Skip Nav Destination

Issue Archive

Select Year

Issue

Volume 9, Issue 5

March 11 2025

In Progress

In this Issue

Unbiased high-throughput screening of drug-repurposing libraries identifies small-molecule inhibitors of clot retraction

Lorena Buitrago,Miriam-Rose Menezes,Chloe Larson,Jihong Li,Thomas Kartika,Priyam Banerjee,Fraser Glickman,Barry Coller

View Articletitled, Unbiased high-throughput screening of drug-repurposing libraries identifies small-molecule inhibitors of clot retraction

Supplemental data

Ubiquitous clot contraction blockers hit ubiquitin and more

John W. Weisel,Rustem I. Litvinov

View Articletitled, Ubiquitous clot contraction blockers hit ubiquitin and more

Ibrutinib for therapy of steroid-refractory chronic graft-versus-host disease: a multicenter real-world analysis

Joseph Pidala,Jongphil Kim,Denise Kalos,Corey Cutler,Zachariah DeFilipp,Mary E. D. Flowers,Betty K. Hamilton,Kuo-Kai Chin,Marcello Rotta,Najla El Jurdi,Mehdi Hamadani,Gulrayz Ahmed,Carrie Kitko,Doris Ponce,Anthony Sung,Helen Tang,Nosha Farhadfar,Eneida Nemecek,Iskra Pusic,Muna Qayed,Hemalatha Rangarajan,William Hogan,Aaron Etra,Samantha Jaglowski

View Articletitled, Ibrutinib for therapy of steroid-refractory chronic graft-versus-host disease: a multicenter real-world analysis

Supplemental data

Hematopoietic cell transplant compared with standard care in adolescents and young adults with sickle cell disease
Clinical Trials & Observations

Mark C. Walters,Mary Eapen,Yiwen Liu,Fuad El Rassi,Edmund K. Waller,John E. Levine,John J. Strouse,Joseph H. Antin,Suhag H. Parikh,Nitya Bakshi,Carlton Dampier,Jennifer J. Jaroscak,Shayla Bergmann,Trisha Wong,Vamsi Kota,Betty Pace,Lazaros J. Lekakis,Premal Lulla,Robert S. Nickel,Kimberly A. Kasow,Uday Popat,Wally Smith,Lolie Yu,Nancy DiFronzo,Nancy Geller,Naynesh Kamani,Elizabeth S. Klings,Kathryn Hassell,Adam Mendizabal,Keith Sullivan,Donna Neuberg,Lakshmanan Krishnamurti

View Articletitled, Hematopoietic cell transplant compared with standard care in adolescents and young adults with sickle cell disease

Supplemental data

Identification of genomic biomarkers of disease progression and survival in primary CNS lymphoma
Clinical Trials & Observations

Huimin Geng,Shirley Mo,Lingjing Chen,Aishwarya Ballapuram,Mazie Tsang,Ming Lu,Andreas M. Rauschecker,Kwun Wah Wen,Walter Patrick Devine,David A. Solomon,James L. Rubenstein

View Articletitled, Identification of genomic biomarkers of disease progression and survival in primary CNS lymphoma

Supplemental data

Treatment patterns and outcomes in follicular lymphoma with POD24: an analysis from the LEO Consortium

Jonathan R. Day,Melissa C. Larson,Urshila Durani,Jean L. Koff,Yucai Wang,Thomas M. Habermann,Izidore S. Lossos,Loretta J. Nastoupil,Christopher Strouse,Dai Chihara,Peter Martin,John P. Leonard,Jonathon B. Cohen,Brad S. Kahl,Jia Ruan,W. Richard Burack,Jonathan W. Friedberg,James R. Cerhan,Christopher R. Flowers,Brian K. Link,Matthew J. Maurer,Carla Casulo

View Articletitled, Treatment patterns and outcomes in follicular lymphoma with POD24: an analysis from the LEO Consortium

Supplemental data

Elotuzumab in combination with pomalidomide, bortezomib, and dexamethasone in relapsed and refractory multiple myeloma
Clinical Trials & Observations

Andrew J. Yee,Jacob P. Laubach,Erica L. Campagnaro,Brea C. Lipe,Omar Nadeem,Robb S. Friedman,Craig E. Cole,Elizabeth K. O’Donnell,Giada Bianchi,Andrew R. Branagan,Robert L. Schlossman,Samantha J. Shapiro,Cynthia C. Harrington,Jill N. Burke,Marilyn T. Gammon,Kathleen J. Lively,Cassandra A. Reimonn,Danielle X. Andrade,Robert Redd,Jens G. Lohr,Kenneth C. Anderson,Paul G. Richardson,Noopur S. Raje

View Articletitled, Elotuzumab in combination with pomalidomide, bortezomib, and dexamethasone in relapsed and refractory multiple myeloma

Supplemental data

Antiviral potential of Vδ2 T cells in children given TCR αβ/CD19 cell-depleted HLA-haploidentical HSCT

Veronica Bordoni,Federica Guarracino,Federica Galaverna,Valentina Bertaina,Giuseppina Li Pira,Marco Rosichini,Angela Pitisci,Giulia Matusali,Fabrizio Maggi,Enrico Velardi,Pietro Merli,Franco Locatelli,Chiara Agrati

View Articletitled, Antiviral potential of Vδ2 T cells in children given TCR αβ/CD19 cell-depleted HLA-haploidentical HSCT

Supplemental data

Advantages of a genomic DNA-based next-generation sequencing assay for detection of mutant NPM1 measurable residual disease in AML

Christian M. Vonk,Tim Grob,Melissa Rijken,François G. Kavelaars,Jolinda M. L. Konijnenburg,Gert J. Ossenkoppele,Markus G. Manz,Violaine Havelange,Yngvar Fløisand,Bob Löwenberg,Peter J. M. Valk

View Articletitled, Advantages of a genomic DNA-based next-generation sequencing assay for detection of mutant <em>NPM1</em> measurable residual disease in AML

Supplemental data

Long-term safety and efficacy of fitusiran prophylaxis, and perioperative management, in people with hemophilia A or B
Clinical Trials & Observations

Steven W. Pipe,Toshko Lissitchkov,Pencho Georgiev,Sarah Mangles,Inga Hegemann,Alice Trinchero,Pratima Chowdary,Adam Forbes,Liqi Feng,Laurel A. Menapace,Salim Kichou,Shauna Andersson,Marek Demissie,Margaret V. Ragni

View Articletitled, Long-term safety and efficacy of fitusiran prophylaxis, and perioperative management, in people with hemophilia A or B

Supplemental data

NAD⁺ metabolism restriction boosts high-dose melphalan efficacy in patients with multiple myeloma

Debora Soncini,Pamela Becherini,Francesco Ladisa,Silvia Ravera,Adithya Chedere,Elisa Gelli,Giulia Giorgetti,Claudia Martinuzzi,Francesco Piacente,Luca Mastracci,Claudia Veneziano,Gianluca Santamaria,Fiammetta Monacelli,Moustafa S. Ghanem,Antonia Cagnetta,Fabio Guolo,Matteo Garibotto,Sara Aquino,Mario Passalaqua,Santina Bruzzone,Axel Bellotti,Michel A. Duchosal,Aimable Nahimana,Emanuele Angelucci,Chandra Nagasuma,Alessio Nencioni,Roberto Massimo Lemoli,Michele Cea

View Articletitled, NAD<sup>+</sup> metabolism restriction boosts high-dose melphalan efficacy in patients with multiple myeloma

Supplemental data

Physiological significance of antithrombin D-helix interaction with vascular GAGs

Indranil Biswas,Sumith R. Panicker,Florea Lupu,Alireza R. Rezaie

View Articletitled, Physiological significance of antithrombin D-helix interaction with vascular GAGs

Supplemental data

Cumulative deficits frailty index and relationship status predict survival in multiple myeloma

Nadine Abdallah,Paul Dizona,Amanika Kumar,Betsy LaPlant,Terri Menser,Gavin Schaeferle,Sarah Aug,Megan Weivoda,Angela Dispenzieri,Francis K. Buadi,Rahma Warsame,Joselle Cook,Martha Q. Lacy,Suzanne Hayman,Morie A. Gertz,S. Vincent Rajkumar,Shaji K. Kumar

View Articletitled, Cumulative deficits frailty index and relationship status predict survival in multiple myeloma

Supplemental data

Improved overall survival with checkpoint inhibition and allogeneic transplantation in relapsed Hodgkin lymphoma

Nadeem Tabbara,Marianna Zahurak,Cole H. Sterling,Iris Margalit Trutzer,Jaroslaw Jedrych,Lode J. Swinnen,Ephraim J. Fuchs,Javier Bolaños-Meade,Nina Wagner-Johnston,Richard J. Jones,Richard F. Ambinder,Ravi Varadhan,Suman Paul

View Articletitled, Improved overall survival with checkpoint inhibition and allogeneic transplantation in relapsed Hodgkin lymphoma

Supplemental data

Impact of clinical factors on accuracy of ovarian cancer detection via platelet RNA profiling

Maksym A. Jopek,Michał Sieczczyński,Krzysztof Pastuszak,Sylwia Łapińska-Szumczyk,Jacek Jassem,Anna J. Żaczek,Matthew T. Rondina,Anna Supernat

View Articletitled, Impact of clinical factors on accuracy of ovarian cancer detection via platelet RNA profiling

Supplemental data

Genome-wide CRISPR/Cas9 screen identifies AraC-daunorubicin-etoposide response modulators associated with outcomes in pediatric AML

Nam H. K. Nguyen,Roya Rafiee,Phani K. Parcha,Abderrahmane Tagmount,Jeffrey Rubnitz,Raul Ribeiro,Xueyuan Cao,Stanley B. Pounds,Christopher D. Vulpe,Jatinder K. Lamba

View Articletitled, Genome-wide CRISPR/Cas9 screen identifies AraC-daunorubicin-etoposide response modulators associated with outcomes in pediatric AML

Supplemental data

Real-world treatment patterns and health care resource use for patients with myelofibrosis: results from the METER study

Vikas Gupta,Ciprian Tomuleasa,Gilberto Israel Barranco Lampón,Hsin-An Hou,Grzegorz Helbig,Pankit Vachhani,Argiris Symeonidis,Ibrahim Haznedaroglu,Kenny Galvez,Fernando Tatsch,Avijeet S. Chopra,Meng Zhang,Tamas Vizkelety,Bryan Murray,David M. Ross

View Articletitled, Real-world treatment patterns and health care resource use for patients with myelofibrosis: results from the METER study

Supplemental data

BCMA-directed CAR T-cell therapy in patients with multiple myeloma and CNS involvement

Mahmoud R. Gaballa,Omar Castaneda Puglianini,Adam Cohen,Dan Vogl,Alfred Chung,Christopher J. Ferreri,Peter Voorhees,Doris K. Hansen,Krina K. Patel

View Articletitled, BCMA-directed CAR T-cell therapy in patients with multiple myeloma and CNS involvement

Anti-FcRL5 CAR-T exhibits anti-MM activity against EMM after progression of anti-BCMA and anti-GPRC5D CAR-T: a case report
Clinical Trials & Observations

Xiaoyuan He,Xiaomei Zhang,Zhengyu Yu,Juanxia Meng,Yanyu Jiang,Yifan Zhao,Hairong Lyu,Xue Bai,Xia Xiao,Mingfeng Zhao

View Articletitled, Anti-FcRL5 CAR-T exhibits anti-MM activity against EMM after progression of anti-BCMA and anti-GPRC5D CAR-T: a case report

Supplemental data

Advancing drug development in myelodysplastic syndromes
Clinical Trials & Observations

Alain Mina,Kathy L. McGraw,Lea Cunningham,Nina Kim,Emily Y. Jen,Katherine R. Calvo,Lori A. Ehrlich,Peter D. Aplan,Guillermo Garcia-Manero,James M. Foran,Jacqueline S. Garcia,Amer M. Zeidan,Amy E. DeZern,Rami Komrokji,Mikkael A. Sekeres,Bart Scott,Rena Buckstein,Sara Tinsley-Vance,Amit Verma,Tanya Wroblewski,Steven Pavletic,Kelly Norsworthy

View Articletitled, Advancing drug development in myelodysplastic syndromes

Platelet potential to switch to procoagulant phenotype compensates bleeding tendency in patients with hemophilia A

Karina Althaus,Sophie Kieninger,Anna Bäuerle,Stefanie Hammer,Nina Wolska,Günalp Uzun,Karoline Weich,Lorenzo Alberio,Alessandro Aliotta,Christoph Faul,Margarete Moyses,Ursula Holzer,Vanya Icheva,David Gorodezki,Sebastian Hörber,Susan Halimeh,Jan Zlamal,Tamam Bakchoul

View Articletitled, Platelet potential to switch to procoagulant phenotype compensates bleeding tendency in patients with hemophilia A

Supplemental data

α-Actinin-1 deficiency in megakaryocytes causes low platelet count, platelet dysfunction, and mitochondrial impairment

Xiangjie Lin,Hanchen Gao,Min Xin,Jian Huang,Xia Li,Yutong Zhou,Keyu Lv,Xin Huang,Jinghan Wang,Yulan Zhou,Dawei Cui,Chao Fang,Lanlan Wu,Xiaofeng Shi,Zhixin Ma,Yu Qian,Hongyan Tong,Jing Dai,Jie Jin,Jiansong Huang

View Articletitled, α-Actinin-1 deficiency in megakaryocytes causes low platelet count, platelet dysfunction, and mitochondrial impairment

Supplemental data

Nivolumab to restore T-cell fitness in CAR-T refractory multiple myeloma
Clinical Trials & Observations

Johannes M. Waldschmidt,Noori Sotudeh,Sankalp Arora,Tushara Vijaykumar,Praveen Anand,Hannah Stuart,Julia Frede,Tim Campbell,Shari M. Kaiser,Xirong Zheng,Nikhil C. Munshi,Kenneth C. Anderson,Hermann Einsele,Andrew J. Yee,Birgit Knoechel,Jens G. Lohr,Noopur S. Raje

View Articletitled, Nivolumab to restore T-cell fitness in CAR-T refractory multiple myeloma

Supplemental data

Integrative cytogenetic and molecular studies unmask “chromosomal mimicry” in hematologic malignancies

Melissa Zhao,Scott Ryall,Samuel J. Brody,Amyah C. Harris,Kristin Cabral,Catherine Brownstein,Jaeseung C. Kim,Adam C. Smith,Paola Dal Cin,Rupa Narayan,Kristin Sikkink,Anthony Schmitt,Gabriela S. Hobbs,Amir T. Fathi,Gabriel K. Griffin,Sheila N. J. Sait,Anthony J. Iafrate,Jon C. Aster,Timothy A. Graubert,Valentina Nardi,Adrian M. Dubuc

View Articletitled, Integrative cytogenetic and molecular studies unmask “chromosomal mimicry” in hematologic malignancies

Supplemental data

Ubiquitous clot contraction blockers hit ubiquitin and more

John W. Weisel,Rustem I. Litvinov

View Articletitled, Ubiquitous clot contraction blockers hit ubiquitin and more

Cover Image

Cover Image

Pattern of HLA-DR expression in a diagnostic specimen of primary central nervous system lymphoma with copy-neutral loss of heterozygosity at chromosome 6p. In situ hybridization demonstrates expression of HLA-DR (red) by infiltrating macrophages but not lymphoma cells (large nuclei [DAPI, 4’,6-diamidino-2-phenylindole; blue]). In situ hybridization confirmed colocalization of HLA-DR with CD68 and macrophages but not with CD20⁺ lymphoma cells (not shown). See the article by Geng et al.

All Issues

Advertisement intended for health care professionals

Email alerts

Continuous Publishing Alert

New Journal Content Alert

Latest
Most Read
Most Cited

Ubiquitous clot contraction blockers hit ubiquitin and more

Anti-FcRL5 CAR-T exhibits anti-MM activity against EMM after progression of anti-BCMA and anti-GPRC5D CAR-T: a case report

Improved overall survival with checkpoint inhibition and allogeneic transplantation in relapsed Hodgkin lymphoma

Impact of clinical factors on accuracy of ovarian cancer detection via platelet RNA profiling

Integrative cytogenetic and molecular studies unmask “chromosomal mimicry” in hematologic malignancies

Advertisement intended for health care professionals

Table of Contents

Unbiased high-throughput screening of drug-repurposing libraries identifies small-molecule inhibitors of clot retraction

Ubiquitous clot contraction blockers hit ubiquitin and more

Ibrutinib for therapy of steroid-refractory chronic graft-versus-host disease: a multicenter real-world analysis

Hematopoietic cell transplant compared with standard care in adolescents and young adults with sickle cell disease
Clinical Trials & Observations

Identification of genomic biomarkers of disease progression and survival in primary CNS lymphoma
Clinical Trials & Observations

Treatment patterns and outcomes in follicular lymphoma with POD24: an analysis from the LEO Consortium

Elotuzumab in combination with pomalidomide, bortezomib, and dexamethasone in relapsed and refractory multiple myeloma
Clinical Trials & Observations

Antiviral potential of Vδ2 T cells in children given TCR αβ/CD19 cell-depleted HLA-haploidentical HSCT

Advantages of a genomic DNA-based next-generation sequencing assay for detection of mutant NPM1 measurable residual disease in AML

Long-term safety and efficacy of fitusiran prophylaxis, and perioperative management, in people with hemophilia A or B
Clinical Trials & Observations

NAD⁺ metabolism restriction boosts high-dose melphalan efficacy in patients with multiple myeloma

Physiological significance of antithrombin D-helix interaction with vascular GAGs

Cumulative deficits frailty index and relationship status predict survival in multiple myeloma

Improved overall survival with checkpoint inhibition and allogeneic transplantation in relapsed Hodgkin lymphoma

Impact of clinical factors on accuracy of ovarian cancer detection via platelet RNA profiling

Genome-wide CRISPR/Cas9 screen identifies AraC-daunorubicin-etoposide response modulators associated with outcomes in pediatric AML

Real-world treatment patterns and health care resource use for patients with myelofibrosis: results from the METER study

BCMA-directed CAR T-cell therapy in patients with multiple myeloma and CNS involvement

Anti-FcRL5 CAR-T exhibits anti-MM activity against EMM after progression of anti-BCMA and anti-GPRC5D CAR-T: a case report
Clinical Trials & Observations

Advancing drug development in myelodysplastic syndromes
Clinical Trials & Observations

Platelet potential to switch to procoagulant phenotype compensates bleeding tendency in patients with hemophilia A

α-Actinin-1 deficiency in megakaryocytes causes low platelet count, platelet dysfunction, and mitochondrial impairment

Nivolumab to restore T-cell fitness in CAR-T refractory multiple myeloma
Clinical Trials & Observations

Integrative cytogenetic and molecular studies unmask “chromosomal mimicry” in hematologic malignancies

Ubiquitous clot contraction blockers hit ubiquitin and more

Email alerts

ASH Publications

American Society of Hematology

Issue Archive

Table of Contents

Hematopoietic cell transplant compared with standard care in adolescents and young adults with sickle cell disease Clinical Trials & Observations

Identification of genomic biomarkers of disease progression and survival in primary CNS lymphoma Clinical Trials & Observations

Elotuzumab in combination with pomalidomide, bortezomib, and dexamethasone in relapsed and refractory multiple myeloma Clinical Trials & Observations

Long-term safety and efficacy of fitusiran prophylaxis, and perioperative management, in people with hemophilia A or B Clinical Trials & Observations

Anti-FcRL5 CAR-T exhibits anti-MM activity against EMM after progression of anti-BCMA and anti-GPRC5D CAR-T: a case report Clinical Trials & Observations

Advancing drug development in myelodysplastic syndromes Clinical Trials & Observations

Nivolumab to restore T-cell fitness in CAR-T refractory multiple myeloma Clinical Trials & Observations

Cover Image

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

Hematopoietic cell transplant compared with standard care in adolescents and young adults with sickle cell disease
Clinical Trials & Observations

Identification of genomic biomarkers of disease progression and survival in primary CNS lymphoma
Clinical Trials & Observations

Elotuzumab in combination with pomalidomide, bortezomib, and dexamethasone in relapsed and refractory multiple myeloma
Clinical Trials & Observations

Long-term safety and efficacy of fitusiran prophylaxis, and perioperative management, in people with hemophilia A or B
Clinical Trials & Observations

Anti-FcRL5 CAR-T exhibits anti-MM activity against EMM after progression of anti-BCMA and anti-GPRC5D CAR-T: a case report
Clinical Trials & Observations

Advancing drug development in myelodysplastic syndromes
Clinical Trials & Observations

Nivolumab to restore T-cell fitness in CAR-T refractory multiple myeloma
Clinical Trials & Observations