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Giovanni Cazzaniga, PhD
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Journal Articles

Incidence and Therapeutic Implications of Germline TP53 Mutations in Hypodiploid Childhood Acute Lymphoblastic Leukemia: A Retrospective Analysis of the Italian Cohort

Laura Rachele Bettini, Claudia Saitta, Barbara Buldini, Geertruij Te Kronnie, Stefano Rebellato, Daniela Silvestri, Elena Barisone, Andrea Pession, Marco Rabusin, Concetta Micalizzi, Franco Locatelli, MD PhD, Carmelo Rizzari, Maria Grazia Valsecchi, PhD, Andrea Biondi, MD, Grazia Fazio, Giovanni Cazzaniga, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 43–44.
https://doi.org/10.1182/blood-2020-142729
Published: 2020
Journal Articles

NUTM1 -Rearranged Infant and Pediatric B Cell Precursor Acute Lymphoblastic Leukemia: A Good Prognostic Subtype Identified in a Collaborative International Study

Judith M. Boer, PhD, Maria Grazia Valsecchi, PhD, Femke M. Hormann, MSc, Zeljko Antic, MD, Marketa Zaliova, MD PhD, Claire Schwab, PhD, Giovanni Cazzaniga, PhD, Chloé Arfeuille, MD, Hélène Cavé, PharmD, PhD, Andishe Attarbaschi, MD, Sabine Strehl, PhD, Gabriele Escherich, MD, Toshihiko Imamura, MD PhD, Kentaro Ohki, MD PhD, Tanja A. Gruber, MD PhD, Rosemary Sutton, BSc MSc PhD, Agata Pastorczak, Tim Lammens, PhD, Frederic Lambert, MD, Chi Kong Li, MD, Enrique Carrillo de Santa Pau, PhD, Steve Hoffmann, MD PhD, Anja Möricke, MD, Christine J. Harrison, PhD FRCPath, Monique L. Den Boer, PhD, Paola De Lorenzo, Ronald W. Stam, PhD, Anke K. Bergmann, MD PhD, Rob Pieters, MDPhDMSc
Journal: Blood
Blood (2020) 136 (Supplement 1): 25–26.
https://doi.org/10.1182/blood-2020-139376
Published: 2020
Journal Articles

Donor-Derived CAR T Cells Engineered with Sleeping Beauty Achieve Anti-Leukemic Activity without Severe Toxicity

Chiara F Magnani, Giuseppe Gaipa, PhD, Federico Lussana, MD, Daniela Belotti, Giuseppe Gritti, MD PhD, Sara Napolitano, MD, Chiara Buracchi, PhD, Gian Maria Borleri, Silvia Zaninelli, Giuliana Rizzuto, Sarah Tettamanti, PhD, Valentina Colombo, Giovanni Cazzaniga, PhD, Benedetta Cabiati, Attilio Rovelli, MD, Ettore Biagi, MD PhD, Stefania Galimberti, PhD, Fabrizio Benedicenti, Eugenio Montini, PhD, Silvia Ferrari, MD, Martino Introna, MD, Adriana Balduzzi, MD, Maria Grazia Valsecchi, PhD, Giuseppe Dastoli, MD, Alessandro Rambaldi, MD, Andrea Biondi, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34.
https://doi.org/10.1182/blood-2020-141236
Published: 2020
Journal Articles

Clinical Implications of Minimal Residual Disease Detection in Infants with KMT2A -Rearranged Acute Lymphoblastic Leukemia Treated on the Interfant-06 Protocol

Janine Stutterheim, MDPhD, Inge M. van der Sluis, MD PhD, Paola De Lorenzo, Julia Alten, MD, Philip Ancliff, MD, Andishe Attarbaschi, MD, Benoit Brethon, MD, Andrea Biondi, MD, Myriam Campbell, MD, Giovanni Cazzaniga, PhD, Gabriele Escherich, MD, Alina Ferster, MD, Rishi Sury Kotecha, MBBChir, PhD, Birgitte Lausen, MD, Chi Kong Li, MD, Luca Lo Nigro, PhDMD, Franco Locatelli, MD PhD, Rolf Marschalek, PhD, Martin Schrappe, MDPhD, Jan Stary, MD PhD, Ajay Vora, MD, Jan Zuna, PhD, Vincent H.J. Van Der Velden, PhD, Tomasz Szczepanski, MD PhD, Maria Grazia Valsecchi, PhD, Rob Pieters, MDPhDMSc
Journal: Blood
Blood (2020) 136 (Supplement 1): 41–42.
https://doi.org/10.1182/blood-2020-134303
Published: 2020
Journal Articles

Poor Prognosis in Children with ABL -Class Fusion Positive B-Cell Acute Lymphoblastic Leukemia Treated According to AIEOP-BFM Protocols

Gunnar Cario, MD PhD, Veronica Leoni, Valentino Conter, MD, Andishe Attarbaschi, MD, Marketa Zaliova, MD PhD, Lucie Sramkova, Giovanni Cazzaniga, PhD, Grazia Fazio, Rosemary Sutton, BSc MSc PhD, Sarah Elitzur, MD, Shai Izraeli, MD, Melchior Lauten, Franco Locatelli, MD PhD, Giuseppe Basso, MD PhD, Barbara Buldini, MD PhD, Anke K Bergmann, Jana Lentes, Doris Steinemann, Gudrun Gohring, Brigitte Schlegelberger, MD, Oskar A Haas, Denis Martin Schewe, Swantje Buchmann, Anja Moericke, Deborah L. White, PhD FFSc (RCPA), Tamas Revesz, Martin Stanulla, Georg Mann, MD, Nicole Bodmer, Nira Arad-Cohen, Jan Zuna, Maria Grazia Valsecchi, PhD, Martin Zimmermann, PhD, Martin Schrappe, MD PhD, Andrea Biondi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1351.
https://doi.org/10.1182/blood-2019-126523
Published: 2019
Journal Articles

Transient Switch to Myeloid Lineage in Acute Lymphoblastic Leukemia during Induction Therapy: The Role of CD371 Expression and Implication for Minimal Residual Disease Detection

Elena Varotto, MD PhD, Margarita Maurer-Granofszky, PhD, Daniela Silvestri, Pamela Scarparo, PhD, Ester Mejstrikova, MD PhD, Monika Brüggemann, Giovanni Cazzaniga, PhD, Valentino Conter, MD, Ondrej Hrusak, MD PhD, Giuseppe Gaipa, PhD, Angela Schumich, Maria Grazia Valsecchi, PhD, Giuseppe Basso, MD PhD, Michael Dworzak, MD, Barbara Buldini, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 377.
https://doi.org/10.1182/blood-2019-127287
Published: 2019
Journal Articles

Donor-Derived CD19 CAR Cytokine Induced Killer (CIK) Cells Engineered with Sleeping Beauty Transposon for Relapsed B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Chiara F Magnani, PhD, Giuseppe Gaipa, PhD, Daniela Belotti, Giada Matera, Sarah Tettamanti, PhD, Benedetta Cabiati, Chiara Buracchi, PhD, Grazia Fazio, Silvia Zaninelli, Silvia Rigamonti, Stefania Cesana, Valentina Colombo, Giovanni Cazzaniga, PhD, Attilio Rovelli, MD, Adriana Balduzzi, MD, Sara Napolitano, MD, Fabrizio Benedicenti, Eugenio Montini, PhD, Gian Maria Borleri, Silvia Ferrari, MD, Giuseppe Gritti, MD PhD, Federico Lussana, MD, Martino Introna, MD, Alessandro Rambaldi, MD, Giuseppe Dastoli, MD, Andrea Biondi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 200.
https://doi.org/10.1182/blood-2019-125894
Published: 2019
Journal Articles

Pre-Clinical Efficacy of the Novel Kinase Inhibitor Nintedanib on PAX5 Fusion Genes in Pediatric Ph-like B-Cell Precursor Acute Lymphoblastic Leukemia

Grazia Fazio, Silvia Bresolin, Claudia Saitta, Daniela Silvestri, Elena Vendramini, Chiara Palmi, Silvia Rigamonti, Marta Galbiati, Manuel Quadri, Stefano Mecca, Angela Maria Savino, Michela Bardini, Andrea Grioni, Maria Grazia Valsecchi, PhD, Geertruy te Kronnie, Andrea Biondi, MD, Giovanni Cazzaniga, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 745.
https://doi.org/10.1182/blood-2019-128509
Published: 2019
Journal Articles

Euroclonality-NGS DNA Capture Panel for Integrated Analysis of IG/TR Rearrangements, Translocations, Copy Number and Sequence Variation in Lymphoproliferative Disorders

Peter Stewart, PhD, Jana Gazdova, MSc, Nikos Darzentas, PhD, Dorte Wren, PhDFRCPath, Paula Proszek, Grazia Fazio, Simona Songia, Miguel Alcoceba, Maria Eugenia Sarasquete, PhD, Patrick Villarese, PhD, Michèle Y van der Klift, Kim Heezen, Neil McCafferty, MSc, Karol Pal, MSc, Mark Catherwood, PhD, Chang Sik Kim, PhD, Shambhavi Srivastava, PhD, Elizabeth Hodges, PhD, Kostas Stamatopoulos, Wolfram Klapper, Simone Ferrero, MD, Michiel van den Brand, MD, Giovanni Cazzaniga, PhD, Frederic Davi, MD PhD, Ramon Garcia-Sanz, MD PhD, Patricia Groenen, Elizabeth Macintyre, PhDMD, Monika Brüggemann, Christiane Pott, MD PhD, Elisa Genuardi, Anton W Langerak, PhD, David Gonzalez, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 888.
https://doi.org/10.1182/blood-2019-127822
Published: 2019
Journal Articles

Bone Marrow Mesenchymal Stromal Cells and Inflammation Contribute to ETV6-RUNX1 + Preleukemic Cells Persistence and DNA Damaging

Linda Beneforti, Erica Dander, PhD, Silvia Bresolin, PhD, Clara Bueno, Geertruy te Kronnie, Anthony Ford, Pablo Menendez, Giovanna D'Amico, BSc, PhD MSc, Andrea Biondi, Chiara Palmi, Giovanni Cazzaniga, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3918.
https://doi.org/10.1182/blood-2018-99-114791
Published: 2018
Journal Articles

MLL-USP2 : An Underestimated New Entity of MLL -Rearranged Leukemia Identified By NGS Analysis

Claus Meyer, PhD, Bruno Lopes, PhD, Aurélie Caye-Eude, PharmD, Hélène Cavé, PharmD, PhD, Chloé Arfeuille, PhD, Rosemary Sutton, PhD, Nicola Venn, BSc, Patrizia Larghero, PhD, Seung Hwan Oh, MD, Grigory Tsaur, MD PhD, Marketa Zaliova, Jan Zuna, Vesa Juvonen, PhD, Renate Panzer-Grümayer, MD, Grazia Fazio, PhD, Giovanni Cazzaniga, PhD, Mariana Emerenciano, PhD, Rolf Marschalek, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3920.
https://doi.org/10.1182/blood-2018-99-112594
Published: 2018
Journal Articles

Successful of Chemo-Free Treatment with Dasatinib and Blinatumomab in a Pediatric EBF1-PDGFRβ Positive Acute Lymphoblastic Leukemia

Fara Petruzziello, MD, Giovanna Giagnuolo, MD, Giovanni Cazzaniga, PhD, Giuliana Beneduce, MD, Franco Locatelli, Pio Stellato, MD, Grazia Fazio, PhD, Giuseppe Mirabelli, PhD, Giuseppe Menna, MD, Rosanna Parasole, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5213.
https://doi.org/10.1182/blood-2018-99-113829
Published: 2018
Journal Articles

Digital-Droplet PCR, an Accurate Method for IG/TR PCR-MRD Stratification in Childhood Acute Lymphoblastic Leukemia

Irene Della Starza, PhD, Vittorio Nunes, Federica Lovisa, Daniela Silvestri, Marzia Cavalli, PhD, Andrea Garofalo, Mimma Campeggio, Lucia Anna De Novi, PhD, Carlotta Oggioni, Andrea Biondi, MD, Anna Guarini, PhD, Maria Grazia Valsecchi, PhD, Valentino Conter, MD, Giuseppe Basso, MD, Robin Foà, MD, Giovanni Cazzaniga, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1544.
https://doi.org/10.1182/blood-2018-99-117954
Published: 2018
Journal Articles

Clinical-Grade Transduction of Allogeneic Cytokine Induced Killer (CIK) Cells with CD19 Chimeric Antigen Receptor (CAR) Using Sleeping Beauty (SB) Transposon: Successful GMP-Compliant Manufacturing for Clinical Applications

Giuseppe Gaipa, PhD, Chiara Francesca Magnani, PhD, Daniela Belotti, Giada Matera, Sarah Tettamanti, PhD, Benedetta Cabiati, Stefania Cesana, Valentina Colombo, Giovanni Cazzaniga, PhD, Grazia Fazio, PhD, Chiara Buracchi, PhD, Silvia Rigamonti, Attilio Rovelli, MD, Adriana Balduzzi, MD, Sara Napolitano, MD, Eugenio Montini, Gian Maria Borleri, Giuseppe Gritti, MD PhD, Federico Lussana, MD PhD, Martino Introna, MD, Alessandro Rambaldi, MD, Giuseppe Dastoli, MD, Andrea Biondi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 196.
https://doi.org/10.1182/blood-2018-196
Published: 2018
Journal Articles

A Treatment Protocol with Imatinib and Intensive Chemotherapy for Pediatric Philadelphia Positive Acute Lymphoblastic Leukemia Patients: A Single-Arm, Intergroup Study (EsPhALL 2010-2014)

Andrea Biondi, MD, Virginie Gandemer, MDPhD, Myriam Campbell, MD, Anders Castor, MD PhD, Rob Pieters, MD PhD, Paola De Lorenzo, PhD, Veronica Leoni, MD, Jan Stary, Gabriele Escherich, MD, Chi Kong Li, MD, Giovanni Cazzaniga, PhD, Helene Cave, PharmD, PhD, Silja Roettgers, PhD, Valentino Conter, MD, Vaskar Saha, MD PhD, Martin Schrappe, MD PhD, Maria Grazia Valsecchi, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 97.
https://doi.org/10.1182/blood.V130.Suppl_1.97.97
Published: 2017
Journal Articles

Efficacy of Dasatinib to Treat Molecular Relapse in an Adolescent with Philadelphia-Positive Acute Lymphoblastic Leukemia

Fara Petruzziello, MD, Giovanna Giagnuolo, MD, Giuseppe Menna, MD, Giovanni Cazzaniga, PhD, Giada Muccioli Casadei, PhD, Salvatore Buffardi, MD, Giovanna Maisto, Rosanna Parasole, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5045.
https://doi.org/10.1182/blood.V130.Suppl_1.5045.5045
Published: 2017
Journal Articles

Biological Properties of Mesenchymal Stromal Cells Obtained from Paediatric Patients with B-Cell Precursor Acute Lymphoblastic Leukemia

Erica Dander, PhD, Federica Portale, Chiara Palmi, Linda Beneforti, Andrea Biondi, MD, Giovanni Cazzaniga, PhD, Giovanna D'Amico, BSc, PhD MSc
Journal: Blood
Blood (2017) 130 (Supplement 1): 4951.
https://doi.org/10.1182/blood.V130.Suppl_1.4951.4951
Published: 2017
Journal Articles

Distinct MiR-126 Expression Describes a Non-Genetic but Functional Intra-Tumoral Heterogeneity in Primary Human B-ALL and Can be Prospectively Used to Identify Aggressive Subclones in NSG Mice

Carolina Caserta, MS, Matteo Maria Naldini, MD, Silvia Nucera, MD, Davide Cittaro, Giacomo Desantis, Francesca Pavesi, MD, Grazia Fazio, PhD, Giovanni Cazzaniga, PhD, Fabio Ciceri, MD, Bernhard Gentner, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 35.
https://doi.org/10.1182/blood.V130.Suppl_1.35.35
Published: 2017
Journal Articles

A Versatile DNA/RNA NGS Targeted Capture Strategy for Detection of Fusion Genes in Pediatric ALL

Grazia Fazio, PhD, Andrea Grioni, Tomas Reigl, Silvia Rigamonti, Vojtech Bystry, Simona Songia, Andrea Biondi, MD, Nikos Darzentas, Giovanni Cazzaniga, PhD
Journal: Blood
Blood (2016) 128 (22): 2913.
https://doi.org/10.1182/blood.V128.22.2913.2913
Published: 2016
Journal Articles

Transcriptional Control of Glucose and Energy Supply Prevents Oncogenic Signaling and B Cell Transformation

Lai N Chan, PhD, Zhengshan Chen, MD PhD, Gang Xiao, PhD, Jaewoong Lee, PhD, Huimin Geng, PhD, Hurtz Christian, PhD, Valeria Cazzaniga, PhD, Giovanni Cazzaniga, PhD, Ross A Dickins, PhD, Markus Müschen, MD PhD
Journal: Blood
Blood (2016) 128 (22): 437.
https://doi.org/10.1182/blood.V128.22.437.437
Published: 2016