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Journal Articles

Correlation of immune fitness with response to teclistamab in relapsed/refractory multiple myeloma in the MajesTEC-1 study

Clinical Trials & Observations
Diana Cortes-Selva, Tatiana Perova, Sheri Skerget, Deeksha Vishwamitra, Sarah Stein, Rengasamy Boominathan, Onsay Lau, Karl Calara-Nielsen, Cuc Davis, Jaymala Patel, Arnob Banerjee, Tara Stephenson, Clarissa Uhlar, Rachel Kobos, Jenna Goldberg, Lixia Pei, Danielle Trancucci, Suzette Girgis, Shun Xin Wang Lin, Liviawati S. Wu, Philippe Moreau, Saad Z. Usmani, Nizar J. Bahlis, Niels W. C. J. van de Donk, Raluca I. Verona
Journal: Blood
Blood (2024) 144 (6): 615–628.
https://doi.org/10.1182/blood.2023022823
Published: 2024
Includes: Supplemental data
Journal Articles

Biomarker Correlates of Response to Ciltacabtagene Autoleucel in Patients with Relapsed or Refractory Multiple Myeloma from CARTITUDE-1, a Phase 1b/2 Open-Label Study, at the ~3 Year Follow-up

Rocio Montes de Oca, Junchen Gu, Hao Zhao, Kathy Zelinsky, Dianna Wu, Cuc Davis, Jaymala Patel, Brad Foulk, Rengasamy Boominathan, Onsay Lau, Denis Smirnov, Yi Lin, Sundar Jagannath, Adam D. Cohen, Nahor Haddish-Berhane, Jean Xu, Deepu Madduri, An-Sofie Stevens, Carolyn Chang Jackson, Jordan M. Schecter, Arnob Banerjee, Dong Geng, Jieqing Zhu, Sifan Xu, Enrique Zudaire
Journal: Blood
Blood (2023) 142 (Supplement 1): 2099.
https://doi.org/10.1182/blood-2023-182298
Published: 2023
Journal Articles

Efficacy and Safety in Patients with Lenalidomide-Refractory Multiple Myeloma after 1-3 Prior Lines Who Received a Single Infusion of Ciltacabtagene Autoleucel As Study Treatment in the Phase 3 CARTITUDE-4 Trial

M Hasib Sidiqi, Paolo Corradini, Duncan Purtill, Hermann Einsele, Binod Dhakal, Lionel Karlin, Salomon Manier, Shinsuke Iida, Sebastian Giebel, Simon J. Harrison, Brea Lipe, Abdullah Khan, Jordan M. Schecter, Carolyn Chang Jackson, Tzu-min Yeh, Arnob Banerjee, William Deraedt, Nikoletta Lendvai, Carolina Lonardi, Ana Slaughter, Katherine Li, Diana Chen, Jane Gilbert, Tito Roccia, Man Zhao, Nitin Patel, Erika Florendo, Mythili Koneru, Octavio Costa Filho, Dong Geng, Jesus San Miguel, Kwee Yong
Journal: Blood
Blood (2023) 142 (Supplement 1): 4866.
https://doi.org/10.1182/blood-2023-178778
Published: 2023
Journal Articles

CAR+ T-Cell Lymphoma Post Ciltacabtagene Autoleucel Therapy for Relapsed Refractory Multiple Myeloma

Simon J. Harrison, Tamia Nguyen, Marzia Rahman, Jeremy Er, Jessica Li, Katherine Li, Nikoletta Lendvai, Jordan M. Schecter, Arnob Banerjee, Tito Roccia, Brad Foulk, Junchen Gu, Hao Zhao, Denis Smirnov, Ana Slaughter, Carolina Lonardi, Erin Lee, Loreta Marquez, Shirin Jadidi, Octavio Costa Filho, Nitin Patel, Dong Geng, Nicole M Haynes, Hannah Kelly, Stephen Lade, Sean Grimmond, Piers Blombery
Journal: Blood
Blood (2023) 142 (Supplement 1): 6939.
https://doi.org/10.1182/blood-2023-178806
Published: 2023
Journal Articles

Model-Based Exploration of the Impact of Prophylactic Tocilizumab on IL-6 Dynamics in Multiple Myeloma Patients Receiving Teclistamab Treatment

Jia Zhou, Deeksha Vishwamitra, Yue Guo, Raluca Verona, Alfredo Perales Puchalt, Tara Stephenson, Caroline Hodin, Arnob Banerjee, Katherine Chastain, Nahor Haddish-Berhane, Weirong Wang
Journal: Blood
Blood (2023) 142 (Supplement 1): 4670.
https://doi.org/10.1182/blood-2023-180208
Published: 2023
Journal Articles

Teclistamab, a B-Cell Maturation Antigen (BCMA) x CD3 Bispecific Antibody, in Patients with Relapsed/Refractory Multiple Myeloma (RRMM): Correlative Analyses from MajesTEC-1

Diana Cortes-Selva, Tineke Casneuf, Deeksha Vishwamitra, Sarah Stein, Tatiana Perova, Sheri Skerget, Elena Ramos, Laure van Steenbergen, Dries De Maeyer, Rengasamy Boominathan, Onsay Lau, Cuc Davis, Arnob Banerjee, Tara Stephenson, Clarissa M. Uhlar, Rachel Kobos, Jenna D. Goldberg, Lixia Pei, Danielle Trancucci, Suzette Girgis, Shun Xin Wang Lin, Liviawati S. Wu, Philippe Moreau, Saad Usmani, Nizar Jacques Bahlis, Niels WCJ Van De Donk, Raluca Verona
Journal: Blood
Blood (2022) 140 (Supplement 1): 241–243.
https://doi.org/10.1182/blood-2022-162709
Published: 2022
Journal Articles

Teclistamab Population Pharmacokinetics and Exposure-Response Relationship Support 1.5 Mg/Kg Dose Regimen in Relapsed/Refractory Multiple Myeloma

Xin Miao, Liviawati S. Wu, Shun Xin Wang Lin, Yan Xu, Yang Chen, Yuki Iwaki, Rachel Kobos, Tara Stephenson, Kristy Kemmerer, Clarissa M. Uhlar, Arnob Banerjee, Jenna D. Goldberg, Danielle Trancucci, Raluca Verona, Lixia Pei, Yaming Su, Daniele Ouellet, Alfred L. Garfall, Amrita Y. Krishnan, Saad Usmani, Suzette Girgis, Honghui Zhou
Journal: Blood
Blood (2022) 140 (Supplement 1): 4382–4383.
https://doi.org/10.1182/blood-2022-162859
Published: 2022
Journal Articles

Drug Interaction Potential As a Result of Cytokine Release Syndrome Using a Physiologically Based Pharmacokinetic Model: Case Study of Teclistamab

Marie-Emilie Willemin, Shun Xin Wang Lin, Loeckie De Zwart, Liviawati S. Wu, Xin Miao, Raluca Verona, Arnob Banerjee, Baolian Liu, Rachel Kobos, Ming Qi, Daniele Ouellet, Jenna D. Goldberg, Suzette Girgis
Journal: Blood
Blood (2022) 140 (Supplement 1): 7253–7254.
https://doi.org/10.1182/blood-2022-162856
Published: 2022
Journal Articles

Updated Results from MajesTEC-1: Phase 1/2 Study of Teclistamab, a B-Cell Maturation Antigen x CD3 Bispecific Antibody, in Relapsed/Refractory Multiple Myeloma

Philippe Moreau, Saad Z. Usmani, Alfred L. Garfall, Niels W.C.J. van de Donk, Hareth Nahi, Jesus San-Miguel, Albert Oriol, Ajay K. Nooka, Thomas Martin, Laura Rosinol, Ajai Chari, Lionel Karlin, Lotfi Benboubker, Maria-Victoria Mateos, Nizar J. Bahlis, Rakesh Popat, Britta Besemer, Joaquín Martínez-López, Surbhi Sidana, Lixia Pei, Danielle Trancucci, Raluca I. Verona, Suzette Girgis, Yunsi Olyslager, Mindy Jaffe, Clarissa M. Uhlar, Tara Stephenson, Rian Van Rampelbergh, Arnob Banerjee, Jenna D. Goldberg, Rachel Kobos, Amrita Y. Krishnan
Journal: Blood
Blood (2021) 138 (Supplement 1): 896.
https://doi.org/10.1182/blood-2021-147915
Published: 2021
Journal Articles

Efficacy and Safety of Ciltacabtagene Autoleucel in Patients With Relapsed/Refractory Multiple Myeloma: CARTITUDE-1 Subgroup Analysis

Andrzej Jakubowiak, Saad Z. Usmani, Jesus G. Berdeja, Mounzer Agha, Adam D Cohen, Parameswaran Hari, Jordan M. Schecter, Deepu Madduri, Tzu-Min Yeh, Yunsi Olyslager, Arnob Banerjee, Carolyn C. Jackson, Alicia Allred, Enrique Zudaire, William Deraedt, Changwei Zhou, Dong Geng, Lida Pacaud, Yi Lin, Thomas Martin, Sundar Jagannath
Journal: Blood
Blood (2021) 138 (Supplement 1): 3938.
https://doi.org/10.1182/blood-2021-146069
Published: 2021
Journal Articles

Updated Results from CARTITUDE-1: Phase 1b/2Study of Ciltacabtagene Autoleucel, a B-Cell Maturation Antigen-Directed Chimeric Antigen Receptor T Cell Therapy, in Patients With Relapsed/Refractory Multiple Myeloma

Thomas Martin, Saad Z. Usmani, Jesús G. Berdeja, Andrzej Jakubowiak, Mounzer Agha, Adam D Cohen, Parameswaran Hari, David Avigan, Abhinav Deol, Myo Htut, Alexander Lesokhin, Nikhil C. Munshi, Elizabeth O'Donnell, A. Keith Stewart, Jordan M. Schecter, Jenna D. Goldberg, Carolyn C. Jackson, Tzu-Min Yeh, Arnob Banerjee, Alicia Allred, Enrique Zudaire, William Deraedt, Deepu Madduri, Yunsi Olyslager, Changwei Zhou, Lida Pacaud, Yi Lin, Sundar Jagannath
Journal: Blood
Blood (2021) 138 (Supplement 1): 549.
https://doi.org/10.1182/blood-2021-146060
Published: 2021
Journal Articles

Health-Related Quality of Life in the Cartitude-1 Study of Ciltacabtagene Autoleucel for Relapsed/Refractory Multiple Myeloma

Thomas Martin, III, MD, Yi Lin, MD PhD, Mounzer Agha, MD, Adam D. Cohen, MD, Myo Htut, MD, A. Keith Stewart, MBChB, Parameswaran Hari, MD MRCP, Jesus G. Berdeja, MD, Deepu Madduri, MD, Saad Z. Usmani, MDMBBS,MBA, Tzu-Min Yeh, Alicia J. Allred, PhD, Yunsi Olyslager, MSc, Arnob Banerjee, MD, Jenna D. Goldberg, MD, Jordan M. Schecter, MD, Carolyn C. Jackson, MD MPH, William Deraedt, MSc, Katharine S. Gries, PhD PharmD, John Fastenau, RPh, MPH, PhD, Xiaoling Wu, PhD, Marlene J. Carrasco, MD PhD MPH, Muhammad Akram, MD, Farah Hossain, PharmD, Andrzej Jakubowiak, MD PhD, Sundar Jagannath, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 41–42.
https://doi.org/10.1182/blood-2020-136368
Published: 2020
Journal Articles

Patient Expectations and Perceptions of Treatment in CARTITUDE-1: Phase 1b/2 Study of Ciltacabtagene Autoleucel in Relapsed/Refractory Multiple Myeloma

Adam D. Cohen, MD, Parameswaran Hari, MD MRCP, Myo Htut, MD, Jesus G. Berdeja, MD, Deepu Madduri, MD, Saad Z. Usmani, MDMBBS,MBA, Alicia J. Allred, PhD, Yunsi Olyslager, MSc, Arnob Banerjee, MD, Jenna D. Goldberg, MD, Jordan M. Schecter, MD, Carolyn C. Jackson, MD MPH, Katharine S. Gries, PhD PharmD, John Fastenau, RPh, MPH, PhD, William Deraedt, MSc, Marlene J. Carrasco, MD PhD MPH, Muhammad Akram, MD, Farah Hossain, PharmD, Sigrid Crawford, MA, Ross Morrison, MPH, Lynda Doward, MRes, Andrzej Jakubowiak, MD PhD, Sundar Jagannath, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–15.
https://doi.org/10.1182/blood-2020-136383
Published: 2020
Journal Articles

CARTITUDE-1: Phase 1b/2 Study of Ciltacabtagene Autoleucel, a B-Cell Maturation Antigen-Directed Chimeric Antigen Receptor T Cell Therapy, in Relapsed/Refractory Multiple Myeloma

Deepu Madduri, MD, Jesus G. Berdeja, MD, Saad Z. Usmani, MDMBBS,MBA, Andrzej Jakubowiak, MD PhD, Mounzer Agha, MD, Adam D. Cohen, MD, A. Keith Stewart, MBChB, Parameswaran Hari, MD MRCP, Myo Htut, MD, Elizabeth O'Donnell, MD, Nikhil C. Munshi, MD, David E. Avigan, MD, Abhinav Deol, MD, Alexander M. Lesokhin, MD, Indrajeet Singh, PhD, Enrique Zudaire, PhD, Tzu-Min Yeh, Alicia J. Allred, PhD, Yunsi Olyslager, MSc, Arnob Banerjee, MD, Jenna D. Goldberg, MD, Jordan M. Schecter, MD, Carolyn C. Jackson, MD MPH, William Deraedt, MSc, Sen Hong Zhuang, MD PhD, Jeffrey R. Infante, MD, Dong Geng, PhD, Xiaoling Wu, PhD, Marlene J. Carrasco, MD PhD MPH, Muhammad Akram, MD, Farah Hossain, PharmD, Syed Rizvi, MD, Frank Fan, MD PhD, Sundar Jagannath, MD, Yi Lin, MD PhD, Thomas Martin, III, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–25.
https://doi.org/10.1182/blood-2020-136307
Published: 2020
Journal Articles

Updated Phase 1 Results of Teclistamab, a B-Cell Maturation Antigen (BCMA) x CD3 Bispecific Antibody, in Relapsed and/or Refractory Multiple Myeloma (RRMM)

Alfred L. Garfall, MD, Saad Z. Usmani, MDMBBS,MBA, María-Victoria Mateos, Hareth Nahi, MD PhD, Niels W.C.J. van de Donk, MD PhD, Jesus F. San-Miguel, MD PhD, Albert Oriol Rocafiguera, MD, Laura Rosinol, MD PhD, Ajai Chari, MD, Manisha Bhutani, MD, Lixia Pei, PhD, Raluca Verona, PhD, Suzette Girgis, PhD BPharm, MS, Tara Stephenson, PhD, Jenna D. Goldberg, MD, Arnob Banerjee, MD, Amrita Krishnan, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 27.
https://doi.org/10.1182/blood-2020-138831
Published: 2020
Journal Articles

Translational Approach of Using Ex Vivo Cytotoxicity and Early Clinical Data to Predict Teclistamab Efficacious Therapeutic Range in Multiple Myeloma Patients

Suzette Girgis, PhD BPharm, MS, Shun Xin Wang Lin, PhD, Kodandaram Pillarisetti, MSc, Arnob Banerjee, MD, Jenna D. Goldberg, MD, Shoba Shetty, PhD, Tara Stephenson, PhD, Brandi W. Hilder, PhD, Brett Hanna, Jennifer Smit, Homer Adams III, PhD, Yu-Nien (Tom) Sun, PhD, Jeffrey R. Infante, MD, Yusri A Elsayed, MD PhD, Amarnath Sharma, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 35.
https://doi.org/10.1182/blood-2020-140565
Published: 2020
Journal Articles

Cytokine Release Syndrome in Patients with Relapsed/Refractory Multiple Myeloma Treated with Ciltacabtagene Autoleucel in the Phase 1b/2 CARTITUDE-1 Study

Yi Lin, MD PhD, Thomas Martin, III, MD, Adam D. Cohen, MD, Andrzej Jakubowiak, MD PhD, Jagoda Jasielec, MD, Saad Z. Usmani, MDMBBS,MBA, Deepu Madduri, MD, Mounzer Agha, MD, A. Keith Stewart, MBChB, Indrajeet Singh, PhD, Enrique Zudaire, PhD, Tzu-Min Yeh, Alicia J. Allred, PhD, Yunsi Olyslager, MSc, Arnob Banerjee, MD, Jenna D. Goldberg, MD, Jordan M. Schecter, MD, Carolyn C. Jackson, MD MPH, William Deraedt, MSc, Dong Geng, PhD, Xiaoling Wu, PhD, Marlene J. Carrasco, MD PhD MPH, Muhammad Akram, MD, Farah Hossain, PharmD, Vickie Wang, PhD, Jesus G. Berdeja, MD, Sundar Jagannath, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 45–46.
https://doi.org/10.1182/blood-2020-136360
Published: 2020
Journal Articles

Results from CARTITUDE-1: A Phase 1b/2 Study of JNJ-4528, a CAR-T Cell Therapy Directed Against B-Cell Maturation Antigen (BCMA), in Patients with Relapsed and/or Refractory Multiple Myeloma (R/R MM)

Deepu Madduri, MD, Saad Z. Usmani, MD, Sundar Jagannath, Indrajeet Singh, PhD, Enrique Zudaire, PhD, Tzu-Min Yeh, Alicia J. Allred, PhD, Arnob Banerjee, MD, Jenna D. Goldberg, MD, Jordan M Schecter, MD, Sen Zhuang, Jeffrey R. Infante, MD, Syed Rizvi, Xiaohu (Frank) Fan, MD PhD, Andrzej Jakubowiak, MD PhD, Jesus G. Berdeja, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 577.
https://doi.org/10.1182/blood-2019-121731
Published: 2019
Journal Articles

Translational Analysis from CARTITUDE-1, an Ongoing Phase 1b/2 Study of JNJ-4528 BCMA-targeted CAR-T Cell Therapy in Relapsed and/or Refractory Multiple Myeloma (R/R MM), Indicates Preferential Expansion of CD8+ T Cell Central Memory Cell Subset

Enrique Zudaire, PhD, Deepu Madduri, MD, Saad Z. Usmani, MD FACP, Andrzej Jakubowiak, MD PhD, Jesus G. Berdeja, MD, Dong Geng, Syed Rizvi, MD, Tonia Nesheiwat, Jordan M Schecter, MD, Jenna D. Goldberg, MD, Arnob Banerjee, MD, Alicia J. Allred, PhD, Indrajeet Singh, PhD, Raluca Verona, PhD, Ian McCaffery, PhD, Sundar Jagannath
Journal: Blood
Blood (2019) 134 (Supplement_1): 928.
https://doi.org/10.1182/blood-2019-127309
Published: 2019
Journal Articles

Reduction of Immunosuppression Does Not Significantly Impact Incidence of Renal Transplant Graft Rejection Following a Diagnosis of Post-Transplant Lymphoproliferative Disorder

Emily K Fay, MD, Abdolreza Haririan, MD MPH, Arnob Banerjee, MDPhD, Seung-Tae Lee, MD PhD, Jennie Y Law, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5216.
https://doi.org/10.1182/blood.V130.Suppl_1.5216.5216
Published: 2017