL TRIALS AND OBSERVATIONS

Progressive silent cerebral infarction is associated with stroke and persistent cognitive impairment in survivors of iTTP
Clinical Trials & Observations
Jia Yu,Jenna Brown,Jay Meade,Gloria F. Gerber,Michael B. Streiff,Peggy Kraus,Samuel Merrill,Allyson M. Pishko,Jennifer Yui,Rakhi P. Naik,Robert A. Brodsky,Doris D. Lin,Shruti Chaturvedi
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Pirtobrutinib, a highly selective, noncovalent (reversible) BTKi in R/R follicular lymphoma: phase 1/2 BRUIN study
Clinical Trials & Observations
Nirav N. Shah,Pier Luigi Zinzani,Michael Wang,Sunita D. Nasta,Ewa Lech-Maranda,Yoshiaki Ogawa,Bita Fakhri,Bryone Kuss,Kaname Miyashita,Krish Patel,Catherine C. Coombs,Shuo Ma,Manish R. Patel,Minal A. Barve,Benoit Tessoulin,Anastasios Stathis,Daisuke Ennishi,Daigo Hashimoto,Kensuke Kojima,Andrew D. Zelenetz,Jonathon B. Cohen,Julie M. Vose,Kami J. Maddocks,Talha Munir,Fangfang Sun,Yuanyuan Bian,Minna Balbas,Donald E. Tsai,Paolo Abada,Chan Y. Cheah
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Supplemental data
Association of PET4 response with outcomes of BV-CHP vs CHOP in the ECHELON-2 trial in CD30+ peripheral T-cell lymphoma
Clinical Trials & Observations
Swaminathan Iyer,Neha Mehta-Shah,Ranjana Advani,Nancy L. Bartlett,Jacob H. Christensen,Franck Morschhauser,Eva Domingo-Domenech,Giuseppe Rossi,Won Seog Kim,Onder Alpdogan,Tatyana A. Feldman,Vincent Camus,Giuseppe Gritti,Pier Luigi Zinzani,David Belada,Jiri Mayer,Ilseung Choi,June-Won Cheong,Evelyn Rustia,Keenan Fenton,Michelle Fanale,Kerry J. Savage,Steven M. Horwitz
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Supplemental data
Impact of tranexamic acid on postpartum hemorrhage in type 1 von Willebrand disease treated with recombinant VWF
Clinical Trials & Observations
Nicoletta C. Machin,Maria M. Brooks,Deborah Vehec,Dana Ivanco,Brandon Lawryk,Craig D. Seaman,Frederico Xavier,Sruti Shiva,Angela Verdoni,Margaret V. Ragni
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International consensus guidelines for the conduct and reporting of CAR T-cell clinical trials in AML
Clinical Trials & Observations
Swati Naik,Richard Aplenc,Susanne H.C. Baumeister,Marco Becilli,Anand S. Bhagwat,Challice L. Bonifant,Lihua E. Budde,Christopher D. Chien,Kevin J. Curran,Anthony F. Daniyan,Alexandra Dreyzin,Rebecca A. Gardner,Sara Ghorashian,Stephen Gottschalk,LaQuisa C. Hill,M. Eric Kohler,Adam Lamble,Franco Locatelli,Maksim Mamonkin,Bilal Omer,Jae H. Park,Concetta Quintarelli,Benedetta Rambaldi,Rebecca M. Richards,David A. Sallman,Tim Sauer,Nirali N. Shah,Marion Subklewe,Corinne Summers,Sarah K. Tasian,Naomi Taylor,Sarah Tettamanti,Michael R. Verneris,M. Paulina Velasquez,Saar I. Gill
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Supplemental data
Comparative infection risk in CAR T vs bispecific antibodies in B-cell lymphoma: a systematic review and meta-analysis
Clinical Trials & Observations
Herman van Besien,Neela Easwar,Michelle Demetres,Michelle Pasciolla,Tsiporah Shore,John Leonard,Juliet Barker,Peter Martin,Samuel Yamshon
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Supplemental data
Reporting infections in cellular therapies
Clinical Trials & Observations
Gemma K. Reynolds,Monica A. Slavin
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Efficacy and safety of luspatercept in non–transfusion-dependent β-thalassemia: long-term results from the BEYOND study
Clinical Trials & Observations
Ali T. Taher,Vip Viprakasit,Antonis Kattamis,Silverio Perrotta,Paolo Ricchi,John B. Porter,Thomas D. Coates,Gian Luca Forni,Khaled M. Musallam,Oriana Esposito,Richard Pilot,Wen-Ling Kuo,Yinzhi Lai,Marta Reverte,Richard Wei,Luciana Moro Bueno,Maria Domenica Cappellini
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Supplemental data
Early clearance of circulating tumor DNA and association with odronextamab response in relapsed/refractory FL and DLBCL
Clinical Trials & Observations
Jon E. Arnason,Matthew Matasar,Stefano Luminari,David Tucker,Dylan Sun,Weiwei Tao,Yuan O. Zhu,Kunal Kundu,Namita T. Gupta,Allen Leary,Vladimir Jankovic,Srikanth Ambati,Hesham Mohamed,Aafia Chaudhry,Jurriaan Brouwer-Visser
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Supplemental data
Camidanlumab tesirine for relapsed or refractory classic Hodgkin lymphoma: a phase 2 study
Clinical Trials & Observations
Alex F. Herrera,Stephen M. Ansell,Pier Luigi Zinzani,John Radford,Kami Maddocks,Antonio Pinto,Graham P. Collins,Veronika Bachanova,Nancy L. Bartlett,Isabelle Bence-Bruckler,Mehdi Hamadani,Justin Kline,Jiří Mayer,Kerry J. Savage,Ranjana H. Advani,Paolo F. Caimi,René-Olivier Casasnovas,Tatyana Feldman,Brian Hess,Mariana Bastos-Oreiro,Sunil Iyengar,Árpád Szomor,William Townsend,Marc André,Jerzy Dyczkowski,Karin Havenith,Marie Toukam,Serafino Pantano,Hans G. Cruz,Luqiang Wang,Yanina Negievich,Melanie Lucero,Jens Wuerthner,Carmelo Carlo-Stella
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Pharma steps back from Hodgkin lymphoma: now what?
Clinical Trials & Observations
Ryan C. Lynch,Ajay K. Gopal
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IMMUNOBIOLOGY AND IMMUNOTHERAPY

mTOR activity and metabolic reprogramming of CD8+ T cells is impaired under hypoxia and within the multiple myeloma bone marrow
Taylor Fulton-Ward,Nancy Gudgeon,Isaac Thirlwell,Emma L. Bishop,Bryan Marzullo,Hannah Giles,Graham McIlroy,Paul Ferguson,Bhuvan Kishore,Kate Rogers,Nuri Alfasi,Timothy Wong,Satnam Aytain,Daniel A. Tennant,Guy Pratt,Sarah Dimeloe
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LYMPHOID NEOPLASIA

Risk of synchronous and second primary malignancies in transplant-ineligible patients with multiple myeloma treated with lenalidomide
Thomas Systchenko,Laly Nsiala,Arthur Bobin,Hélène Gardeney,Carine Motard,Gaelle Olivier,Florence Borde,Anne Corby,Christophe Roul,Emmanuel Fleck,Guillaume Denis,Céline Dieval,Philippe Mottaz,Annick Boscagli,Gautier Defossez,Xavier Leleu
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Supplemental data
Identification of 4 autophagy-related genetic variants as risk factors for chronic lymphocytic leukemia
Antonio José Cabrera-Serrano,José Manuel Sánchez-Maldonado,Juan José Rodríguez-Sevilla,Fernando Jesús Reyes-Zurita,Rosa Collado,Anna Puiggros,Elena Cornejo-Calvo,Paloma García-Martín,Rob Ter Horst,Yolanda Benavente,Andrés Jerez,Stefano Landi,Blanca Espinet,Rossana Maffei,Miguel Ángel López-Nevot,Silvia Ramos-Campoy,Carmen González-Olmedo,Tzu-Hua Chen-Liang,Víctor Moreno,Fatin Jannus,Rafael Marcos-Gragera,María Carretero-Fernández,Belém Sampaio-Marques,Irene Gámez,María García-Álvarez,Nicola J. Camp,Trinidad Dierssen-Sotos,Joanna Kamaso,Eva María Pérez,Aaron D. Norman,Mario Luppi,Yang Li,Miguel Alcoceba,Daniele Campa,Silvia de San José,Roberto Marasca,Paula Ludovico,Alyssa Clay-Gilmour,Federico Canzian,Marian Ibañez,Mihai G. Netea,James McKay,Delphine Casabonne,Sonja I. Berndt,Susan L. Slager,Juan Sainz
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MYELOID NEOPLASIA

Cardiovascular degeneration in Erdheim-Chester disease: prevalence, burden, and outcomes
Reema K. Tawfiq,Grant M. Spears,Jason R. Young,Madeline K. Mahowald,W. Oliver Tobin,Ubenthira Patgunarajah,Gordon J. Ruan,Dongni Yi,Saurabh Zanwar,Karen Rech,Matthew J. Koster,Aldo A. Acosta-Medina,Lucinda Gruber,Aishwarya Ravindran,Mithun Vinod Shah,N. Nora Bennani,Muhamad Alhaj Moustafa,Talal Hilal,Julio C. Sartori Valinotti,Robert Vassallo,Jay H. Ryu,Caroline Davidge-Pitts,Surendra Dasari,Thomas E. Witzig,Ronald S. Go,Gaurav Goyal,Jithma P. Abeykoon,on behalf of the Histio-Care Network
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The lncRNA ELDR suppresses tumorigenicity of AML by interfering with DNA replication and chromatin accessibility
Kaifee Arman,Julie Ross,Eva-Maria Piskor,Luca Lazzari,Virginie Calderon,Gaspard Reulet,Maria Vera,Edlie St-Hilaire,Hugo Wurtele,Brian T. Wilhelm,Tarik Möröy
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Supplemental data
Statins enhance the efficacy of pegylated interferon-alfa2 in Philadelphia-negative chronic myeloproliferative neoplasms
Isabella Diana Davidsen,Morten Kranker Larsen,Lea Löffler,Vibe Skov,Lasse Kjær,Trine Alma Knudsen,Anders Lindholm Sørensen,Sarah Friis Christensen,Sabrina Cordua,Christina Schjellerup Eickhardt-Dalbøge,Marie Hvelplund Kristiansen,Christina Ellervik,Troels Wienecke,Hans Carl Hasselbalch
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PLASMA CELL DISORDERS

Safety and efficacy of BCMA-directed chimeric antigen receptor T-cell therapy for the treatment of plasma cell leukemia
Gliceida M. Galarza Fortuna,Lauren Peres,Elena Nazarenko,Andre De Menezes Silva Corraes,Vanna N. Hovanky,Leyla Shune,Joseph McGuirk,Gabriel De Avilla,Jack Khouri,Danai Dima,Mahmoud Gaballa,Binod Dhakal,Peter Forsberg,Amandeep Godara,Aimaz Afrough,Larry Anderson,Megan M. Herr,James A. Davis,Hashim Mann,Sneha Purvey,William Clark,Myo Htut,Amer Beitinjaneh,Denise L. Pereira,Mehmet H. Kocoglu,Christopher James Ferreri,Shebli Atrash,Peter M. Voorhees,Adriana Rossi,Richard Shambavi,Hamza Hashmi,Krina Patel,Surbhi Sidana,Yi Lin,Doris K. Hansen,Douglas W. Sborov
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RED CELLS, IRON, AND ERYTHROPOIESIS

Use of Emergency Severity Index 2 reduces time to first analgesia in sickle cell disease vaso-occlusive crisis
Abdulaziz Abu Haimed,Drupad Patel,Octavia Clopton,Maria R. Baer,Benoit Stryckman,Richard Gentry Wilkerson,Jennie Y. Law
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A mouse model for hemoglobin SC disease recapitulates characteristic human pathologies
Jinbin Zhai,James B. Papizan,Yu Yao,Elizabeth D. Arnold,Jing Yu,Tam Tran,Natalie Geiger,Jahnavi Gollamudi,Danielle R. Little,Ravirajsinh N. Jadeja,Jaison John,Ali Khalighifar,Kalin Mayberry,Justina McEvoy,Randi Rooney,Krishnan Venkataraman,Hieu S. Vu,Jingjing Zhang,Michael Dyer,Patrick G. Gallagher,Hyacinth I. Hyacinth,Laura J. Janke,Pamela M. Martin,Min Ni,Jian Xu,Jonathan S. Yen,Yan Zheng,Mitchell J. Weiss,Shondra M. Pruett-Miller
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A tale of 2 mice
David C. Rees,John S. Gibson
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THROMBOSIS AND HEMOSTASIS

Arterial human blood flow can be stopped by cables of VWF and platelets without coagulation
Edouard L. V. Machenaud,John W. Weisel,Rustem I. Litvinov,Chandrasekaran Nagaswami,David N. Ku
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The clot thickens: transverse cables under high shear flow
Yevgeniy Kreinin,Netanel Korin
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RESEARCH LETTERS

Efficacy of MRD-triggered anti-CD20 retreatment in patients with high-risk chronic lymphocytic leukemia: a case series
Ellinor Goergen,Sandra Robrecht,Rudy Ligtvoet,Kirsten Fischer,Barbara Eichhorst,Petra Langerbeins,Michael Hallek
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Biological parenthood rates among men with sickle cell disease
Anyssa N. Young,Sarah R. Hayford,Sapuni S. Chandrasena,Sara Conroy,Tanvi P. Karkare,Barbara L. Kroner,Allison King,Robert M. Cronin,Luca Badolato,Leena Nahata,Susan E. Creary
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NKTR-255 enhances complete response following CD19 CAR T-cell therapy in patients with relapsed/refractory large B-cell lymphoma
Clinical Trials & Observations
Sairah Ahmed,John DiPersio,James Essell,Catherine Diefenbach,Miguel-Angel Perales,Cristina Castilla-Llorente,Saurabh Dahiya,Yi Liu,Heng Xu,Christie Fanton,Sohail Chaudhry,Zachary H. Lee,A. Mario Q. Marcondes,Mary A. Tagliaferri,Jonathan Zalevsky,David Miklos,Cameron J. Turtle,Joseph McGuirk
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Addition of ADAMTS13 testing to cryptogenic stroke evaluation: index case and single-center screening initial experience
Aaron Boothby,Jorge N. Ruiz Lopez,Livia Hegerova,Dharmini Manogna,Rangaswamy Chintapatla,Samantha Harris,Gayle Teramura,David Tirschwell,Breana Taylor,Siobán Keel
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Acupressure alleviates pain and clinical symptoms in patients with sickle cell disease
Clinical Trials & Observations
Lina Houran,Andrew Q. Pucka,Mio Jiang,Ziyue Liu,Andrew R. W. O’Brien,Steven E. Harte,Richard E. Harris,Zahra Pakbaz,Ying Wang
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ERRATA

Tometten M, Beier F, Kirschner M, et al. Late-onset telomere biology disorders in adults: clinical insights and treatment outcomes from a retrospective registry cohort. Blood Adv. 2025;9(9):2183-2191.
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Akin S, Hosing C, Khouri I, et al. Autologous stem cell transplantation for large B-cell lymphoma with secondary central nervous system involvement. Blood Adv. 2022;6(7):2267-2274.
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  • Cover Image

    Cover Image

    issue cover

    Virus-specific T cells (VSTs) can be manufactured from peripheral blood mononuclear cells from hematopoietic stem cell donors (left) or healthy third-party donors (right) using similar methods, including cell selection or ex vivo expansion. Following required quality assurance/control testing, VSTs can be cryopreserved for either directed use or banking and infused into patients for either prevention or treatment of targeted viral infections. Response assessment is dependent on trending of viral polymerase chain reactions, though correlative studies of cellular responses to viral antigens may also be useful when available. Image created by Biorender. See article by Djassemi et al.

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