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Journal Articles

The Yin and Yang of Interleukin-21 in Allergy, Autoimmunity and Cancer

Warren J. Leonard, MD

Blood (2011) 118 (21): SCI-6.

https://doi.org/10.1182/blood.V118.21.SCI-6.SCI-6

Published: 2011

Journal Articles

Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL

Alan M. Hanash, Lucy W. Kappel, Nury L. Yim, Rebecca A. Nejat, Gabrielle L. Goldberg, Odette M. Smith, Uttam K. Rao, Lindsay Dykstra, Il-Kang Na, Amanda M. Holland, Jarrod A. Dudakov, Chen Liu, George F. Murphy, Warren J. Leonard, Glenn Heller, Marcel R. M. van den Brink

Blood (2011) 118 (2): 446–455.

https://doi.org/10.1182/blood-2010-07-294785

Published: 2011

Includes: Supplemental data

Journal Articles

p90RSK2 is essential for FLT3-ITD– but dispensable for BCR-ABL–induced myeloid leukemia

Shannon Elf, Dean Blevins, Lingtao Jin, Tae-Wook Chung, Ifor R. Williams, Benjamin H. Lee, Jian-Xin Lin, Warren J. Leonard, Jack Taunton, Hanna J. Khoury, Sumin Kang

Blood (2011) 117 (25): 6885–6894.

https://doi.org/10.1182/blood-2010-10-315721

Published: 2011

Includes: Supplemental data

Journal Articles

Abrogation of Donor T Cell IL-21 Signaling Leads to Tissue-Specific Modulation of Immunity and Separation of Gvhd From GVL

Alan M. Hanash, MD, PhD, Lucy W. Kappel, Nury L. Yim, Rebecca A. Nejat, Gabrielle L. Goldberg, Odette M. Smith, Uttam K. Rao, Lindsay Dykstra, Il-Kang Na, Amanda M. Holland, Chen Liu, George F. Murphy, Warren J Leonard, Glenn Heller, PhD, Marcel R.M. van den Brink, MD, PhD

Blood (2010) 116 (21): 729.

https://doi.org/10.1182/blood.V116.21.729.729

Published: 2010

Journal Articles

Lack of IL-21 Signal Attenuates Graft-Versus-Leukemia Effect In the Absence of CD8 T-Cells.

Katsutoshi Ozaki, MD, PhD, Akiko Meguro, Keiko Hatanaka, Iekuni Oh, Haruko Matsu, Raine Tatara, Kazuya Sato, MD, Warren J Leonard, Keiya Ozawa, MD, PhD

Blood (2010) 116 (21): 3739.

https://doi.org/10.1182/blood.V116.21.3739.3739

Published: 2010

Journal Articles

Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities

Fouad Eddahri, Sébastien Denanglaire, Fabrice Bureau, Rosanne Spolski, Warren J. Leonard, Oberdan Leo, Fabienne Andris

Blood (2009) 113 (11): 2426–2433.

https://doi.org/10.1182/blood-2008-04-154682

Published: 2009

Includes: Supplemental data

Journal Articles

Angiostatic activity of the antitumor cytokine interleukin-21

Karolien Castermans, Sebastien P. Tabruyn, Rong Zeng, Judy R. van Beijnum, Cheryl Eppolito, Warren J. Leonard, Protul A. Shrikant, Arjan W. Griffioen

Blood (2008) 112 (13): 4940–4947.

https://doi.org/10.1182/blood-2007-09-113878

Published: 2008

Includes: Supplemental data

Journal Articles

The IL-15 receptor α chain cytoplasmic domain is critical for normal IL-15Rα function but is not required for trans -presentation

Zheng Wu, Hai-Hui Xue, Jérôme Bernard, Rong Zeng, Dmitry Issakov, Julie Bollenbacher-Reilley, Igor M. Belyakov, SangKon Oh, Jay A. Berzofsky, Warren J. Leonard

Blood (2008) 112 (12): 4411–4419.

https://doi.org/10.1182/blood-2007-03-080697

Published: 2008

Journal Articles

Blocking of IL-21 Signal Attenuates Graft-Versus-Host Disease but Not Graft-Versus-Leukemia Effect in a Mouse Model

Akiko Meguro, Katsutoshi Ozaki, Iekuni Oh, Haruko Matsu, Keiko Hatanaka, Raine Tatara, Warren J Leonard, Kazuya Sato, Keiya Ozawa

Blood (2008) 112 (11): 1248.

https://doi.org/10.1182/blood.V112.11.1248.1248

Published: 2008

Journal Articles

A Phase I/II Trial of the Kinesin Spindle Protein (KSP) Inhibitor SB- 743921 Administered on Days 1 and 15 Every 28 Days without and with Prophylactic G-CSF in Non-Hodgkin or Hodgkin Lymphoma.

John Gerecitano, O. O’Connor, H. Van Deventer, J. Hainsworth, J. Leonard, A. Goy, B. Afanasyev, M. Chen, K. Saikali, M. G Conlan, R Escandon, A Wolff

Blood (2008) 112 (11): 1563.

https://doi.org/10.1182/blood.V112.11.1563.1563

Published: 2008

Journal Articles

Development of regulatory T cells requires IL-7Rα stimulation by IL-7 or TSLP

Renata Mazzucchelli, Julie A. Hixon, Rosanne Spolski, Xin Chen, Wen Qing Li, Veronica L. Hall, Jami Willette-Brown, Arthur A. Hurwitz, Warren J. Leonard, Scott K. Durum

Blood (2008) 112 (8): 3283–3292.

https://doi.org/10.1182/blood-2008-02-137414

Published: 2008

Journal Articles

IL-2 and IL-21 confer opposing differentiation programs to CD8 + T cells for adoptive immunotherapy

Christian S. Hinrichs, Rosanne Spolski, Chrystal M. Paulos, Luca Gattinoni, Keith W. Kerstann, Douglas C. Palmer, Christopher A. Klebanoff, Steven A. Rosenberg, Warren J. Leonard, Nicholas P. Restifo

Blood (2008) 111 (11): 5326–5333.

https://doi.org/10.1182/blood-2007-09-113050

Published: 2008

Includes: Supplemental data

Journal Articles

Thymic stromal lymphopoietin is not necessary or sufficient to mediate the thymopoietic effects of keratinocyte growth factor

Martin Guimond, Warren J. Leonard, Rosanne Spolski, Simona W. Rossi, Rachelle G. Veenstra, Georg A. Hollander, Crystal L. Mackall, Bruce R. Blazar

Blood (2008) 111 (2): 969–970.

https://doi.org/10.1182/blood-2007-09-113316

Published: 2008

Journal Articles

Critical role for Rsk2 in T-lymphocyte activation

Jian-Xin Lin, Rosanne Spolski, Warren J. Leonard

Blood (2008) 111 (2): 525–533.

https://doi.org/10.1182/blood-2007-02-072207

Published: 2008

Includes: Supplemental data

Journal Articles

A Stat5b transgene is capable of inducing CD8 + lymphoblastic lymphoma in the absence of normal TCR/MHC signaling

Katherine Bessette, Mark L. Lang, Roy A. Fava, Martin Grundy, Jennifer Heinen, Laurie Horne, Rosanne Spolski, Amin Al-Shami, Herbert C. Morse, III, Warren J. Leonard, John A. Kelly

Blood (2008) 111 (1): 344–350.

https://doi.org/10.1182/blood-2007-04-084707

Published: 2008

Includes: Supplemental data

Journal Articles

The molecular basis of IL-21–mediated proliferation

Rong Zeng, Rosanne Spolski, Esther Casas, Wei Zhu, David E. Levy, Warren J. Leonard

Blood (2007) 109 (10): 4135–4142.

https://doi.org/10.1182/blood-2006-10-054973

Published: 2007

Journal Articles

Lenalidomide Induced Myelosupression Is Potentially Associated with Renal Dysfunction in Treatment Naïve Myeloma (MM) Patients Receiving BiRD (Biaxin®/Revlimid®/Dexamethasone) Combination Therapy (Rx).

Ruben Niesvizky, MD, D.S. Jayabalan, F. Zafar, P. Christos, R. Lent, MD, R. Pearse, MD,PhD, J. Tepler, MD, S. Ely, MD, T. Shore, MD, J. Harpel, MD, PhD, M. Schuster, MD, K. Pekle, J.B. Jalbrzikowski, H.J. Cho, MD,PhD, J. Leonard, MD, M. Mazumdar, S. Chen-Kiang, PhD, M. Coleman, MD

Blood (2006) 108 (11): 3549.

https://doi.org/10.1182/blood.V108.11.3549.3549

Published: 2006

Journal Articles

Maturation stage–specific regulation of megakaryopoiesis by pointed-domain Ets proteins

Liyan Pang, Hai-Hui Xue, Gabor Szalai, Xun Wang, Yuhuan Wang, Dennis K. Watson, Warren J. Leonard, Gerd A. Blobel, Mortimer Poncz

Blood (2006) 108 (7): 2198–2206.

https://doi.org/10.1182/blood-2006-04-019760

Published: 2006

Journal Articles

BiRD (Biaxin®/Revlimid®/Dexamethasone) Combination Therapy (Rx) Results in High Complete Remissions (CR) and Overall Responses in Myeloma (MM) with Poor Prognostic Features.

Ruben Niesvizky, MD, K. Pekle, RN, ANPC, U. Gelbshtein, F. Zafar, RPAC, S. Ostrow, MD, R. Pearse, MD, PhD, H. Cho, MD, PhD, J. Tepler, MD, S. Ely, MD, R. Lent, PhD, D. Jayabalan, T. Shore, MD, J. Harpel, MD, PhD, M. Schuster, MD, L. Lyons, R. Furman, MD, J. Leonard, MD, S. Chen-Kiang, PhD, M. Coleman, MD

Blood (2005) 106 (11): 642.

https://doi.org/10.1182/blood.V106.11.642.642

Published: 2005

Journal Articles

HTLV-1 p12 I protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells

Christophe Nicot, James C. Mulloy, Maria G. Ferrari, Julie M. Johnson, Kaisong Fu, Risaku Fukumoto, Raffaella Trovato, Jake Fullen, Warren J. Leonard, Genoveffa Franchini

Blood (2001) 98 (3): 823–829.

https://doi.org/10.1182/blood.V98.3.823

Published: 2001

NARROW

The Yin and Yang of Interleukin-21 in Allergy, Autoimmunity and Cancer

Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL

p90RSK2 is essential for FLT3-ITD– but dispensable for BCR-ABL–induced myeloid leukemia

Abrogation of Donor T Cell IL-21 Signaling Leads to Tissue-Specific Modulation of Immunity and Separation of Gvhd From GVL

Lack of IL-21 Signal Attenuates Graft-Versus-Leukemia Effect In the Absence of CD8 T-Cells.

Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities

Angiostatic activity of the antitumor cytokine interleukin-21

The IL-15 receptor α chain cytoplasmic domain is critical for normal IL-15Rα function but is not required for trans -presentation

Blocking of IL-21 Signal Attenuates Graft-Versus-Host Disease but Not Graft-Versus-Leukemia Effect in a Mouse Model

A Phase I/II Trial of the Kinesin Spindle Protein (KSP) Inhibitor SB- 743921 Administered on Days 1 and 15 Every 28 Days without and with Prophylactic G-CSF in Non-Hodgkin or Hodgkin Lymphoma.

Development of regulatory T cells requires IL-7Rα stimulation by IL-7 or TSLP

IL-2 and IL-21 confer opposing differentiation programs to CD8 + T cells for adoptive immunotherapy

Thymic stromal lymphopoietin is not necessary or sufficient to mediate the thymopoietic effects of keratinocyte growth factor

Critical role for Rsk2 in T-lymphocyte activation

A Stat5b transgene is capable of inducing CD8 + lymphoblastic lymphoma in the absence of normal TCR/MHC signaling

The molecular basis of IL-21–mediated proliferation

Lenalidomide Induced Myelosupression Is Potentially Associated with Renal Dysfunction in Treatment Naïve Myeloma (MM) Patients Receiving BiRD (Biaxin®/Revlimid®/Dexamethasone) Combination Therapy (Rx).

Maturation stage–specific regulation of megakaryopoiesis by pointed-domain Ets proteins

BiRD (Biaxin®/Revlimid®/Dexamethasone) Combination Therapy (Rx) Results in High Complete Remissions (CR) and Overall Responses in Myeloma (MM) with Poor Prognostic Features.

HTLV-1 p12 I protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells

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American Society of Hematology

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American Society of Hematology

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