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Asish K. Ghosh
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Journal Articles

MER Signaling Axis: A Novel Therapeutic Target in Chronic Lymphocytic Leukemia

Mariana T. Mendez, Asish K Ghosh, Murali Mamidi, Sara K. Vesely, Jennifer Holter-Chakrabarty
Journal: Blood
Blood (2022) 140 (Supplement 1): 6990.
https://doi.org/10.1182/blood-2022-158766
Published: 2022
Journal Articles

Β-Catenin and Axl Receptor Tyrosine Kinase Modulation in CLL B-Cells with Co-Culture on Marrow Stromal Cells: Implications for Drug Resistance

Sutapa Sinha, PhD, Charla R Secreto, Justin C. Boysen, Steven L. Warner, PhD, David J. Bearss, PhD, Asish K Ghosh, PhD, Neil E. Kay, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1739.
https://doi.org/10.1182/blood-2019-121772
Published: 2019
Journal Articles

Enhanced Expression of Beta-Catenin and Axl Receptor Tyrosine Kinase (RTK) in Chronic Lymphocytic Leukemia (CLL) B-Cells with Co-Culture on Marrow Stromal Cells: Implications for Leukemic Cell Drug Resistance

Sutapa Sinha, PhD, Charla R Secreto, Justin C. Boysen, Steven L. Warner, PhD, David J. Bearss, PhD, Asish K Ghosh, PhD, Neil E. Kay, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3125.
https://doi.org/10.1182/blood-2018-99-110981
Published: 2018
Journal Articles

Sensitivity of Ibrutinib Exposed Chronic Lymphocytic Leukemia B-Cells to Inhibition of Axl Receptor Tyrosine Kinase

Sutapa Sinha, PhD, Justin C Boysen, Kari G. Chaffee, MS, Brian F Kabat, Susan L. Slager, PhD, Sameer A. Parikh, MD, Charla R Secreto, Tait D. Shanafelt, MD, Jose F. Leis, MD PhD, Steven L. Warner, PhD, David J. Bearss, PhD, Asish K Ghosh, PhD, Neil E. Kay, MD
Journal: Blood
Blood (2016) 128 (22): 2020.
https://doi.org/10.1182/blood.V128.22.2020.2020
Published: 2016
Journal Articles

Epigenetic Silencing of Catalase Induces Accumulation of Reactive Oxygen Species in Chronic Lymphocytic Leukemia B Cells Leading to Activation of Axl: An Escape Strategy?

Guru P Maiti, PhD MSc, Sutapa Sinha, PhD, Justin C Boysen, Neil E. Kay, MD, Asish K Ghosh, PhD
Journal: Blood
Blood (2016) 128 (22): 4363.
https://doi.org/10.1182/blood.V128.22.4363.4363
Published: 2016
Journal Articles

Targeted Inhibition of Axl Primes Chronic Lymphocytic Leukemia B-Cells for Apoptosis: Synergistic/Additive Effects in Combination with Bruton Tyrosine Kinase Inhibitors

Sutapa Sinha, PhD, Justin Boysen, Michael Nelson, Charla Secreto, Steven L. Warner, PhD, David J. Bearss, PhD, Connie Lesnick, M.Sc, Tait D. Shanafelt, MD, Neil E. Kay, MD, Asish K Ghosh, PhD
Journal: Blood
Blood (2014) 124 (21): 1946.
https://doi.org/10.1182/blood.V124.21.1946.1946
Published: 2014
Journal Articles

Activated Chronic Lymphocytic Leukemia B-Cells Preferentially Shed CD52 + Microvesicles, but Not CD19 + , and May Predict Therapeutic Outcome

Sutapa Sinha, PhD, Justin Boysen, Michael Nelson, Connie Lesnick, M.Sc, Tait D. Shanafelt, MD, Neil E. Kay, MD, Asish K Ghosh, PhD
Journal: Blood
Blood (2014) 124 (21): 1961.
https://doi.org/10.1182/blood.V124.21.1961.1961
Published: 2014
Journal Articles

Axl Regulates Fibroblast Growth Factor Receptor Signaling in B-Cell Chronic Lymphocytic Leukemia: Dual Targeting in CLL Therapy

Sutapa Sinha, PhD, Justin Boysen, Charla Secreto, Steven L. Warner, PhD, Neil E. Kay, MD, Asish K Ghosh, PhD
Journal: Blood
Blood (2014) 124 (21): 831.
https://doi.org/10.1182/blood.V124.21.831.831
Published: 2014
Journal Articles

Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia

Alessandra Ferrajoli, Tait D. Shanafelt, Cristina Ivan, Masayoshi Shimizu, Kari G. Rabe, Nazila Nouraee, Mariko Ikuo, Asish K. Ghosh, Susan Lerner, Laura Z. Rassenti, Lianchun Xiao, Jianhua Hu, James M. Reuben, Steliana Calin, M. James You, John T. Manning, William G. Wierda, Zeev Estrov, Susan O’Brien, Thomas J. Kipps, Michael J. Keating, Neil E. Kay, George A. Calin
Journal: Blood
Blood (2013) 122 (11): 1891–1899.
https://doi.org/10.1182/blood-2013-01-478222
Published: 2013
Includes: Supplemental data
Journal Articles

Novel Pharmacological Agents Differentially Modulate Cytokine Release On CLL B-Cell-Stromal Cell Co-Culture: Implications for Stromal Rescue of CLL B-Cells From Chemotherapy

Connie Lesnick, M.Sc, Asish K Ghosh, PhD, Betsy R. LaPlant, Wei Ding, MD, PhD, Neil E. Kay, MD, Tait D. Shanafelt, MD
Journal: Blood
Blood (2012) 120 (21): 3927.
https://doi.org/10.1182/blood.V120.21.3927.3927
Published: 2012
Journal Articles

Epigallocatechin-3-Gallate (EGCG) Modulates Cytokine Production When Leukemic CLL B-Cells and Marrow Stromal Cells Are Co-Cultured: Correlations with Clinical Activity in a Phase II Trial,

Connie Lesnick, Neil Kay, MD, Betsy R. LaPlant, Asish K Ghosh, PhD, Tait D. Shanafelt, MD
Journal: Blood
Blood (2011) 118 (21): 3882.
https://doi.org/10.1182/blood.V118.21.3882.3882
Published: 2011
Journal Articles

Axl Receptor Tyrosine Kinase Signaling Pathway and the p53 Tumor Suppressor Protein Exist In A Novel Regulatory Loop In B-Cell Chronic Lymphocytic Leukemia Cells

Asish K Ghosh, PhD, Justin Boysen, Tammy Price-troska, Charla Secreto, Clive S. Zent, MD, Neil Kay, MD
Journal: Blood
Blood (2011) 118 (21): 799.
https://doi.org/10.1182/blood.V118.21.799.799
Published: 2011
Journal Articles

TRIS (DIBENZYLIDENEACETONE) Dipalladium a Small-Molecule Palladium Complex Is Effective in the Induction of Apoptosis for B-Chronic Lymphocytic Leukemia B-Cells

Neil Kay, MD, Traci Sassoon, Charla Secreto, Asish K Ghosh, PhD, Jack L Arbiser
Journal: Blood
Blood (2011) 118 (21): 2851.
https://doi.org/10.1182/blood.V118.21.2851.2851
Published: 2011
Journal Articles

The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy

Asish K. Ghosh, Charla Secreto, Justin Boysen, Traci Sassoon, Tait D. Shanafelt, Debabrata Mukhopadhyay, Neil E. Kay
Journal: Blood
Blood (2011) 117 (6): 1928–1937.
https://doi.org/10.1182/blood-2010-09-305649
Published: 2011
Includes: Supplemental data
Journal Articles

A Novel Receptor Tyrosine Kinase Axl is Constitutively Active in B-Cell Chronic Lymphocytic Leukemia and Acts as a Docking Site of Non-Receptor Kinases: Implications for Therapy

Asish K Ghosh, PhD, Charla Secreto, Justin Boysen, Traci Sassoon, Sacha Holland, Tait Shanafelt, MD, Debabrata Mukhopadhyay, Neil E. Kay
Journal: Blood
Blood (2010) 116 (21): 54.
https://doi.org/10.1182/blood.V116.21.54.54
Published: 2010
Journal Articles

Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression

Asish K. Ghosh, Charla R. Secreto, Traci R. Knox, Wei Ding, Debabrata Mukhopadhyay, Neil E. Kay
Journal: Blood
Blood (2010) 115 (9): 1755–1764.
https://doi.org/10.1182/blood-2009-09-242719
Published: 2010
Includes: Supplemental data
Journal Articles

Bosutinib, a Src/Abl Kinase Inhibitor Induces Apoptosis in CLL B Cells by Targeting Multiple Tyrosine Kinases and Overcomes Stroma Protection.

Asish K Ghosh, PhD, Debabrata Mukhopadhyay, Neil E. Kay, MD
Journal: Blood
Blood (2009) 114 (22): 2368.
https://doi.org/10.1182/blood.V114.22.2368.2368
Published: 2009
Journal Articles

Role of Platelet-Derived Growth Factor On Vascular Endothelial Growth Factor Synthesis by Mesenchymal Stem Cells in Chronic Lymphocytic Leukemia: Implications for Clinical Progression.

Wei Ding, MD, PhD, Traci Knox, Susan Schwager, Charla Secreto, Asish K Ghosh, PhD, Wenting Wu, Neil E. Kay, MD
Journal: Blood
Blood (2009) 114 (22): 804.
https://doi.org/10.1182/blood.V114.22.804.804
Published: 2009
Journal Articles

Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells

Asish K. Ghosh, Tait D. Shanafelt, Amelia Cimmino, Cristian Taccioli, Stefano Volinia, Chang-gong Liu, George A. Calin, Carlo M. Croce, Denise A. Chan, Amato J. Giaccia, Charla Secreto, Linda E. Wellik, Yean K. Lee, Debabrata Mukhopadhyay, Neil E. Kay
Journal: Blood
Blood (2009) 113 (22): 5568–5574.
https://doi.org/10.1182/blood-2008-10-185686
Published: 2009
Journal Articles

Aberrant Regulation of pVHL Levels by Microrna May Explain Autocrine Secretion of VEGF in CLL B Cells.

Asish K Ghosh, PhD, Tait Shanafelt, MD, George A Calin, MD, PhD, Carlo M. Croce, MD, Linda Wellik, Debabrata Mukhopadhyay, Neil Kay
Journal: Blood
Blood (2008) 112 (11): 1064.
https://doi.org/10.1182/blood.V112.11.1064.1064
Published: 2008